Type 1 Diabetes

The Autoimmune Diseases, Fourth Edition

Volumn , Issue , 2006, Pages 483-500

  Bach, Jean François ^a  

^a Immunologie Clinique Hôpital   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77954287612     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012595961-2/50039-1     Document Type: Chapter

References (177)

1. T.E. Adams, S. Alpert and D. Hanahan (1987) Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature 325 223-228.
2. H.F. Allen, G.J. Klingensmith, P. Jensen, E. Simoes, A. Hayward and H.P. Chase (1999) Effect of Bacillus Calmette-Guerin vaccination on new-onset type 1 diabetes. A randomized clinical study. Diabetes Care 22 1703-1707.
3. D.G. Alleva, A. Gaur, L. Jin, D. Wegmann, P.A. Gottlieb, A. Pahuja, E.B. Johnson, T. Motheral, A. Putnam, P.D. Crowe, N. Ling, S.A. Boehme and P.J. Conlon (2002) Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9–23) peptide. Diabetes 51 2126-2134.
4. M.A. Alyanakian, S. You, D. Damotte, C. Gouarin, A. Esling, C. Garcia, S. Havouis, L. Chatenoud and J.F. Bach (2003) Diversity of regulatory CD4+T-cells controlling distinct organ-specific autoimmune diseases. Proc. Natl. Acad. Sci. USA 100 15806-15811.
5. A. Amrani, J. Verdaguer, P. Serra, S. Tafuro, R. Tan and P. Santamaria (2000) Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 406 739-742.
6. M.S. Anderson, E.S. Venanzi, L. Klein, Z. Chen, S.P. Berzins, S.J. Turley, H. Von Boehmer, R. Bronson, A. Dierich, C. Benoist and D. Mathis (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298 1395-1401.
7. M. Asano, M. Toda, N. Sakaguchi and S. Sakaguchi (1996) Autoimmune disease as a consequence of developmental abnormality of a T-cell subpopulation. J. Exp. Med. 184 387-396.
8. C.M. Asplin, M.K. Cooney, J.R. Crossley, T.L. Dornan, P. Raghu and J.P. Palmer (1982) Coxsackie B4 infection and islet-cell antibodies three years before overt diabetes. J. Pediatr. 101 398-400.
9. M.A. Atkinson and S.B. Wilson (2002) Fatal attraction: chemokines and type 1 diabetes. J. Clin. Invest. 110 1611-1613.
10. M.A. Atkinson, D.L. Kaufman, L. Campbell, K.A. Gibbs, S.C. Shah, D.F. Bu, M.G. Erlander, A.J. Tobin and N.K. MacLaren (1992) Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339 458-459.
11. M.A. Atkinson, M.A. Bowman, L. Campbell, B.L. Darrow, D.L. Kaufman and N.K. MacLaren (1994) Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94 2125-2129.
12. J.F. Bach (1994) Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15 516-542.
13. J.F. Bach (2002) Immunotherapy of type 1 diabetes: lessons for other autoimmune diseases. Arthritis Res. 4 S3-S15.
14. J.F. Bach (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347 911-920.
15. J.F. Bach and D. Mathis (Eds) (1997) The NOD mouse, 70th Forum in Immunology Res. Immunol. 148 285-366.
16. S. Baekkeskov, H.J. Aanstoot, S. Christgau, A. Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richter-Olesen and P. de Camilli (1990) Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347 151-156.
17. F.J. Baker, M. Lee, Y.H. Chien and M.M. Davis (2002) Restricted islet-cell reactive T-cell repertoire of early pancreatic islet infiltrates in NOD mice. Proc. Natl. Acad. Sci. USA 99 9374-9379.
18. A.G. Baxter and T.E. Mandel (1991) Hemolytic anemia in non-obese diabetic mice. Eur. J. Immunol. 21 2051-2055.
19. A.G. Baxter, A.C. Horsfall, D. Healey, P. Ozegbe, S. Day, D.G. Williams and A. Cooke (1994) Mycobacteria precipitate an SLE-like syndrome in diabetes-prone NOD mice. Immunology 83 227-231.
20. M. Belghith, J.A. Bluestone, S. Barriot, J. Megret, J.F. Bach and L. Chatenoud (2003) TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 9 1202-1208.
21. A. Bendelac, C. Carnaud, C. Boitard and J.F. Bach (1987) Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+T-cells. J. Exp. Med. 166 823-832.
22. A. Bendelac, C. Boitard, P. Bedossa, H. Bazin, J.F. Bach and C. Carnaud (1988) Adoptive T-cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes. J. Immunol. 141 2625-2628.
23. C.L. Bennett, J. Christie, F. Ramsdell, M.E. Brunkow, P.J. Ferguson, L. Whitesell, T.E. Kelly, F.T. Saulsbury, P.F. Chance and H.D. Ochs (2001) The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27 20-21.
24. M.L. Bergman, N. Duarte, S. Campino, M. Lundholm, V. Motta, K. Lejon, C. Penha Goncalves and D. Holmberg (2003) Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains. Diabetes 52 1677-1682.
25. C. Boitard, R. Yasunami, M. Dardenne and J.F. Bach (1989) T-cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J. Exp. Med. 169 1669-1680.
26. D. Bonn (1999) Q fever vaccine on trial for type 1 diabetes. Mol. Med. Today 5 143.
27. E. Bosi, S. Braghi, P. Maffi, M. Scirpoli, F. Bertuzzi, G. Pozza, A. Secchi and E. Bonifacio (2001) Autoantibody response to islet transplantation in type 1 diabetes. Diabetes 50 2464-2471.
28. G.F. Bottazzo, A. Florin-Christensen and D. Doniach (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2 1279-1283.
29. G.F. Bottazzo, B.M. Dean, J.M. McNally, E.H. MacKay, P.G. Swift and D.R. Gamble (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N. Engl. J. Med. 313 353-360.
30. O. Boulard, D. Damotte, N. Deruytter, G. Fluteau, C. Carnaud and H.J. Garchon (2002) An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat 1) in nonobese diabetic mice. Diabetes 51 2141-2147.
31. B.J. Bradley, K. Haskins, F.G. La Rosa and K.J. Lafferty (1992) CD8 T-cells are not required for islet destruction induced by a CD4+islet-specific T-cell clone. Diabetes 41 1603-1608.
32. H.H. Brenner, V. Burkart, H. Rothe and H. Kolb (1993) Oxygen radical production is increased in macrophages from diabetes prone BB rats. Autoimmunity 15 93-98.
33. G.E. Burch and J.M. Harb (1975) Coxsackie B4 virus crystal formation in mouse pancreas. Proc. Soc. Exp. Biol. Med. 149 893-895.
34. K. Buschard and J. Rygaard (1978) T-lymphocytes transfer streptozotocin induced diabetes mellitus in mice. Acta Pathol. Microbiol. Scand. 86C 277-282.
35. I.L. Campbell, L. Oxbrow, M. Koulmanda and L.C. Harrison (1988) IFN-gamma induces islet-cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse. J. Immunol. 140 1111-1116.
36. CERCTG (1988) The Canadian-European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 37 1574-1582.
37. L. Chatenoud, E. Thervet, J. Primo and J.F. Bach (1994) Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 91 123-127.
38. T.J. Coleman, K.W. Taylor and D.R. Gamble (1974) The development of diabetes following Coxsackie B virus infection in mice. Diabetologia 10 755-759.
39. J.E. Craighead and M.F. McLane (1968) Diabetes mellitus: induction in mice by encephalomyocarditis virus. Science 162 913-914.
40. L. Crisa, J.P. Mordes and A.A. Rossini (1992) Autoimmune diabetes mellitus in the BB rat. Diabetes Metab. Rev. 8 9-37.
41. D. Daniel and D.R. Wegmann (1996) Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9–23). Proc. Natl. Acad. Sci. USA 93 956-960.
42. M. Dardenne, F. Lepault, A. Bendelac and J.F. Bach (1989) Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning. Eur. J. Immunol. 19 889-895.
43. A. Davoodi-Semiromi, J.J. Yang and J.X. She (2002) IL-12p40 is associated with type 1 diabetes in Caucasian-American families. Diabetes 51 2334-2336.
44. DCCT (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N. Engl. J. Med. 329 977-986.
45. M. Debray-Sachs, C. Carnaud, C. Boitard, H. Cohen, I. Gresser, P. Bedossa and J.F. Bach (1991) Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma. J. Autoimmun. 4 237-248.
46. J. Diez, Y. Park, M. Zeller, D. Brown, D. Garza, C. Ricordi, J. Hutton, G.S. Eisenbarth and A. Pugliese (2001) Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. Diabetes 50 895-900.
47. I. Durinovic-Bello, M. Hummel and A.G. Ziegler (1996) Cellular immune response to diverse islet-cell antigens in IDDM. Diabetes 45 795-800.
48. R.B. Elliott and J.M. Martin (1984) Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia 26 297-299.
49. J. Endl, H. Otto, G. Jung, B. Dreisbusch, F. Donie, P. Stahl, R. Elbracht, G. Schmitz, E. Meinl, M. Hummel, A.G. Ziegler, R. Wank and D.J. Schendel (1997) Identification of naturally processed T-cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J. Clin. Invest. 99 2405-2415.
50. EURODIAB (2000) Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group. Lancet 355 873-876.
51. A. Falorni and F. Calcinaro (2002) Autoantibody profile and epitope mapping in latent autoimmune diabetes in adults. Ann. N. Y. Acad. Sci. 958 99-106.
52. G. Feutren, L. Papoz, R. Assan, B. Vialettes, G. Karsenty, P. Vexiau, H. Du Rostu, M. Rodier, J. Sirmai, A. Lallemand and J.F. Bach (1986) Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet 2 119-124.
53. J.S. Flier, C.R. Kahn, J. Roth and R.S. Bar (1975) Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science 190 63-65.
54. A.K. Foulis, M.A. Farquharson and A. Meager (1987) Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet 2 1423-1427.
55. D. Fowell and D. Mason (1993) Evidence that the T-cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+T-cell subset that inhibits this autoimmune potential. J. Exp. Med. 177 627-636.
56. S. Frigerio, T. Junt, B. Lu, C. Gerard, U. Zumsteg, G.A. Hollander and L. Piali (2002) Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat. Med. 8 1414-1420.
57. D.P. Funda, A. Kaas, T. Bock, H. Tlaskalova-Hogenova and K. Buschard (1999) Gluten-free diet prevents diabetes in NOD mice. Diabetes Metab. Res. Rev. 15 323-327.
58. E.A. Gale (2002) The rise of childhood type 1 diabetes in the 20th century. Diabetes 51 3353-3361.
59. E.A. Gale, P.J. Bingley, C.L. Emmett and T. Collier (2004) European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 363 925-931.
60. I.C. Gerling, H. Friedman, D.L. Greiner, L.D. Shultz and E.H. Leiter (1994) Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes 43 433-440.
61. J.M. Gombert, A. Herbelin, E. Tancrede-Bohin, M. Dy, C. Carnaud and J.F. Bach (1996) Early quantitative and functional deficiency of NK1(+)-like thymocytes in the NOD mouse. Eur. J. Immunol. 26 2989-2998.
62. C. Gonzalez, J. Menissier de Murcia, P. Janiak, J.P. Bidouard, C. Beauvais, S. Karray, H.J. Garchon and M. Levi Strauss (2002) Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes. Diabetes 51 1470-1476.
63. P.A. Gottlieb and G.S. Eisenbarth (1998) Diagnosis and treatment of preinsulin dependent diabetes. Annu. Rev. Med. 49 391-405.
64. S.A. Greeley, M. Katsumata, L. Yu, G.S. Eisenbarth, D.J. Moore, H. Goodarzi, C.F. Barker, A. Naji and H. Noorchashm (2002) Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat. Med. 8 399-402.
65. E.A. Green, L. Gorelik, C.M. McGregor, E.H. Tran and R.A. Flavell (2003) CD4+CD25+ T regulatory cells control anti-islet CD8+ T-cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. USA 100 10878-10883.
66. D.L. Guberski, V.A. Thomas, W.R. Shek, A.A. Like, E.S. Handler, A.A. Rossini, J.E. Wallace and R.M. Welsh (1991) Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats. Science 254 1010-1013.
67. M. Halonen, H. Kangas, T. Ruppell, T. Ilmarinen, J. Ollila, M. Kolmer, M. Vihinen, J. Palvimo, J. Saarela, I. Ulmanen and P. Eskelin (2004) APECED-causing mutations in AIRE reveal the functional domains of the protein. Hum. Mutat 23 245-257.
68. T. Hanafusa, A. Miyazaki, J. Miyagawa, S. Tamura, M. Inada, K. Yamada, Y. Shinji, H. Katsura, K. Yamagata, N. Itoh, H. Asakawa, C. Nakagawa, A. Otsuka, S. Kawata, N. Kono and S. Tarui (1990) Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetologia 33 105-111.
69. K. Haskins and M. McDuffie (1990) Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T-cell clone. Science 249 1433-1436.
70. K.C. Herold, A.G. Montag and F.W. Fitch (1987) Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozocin. Diabetes 36 796-801.
71. K.C. Herold, W. Hagopian, J.A. Auger, E. Poumian-Ruiz, L. Taylor, D. Donaldson, S.E. Gitelman, D.M. Harlan, D.L. Xu, R.A. Zivin and J.A. Bluestone (2002) Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346 1692-1698.
72. P. Hoglund, J. Mintern, C. Waltzinger, W. Heath, C. Benoist and D. Mathis (1999) Initiation of autoimmune diabetes by developmentally regulated presentation of islet-cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189 331-339.
73. M.C. Honeyman, B.S. Coulson, N.L. Stone, S.A. Gellert, P.N. Goldwater, C.E. Steele, J.J. Couper, B.D. Tait, P.G. Colman and L.C. Harrison (2000) Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes 49 1319-1324.
74. S. Hong, M.T. Wilson, I. Serizawa, L. Wu, N. Singh, O.V. Naidenko, T. Miura, T. Haba, D.C. Scherer, J. Wei, M. Kronenberg, Y. Koezuka and L. Van Kaer (2001) The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7 1052-1056.
75. L. Hornum, M. Jackerott and H. Markhoist (1995) The rat T-cell lymphopepia resistance gene (Lyp) maps between D4Mit6 and Npy on RN04. Mamm. Genome 6 371-372.
76. M.S. Horwitz, L.M. Bradley, J. Harbertson, T. Krahl, J. Lee and N. Sarvetnick (1998) Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4 781-785.
77. A. Ide and G.S. Eisenbarth (2003) Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders. Rev. Endocr. Metab. Disord 4 243-253.
78. A. Imagawa, T. Hanafusa, S. Tamura, M. Moriwaki, N. Itoh, K. Yamamoto, H. Iwahashi, K. Yamagata, M. Waguri, T. Nanmo, S. Uno, H. Nakajima, M. Namba, S. Kawata, J.I. Miyagawa and Y. Matsuzawa (2001) Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity. Diabetes 50 1269-1273.
79. S. Johansson, B.A. Lie, J.A. Todd, F. Pociot, J. Nerup, A. Cambon-Thomsen, I. Kockum, H.E. Akselsen, E. Thorsby and D.E. Undlien (2003) Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1. Genes Immun. 4 46-53.
80. S. Juhela, H. Hyoty, M. Roivainen, T. Harkonen, A. Putto Laurila, O. Simell and J. Ilonen (2000) T-cell responses to enterovirus antigens in children with type 1 diabetes. Diabetes 49 1308-1313.
81. H.S. Jun and J.W. Yoon (2003) A new look at viruses in type 1 diabetes. Diabetes Metab. Res. Rev. 19 8-31.
82. J. Karjalainen, J.M. Martin, M. Knip, J. Ilonen, B.H. Robinson, E. Savilahti, H.K. Akerblom and H.M. Dosch (1992) A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N. Engl. J. Med. 327 302-307.
83. M. Karvonen, A. Sekikawa, R. La Porte, J. Tuomilehto and E. Tuomilehto-Wolf (2001) Type 1 diabetes: global epidemiology. J.M. Ekoe, P. Zimmet, R. Williams (Eds) The Epidemiology of Diabetes Mellitus. An International Perspective Chichester: Wiley 71-102.
84. J.D. Katz, B. Wang, K. Haskins, C. Benoist and D. Mathis (1993) Following a diabetogenic T-cell from genesis through pathogenesis. Cell 74 1089-1100.
85. D.L. Kaufman, M. Clare-Salzler, J. Tian, T. Forsthuber, G.S.P. Ting, P. Robinson, M.A. Atkinson, E.E. Sercarz, A.J. Tobin and P.V. Lehmann (1993) Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366 69-72.
86. B. Keymeulen, E. Vandemeulebroucke, A.G. Ziegler, C. Mathieu, L. Kaufman, G. Hale, F. Gorus, M. Goldman, M. Walter, S. Candon, L. Schandene, L. Crenier, C. De Block, J-M. Seigneurin, P. De Pauw, D. Pierard, I. Weets, P. Rebellow, E. Berrie, M. Frewin, H. Waldmann, J.-F. Bach, D. Pipeleers and L. Chatenoud (2005) Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N. Engl. J. Med. 352 2598-2608.
87. S.H. Kim, M.M. Cleary, H.S. Fox, D. Chantry and N. Sarvetnick (2002) CCR4-bearing T-cells participate in autoimmune diabetes. J. Clin. Invest. 110 1675-1686.
88. C. King, A. Ilic, K. Koelsch and N. Sarvetnick (2004) Homeostatic expansion of T-cells during immune insufficiency generates autoimmunity. Cell 117 265-277.
89. H. Kishimoto and J. Sprent (2001) A defect in central tolerance in NOD mice. Nat. Immunol. 2 1025-1031.
90. A. Kukreja, G. Cost, J. Marker, C. Zhang, Z. Sun, K. Lin Su, S. Ten, M. Sanz, M. Exley, B. Wilson, S. Porcelli and N. MacLaren (2002) Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Invest. 109 131-140.
91. M.O. Kurrer, S.V. Pakala, H.L. Hanson and J.D. Katz (1997) Beta cell apoptosis in T-cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94 213-218.
92. E.F. Lampeter, A. Klinghammer, W.A. Scherbaum, E. Heinze, B. Haastert, G. Giani and H. Kolb (1998) The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group. Diabetes 47 980-984.
93. M.S. Lan, C. Wasserfall, N.K. MacLaren and A.L. Notkins (1996) IA-2, a transmembrane protein of the protein tyrosine phosphatase family is a major autoantigen in insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA 93 6367-6370.
94. E. Larger, C. Becourt, J.F. Bach and C. Boitard (1995) Pancreatic islet beta cells drive T-cell-immune responses in the nonobese diabetic mouse model. J. Exp. Med. 181 1635-1642.
95. D.J. Lenschow, K.C. Herold, L. Rhee, L. Patel, A. Koons, H.Y. Qin, E. Fuchs, B. Singh, C.B. Thompson and J.A. Bluestone (1996) CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 5 285-293.
96. S. Lesage, S.B. Hartley, S. Akkaraju, J. Wilson, M. Townsend and C.C. Goodnow (2002) Failure to censor forbidden clones of CD4 T-cells in autoimmune diabetes. J. Exp. Med. 196 1175-1188.
97. B.A. Lie, J.A. Todd, F. Pociot, J. Nerup, H.E. Akselsen, G. Joner, K. Dahl-Jorgensen, K.S. Ronningen, E. Thorsby and D.E. Undlien (1999) The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene. Am. J. Hum. Genet. 64 793-800.
98. S.M. Lieberman, A.M. Evans, B. Han, T. Takaki, Y. Vinnitskaya, J.A. Caldwell, D.V. Serreze, J. Shabanowitz, D.F. Hunt, S.G. Nathenson, P. Santamaria and T.P. Dilorenzo (2003) Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+T-cells in autoimmune diabetes. Proc. Natl. Acad. Sci. USA 100 8384-8388.
99. A.A. Like, A.A. Rossini, D.L. Guberski, M.C. Appel and R.M. Williams (1979) Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science 206 1421-1423.
100. C.P. Liu, K. Jiang, C.H. Wu, W.H. Lee and W.J. Lin (2000) Detection of glutamic acid decarboxylase-activated T-cells with I-Ag7 tetramers. Proc. Natl. Acad. Sci. USA 97 14596-14601.
101. M. Lonnrot, K. Korpela, M. Knip, J. Ilonen, O. Simell, S. Korhonen, K. Savola, P. Muona, T. Simell, P. Koskela and H. Hyoty (2000) Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study. Diabetes 49 1314-1318.
102. S. Makino, K. Kunimoto, Y. Muraoka, Y. Mizushima, K. Katagiri and Y. Tochino (1980) Breeding of a non-obese, diabetic strain of mice. Exp. Anim. 29 1-13.
103. T. Mandrup-Poulsen (2003) Apoptotic signal transduction pathways in diabetes. Biochem. Pharmacol. 66 1433-1440.
104. C.C. Martin, L.J. Bischof, B. Bergman, L.A. Hornbuekle, C. Hilliker, C. Frigeri, D. Wahl, C.A. Svitek, R. Wong, J.K. Goldman, J.K. Oeser, F. Lepretre, P. Froguel, R.M. O'Brien and J.C. Hutton (2001) Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. J. Biol. Chem. 276 25197-25207.
105. D. Maugendre, E. Sonnet, C. Derrien, M.C. Le Golff, M.C. Grais, H. Allannic and M. Delamaire (1999) Combined analysis of long-term anti-beta-cell humoral reactivity in type 1 diabetes with and without thyroid disease. Diabetes Metab. 25 28-33.
106. D.B. Mirel, A.M. Valdes, L.C. Lazzeroni, R.L. Reynolds, H.A. Erlich and J.A. Noble (2002) Association of IL4R haplotypes with type 1 diabetes. Diabetes 51 3336-3341.
107. A. Moore, S. Bonner Weir and R. Weissleder (2001) Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. Diabetes 50 2231-2236.
108. H. Moriyama, L. Wen, N. Abiru, E. Liu, L. Yu, D. Miao, R. Gianani, F.S. Wong and G.S. Eisenbarth (2002) Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc. Natl. Acad. Sci. USA 99 5539-5544.
109. H. Moriyama, N. Abiru, J. Paronen, K. Sikora, E. Liu, D. Miao, D. Devendra, J. Beilke, R. Gianani, R.G. Gill and G.S. Eisenbarth (2003) Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc. Natl. Acad. Sci. USA 100 10376-10381.
110. A. Muir, A. Peck, M. Clare-Salzler, Y.H. Song, J. Cornelius, R. Luchetta, J. Krischer and N. MacLaren (1995) Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J. Clin. Invest. 95 628-634.
111. A.F. Nakhooda, A.A. Like, C.I. Chappel, F.T. Murray and E.B. Marliss (1977) The spontaneously diabetic Wistar rat. Metabolic and morphologic studies. Diabetes 26 100-112.
112. P. Narendran, S.I. Mannering and L.C. Harrison (2003) Proinsulin—a pathogenic autoantigen in type 1 diabetes. Autoimmun. Rev 2 204-210.
113. J. Nerup, P. Platz, O.O. Andersen, M. Christy, J. Lyngsoe, J.E. Poulsen, L.P. Ryder, L.S. Nielsen, M. Thomsen and A. Svejgaard (1974) HLA antigens and diabetes mellitus. Lancet 2 864-866.
114. P.S. Ohashi, S. Oehen, K. Buerki, H. Pircher, C.T. Ohashi, B. Odermatt, B. Malissen, R.M. Zinkernagel and H. Hengartner (1991) Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65 305-317.
115. M.B. Oldstone (1990) Viruses as therapeutic agents. I. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes mellitus while maintaining general immune competence. J. Exp. Med. 171 2077-2089.
116. S. Orlow, R. Yasunami, C. Boitard and J.F. Bach (1987) Induction précoce du diabète chez la souris NOD par la streptozotocine. C. R. Acad. Sci. III 304 77-78.
117. S.G. Paik, N. Fleischer and S.I. Shin (1980) Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes. Proc. Natl. Acad. Sci. USA 77 6129-6133.
118. C.C. Patterson, D.J. Carson and D.R. Hadden (1996) Epidemiology of childhood IDDM in Northern Ireland 1989–1994: low incidence in areas with highest population density and most household crowding. Diabetologia 39 1063-1069.
119. M. Peakman, E.J. Stevens, T. Lohmann, P. Narendran, J. Dromey, A. Alexander, A.J. Tomlinson, M. Trucco, J.C. Gorga and R.M. Chicz (1999) Naturally processed and presented epitopes of the islet-cell autoantigen IA-2 eluted from HLA-DR4. J. Clin. Invest. 104 1449-1457.
120. K.J. Pennline, E. Roque-Gaffney and M. Monahan (1994) Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol. Immunopathol. 71 169-175.
121. P. Peterson, J. Pitkanen, N. Sillanpaa and K. Krohn (2004) Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity. Clin. Exp. Immunol. 135 348-357.
122. F. Pociot and M.F. McDermott (2002) Genetics of type 1 diabetes mellitus. Genes Immun 3 235-249.
123. P. Poussier, A.F. Nakhooda, J.A. Falk, C. Lee and E.B. Marliss (1982) Lymphopenia and abnormal lymphocyte subsets in the “BB” rat: relationship to the diabetic syndrome. Endocrinology 110 1825-1827.
124. P. Pozzilli and U. Di Mario (2001) Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult): definition, characterization, and potential prevention. Diabetes Care 24 1460-1467.
125. A. Pugliese, D. Brown, D. Garza, D. Murchison, M. Zeller, M. Redondo, J. Diez, G.S. Eisenbarth, D.D. Patel and C. Ricordi (2001) Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J. Clin. Invest 107 555-564.
126. H.Y. Qin, M.W. Sadelain, C. Hitchon, J. Lauzon and B. Singh (1993) Complete Freund's adjuvant-induced T-cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol. 150 2072-2080.
127. A. Rabinovitch, W.L. Suarez-Pinzon, O. Sorensen, R.C. Bleackley and R.F. Power (1995) IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 154 4874-4882.
128. S. Ramanathan, M.T. Bihoreau, A.D. Paterson, L. Marandi, D. Gauguier and P. Poussier (2002) Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats. Diabetes 51 2975-2981.
129. M.J. Rapoport, A. Jaramillo, D. Zipris, A.H. Lazarus, D.V. Serreze, E.H. Leiter, P. Cyopick, J.S. Danska and T.L. Delovitch (1993) Interleukin 4 reverses T-cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178 87-99.
130. I. Raz, D. Elias, A. Avron, M. Tamir, M. Metzger and I.R. Cohen (2001) Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep 277): a randomised, doubleblind, phase II trial. Lancet 358 1749-1753.
131. H. Reijonen, E.J. Novak, S. Kochik, A. Heninger, A.W. Liu, W.W. Kwok and G.T. Nepom (2002) Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. Diabetes 51 1375-1382.
132. B.O. Roep, M.A. Atkinson, P.M. Van Endert, P.A. Gottlieb, S.B. Wilson and J.A. Sachs (1999) Autoreactive T-cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T-cell assays. J. Autoimmun 13 267-282.
133. N.R. Rose and C. Bona (1993) Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol. Today 14 426-430.
134. A. Sarukhan, P. Bedossa, H.J. Garchon, J.F. Bach and C. Carnaud (1995) Molecular analysis of TCR junctional variability in individual infiltrated islets of non-obese diabetic mice: evidence for the constitution of largely autonomous T-cell foci within the same pancreas. Int. Immunol. 7 139-146.
135. T. Scheinin (1988) Characteristics of blood cells responding to insulin in children with insulin-dependent diabetes. Immunol. Lett 17 273-277.
136. N.C. Schloot, G. Meierhoff, M. Karlsson Faresjo, P. Ott, A. Putnam, P. Lehmann, P. Gottlieb, B.O. Roep, M. Peakman and T Trec (2003) Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T-cells. Report of the third immunology of diabetes society T-cell workshop. J. Autoimmun 21 365-376.
137. B. Scott, R. Liblau, S. Degermann, L.A. Marconi, L. Ogata, A.J. Caton, H.O. McDevitt and D. Lo (1994) A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1 73-82.
138. P. Sempe, P. Bedossa, M.F. Richard, M.C. Villa, J.F. Bach and C. Boitard (1991) Anti-alpha/beta T-cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice. Eur. J. Immunol. 21 1163-1169.
139. D.V. Serreze, S.A. Fleming, H.D. Chapman, S.D. Richard, E.H. Leiter and R.M. Tisch (1998) B lymphocytes are critical antigen-presenting cells for the initiation of T-cell-mediated autoimmune diabetes in nonobese diabetic mice. J. Immunol. 161 3912-3918.
140. D.V. Serreze, C.M. Post, H.D. Chapman, E.A. Johnson, B.F. Lu and P.B. Rothman (2000) Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Diabetes 49 2007-2011.
141. D.V. Serreze, H.D. Chapman, C.M. Post, E.A. Johnson, W.L. Suarez-Pinzon and A. Rabinovitch (2001) Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J. Immunol. 166 1352-1359.
142. S.C. Shah, J.I. Malone and N.E. Simpson (1989) A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N. Engl. J. Med. 320 550-554.
143. S. Sharif, G.A. Arraeza, P. Zucker, Q.S. Mi, J. Sondhi, O.V. Naidenko, M. Kronenberg, Y. Koezuka, T.L. Delovitch, J.M. Gombert, M. Leite de Moraes, C. Gouarin, R. Zhu, A. Hameg, T. Nakayama, M. Taniguchi, F. Lepault, A. Lehuen, J.F. Bach and A. Herbelin (2001) Activation of natural killer T-cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat. Med. 7 1057-1062.
144. J.A. Shizuru, C. Taylor-Edwards, A. Livingstone and C.G. Fathman (1991) Genetic dissection of T-cell receptor V beta gene requirements for spontaneous murine diabetes. J. Exp. Med. 174 633-638.
145. J. Silverstein, N. MacLaren, W. Riley, R. Spillar, D. Radjenovic and S. Johnson (1988) Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. N. Engl. J. Med. 319 599-604.
146. S. Sreenan, A.J. Pick, M. Levisetti, A.C. Baldwin, M. Pugh and K.S. Polonsky (1999) Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48 989-996.
147. S. Srikanta, A.T. Ricker, D.K. McCulloch, J.S. Soeldner, G.S. Eisenbarth and J.P. Palmer (1986) Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus. Diabetes 35 139-142.
148. A. Staines, S. Hanif, S. Ahmed, P.A. McKinney, S. Shera and H.J. Bodansky (1997) Incidence of insulin dependent diabetes mellitus in Karachi, Pakistan. Arch. Dis. Child. 76 121-123.
149. E. Strandell, D.L. Eizirik and S. Sandler (1990) Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus. J. Clin. Invest. 85 1944-1950.
150. K.V. Tarbell, M. Lee, E. Ranheim, C.C. Chao, M. Sanna, S.K. Kim, P. Dickie, L. Teyton, M. Davis and H. McDevitt (2002) CD4(+) T-cells from glutamic acid decarboxylase (GAD)65-specific T-cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer. J. Exp. Med. 196 481-492.
151. C. Thivolet, A. Bendelac, P. Bedossa, J.F. Bach and C. Carnaud (1991) CD8+ T-cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T-cell-dependent. J. Immunol. 146 85-88.
152. R. Tisch, X.D. Yang, S.M. Singer, R.S. Liblau, L. Fugger and H.O. McDevitt (1993) Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366 72-75.
153. R. Tisch, B. Wang and D.V. Serreze (1999) Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent. J. Immunol. 163 1178-1187.
154. J.A. Todd (1999) From genome to aetiology in a multifactorial disease, type 1 diabetes. Bioessays 21 164-174.
155. J.A. Todd, J.I. Bell and H.O. McDevitt (1987) HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329 599-604.
156. S. Trembleau, G. Penna, E. Bosi, A. Mortara, M.K. Gately and L. Adorini (1995) Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181 817-821.
157. J.D. Trudeau, J.P. Dutz, E. Arany, D.J. Hill, W.E. Fieldus and D.T. Finegood (2000) Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes? Diabetes 49 1-7.
158. R. Turner, I. Stratton, V. Horton, S. Manley, P. Zimmet, I.R. MacKay, M. Shattock, G.F. Bottazzo and R. Holman (1997) UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 350 1288-1293.
159. G.E. Umpierrez, K.A. Latif, M.B. Murphy, H.C. Lambeth, F. Stentz, A. Bush and A.E. Kitabchi (2003) Thyroid dysfunction in patients with type 1 diabetes—a longitudinal study. Diabetes Care 26 1181-1185.
160. C.L. Vanderlugt and S.D. Miller (2002) Epitope spreading in immunemediated diseases: implications for immunotherapy. Nat. Rev. Immunol. 2 85-95.
161. C.F. Verge, P. Vardi, S. Babu, F. Bao, H.A. Erlich, T. Bugawan, D. Tiosano, L. Yu, G.S. Eisenbarth and P.R. Fain (1998) Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family. J. Clin. Invest. 102 1569-1575.
162. M.G. Von Herrath (2002) Regulation of virally induced autoimmunity and immunopathology: contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus. Curr. Top. Microbiol. Immunol. 263 145-175.
163. M.G. Von Herrath, D. Homann, J.E. Gairin and M.B. Oldstone (1997) Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model. Biochem. Soc. Trans. 25 630-635.
164. B. Wang, A. Gonzalez, P. Hoglund, J.D. Katz, C. Benoist and D. Mathis (1998) Interleukin-4 deficiency does not exacerbate disease in NOD mice. Diabetes 47 1207-1211.
165. B. Wang, Y.B. Geng and C.R. Wang (2001) CD1-restricted NK T-cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194 313-320.
166. J.H. Warram, A.S. Krolewski, M.S. Gottlieb and C.R. Kahn (1984) Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N. Engl. J. Med. 311 149-152.
167. L. Wen, N.Y. Chen, J. Tang, R. Sherwin and F.S. Wong (2001) The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. J. Clin. Invest. 107 871-880.
168. L.S. Wicker, J.A. Todd and L.B. Peterson (1995) Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13 179-200.
169. R.S. Wildin, F. Ramsdell, J. Peake, F. Faravelli, J.L. Casanova, N. Buist, E. Levy-Lahad, M. Mazzella, O. Goulet, L. Perroni, F.D. Bricarelli, G. Byrne, M. McEuen, S. Proll, M. Appleby and M.E. Brunkow (2001) X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27 18-20.
170. S.B. Wilson, S.C. Kent, K.T. Patton, T. Orban, R.A. Jackson, M. Exley, S. Porcelli, D.A. Schatz, M.A. Atkinson, S.P. Balk, J.L. Strominger and D.A. Hafler (1998) Extreme Th1 bias of invariant V-alpha-24J-alpha-Q T-cells in type 1 diabetes. Nature 391 177-186.
171. F.S. Wong, I. Visintin, L. Wen, R.A. Flavell and C.A. Janeway (1996) CD8 T-cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183 67-76.
172. S. Wong, S. Guerder, I. Visintin, E.P. Reich, K.E. Swenson, R.A. Flavell and C.A. Janeway (1995) Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse. Diabetes 44 326-329.
173. Y. Yang and P. Santamaria (2003) Dissecting autoimmune diabetes through genetic manipulation of non-obese diabetic mice. Diabetologia 46 1447-1464.
174. R. Yasunami and J.F. Bach (1988) Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice. Eur. J. Immunol. 18 481-484.
175. S. You, G. Slehoffer, S. Barriot, L. Chatenoud and J.F. Bach (2004) Unique role of CD4+ CD62L+ regulatory T-cells in the control of autoimmune diabetes in T-cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA. 101(Suppl 2), 14580-14585.
176. P. Zaccone, Z. Fehervari, F.M. Jones, S. Sidobre, M. Kronenberg, D.W. Dunne and A. Cooke (2003) Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. Eur. J. Immunol. 33 1439-1449.
177. Z.J. Zhang, L. Davidson, G. Eisenbarth and H.L. Weiner (1991) Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88 10252-10256.