S18616, a highly potent, spiroimidazoline agonist at α2-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 3, 2000, Pages 1192-1205

  Millan, Mark J ^a   Dekeyne, Anne ^a   Newman Tancredi, Adrian ^a   Cussac, Didier ^a   Audinot, Valérie ^a   Milligan, Graeme ^b   Duqueyroix, Delphine ^a   Girardon, Sylvie ^a   Mullot, Jimmy ^a   Boutin, Jean A ^a   Nicolas, Jean Paul ^a   Renouard Try, Anne ^a   Lacoste, Jean Michel ^a   Cordi, Alex ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ATIPAMEZOLE; CARBACHOL; CLONIDINE; DEXMEDETOMIDINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); IDAZOXAN; IMIDAZOLINE; IMIDAZOLINE DERIVATIVE; OXOTREMORINE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL; PRAZOSIN; S 18616; SPIRO[(1 OXA 2 AMINO 3 AZACYCLOPENT 2 ENE) 4,2' (8' CHLORO 1',2',3',4' TETRAHYDRONAPHTHALENE)]; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CHO CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; HYPOTHERMIA; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS, NON-NARCOTIC; ANIMALS; BODY TEMPERATURE; CHO CELLS; CLONIDINE; CRICETINAE; DEXMEDETOMIDINE; HUMANS; IMIDAZOLES; MALE; MICE; OXAZOLES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG;

EID: 16744367439     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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