Potential vascular α1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat

European Journal of Pharmacology

Volumn 535, Issue 1-3, 2006, Pages 234-242

  Centurión, David ^a   Mehotra, Suneet ^b   Sánchez López, Araceli ^a   Gupta, Saurabh ^b   MaassenVanDenBrink, Antoinette ^b   Villalón, Carlos M ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

1 Adrenoceptors; 5 HT receptor ligands; Blood pressure; Phenylephrine; Pithed rat

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BUSPIRONE; CLOZAPINE; ERGOTAMINE; GRANISETRON; IPSAPIRONE; KETANSERIN; LISURIDE; MESULERGINE; METERGOLINE; METHYSERGIDE; METITEPINE; METOCLOPRAMIDE; N (2 HYDROXYCYCLOPENTYL) 1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXAMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; PHENYLEPHRINE; PIZOTIFEN; PRAZOSIN; RITANSERIN; SEROTONIN RECEPTOR; SPIPERONE; TROPISETRON; YOHIMBINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG BINDING; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; HEART HEMODYNAMICS; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD PRESSURE; DECEREBRATION; DRUG ANTAGONISM; DRUG INTERACTION; HEART RATE; PHYSIOLOGY; WISTAR RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; BUSPIRONE; CLOZAPINE; DECEREBRATE STATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ERGOTAMINE; HEART RATE; KETANSERIN; LISURIDE; MALE; METERGOLINE; METHIOTHEPIN; METHYSERGIDE; PHENYLEPHRINE; PIPERAZINES; PIZOTYLINE; PRAZOSIN; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; YOHIMBINE;

EID: 33645403159     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.02.010     Document Type: Article

References (50)

1. 2C adrenergic receptor subtype in the opossum kidney and in the OK cell line J. Pharmacol. Exp. Ther. 259 1991 323 329
2. 3H]idazoxan in rat brain J. Pharmacol. Exp. Ther. 241 1987 1092 1098
3. 1A receptor agonists and subtypes of alpha 1-adrenoceptors on rabbit aorta Eur. J. Pharmacol. 241 1993 141 148
4. 1A receptor agonists on the blood pressure of pithed rats Arch. Med. Res. 26 1995 251 255
5. 2A receptor subtype Br. J. Pharmacol. 135 2002 1531 1539
6. 1A-adrenoceptors Eur. J. Pharmacol. 202 1991 33 44
7. N.A. Flavahan, T.L. Grant, J. Greig, and J.C. McGrath Analysis of the alpha-adrenoceptor-mediated, and other, components in the sympathetic vasopressor responses of the pithed rat Br. J. Pharmacol. 86 1985 265 274
8. J.R. Fozard Mechanism of the hypotensive effect of ketanserin J. Cardiovasc. Pharmacol. 4 1982 829 838
9. S. Guimaraes, and D. Moura Vascular adrenoceptors: an update Pharmacol. Rev. 53 2001 319 356
10. H. Hall, M. Sallemark, and E. Jerning Effects of remoxipride and some related new substituted salicylamides on rat brain receptors Acta Pharmacol. Toxicol. (Copenh.) 58 1986 61 70
11. 1 recognition sites J. Recept. Res. 8 1988 59 81
12. D. Hoyer, D.E. Clarke, J.R. Fozard, P.R. Hartig, G.R. Martin, E.J. Mylecharane, P.R. Saxena, and P.P. Humphrey International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) Pharmacol. Rev. 46 1994 157 203
13. M. Ibarra, J.A. Terrón, J.J. López-Guerrero, and R. Villalobos-Molina Evidence for an age-dependent functional expression of alpha 1D-adrenoceptors in the rat vasculature Eur. J. Pharmacol. 322 1997 221 224
14. 125I]-4-hydroxyphenyl-ethyl-aminomethyl- tetralone J. Pharmacol. Exp. Ther. 241 1987 875 881
15. L.I. Kleinman, and E.P. Radford Ventilation standards for small mammals J. Appl. Physiol. 19 1964 360 362
16. C. Korstanje, R. Sprenkels, H.N. Doods, J.G. Hugtenburg, E. Boddeke, H.D. Batink, M.J. Thoolen, and P.A. Van Zwieten Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in vivo alpha 1-, alpha 2- and 5-HT2-receptor antagonism and in vitro affinity for alpha 1-, alpha 2- and 5-HT2-receptors: comparison with ketanserin J. Pharm. Pharmacol. 38 1986 374 379
17. M.J. Lew, and J.A. Angus Analysis of competitive agonist-antagonist interactions by nonlinear regression Trends Pharmacol. Sci. 16 1995 328 337
18. J.E. Leysen Serotonergic binding sites P.M. Vanhoutte Serotonin and the Cardiovascular System 1985 Raven press New York 43 62
19. J.E. Leysen, and W. Gommeren In vitro binding profile of drugs used in migraine W.K. Amery J.M. Van Nueten A. Wauquier The Pharmacological Basis of Migraine Therapy 1984 Pitman Publishing Ltd. London 255 266
20. M.J. Millan, A. Newman-Tancredi, V. Audinot, D. Cussac, F. Lejeune, J.P. Nicolas, F. Coge, J.P. Galizzi, J.A. Boutin, J.M. Rivet, A. Dekeyne, and A. Gobert Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states Synapse 35 2000 79 95
21. M.J. Millan, L. Maiofiss, D. Cussac, V. Audinot, J.A. Boutin, and A. Newman-Tancredi Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes J. Pharmacol. Exp. Ther. 303 2002 791 804
22. H. Motulsky, and A. Christopoulos Fitting Models to Biological Data Using Linear and Nonlinear Regression. A Practical Guide to Curve Fitting First ed. 2004 Oxford University Press New York
23. R.R. Neubig, M. Spedding, T. Kenakin, and A. Christopoulos International union of pharmacology committee on receptor nomenclature and drug classification. XXXVIII. Update on terms and symbols in quantitative pharmacology Pharmacol. Rev. 55 2003 597 606
24. 1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935 Eur. J. Pharmacol. 300 1996 141 145
25. 5A) in the spinal cord J. Comp. Neurol. 476 2004 313 315
26. E. Richelson, and A. Nelson Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro Eur. J. Pharmacol. 103 1984 197 204
27. T.J. Rimele, D.E. Henry, D.K. Lee, G. Geiger, R.J. Heaslip, and D. Grimes Tissue-dependent alpha adrenoceptor activity of buspirone and related compounds J. Pharmacol. Exp. Ther. 241 1987 771 778
28. J. Roquebert, and B. Grenie Alpha 2-adrenergic agonist and alpha 1-adrenergic antagonist activity of ergotamine and dihydroergotamine in rats Arch. Int. Pharmacodyn. Ther. 284 1986 30 37
29. 5A/5B receptors Br. J. Pharmacol. 140 2003 725 735
30. R. Sawyer, and J.R. Docherty Direct cardiac actions of phenylephrine when used in assessment of baroreflex function in the rat J. Auton. Pharm. 6 1986 215 217
31. P.R. Saxena Further characterisation of 5-hydroxytryptamine1-like receptors mediating tachycardia in the cat: no apparent relationship to known subtypes of the 5-hydroxytryptamine1 binding sites Drug Dev. Res. 13 1988 245 258
32. P.R. Saxena, and C.M. Villalón Cardiovascular effects of serotonin agonists and antagonists J. Cardiovasc. Pharmacol. 15 Suppl. 7 1990 S17 S34
33. D.A. Schwinn, G.I. Johnston, S.O. Page, M.J. Mosley, K.H. Wilson, N.P. Worman, S. Campbell, M.D. Fidock, L.M. Furness, and D.J. Parry-Smith Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues J. Pharmacol. Exp. Ther. 272 1995 134 142
34. R.E. Shipley, and J.H. Tilden A pithed rat preparation suitable for assaying pressor substances Proc. Soc. Exp. Biol. Med. 64 1947 453
35. R.G.D. Steel, and J.H. Torrie Principles and Procedures of Statistics. A Biomedical Approach 2nd edition 1980 McGraw-Hill Kogakusha Ltd Tokyo
36. R.J. Summers, N. Broxton, D.S. Hutchinson, and B.A. Evans The Janus faces of adrenoceptors: factors controlling the coupling of adrenoceptors to multiple signal transduction pathways Clin. Exp. Pharmacol. Physiol. 31 2004 822 827
37. J.A. Terrón, V. Ransanz, M. Ibarra, E. Hong, and C.M. Villalón Alpha 1-adrenoceptor blocking properties of spiroxatrine in rat aorta Life Sci. 51 1992 L1 L6
38. J.A. Terrón, E. Hong, F.J. López-Munoz, and C.M. Villalón Inhibition of serotonin-induced increase in canine external carotid blood flow by drugs that decrease the sympathetic outflow J. Auton. Pharm. 14 1994 165 175
39. J.A. Terrón, E. Ramírez-San Juan, E. Hong, and C.M. Villalón Role of alpha1-adrenoceptors in the reduction of external carotid blood flow induced by buspirone and ipsapirone in the dog Life Sci. 58 1996 63 73
40. R. Testa, L. Guarneri, E. Poggesi, P. Angelico, C. Velasco, M. Ibba, A. Cilia, G. Motta, C. Riva, and A. Leonardi Effect of several 5- hydroxytryptamine(1A) receptor ligands on the micturition reflex in rats: comparison with WAY 100635 J. Pharmacol. Exp. Ther. 290 1999 1258 1269
41. 1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs Naunyn- Schmiedeberg's Arch. Pharmacol. 370 2004 46 53
42. H.M. Vargas, L. Zhou, and A.J. Gorman Role of vascular alpha-1 adrenoceptor subtypes in the pressor response to sympathetic nerve stimulation in the pithed rat J. Pharmacol. Exp. Ther. 271 1994 748 754
43. 1A receptor antagonist, is related to vascular alpha 1-adrenoceptor blockade in the adult rat Auton. Autacoid. Pharmacol. 22 2002 171 176
44. C.M. Villalón, E. Hong, and J.A. Terrón Influence of sympathetic tone on the reactivity to indorenate in the external carotid vascular bed of the dog Arch. Med. Res. 24 1993 147 154
45. 1-like receptors mediating the increases in external carotid blood flow in the dog Drug Dev. Res. 29 1993 271 281
46. C.M. Villalón, J. Contreras, E. Ramírez-San Juan, C. Castillo, M. Perusquía, F.J. López-Munoz, and J.A. Terrón 5-hydroxytryptamine inhibits pressor responses to preganglionic sympathetic nerve stimulation in pithed rats Life Sci. 57 1995 803 812
47. C.M. Villalón, J. Contreras, E. Ramírez-San Juan, C. Castillo, M. Perusquía, and J.A. Terrón Characterization of prejunctional 5-HT receptors mediating inhibition of sympathetic vasopressor responses in the pithed rat Br. J. Pharmacol. 116 1995 3330 3336
48. 1-like receptors mediating external carotid vasoconstriction in vagosympathectomized dogs. Close resemblance to the 5-HT1D receptor subtype Naunyn-Schmiedeberg's Arch. Pharmacol. 354 1996 550 556
49. R. Yoshio, T. Taniguchi, H. Itoh, and I. Muramatsu Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes Jpn. J. Pharmacol. 86 2001 189 195
50. L. Zhou, and H.M. Vargas Vascular alpha 1D-adrenoceptors have a role in the pressor response to phenylephrine in the pithed rat Eur. J. Pharmacol. 305 1996 173 176