Sequential and γ-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth

Journal of Cell Science

Volumn 123, Issue 13, 2010, Pages 2319-2331

  Stoeck, Alexander ^a   Shang, Li ^a   Dempsey, Peter J ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

ADAM10; Betacellulin; Palmitoylation; Regulated intramembrane proteolysis; Reverse signaling

Indexed keywords

ADAM10 ENDOPEPTIDASE; BETACELLULIN; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2; ADAM PROTEIN; ADAM10 PROTEIN, MOUSE; BTC PROTEIN, HUMAN; BTC PROTEIN, MOUSE; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PROTEIN PRECURSOR; SECRETASE; SIGNAL PEPTIDE;

ARTICLE; CELL DIVISION; CELL FUNCTION; CELL GROWTH; CELL NUCLEUS MEMBRANE; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTANT; PALMITOYLATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CELL PROLIFERATION; CHEMISTRY; GENETICS; KNOCKOUT MOUSE; LIPOYLATION; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN TERTIARY STRUCTURE;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CELL PROLIFERATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOYLATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; BETACELLULIN;

EID: 77954380513     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.060830     Document Type: Article

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