Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis

British Journal of Haematology

Volumn 106, Issue 3, 1999, Pages 752-755

  Cazzola, Mario ^a,d   Beguin, Yves ^b   Bergamaschi, Gaetano ^a   Guarnone, Roberta ^a   Cerani, Paola ^a   Barella, Susanna ^c   Cao, Antonio ^c   Galanello, Renzo ^c  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Anaemia; Erythropoiesis; Erythropoietin; Iron overload; Soluble transferrin receptor

Indexed keywords

TRANSFERRIN RECEPTOR;

ADULT; AGED; ANEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROPOIESIS; FERRITIN BLOOD LEVEL; HUMAN; IRON METABOLISM; IRON OVERLOAD; PRIORITY JOURNAL; REGRESSION ANALYSIS; SCHOOL CHILD; SIDEROBLASTIC ANEMIA;

ADOLESCENT; ADULT; AGED; ANEMIA, DYSERYTHROPOIETIC, CONGENITAL; ANEMIA, SIDEROBLASTIC; BETA-THALASSEMIA; CHILD; ERYTHROPOIESIS; HETEROZYGOTE; HUMANS; IRON OVERLOAD; MIDDLE AGED; MUTATION; RECEPTORS, TRANSFERRIN;

EID: 0032877032     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01600.x     Document Type: Article

References (12)

1. Baynes, R.D. (1995) Transferrin reduces the production of soluble transferrin receptor. Proceedings of the Society for Experimental Biology and Medicine, 209, 286-294.
2. Cazzola, M., Barosi, G., Bergamaschi, G., Dezza, L., Palestra, P., Polino, G., Ramella, S., Spriano, P. & Ascari, E. (1983) Iron loading in congenital dyserythropoietic anaemias and congenital sideroblastic anaemias. British Journal of Haematology, 54, 649-654.
3. Feder, J.N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D.A., Basava, A., Dormishian, F., Domingo, R., Jr, Ellis, M.C., Fullan, A., Hinton, L.M., Jones, N.L., Kimmel, B.E., Kronmal, G.S., Lauer, P., Lee, V.K., Loeb, D.B., Mapa, F.A., McClelland, E., Meyer, N.C., Mintier, G.A., Moeller, N., Moore, T., Morikang, E., Prass, C.E., Quintana, L., Starnes, S.M., Schatzman, R.C., Brunke, K.J., Drayna, D.T., Risch, N.J., Bacon, B.R. & Wolff, RK. (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genetics, 13, 399-408.
4. Feder, J.N., Penny, D.M., Irrinki, A., Lee, V.K., Lebroacuten, J.A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P.J. & Schatzman, R.C. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proceedings of the National Academy of Sciences of the United States of America, 95, 1472-1477.
5. Finch, C.A. (1994) Regulators of iron balance in humans. Blood, 84, 1697-1702.
6. Huebers, H.A., Beguin, Y., Pootrakul, P., Einspahr, D. & Finch, C.A. (1990) Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood, 75, 102-107.
7. Lebron, J.A., Bennett, M.J., Vaughn, D.E., Chirino, A.J., Snow, P.M., Mintier, G.A., Feder, J.N. & Bjorkman, P.J. (1998) Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell, 93, 11-123.
8. Peto, T.E., Pippard, M.J. & Weatherall, D.J. (1983) Iron overload in mild sideroblastic anaemias. Lancet, i, 375-378.
9. Pippard, M.J., Callender, S.T., Warner, G.T. & Weatherall, D.J. (1979) Iron absorption and loading in β-thalassaemia intermedia. Lancet, ii, 819-821.
10. Pootrakul, P., Kitcharoen, K., Yansukon, P., Wasi, P., Fucharoen, S., Charoenlarp, P., Brittenham, G., Pippard, M.J. & Finch, C.A. (1988) The effect of erythroid hyperplasia on iron balance. Blood, 71, 1124-1129.
11. Shih, Y.J., Baynes, R.D., Hudson, B.G., Flowers, C.H., Skikne, B.S. & Cook, J.D. (1990) Serum transferrin receptor is a truncated form of tissue receptor. Journal of Biological Chemistry, 265, 19077-19081.
12. Weiss, G., Houston, T., Kastner, S., Johrer, K., Grunewald, K. & Brock, J.H. (1997) Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells. Blood, 89, 680-687.