Localized intermittent delivery of simvastatin hydroxyacid stimulates bone formation in rats

Journal of Periodontology

Volumn 79, Issue 8, 2008, Pages 1457-1464

  Ju, Hyeong Jeon ^a   Piepgrass, Ward T ^b   Lin, Yi Ling ^b   Thomas, Mark V ^b   Puleo, David A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY COLLEGE OF DENTISTRY   (United States)

Author keywords

Controlled release; Osteogenesis; Simvastatin; Simvastatin hydroxyacid; Sustained release

Indexed keywords

CELLACEFATE; CELLULOSE; DRUG CARRIER; DRUG DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LACTIC ACID; MACROGOL DERIVATIVE; MICROSPHERE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; SIMVASTATIN; SIMVASTATIN HYDROXYACID;

ANIMAL; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; MALE; PATHOLOGY; RAT; SKULL; SPRAGUE DAWLEY RAT; TIME; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; CELLULOSE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LACTIC ACID; MALE; MICROSPHERES; MODELS, ANIMAL; OSTEOGENESIS; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SKULL; TIME FACTORS;

EID: 49149115530     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2008.080004     Document Type: Article

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