The serotonin 5-hydroxytryptaphan1A receptor agonist, (+)8-hydroxy-2-(di-n-propylamino)-tetralin, stimulates sympathetic-dependent increases in venous tone during hypovolemic shock

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 2, 2006, Pages 776-782

  Tiniakov, Ruslan ^a   Scrogin, Karie E ^a,b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b Department of Pharmacology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 HYDROXYTRYPTOPHAN1A RECEPTOR AGONIST; ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; GANGLION BLOCKING AGENT; HEXAMETHONIUM CHLORIDE; N [2 (1,3,4,6,7,12B HEXAHYDRO 2' OXOSPIRO[2H BENZOFURO[2,3 A]QUINOLIZINE 2,4' IMIDAZOLIDIN] 3' YL)ETHYL]METHANESULFONAMIDE; PRAZOSIN; SEROTONIN 1A AGONIST; UNCLASSIFIED DRUG; QUINOLIZINE DERIVATIVE; SEROTONIN AGONIST;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CELL ACTIVATION; CIRCULATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DOSE REGIMEN; GANGLION BLOCK; HEMODYNAMICS; HYPOVOLEMIC SHOCK; MALE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT; VASOCONSTRICTION; VEIN TONE; ADRENERGIC SYSTEM; ANIMAL; CENTRAL VENOUS PRESSURE; DRUG EFFECT; HEART RATE; PATHOPHYSIOLOGY; PHYSIOLOGY; SHOCK; SPRAGUE DAWLEY RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CENTRAL VENOUS PRESSURE; HEART RATE; MALE; PRAZOSIN; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS; SHOCK; SYMPATHETIC NERVOUS SYSTEM;

EID: 33751164225     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.108944     Document Type: Article

References (27)

1. Abdelrahman A and Pang CC (1990) Differential venous effects of isoprenaline in conscious rats. Eur J Pharmacol 190:321-327.
2. 1A agonists: a new therapeutic principle for stroke treatment. Stroke 21:IV161-IV163.
3. Cleare AJ, Forsling M, and Bond AJ (1998) Neuroendocrine and hypothermic effects of 5-HT1A receptor stimulation with ipsapirone in healthy men: a placebo-controlled study. Int Clin Psychopharmacol 13:23-32.
4. Del Basso P, Keller EA, Salica C, and Orsingher OA (1983) Vascular reactivity in perinatally undernourished rats. Eur J Pharmacol 87:107-111.
5. D'Oyley HM and Pang CC (1990) Effects of alpha 1- and alpha 2-adrenoceptor antagonists on venous tone in conscious rats. Eur J Pharmacol 182:283-290.
6. Guyton AC, Polizo D, and Armstrong GG (1954) Mean circulatory filling pressure measured immediately after cessation of heart pumping. Am J Physiol 179:261-267.
7. Handy DE, Flordellis CS, Bogdanova NN, Bresnahan MR, and Gavras H (1993) Diverse tissue expression of rat alpha 2-adrenergic receptor genes. Hypertension 21:861-865.
8. Henze M, Osei-Owusu P, and Scrogin KE (2005) The baroreflex mediates the disinhibition of sympathetic drive in response to prolonged hemorrhage. FASEB J 19: A614.
9. Ito H and Hirakawa S (1984) Effects of vasodilators on the systemic capacitance vessels, a study with the measurement of the mean circulatory pressure in dogs. Jpn Circ J 48:388-404.
10. Kam PC, Williams S, and Yoong FF (2004) Vasopressin and terlipressin: pharmacology and its clinical relevance. Anaesthesia 59:993-1001.
11. Kaufman S and Deng Y (1993) Splenic control of intravascular volume in the rat. J Physiol 468:557-565.
12. Kuwahira I, Kamiya U, Iwamoto T, Moue Y, Urano T, Ohta Y, and Gonzalez NC (1999) Splenic contraction-induced reversible increase in hemoglobin concentration in intermittent hypoxia. J Appl Physiol 86:181-187.
13. Meier-Hellmann A, Reinhart K, Bredle DL, Specht M, Spies CD, and Hannemann L (1997) Epinephrine impairs splanchnic perfusion in septic shock. Crit Care Med 25:399-404.
14. Oberg B and Thoren P (1970) Increased activity in vagal cardiac afferents correlated to the appearance of reflex bradycardia during severe hemorrhage in cats. Acta Physiol Scand 80:22A-23A.
15. Osei-Owusu P and Scrogin KE (2004a) 5-HT1A receptor activation attenuates reperfusion injury after prolonged hypovolemia. FASEB J 18:A1244.
16. Osei-Owusu P and Scrogin KE (2004b) Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. J Pharmacol Exp Ther 309:1132-1140.
17. Pang CC (2001) Autonomic control of the venous system in health and disease: effects of drugs. Pharmacol Ther 90:179-230.
18. Pang CC and Tabrizchi R (1986) The effects of noradrenaline, B-HT 920, methoxamine, angiotensin II and vasopressin on mean circulatory filling pressure in conscious rats. Br J Pharmacol 89:389-394.
19. Rowe BP, Noble AR, and Munday KA (1979) Blockade of pressor responses to angiotensins I and II and noradrenaline using phentolamine, propranolol and hexamethonium in conscious rabbits. Pflueg Arch Eur J Physiol 382:269-274.
20. Schadt JC and Ludbrook J (1991) Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. Am J Physiol 260:H305-H318.
21. Scrogin KE (2003) 5-HT1A receptor agonist 8-OH-DPAT acts in the hindbrain to reverse the sympatholytic response to severe hemorrhage. Am J Physiol 284:R782-R791.
22. Seki K, Aibiki M, and Ogura S (1997) 3.5% hypertonic saline produces sympathetic activation in hemorrhaged rabbits. J Auton Nerv Syst 64:49-56.
23. Semkova I, Wolz P, and Krieglstein J (1998) Neuroprotective effect of 5-HT1A receptor agonist, Bay X 3702, demonstrated in vitro and in vivo. Eur J Pharmacol 359:251-260.
24. Shiah IS, Yatham LN, Lam RW, Tam EM, and Zis AP (1998) Cortisol, hypothermic, and behavioral responses to ipsapirone in patients with bipolar depression and normal controls. Neuropsychobiology 38:6-12.
25. van Lieshout JJ, Wieling W, Karemaker JM, and Secher NH (2003) Syncope, cerebral perfusion, and oxygenation. J Appl Physiol 94:833-848.
26. Warner TD (1990) Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists. Br J Pharmacol 99:427-433.
27. Yamamoto J, Trippodo NC, Ishise S, and Frohlich ED (1980) Total vascular pressure-volume relationship in the conscious rat. Am J Physiol 238:H823-H828.