Soluble transferrin receptor-1 levels in mice do not affect iron absorption

Acta Haematologica

Volumn 116, Issue 4, 2006, Pages 249-254

  Flanagan, Jonathan M ^a   Peng, Hongfan ^a   Wang, Lei ^a   Gelbart, Terri ^a   Lee, Pauline ^a   Johnson Sasu, Barbra ^b   Beutler, Ernest ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b AMGEN INC   (United States)

Author keywords

Erythropoiesis; Iron absorption; Transferrin receptor 1, soluble

Indexed keywords

CD71 ANTIGEN; HEPCIDIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ERYTHROPOIESIS; FEMALE; GENE CONSTRUCT; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; IRON ABSORPTION; IRON BLOOD LEVEL; MALE; MEASUREMENT; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; FEMALE; GENE TRANSFER TECHNIQUES; HUMANS; INTESTINAL ABSORPTION; IRON; LIVER; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 33751281494     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095875     Document Type: Article

References (28)

1. Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K: LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-150.
2. Park CH, Valore EV, Waring AJ, Ganz T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-7810.
3. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-7819.
4. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-8785.
5. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S: The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-1044.
6. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J: Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-2093.
7. Beguin Y, Huebers HA, Josephson B, Finch CA: Transferrin receptors in rat plasma. Proc Natl Acad Sci USA 1988;85:637-640.
8. Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD: Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem 1990;265:19077-19081.
9. Ahn J, Johnstone RM: Origin of a soluble truncated transferrin receptor. Blood 1993;81:2442-2451.
10. Hikawa H, Nomata Y, Suzuki H, Ozasa H, Yamada O: Soluble transferrin receptor-transferrin complex in serum: measurement by latex agglutination nephelometric immunoassay. Clin Chim Acta 1996;254:159-172.
11. Kogan A, Filatov V, Gusev N, Bereznikova A, Kolosova O, Katrukha A: Immunological study of complex formation between soluble transferrin receptor and transferrin. Am J Hematol 2005;79:281-287.
12. Skikne BS, Flowers CH, Cook JD: Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood 1990;75:1870-1876.
13. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA: Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 1990;75:102-107.
14. Yang PL, Althage A, Chung J, Chisari FV: Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 2002;99:13825-13830.
15. Zhang G, Gao J, Song YK, Vollmer R, Stolz DB, Gasiorowski JZ, Dean DA, Liu D: Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther 2004;11:675-682.
16. Arad U, Zeira E, El Latif MA, Mukherjee S, Mitchell L, Pappo O, Galun E, Oppenheim A: Liver-targeted gene therapy by SV40-based vectors using the hydrodynamic injection method. Hum Gene Ther 2005;16:371-381.
17. Zhang G, Budker V, Wolff JA: High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999;10:1735-1737.
18. Beutler E, Kelly BM: The relationship between iron dosage and iron absorption. Am J Clin Nutr 1962;10:348.
19. Lee P, Peng H, Gelbart T, Wang L, Beutler E: Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005;102:1906-1910.
20. Das Gupta A, Abbi A: High serum transferrin receptor level in anemia of chronic disorders indicates coexistent iron deficiency. Am J Hematol 2003;72:158-161.
21. Duits AJ, Rojer RA, van Endt T, Mac Gillavry MR, Ten Cate H, Brandjes DPM, Schnog JB: Erythropoiesis and serum sVCAM-1 levels in adults with sickle cell disease. Ann Hematol 2003;82:171-174.
22. Beguin Y: Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta 2003;329:9-22.
23. Finch CA: Erythropoiesis, erythropoietin, and iron. Blood 1982;60:1241-1246.
24. Greenman J, Jacobs A: The effect of iron stores on iron absorption in the rat: the possible role of circulating ferritin. Gut 1975;16:613-616.
25. Wheby MS, Umpire G: Effect of transferrin saturation on iron absorption in man. N Engl J Med 1964;271:1391-1395.
26. Wilkins SJ, Frazer DM, Millard KN, McLaren GD, Anderson GJ: Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood 2006;107:1659-1664.
27. Ponka P, Lok CN: The transferrin receptor: role in health and disease. Int J Biochem Cell Biol 1999;31:1111-1137.
28. Lim JE, Jin O, Bennett C, Morgan K, Wang F, Trenor CC, Fleming MD, Andrews NC: A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. Nat Genet 2005;37:1270-1273.