Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation

Journal of Cell Biology

Volumn 157, Issue 6, 2002, Pages 1049-1060

  Zhao, Ming ^a   Harris, Stephen E ^b   Horn, Diane ^a   Geng, Zhaopo ^a   Nishimura, Riko ^c   Mundy, Gregory R ^a   Chen, Di ^a,d  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

BMP; Bone formation; Osteoblast differentiation; Receptor; Transgenic mice

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DENSITY; BONE GROWTH; BONE MATRIX; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINEAGE; CELL VIABILITY; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; ENZYME SPECIFICITY; HOMOZYGOSITY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

ANIMALS; BODY WEIGHT; BONE DENSITY; BONE DEVELOPMENT; BONE DISEASES, METABOLIC; BONE MATRIX; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; CELL DIFFERENTIATION; CELLS, CULTURED; MICE; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOGENESIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0037054548     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200109012     Document Type: Article

References (54)

1. Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells
2. Cartilage-derived morphogenetic proteins
3. Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4 and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts
4. Differential roles for BMP receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages
5. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
6. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
7. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
8. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
9. XBMPRII, a novel Xenopus type II receptor mediating BMP signaling in embryonic tissues
10. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vitro
11. Head induction by simultaneous repression of Bmp and Wnt signaling in Xenopus
12. MADRI, a MAD-related protein that functions in BMP2 signaling pathways
13. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation
14. Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-κ B ligand
15. BMP signaling during bone pattern determination in the developing limb
16. Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes
17. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells
18. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest ofosteoblasts
19. Characterization of a bone morphogenetic protein-responsive Smad-binding element
20. Human type II receptor for bone morphogenetic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
21. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
22. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
23. A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: Roles of animal pole tissue in the development of ventral mesoderm
24. In vivo effects of human recombinant transforming growth factor beta on bone turnover in normal mice
25. Hybridization of nucleic acids immobilized on solid supports
26. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
27. Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5
28. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats
29. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
30. Separate cis-acting DNA elements of the mouse pro-1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice
31. Identification of a minimal sequence of the mouse pro-1(I) collagen promoter that confers high-level osteablast expression in transgenic mice and that binds a protein selectively present in osteoblasts
32. Recombinant human osteogenic protein-1 (hOP-1) induces bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro
33. GDF5 coordinates bone and joint formation during digit development
34. Limb alterations in brachypodism mice due to mutations in a new member of the TGF-superfamily
35. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
36. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
37. A human chondrodysplasia due to a mutation in a TGF superfamily member
38. Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
39. 5-Lipoxygenase metabolites inhibit bone formation in vitro
40. Bone formation by autoinduction
41. Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo
42. Utilization of bone morphogenetic protein receptors during chondrocyte maturation
43. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
44. The bone morphogenetic protein family and osteogenesis
45. Novel regulators of bone formation: Molecular clones and activities
46. A mammalian serinel threonine kinase receptor specifically binds BMP-2 and BMP-4
47. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
48. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
49. The type I BMP receptor Bmpr1B is essential for female reproductive function
50. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
51. Requirement for BMP signaling in interdigital apoptosis and scale formation
52. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage