Actions of the prototypical 5-HT1A receptor agonist 8-OH-DPAT at human α2-adrenoceptors: (+)8-OH-DPAT, but not (-)8-OH-DPAT is an α2B subtype preferential agonist

European Journal of Pharmacology

Volumn 640, Issue 1-3, 2010, Pages 8-14

  Heusler, Peter ^a   Rauly Lestienne, Isabelle ^a   Tourette, Amélie ^a   Tardif, Stéphanie ^a   Ailhaud, Marie Christine ^a   Croville, Guillaume ^a   Cussac, Didier ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

2 adrenoceptor subtype; (+)8 OH DPAT; 35S GTP S binding; G protein coupled inwardly rectifying potassium channel; Radioligand binding

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; SEROTONIN 1A AGONIST; TRITIUM; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; SEROTONIN 1 AGONIST;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; ENANTIOMER; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; RACEMIC MIXTURE; RADIOASSAY; RECEPTOR AFFINITY; XENOPUS; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; ELECTRIC CONDUCTIVITY; HAMSTER; HUMAN; METABOLISM; STEREOISOMERISM;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ELECTRIC CONDUCTIVITY; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-2; STEREOISOMERISM; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; SEROTONIN 5-HT1 RECEPTOR AGONISTS;

EID: 77953872451     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.04.034     Document Type: Article

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