Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation

Immunology and Cell Biology

Volumn 88, Issue 5, 2010, Pages 545-554

  Aguiló, Juan I ^a   Anel, Alberto ^a   Catalán, Elena ^a   Sebastián, Alvaro ^a   Acín Pérez, Rebeca ^a   Naval, Javier ^a   Wallich, Reinhard ^b   Simon, Markus M ^c   Pardo, Julián ^a,c,d  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d CENTRO DE INVESTIGACIÓN Y TECNOLOGÍA AGROALIMENTARIA DE ARAGÓN CITA   (Spain)

Author keywords

cell death; granzyme B; NADPH oxidase; reactive oxygen species

Indexed keywords

APOCYNIN; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CYTOCHROME C; GRANZYME B; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STREPTOLYSIN; SUPEROXIDE; CASPASE; GRANZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL LINE; CELL STRUCTURE; CONFORMATIONAL TRANSITION; CYTOTOXIC T LYMPHOCYTE; ELECTRON TRANSPORT; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME RELEASE; GENE TRANSLOCATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; RESPIRATORY CHAIN; ANIMAL; APOPTOSIS; C57BL MOUSE; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; MITOCHONDRION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE; ENZYME ACTIVATION; GRANZYMES; HUMANS; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NADPH OXIDASE; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 77954310631     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2010.5     Document Type: Article

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