Inhibitors of HIV-1 protease: Current state of the art 10 years after-their Introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents Based on aspartic protease inhibitors

Current Medicinal Chemistry

Volumn 14, Issue 26, 2007, Pages 2734-2748

  Mastrolorenzo, Antonio ^a   Rusconi, Stefano ^b   Scozzafava, Andrea ^a   Barbaro, Giuseppe ^c   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Amprenavir; Anti influenza agent; Antibacterial; Antifungal; Antimalarial; AntiSARS; Antitumor; Apoptosis enhancer; Atazanavir; Candida albicans; Fosamprenavir; HAART; HIV 1; Indinavir; Lopinavir; Mycobacterium tuberculosis infection; Nelfinavir; Prodrug; Ritonavir; Saquinavir; Tipranavir; TMC 114

Indexed keywords

4 CYANO N [3 [(CYCLOPROPYL)(5,6,7,8,9,10 HEXAHYDRO 4 HYDROXY 2 OXO 2H CYCLOOCTA[B]PYRAN 3 YL)METHYL]PHENYL]BENZENESULFONAMIDE; AMPRENAVIR; AMPRENAVIR PHOSPHATE; ANTACID AGENT; ANTIEMETIC AGENT; ANTIRETROVIRUS AGENT; ATAZANAVIR; ATORVASTATIN; CLARITHROMYCIN; DARUNAVIR; DIDANOSINE; DPC 681; EFAVIRENZ; FLUCONAZOLE; INDINAVIR; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; MEVINOLIN; NELFINAVIR; PROTEINASE INHIBITOR; RIFABUTIN; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; SIMVASTATIN; TENOFOVIR; TIPRANAVIR; TMC 126; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; CANCER INHIBITION; CARDIOVASCULAR RISK; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DIABETES MELLITUS; DIARRHEA; DIET SUPPLEMENTATION; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG MONITORING; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TOLERABILITY; DYSLIPIDEMIA; GASTROINTESTINAL SYMPTOM; HEAD AND NECK CARCINOMA; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED LIPODYSTROPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERBILIRUBINEMIA; HYPERSENSITIVITY REACTION; INSULIN RESISTANCE; KAPOSI SARCOMA; LIPID BLOOD LEVEL; LIPODYSTROPHY; LIVER FAILURE; LIVER TOXICITY; LOW DRUG DOSE; METABOLIC DISORDER; MONOTHERAPY; NAUSEA; NEPHROLITHIASIS; NONHUMAN; OPPORTUNISTIC INFECTION; PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA; RECOMMENDED DRUG DOSE; REVIEW; SEVERE ACUTE RESPIRATORY SYNDROME; SIDE EFFECT; SUPERINFECTION; UNSPECIFIED SIDE EFFECT; VIRUS INHIBITION; VIRUS LOAD; VIRUS MUTATION; VIRUS RESISTANCE; VOMITING;

ANTI-BACTERIAL AGENTS; ANTI-RETROVIRAL AGENTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ASPARTIC ENDOPEPTIDASES; DRUG DESIGN; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MOLECULAR STRUCTURE;

EID: 36248969694     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986707782360141     Document Type: Review

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