A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration

Tissue Engineering - Part A

Volumn 16, Issue 7, 2010, Pages 2369-2379

  Yoshii, Toshitaka ^a,b   Hafeman, Andrea E ^a,c   Nyman, Jeffry S ^a,d   Esparza, Javier M ^a   Shinomiya, Kenichi ^b   Spengler, Dan M ^a   Mundy, Gregory R ^a   Gutierrez, Gloria E ^a   Guelcher, Scott A ^a,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c VANDERBILT UNIVERSITY   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BONE; TISSUE ENGINEERING;

BIODEGRADABLE POLYURETHANES; BONE FORMATION; BONE REGENERATION; BONE TISSUE ENGINEERING; BONE TISSUE REGENERATION; DEFECT MODEL; DELIVERY SYSTEMS; IN-VITRO; IN-VIVO; INTERCONNECTED PORES; LOVASTATIN; MATRIX; OSTEOBLASTIC CELLS; OSTEOCONDUCTIVE; OSTEOGENIC DIFFERENTIATION; POLYURETHANE SCAFFOLDS; POROUS STRUCTURES; SUSTAINED RELEASE; TWO-COMPONENT;

SCAFFOLDS;

RATTUS;

BIOMATERIAL; ELASTOMER; MEVINOLIN; POLYURETHAN; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BONE; BONE DEVELOPMENT; BONE REGENERATION; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DELAYED RELEASE FORMULATION; DRUG EFFECT; KINETICS; MALE; MOUSE; RAT; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE REGENERATION; CELL DIFFERENTIATION; DELAYED-ACTION PREPARATIONS; ELASTOMERS; KINETICS; LOVASTATIN; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; OSTEOGENESIS; POLYURETHANES; RATS; RATS, SPRAGUE-DAWLEY; TISSUE SCAFFOLDS;

EID: 77954525751     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0585     Document Type: Article

References (65)

1. Lysaght, M.J., and Reyes, J. The growth of tissue engineering. Tissue Eng 7, 485, 2001.
2. Enneking, W.F., Eady, J.L., and Burchardt, H. Autogenous cortical bone grafts in the reconstruction of segmental skeletal defects. J Bone Joint Surg Am 62, 1039, 1980.
3. Younger, E.M., and Chapman, M.W. Morbidity at bone graft donor sites. J Orthop Trauma 3, 192, 1989.
4. Perry, C.R. Bone repair techniques, bone graft, and bone graft substitutes. Clin Orthop Relat Res 360, 71, 1999.
5. Finkemeier, C.G. Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am 84-A, 454, 2002.
6. Giannoudis, P.V., Dinopoulos, H., and Tsiridis, E. Bone substitutes: an update. Injury 36 Suppl 3, S20, 2005.
7. Zhang, J.Y., Beckman, E.J., Hu, J., Yang, G.G., Agarwal, S., and Hollinger, J.O. Synthesis, biodegradability, and bio-compatibility of lysine diisocyanate-glucose polymers. Tissue Eng 8, 771, 2002.
8. Li, B., Davidson, J.M., and Guelcher, S.A. The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds. Biomaterials 30, 3486, 2009.
9. Hafeman, A.E., Li, B., Yoshii, T., Zienkiewicz, K., Davidson, J.M., and Guelcher, S.A. Injectable biodegradable polyure-thane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration. Pharm Res 25, 2387, 2008.
10. Guan, J., Sacks, M.S., Beckman, E.J., and Wagner, W.R. Synthesis, characterization, and cytocompatibility of elastomeric, biodegradable poly(ester-urethane)ureas based on poly(cap-rolactone) and putrescine. J Biomed Mater Res 61, 493, 2002.
11. Fujimoto, K.L., Guan, J., Oshima, H., Sakai, T., and Wagner, W.R. In vivo evaluation of a porous, elastic, biodegradable patch for reconstructive cardiac procedures. Ann Thorac Surg 83, 648, 2007.
12. Gorna, K., and Gogolewski, S. Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes. J Biomed Mater Res A 67, 813, 2003.
13. Adhikari, R., Gunatillake, P.A., Griffiths, I., Tatai, L., Wick-ramaratna, M., Houshyar, S., et al. Biodegradable injectable polyurethanes: synthesis and evaluation for orthopaedic applications. Biomaterials 29, 3762, 2008.
14. Guelcher, S.A., Patel, V., Gallagher, K.M., Connolly, S., Didier, J.E., Doctor, J.S., and Hollinger, J.O. Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds. Tissue Eng 12, 1247, 2006.
15. Guelcher, S., Srinivasan, A., Hafeman, A., Gallagher, K., Doctor, J., Khetan, S., McBride, S., and Hollinger, J. Synthesis, in vitro degradation, and mechanical properties of two-component poly(ester urethane)urea scaffolds: effects of water and polyol composition. Tissue Eng 13, 2321, 2007.
16. Guelcher, S.A. Biodegradable polyurethanes: synthesis and applications in regenerative medicine. Tissue Eng Part B Rev 14, 3, 2008.
17. Guan, J., Stankus, J.J., and Wagner, W.R. Biodegradable elastomeric scaffolds with basic fibroblast growth factor release. J Control Release 120, 70, 2007.
18. Li, B., Yoshii, T., Hafeman, A.E., Nyman, J.S., Wenke, J.C., and Guelcher, S.A. The effects of rhBMP-2 released from biodegradable polyurethane=microsphere composite scaffolds on new bone formation in rat femora. Biomaterials 30, 6768, 2009.
19. Liao, J.K., and Laufs, U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45, 89, 2005.
20. Almuti, K., Rimawi, R., Spevack, D., and Ostfeld, R.J. Effects of statins beyond lipid lowering: potential for clinical benefits. Int J Cardiol 109, 7, 2006.
21. Weber, M.S., Youssef, S., Dunn, S.E., Prod'homme, T., Neuhaus, O., Stuve, O., Greenwood, J., Steinman, L., and Zamvil, S.S. Statins in the treatment of central nervous system autoimmune disease. J Neuroimmunol 178, 140, 2006.
22. Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M., and Gutierrez, G. Stimulation of bone formation in vitro and in rodents by statins. Science 286, 1946, 1999.
23. Garrett, I.R., Gutierrez, G., and Mundy, G.R. Statins and bone formation. Curr Pharm Des 7, 715, 2001.
24. Maeda, T., Matsunuma, A., Kawane, T., and Horiuchi, N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun 280, 874, 2001.
25. Maeda, T., Matsunuma, A., Kurahashi, I., Yanagawa, T., Yoshida, H., and Horiuchi, N. Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells. J Cell Biochem 92, 458, 2004.
26. Baek, K.H., Lee, W.Y., Oh, K.W., Tae, H.J., Lee, J.M., Lee, E.J., Han, J.H., Kang, M.I., Cha, B.Y., Lee, K.W., Son, H.Y., and Kang, S.K. The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells. J Korean Med Sci 20, 438, 2005.
27. Schachter, M. Chemical, pharmacokinetic and pharmacody-namic properties of statins: an update. Fundam Clin Pharmacol 19, 117, 2005.
28. Armitage, J. The safety of statins in clinical practice. Lancet 370, 1781, 2007.
29. Mundy, G.R. Statins and their potential for osteoporosis. Bone 29, 495, 2001.
30. Gonyeau, M.J. Statins and osteoporosis: a clinical review. Pharmacotherapy 25, 228, 2005.
31. Gutierrez, G.E., Lalka, D., Garrett, I.R., Rossini, G., and Mundy, G.R. Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporos Int 17, 1033, 2006.
32. Toh, S., and Hernandez-Diaz, S. Statins and fracture risk. A systematic review. Pharmacoepidemiol Drug Saf 16, 627, 2007.
33. Stein, D., Lee, Y., Schmid, M.J., Killpack, B., Genrich, M.A., Narayana, N., et al. Local simvastatin effects on mandibu-lar bone growth and inflammation. J Periodontol 76, 1861, 2005.
34. Nyan, M., Sato, D., Oda, M., Machida, T., Kobayashi, H., Nakamura, T., and Kasugai, S. Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect. J Pharmacol Sci 104, 384, 2007.
35. Whang, K., McDonald, J., Khan, A., and Satsangi, N. A novel osteotropic biomaterial OG-PLG: synthesis and in vitro release. J Biomed Mater Res A 74A, 237, 2005.
36. Benoit, D.S., Nuttelman, C.R., Collins, S.D., and Anseth, K.S. Synthesis and characterization of a fluvastatin-releasing hy-drogel delivery systemtomodulate hMSC differentiation and function for bone regeneration. Biomaterials 27, 6102, 2006.
37. Garrett, I.R., Gutierrez, G.E., Rossini, G., Nyman, J., McCluskey, B., Flores, A., and Mundy, G.R. Locally delivered lovastatin nanoparticles enhance fracture healing in rats. J Orthop Res 25, 1351, 2007.
38. Jeon, J.H., Piepgrass, W.T., Lin, Y.L., Thomas, M.V., and Puleo, D.A. Localized intermittent delivery of simvastatin hydroxyacid stimulates bone formation in rats. J Periodontol 79, 1457, 2008.
39. Wutticharoenmongkol, P., Pavasant, P., and Supaphol, P. Osteoblastic phenotype expression of MC3T3-E1 cultured on electrospun polycaprolactone fiber mats filled with hy-droxyapatite nanoparticles. Biomacromolecules 8, 2602, 2007.
40. Zhang, L.F., Yang de, J., Chen, H.C., Sun, R., Xu, L., Xiong, Z.C., Govender, T., and Xiong, C.D. An ionically crosslinked hydrogel containing vancomycin coating on a porous scaffold for drug delivery and cell culture. Int J Pharm 353, 74, 2008.
41. Zhao, M., Ko, S.Y., Liu, J.H., Chen, D., Zhang, J., Wang, B., Harris, S.E., Oyajobi, B.O., and Mundy, G.R. Inhibition of microtubule assembly in osteoblasts stimulates bone mor-phogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol Cell Biol 29, 1291, 2009.
42. Karp, J.M., Rzeszutek, K., Shoichet, M.S., and Davies, J.E. Fabrication of precise cylindrical three-dimensional tissue engineering scaffolds for in vitro and in vivo bone engineering applications. J Craniofac Surg 14, 317, 2003.
43. Torigoe, I., Sotome, S., Tsuchiya, A., Yoshii, T., Maehara, H., Sugata, Y., Inchinose, S., Shinomiya, K., and Okawa, A. Bone regeneration with autologous plasma, bone marrow stromal cells, and porous beta-tricalcium phosphate in nonhuman primates. Tissue Eng Part A 15, 1489, 2009.
44. Gorna, K., and Gogolewski, S. Biodegradable polyurethanes for implants. II. In vitro degradation and calcification of materials from poly(epsilon-caprolactone)-poly(ethylene oxide) diols and various chain extenders. J Biomed Mater Res 60, 592, 2002.
45. Zhao, M., Harris, S.E., Horn, D., Geng, Z., Nishimura, R., Mundy, G.R., and Chen, D. Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol 157, 1049, 2002.
46. Im, G.I., Qureshi, S.A., Kenney, J., Rubash, H.E., and Shanbhag, A.S. Osteoblast proliferation and maturation by bisphosphonates. Biomaterials 25, 4105, 2004.
47. Reinholz, G.G., Getz, B., Pederson, L., Sanders, E.S., Sub-ramaniam, M., Ingle, J.N., and Spelsberg, T.C. Bispho-sphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts. Cancer Res 60, 6001, 2000.
48. Plotkin, L.I., Weinstein, R.S., Parfitt, A.M., Roberson, P.K., Manolagas, S.C., and Bellido, T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest 104, 1363, 1999.
49. Rose, F.R., Hou, Q., and Oreffo, R.O. Delivery systems for bone growth factors-the new players in skeletal regeneration. J Pharm Pharmacol 56, 415, 2004.
50. Drosse, I., Volkmer, E., Capanna, R., De Biase, P., Mutschler, W., and Schieker, M. Tissue engineering for bone defect healing: an update on a multi-component approach. Injury 39 Suppl 2, S9, 2008.
51. Hafeman, A.E., Zienkiewicz, K.J., Carney, E., Litzner, B., Stratton, C.W., Wenke, J.C., and Guelcher, S.A. Local delivery of tobramycin from injectable biodegradable poly-urethane scaffolds. J Biomater Sci Polym Ed 21, 95, 2010.
52. Park, K. Controlled Drug Delivery: Challenges and Strategies. Washington, DC: American Chemical Society
53. Guelcher, S.A., Dumas, J., Srinivasan, A., Didier, J.E., and Hollinger, J.O. Synthesis, mechanical properties, biocom-patibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Biomaterials 29, 1762, 2008.
54. Alessandri, C., and Peverini, F. [Hypercholesterolemia: therapeutic approach]. Clin Ter 137, 373, 1991.
55. Mont, M.A., Ragland, P.S., Biggins, B., Friedlaender, G., Patel, T., Cook, S., et al. Use of bone morphogenetic proteins for musculoskeletal applications. An overview. J Bone Joint Surg Am 86-A Suppl 2, 41, 2004.
56. Wozney, J.M., and Rosen, V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res 346, 26, 1998.
57. Termaat, M.F., Den Boer, F.C., Bakker, F.C., Patka, P., and Haarman, H.J. Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects. J Bone Joint Surg Am 87, 1367, 2005.
58. Paderni, S., Terzi, S., and Amendola, L. Major bone defect treatment with an osteoconductive bone substitute. Chir Organi Mov 93, 89, 2009.
59. Wong, R.W., and Rabie, A.B. Statin collagen grafts used to repair defects in the parietal bone of rabbits. Br J Oral Maxillofac Surg 41, 244, 2003.
60. Wong, R.W., and Rabie, A.B. Histologic and ultrastructural study on statin graft in rabbit skulls. J Oral Maxillofac Surg 63, 1515, 2005.
61. Alam, S., Ueki, K., Nakagawa, K., Marukawa, K., Hashiba, Y., Yamamoto, E., Sakulsak, N., and Iseki, S. Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107, 22, 2009.
62. Seeherman, H., Li, R., Bouxsein, M., Kim, H., Li, X.J., Smith-Adaline, E.A., Aiolova, M., and Wozney, J.M. rhBMP-2= calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations. J Bone Joint Surg Am 88, 144, 2006.
63. th Orthopaedic Research Society Annual Meeting, Las Vegas, NV, 2009. Abstract no. 130.
64. Moore, D.C., Pedrozo, H.A., Crisco, J.J., 3rd, and Ehrlich, M.G. Preformed grafts of porcine small intestine submucosa (SIS) for bridging segmental bone defects. J Biomed Mater Res A 69, 259, 2004.
65. Chu, T.M., Warden, S.J., Turner, C.H., and Stewart, R.L. Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2. Biomaterials 28, 459, 2007.