메뉴 건너뛰기




Volumn 3, Issue , 2010, Pages 15-23

Controlling adenoviral replication to induce oncolytic efficacy

Author keywords

Adenovirus; Cancer gene therapy; Cancer virotherapy; Insulators; Oncolysis; Post transcriptional targeting; Transcriptional targeting; Tumor microenvironment

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYCLOOXYGENASE 2; E1A PROTEIN; E1B PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MESOTHELIN; MICRORNA; ONCOLYTIC ADENOVIRUS; ONYX 015; PROSTATE SPECIFIC ANTIGEN; PROTEIN KINASE R; RETINOBLASTOMA PROTEIN; SURVIVIN; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR E2F; UROKINASE RECEPTOR; UROPLAKIN; WNT PROTEIN;

EID: 77953765248     PISSN: None     EISSN: 18750370     Source Type: Journal    
DOI: 10.2174/1875037001003020015     Document Type: Article
Times cited : (4)

References (114)
  • 1
    • 65749089629 scopus 로고    scopus 로고
    • Targeting cancer by transcriptionalcontrol in cancer gene therapy and viral oncolysis
    • Dorer DE, Nettelbeck DM. Targeting cancer by transcriptionalcontrol in cancer gene therapy and viral oncolysis. Adv Drug DelivRev 2009; 61(7-8): 554-71.
    • (2009) Adv Drug DelivRev , vol.61 , Issue.7-8 , pp. 554-571
    • Dorer, D.E.1    Nettelbeck, D.M.2
  • 2
    • 0142010649 scopus 로고    scopus 로고
    • Ad-mTERT delta19, a conditionalreplication competent adenovirus driven by the human telomerase promoter, selectively replicates in and elicits cytopathic effect in acancer cell specific manner
    • Kim E, Kim JH, Shin HY, et al. Ad-mTERT delta19, a conditionalreplication competent adenovirus driven by the human telomerase promoter, selectively replicates in and elicits cytopathic effect in acancer cell specific manner. Hum Gene Ther 2003; 14(15): 1415-28.
    • (2003) Hum Gene Ther , vol.14 , Issue.15 , pp. 1415-1428
    • Kim, E.1    Kim, J.H.2    Shin, H.Y.3
  • 3
    • 3442879516 scopus 로고    scopus 로고
    • Effective gene viral therapy fortelomerase positive cancers by selective replicative competentadenovirus combining with endostatin gene
    • Zhang Q, Nie M, Sham J, et al. Effective gene viral therapy fortelomerase positive cancers by selective replicative competentadenovirus combining with endostatin gene. Cancer Res 2004;64(15): 5390-7.
    • (2004) Cancer Res , vol.64 , Issue.15 , pp. 5390-5397
    • Zhang, Q.1    Nie, M.2    Sham, J.3
  • 4
    • 0842329844 scopus 로고    scopus 로고
    • A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent
    • Zou W, Luo C, Zhang Z, et al. A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent. Oncogene2004; 23(2): 457-64.
    • (2004) Oncogene , vol.23 , Issue.2 , pp. 457-464
    • Zou, W.1    Luo, C.2    Zhang, Z.3    Et al.4
  • 5
    • 57649125119 scopus 로고    scopus 로고
    • An oncolytic adenovirus expressing granulocyte macrophage colony stimulating factor shows improved specificity and efficacy for treating human solid tumors
    • Lei N, Shen FB, Chang JH, et al. An oncolytic adenovirus expressing granulocyte macrophage colony stimulating factor shows improved specificity and efficacy for treating human solid tumors.Cancer Gene Ther 2009; 16(1): 33-43.
    • (2009) Cancer Gene Ther , vol.16 , Issue.1 , pp. 33-43
    • Lei, N.1    Shen, F.B.2    Chang, J.H.3    Et al.4
  • 6
    • 33749011709 scopus 로고    scopus 로고
    • Eliminating established tumor innu/nu nude mice by a tumor necrosis factor alpha related apopto-sis inducing ligandarmed oncolytic adenovirus
    • Dong F, Wang L, Davis JJ, et al. Eliminating established tumor innu/nu nude mice by a tumor necrosis factor alpha related apopto-sis inducing ligandarmed oncolytic adenovirus. Clin Cancer Res2006; 12(17): 5224-30.
    • (2006) Clin Cancer Res , vol.12 , Issue.17 , pp. 5224-5230
    • Dong, F.1    Wang, L.2    Davis, J.J.3    Et al.4
  • 7
    • 21044457510 scopus 로고    scopus 로고
    • Enhanced oncolysis by atropism modified telomerase specific replication selective adenovi-ral agent OBP-405 ('Telomelysin-RGD')
    • Taki M, Kagawa S, Nishizaki M, et al. Enhanced oncolysis by atropism modified telomerase specific replication selective adenovi-ral agent OBP-405 ('Telomelysin-RGD'). Oncogene 2005; 24(19):3130-40.
    • (2005) Oncogene , vol.24 , Issue.19 , pp. 3130-3140
    • Taki, M.1    Kagawa, S.2    Nishizaki, M.3
  • 8
    • 27944486111 scopus 로고    scopus 로고
    • Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors dueto hTERT promoterregulated E4 gene expression
    • Kuppuswamy M, Spencer JF, Doronin K, et al. Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors dueto hTERT promoterregulated E4 gene expression. Gene Ther2005; 12(22): 1608-17.
    • (2005) Gene Ther , vol.12 , Issue.22 , pp. 1608-1617
    • Kuppuswamy, M.1    Spencer, J.F.2    Doronin, K.3    Et al.4
  • 9
    • 67349228816 scopus 로고    scopus 로고
    • Armed replicating adenoviruses for cancervirotherapy
    • Cody JJ, Douglas JT. Armed replicating adenoviruses for cancervirotherapy. Cancer Gene Ther 2009; 16(6): 473-88.
    • (2009) Cancer Gene Ther , vol.16 , Issue.6 , pp. 473-488
    • Cody, J.J.1    Douglas, J.T.2
  • 10
    • 33847074257 scopus 로고    scopus 로고
    • Modulation oftelomerase promoter tumor selectivity in the context of oncolyticadenoviruses
    • Bilsland AE, Merron A, Vassaux G, Keith WN. Modulation oftelomerase promoter tumor selectivity in the context of oncolyticadenoviruses. Cancer Res 2007; 67(3): 1299-307.
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1299-1307
    • Bilsland, A.E.1    Merron, A.2    Vassaux, G.3    Keith, W.N.4
  • 11
    • 0037096881 scopus 로고    scopus 로고
    • An E2F-responsive replication selective adenovirus targetedto the defective cell cycle in cancer cells: Potent antitumoral efficacy but no toxicity to normal cell
    • Tsukuda K, Wiewrodt R, Molnar-Kimber K, Jovanovic VP, AminKM. An E2F-responsive replication selective adenovirus targetedto the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell. Cancer Res 2002; 62(12): 3438-47.
    • (2002) Cancer Res , vol.62 , Issue.12 , pp. 3438-3447
    • Tsukuda, K.1    Wiewrodt, R.2    Molnar-Kimber, K.3    Jovanovic, V.P.4    Amin, K.M.5
  • 12
    • 4043135736 scopus 로고    scopus 로고
    • Antitumor efficacy andtumor selective replication with a single intravenous injection ofOAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer
    • Ryan PC, Jakubczak JL, Stewart DA, et al. Antitumor efficacy andtumor selective replication with a single intravenous injection ofOAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer. Cancer Gene Ther 2004; 11(8): 555-69.
    • (2004) Cancer Gene Ther , vol.11 , Issue.8 , pp. 555-569
    • Ryan, P.C.1    Jakubczak, J.L.2    Stewart, D.A.3
  • 13
    • 29344455240 scopus 로고    scopus 로고
    • Dual promoter controlledoncolytic adenovirus CG5757 has strong tumor selectivity and significant antitumor efficacy in preclinical models
    • Li Y, Idamakanti N, Arroyo T, et al. Dual promoter controlledoncolytic adenovirus CG5757 has strong tumor selectivity and significant antitumor efficacy in preclinical models. Clin Cancer Res2005; 11(24 1): 8845-55.
    • (2005) Clin Cancer Res , vol.11 , Issue.1 , pp. 8845-8855
    • Li, Y.1    Idamakanti, N.2    Arroyo, T.3    Et al.4
  • 14
    • 34548565837 scopus 로고    scopus 로고
    • Improved glioblastoma treatment with Ad5/35 fiber chimeric conditionally replicating adenoviruses
    • Hoffmann D, Meyer B, Wildner O. Improved glioblastoma treatment with Ad5/35 fiber chimeric conditionally replicating adenoviruses. J Gene Med 2007; 9(9): 764-78.
    • (2007) J Gene Med , vol.9 , Issue.9 , pp. 764-778
    • Hoffmann, D.1    Meyer, B.2    Wildner, O.3
  • 15
    • 34548558821 scopus 로고    scopus 로고
    • ICOVIR-5shows E2F1 addiction and potent antiglioma effect in vivo
    • Alonso MM, Cascallo M, Gomez-Manzano C, et al. ICOVIR-5shows E2F1 addiction and potent antiglioma effect in vivo. CancerRes 2007; 67(17): 8255-63.
    • (2007) CancerRes , vol.67 , Issue.17 , pp. 8255-8263
    • Alonso, M.M.1    Cascallo, M.2    Gomez-Manzano, C.3
  • 16
    • 34548137729 scopus 로고    scopus 로고
    • Systemic toxicity efficacyprofile of ICOVIR-5, a potent and selective oncolytic adenovirusbased on the pRB pathway
    • Cascallo M, Alonso MM, Rojas JJ, et al. Systemic toxicity efficacyprofile of ICOVIR-5, a potent and selective oncolytic adenovirusbased on the pRB pathway. Mol Ther 2007;15(9): 1607-15.
    • (2007) Mol Ther , vol.15 , Issue.9 , pp. 1607-1615
    • Cascallo, M.1    Alonso, M.M.2    Rojas, J.J.3
  • 18
    • 0141483028 scopus 로고    scopus 로고
    • Infectivity enhanced,cyclooxygenase-2 promoter based conditionally replicative adeno-virus for pancreatic cancer
    • Yamamoto M, Davydova J, Wang M, et al. Infectivity enhanced,cyclooxygenase-2 promoter based conditionally replicative adeno-virus for pancreatic cancer. Gastroenterology 2003; 125(4): 1203-18.
    • (2003) Gastroenterology , vol.125 , Issue.4 , pp. 1203-1218
    • Yamamoto, M.1    Davydova, J.2    Wang, M.3
  • 19
    • 3042523468 scopus 로고    scopus 로고
    • Infectivity-enhanced cy-clooxygenase-2-based conditionally replicative adenoviruses foresophageal adenocarcinoma treatment
    • Davydova J, Le LP, Gavrikova T, et al. Infectivity-enhanced cy-clooxygenase-2-based conditionally replicative adenoviruses foresophageal adenocarcinoma treatment. Cancer Res 2004; 64(12):4319-27.
    • (2004) Cancer Res , vol.64 , Issue.12 , pp. 4319-4327
    • Davydova, J.1    Le, L.P.2    Gavrikova, T.3
  • 20
    • 3042734847 scopus 로고    scopus 로고
    • A cox-2 promoter-basedreplication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells
    • Shirakawa T, Hamada K, Zhang Z, et al. A cox-2 promoter-basedreplication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells. Clin Cancer Res2004;10(13): 4342-8.
    • (2004) Clin Cancer Res , vol.10 , Issue.13 , pp. 4342-4348
    • Shirakawa, T.1    Hamada, K.2    Zhang, Z.3    Et al.4
  • 21
    • 20444397790 scopus 로고    scopus 로고
    • Promoter-controlledinfectivity-enhanced conditionally replicative adenoviral vectorsfor the treatment of gastric cancer
    • Ono HA, Davydova JG, Adachi Y, et al. Promoter-controlledinfectivity-enhanced conditionally replicative adenoviral vectorsfor the treatment of gastric cancer. J Gastroenterol 2005; 40(1): 31-42.
    • (2005) J Gastroenterol , vol.40 , Issue.1 , pp. 31-42
    • Ono, H.A.1    Davydova, J.G.2    Adachi, Y.3
  • 22
    • 18044378377 scopus 로고    scopus 로고
    • Oncolytic adenoviraltherapy in gallbladder carcinoma
    • Tekant Y, Davydova J, Ramirez PJ, et al. Oncolytic adenoviraltherapy in gallbladder carcinoma. Surgery 2005; 137(5): 527-35.
    • (2005) Surgery , vol.137 , Issue.5 , pp. 527-535
    • Tekant, Y.1    Davydova, J.2    Ramirez, P.J.3
  • 23
    • 33644970643 scopus 로고    scopus 로고
    • Restriction of adenoviral replicationto the transcriptional intersection of two different promoters for colorectal and pancreatic cancer treatment
    • Hoffmann D, Wildner O. Restriction of adenoviral replicationto the transcriptional intersection of two different promoters for colorectal and pancreatic cancer treatment. Mol Cancer Ther 2006;5(2): 374-81.
    • (2006) Mol Cancer Ther , vol.5 , Issue.2 , pp. 374-381
    • Hoffmann, D.1    Wildner, O.2
  • 24
    • 34547515098 scopus 로고    scopus 로고
    • Comparative evalua-tion of survivin, midkine and CXCR4 promoters for transcriptionaltargeting of glioma gene therapy
    • Ulasov IV, Rivera AA, Sonabend AM, et al. Comparative evalua-tion of survivin, midkine and CXCR4 promoters for transcriptionaltargeting of glioma gene therapy. Cancer Biol Ther 2007; 6(5):679-85.
    • (2007) Cancer Biol Ther , vol.6 , Issue.5 , pp. 679-685
    • Ulasov, I.V.1    Rivera, A.A.2    Sonabend, A.M.3
  • 25
    • 34547523121 scopus 로고    scopus 로고
    • Survivin-driven andfiber modified oncolytic adenovirus exhibits potent antitumor ac-tivity in established intracranial glioma
    • Ulasov IV, Zhu ZB, Tyler MA, et al. Survivin-driven andfiber modified oncolytic adenovirus exhibits potent antitumor ac-tivity in established intracranial glioma. Hum Gene Ther 2007;18(7): 589-602.
    • (2007) Hum Gene Ther , vol.18 , Issue.7 , pp. 589-602
    • Ulasov, I.V.1    Zhu, Z.B.2    Tyler, M.A.3
  • 28
    • 63949085760 scopus 로고    scopus 로고
    • Combination of adenovi-ral virotherapy and temozolomide chemotherapy eradicatesmalignant glioma through autophagic and apoptotic cell death invivo
    • Ulasov IV, Sonabend AM, Nandi S, et al. Combination of adenovi-ral virotherapy and temozolomide chemotherapy eradicatesmalignant glioma through autophagic and apoptotic cell death invivo. Br J Cancer 2009; 100(7): 1154-64.
    • (2009) Br J Cancer , vol.100 , Issue.7 , pp. 1154-1164
    • Ulasov, I.V.1    Sonabend, A.M.2    Nandi, S.3
  • 30
    • 33750526892 scopus 로고    scopus 로고
    • A survivin-mediated oncolytic adenovirusinduces non-apoptotic cell death in lung cancer cells and showsantitumoral potential in vivo
    • Li B, Liu X, Fan J, et al. A survivin-mediated oncolytic adenovirusinduces non-apoptotic cell death in lung cancer cells and showsantitumoral potential in vivo. J Gene Med 2006; 8(10): 1232-42.
    • (2006) J Gene Med , vol.8 , Issue.10 , pp. 1232-1242
    • Li, B.1    Liu, X.2    Fan, J.3
  • 31
    • 33846220985 scopus 로고    scopus 로고
    • Targeting lung cancerusing an infectivity enhanced CXCR4-CRAd
    • Zhu ZB, Rivera AA, Makhija SK, et al. Targeting lung cancerusing an infectivity enhanced CXCR4-CRAd. Lung Cancer 2007;55(2): 145-56.
    • (2007) Lung Cancer , vol.55 , Issue.2 , pp. 145-156
    • Zhu, Z.B.1    Rivera, A.A.2    Makhija, S.K.3
  • 32
    • 33846573725 scopus 로고    scopus 로고
    • Combining high selec-tivity of replication via CXCR4 promoter with fiber chimerism foreffective adenoviral oncolysis in breast cancer
    • Stoff-Khalili MA, Rivera AA, Stoff A, et al. Combining high selec-tivity of replication via CXCR4 promoter with fiber chimerism foreffective adenoviral oncolysis in breast cancer. Int J Cancer 2007;120(4): 935-41.
    • (2007) Int J Cancer , vol.120 , Issue.4 , pp. 935-941
    • Stoff-Khalili, M.A.1    Rivera, A.A.2    Stoff, A.3
  • 33
    • 38449122062 scopus 로고    scopus 로고
    • Targeting of a condition-ally replicative adenovirus agent to human squamous cell carcino-mas of the head and neck
    • Zhu ZB, Mathis JM, Makhija SK, et al. Targeting of a condition-ally replicative adenovirus agent to human squamous cell carcino-mas of the head and neck. Int J Oncol 2007; 31(5): 1213-22.
    • (2007) Int J Oncol , vol.31 , Issue.5 , pp. 1213-1222
    • Zhu, Z.B.1    Mathis, J.M.2    Makhija, S.K.3
  • 34
    • 66449132325 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activa-tor receptor transcriptionally controlled adenoviruses eradicatepancreatic tumors and liver metastasis in mouse models
    • 4 p following 28
    • Huch M, Gros A, Jose A, et al. Urokinase-type plasminogen activa-tor receptor transcriptionally controlled adenoviruses eradicatepancreatic tumors and liver metastasis in mouse models. Neoplasia2009; 11(6): 518-28, 4 p following 28.
    • (2009) Neoplasia , vol.11 , Issue.6 , pp. 518-528
    • Huch, M.1    Gros, A.2    Jose, A.3    Et al.4
  • 35
    • 23044439544 scopus 로고    scopus 로고
    • RAD001 (everolimus)improves the efficacy of replicating adenoviruses that target coloncancer
    • Homicsko K, Lukashev A, Iggo RD. RAD001 (everolimus)improves the efficacy of replicating adenoviruses that target coloncancer. Cancer Res 2005; 65(15): 6882-90.
    • (2005) Cancer Res , vol.65 , Issue.15 , pp. 6882-6890
    • Homicsko, K.1    Lukashev, A.2    Iggo, R.D.3
  • 36
    • 70350733628 scopus 로고    scopus 로고
    • Targeted radionuclide therapyusing a Wnt-targeted replicating adenovirus encoding the Na/Isymporter
    • Peerlinck I, Merron A, Baril P, et al. Targeted radionuclide therapyusing a Wnt-targeted replicating adenovirus encoding the Na/Isymporter. Clin Cancer Res 2009; 15(21): 6595-601.
    • (2009) Clin Cancer Res , vol.15 , Issue.21 , pp. 6595-6601
    • Peerlinck, I.1    Merron, A.2    Baril, P.3
  • 37
    • 0036764790 scopus 로고    scopus 로고
    • Adenoviral vectors with E1Aregulated by tumor-specific promoters are selectively cytolytic forbreast cancer and melanoma
    • Zhang L, Akbulut H, Tang Y, et al. Adenoviral vectors with E1Aregulated by tumor-specific promoters are selectively cytolytic forbreast cancer and melanoma. Mol Ther 2002; 6(3): 386-93.
    • (2002) Mol Ther , vol.6 , Issue.3 , pp. 386-393
    • Zhang, L.1    Akbulut, H.2    Tang, Y.3
  • 38
    • 4444354567 scopus 로고    scopus 로고
    • Analyses of melanoma-targeted oncolytic adenoviruses with tyrosinase enhancer/promoter-driven E1A, E4, or both in submerged cells and organotypiccultures
    • Banerjee NS, Rivera AA, Wang M, et al. Analyses of melanoma-targeted oncolytic adenoviruses with tyrosinase enhancer/promoter-driven E1A, E4, or both in submerged cells and organotypiccultures. Mol Cancer Ther 2004; 3(4): 437-49.
    • (2004) Mol Cancer Ther , vol.3 , Issue.4 , pp. 437-449
    • Banerjee, N.S.1    Rivera, A.A.2    Wang, M.3
  • 39
    • 51349165471 scopus 로고    scopus 로고
    • Treatment of hepatocel-lular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice
    • Sagawa T, Yamada Y, Takahashi M, et al. Treatment of hepatocel-lular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice. Hepatology 2008; 48(3): 828-40.
    • (2008) Hepatology , vol.48 , Issue.3 , pp. 828-840
    • Sagawa, T.1    Yamada, Y.2    Takahashi, M.3
  • 40
    • 62849119122 scopus 로고    scopus 로고
    • Transthyretin-driven oncolyticadenovirus suppresses tumor growth in orthotopic and ascitesmodels of hepatocellular carcinoma
    • Hsieh JL, Lee CH, Teo ML, et al. Transthyretin-driven oncolyticadenovirus suppresses tumor growth in orthotopic and ascitesmodels of hepatocellular carcinoma. Cancer Sci 2009; 100(3): 537-45.
    • (2009) Cancer Sci , vol.100 , Issue.3 , pp. 537-545
    • Hsieh, J.L.1    Lee, C.H.2    Teo, M.L.3
  • 41
    • 2442660335 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-producingcell-specific oncolytic adenovirus, OV798, for colorectal cancertherapy
    • Li Y, Chen Y, Dilley J, et al. Carcinoembryonic antigen-producingcell-specific oncolytic adenovirus, OV798, for colorectal cancertherapy. Mol Cancer Ther 2003; 2(10): 1003-9.
    • (2003) Mol Cancer Ther , vol.2 , Issue.10 , pp. 1003-1009
    • Li, Y.1    Chen, Y.2    Dilley, J.3
  • 42
    • 65649142589 scopus 로고    scopus 로고
    • A novel A33 pro-moter-based conditionally replicative adenovirus suppresses tumorgrowth and eradicates hepatic metastases in human colon cancermodels
    • Cafferata EG, Maccio DR, Lopez MV, et al. A novel A33 pro-moter-based conditionally replicative adenovirus suppresses tumorgrowth and eradicates hepatic metastases in human colon cancermodels. Clin Cancer Res 2009; 15(9): 3037-49.
    • (2009) Clin Cancer Res , vol.15 , Issue.9 , pp. 3037-3049
    • Cafferata, E.G.1    Maccio, D.R.2    Lopez, M.V.3
  • 43
    • 0036645430 scopus 로고    scopus 로고
    • Identification of humanuroplakin II promoter and its use in the construction of CG8840, aurothelium-specific adenovirus variant that eliminates establishedbladder tumors in combination with docetaxel
    • Zhang J, Ramesh N, Chen Y, et al. Identification of humanuroplakin II promoter and its use in the construction of CG8840, aurothelium-specific adenovirus variant that eliminates establishedbladder tumors in combination with docetaxel. Cancer Res 2002;62(13): 3743-50.
    • (2002) Cancer Res , vol.62 , Issue.13 , pp. 3743-3750
    • Zhang, J.1    Ramesh, N.2    Chen, Y.3
  • 44
    • 37349028068 scopus 로고    scopus 로고
    • Targeting malignantgliomas with a glial fibrillary acidic protein (GFAP)-selective on-colytic adenovirus
    • Horst M, Brouwer E, Verwijnen S, et al. Targeting malignantgliomas with a glial fibrillary acidic protein (GFAP)-selective on-colytic adenovirus. J Gene Med 2007; 9(12): 1071-9.
    • (2007) J Gene Med , vol.9 , Issue.12 , pp. 1071-1079
    • Horst, M.1    Brouwer, E.2    Verwijnen, S.3
  • 45
    • 50349083397 scopus 로고    scopus 로고
    • A fiber-modifiedmesothelin promoter-based conditionally replicating adenovirus fortreatment of ovarian cancer
    • Tsuruta Y, Pereboeva L, Breidenbach M, et al. A fiber-modifiedmesothelin promoter-based conditionally replicating adenovirus fortreatment of ovarian cancer. Clin Cancer Res 2008; 14(11): 3582-8.
    • (2008) Clin Cancer Res , vol.14 , Issue.11 , pp. 3582-3588
    • Tsuruta, Y.1    Pereboeva, L.2    Breidenbach, M.3
  • 46
    • 0035887153 scopus 로고    scopus 로고
    • A phase I trial of CV706,a replication-competent, PSA selective oncolytic adenovirus, forthe treatment of locally recurrent prostate cancer following radia-tion therapy
    • DeWeese TL, van der Poel H, Li S, et al. A phase I trial of CV706,a replication-competent, PSA selective oncolytic adenovirus, forthe treatment of locally recurrent prostate cancer following radia-tion therapy. Cancer Res 2001; 61(20): 7464-72.
    • (2001) Cancer Res , vol.61 , Issue.20 , pp. 7464-7472
    • Deweese, T.L.1    van der Poel, H.2    Li, S.3
  • 47
    • 0038496739 scopus 로고    scopus 로고
    • A conditionally repli-cating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization
    • Ahmed A, Thompson J, Emiliusen L, et al. A conditionally repli-cating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization. Nat Biotechnol 2003; 21(7):771-7.
    • (2003) Nat Biotechnol , vol.21 , Issue.7 , pp. 771-777
    • Ahmed, A.1    Thompson, J.2    Emiliusen, L.3
  • 48
    • 48949120132 scopus 로고    scopus 로고
    • Thecyclo-oxygenase 2 promoter is induced in nontarget cells followingadenovirus infection, but an AU-rich 3prime-untranslated regiondestabilization element can increase specificity
    • Särkioja M, Hakkarainen T, Eriksson M, et al. Thecyclo-oxygenase 2 promoter is induced in nontarget cells followingadenovirus infection, but an AU-rich 3prime-untranslated regiondestabilization element can increase specificity. Gene Med 2008;10(7): 744-53.
    • (2008) Gene Med , vol.10 , Issue.7 , pp. 744-753
    • Särkioja, M.1    Hakkarainen, T.2    Eriksson, M.3
  • 49
    • 43049140850 scopus 로고    scopus 로고
    • Cancer-specific targeting of a conditionally replicative adenovirus usingmRNA translational control
    • Stoff-Khalili M, Rivera A, Nedeljkovic-Kurepa A, et al. Cancer-specific targeting of a conditionally replicative adenovirus usingmRNA translational control. Breast Cancer Res Treatment 2008;108(1): 43-55.
    • (2008) Breast Cancer Res Treatment , vol.108 , Issue.1 , pp. 43-55
    • Stoff-Khalili, M.1    Rivera, A.2    Nedeljkovic-Kurepa, A.3
  • 50
    • 33646564701 scopus 로고    scopus 로고
    • Endoge-nous microRNA regulation suppresses transgene expression inhematopoietic lineages and enables stable gene transfer
    • Brown BD, Venneri MA, Zingale A, Sergi LS, Naldini L. Endoge-nous microRNA regulation suppresses transgene expression inhematopoietic lineages and enables stable gene transfer. Nat Med2006; 12(5): 585-91.
    • (2006) Nat Med , vol.12 , Issue.5 , pp. 585-591
    • Brown, B.D.1    Venneri, M.A.2    Zingale, A.3    Sergi, L.S.4    Naldini, L.5
  • 52
    • 55549100223 scopus 로고    scopus 로고
    • EngineeringmicroRNA responsiveness to decrease virus pathogenicity
    • Kelly EJ, Hadac EM, Greiner S, Russell SJ. EngineeringmicroRNA responsiveness to decrease virus pathogenicity. NatMed 2008; 14(11): 1278-83.
    • (2008) NatMed , vol.14 , Issue.11 , pp. 1278-1283
    • Kelly, E.J.1    Hadac, E.M.2    Greiner, S.3    Russell, S.J.4
  • 53
    • 69349091681 scopus 로고    scopus 로고
    • MicroRNA Regulation of Onco-lytic Herpes Simplex Virus-1 for Selective Killing of Prostate Can-cer Cells
    • Lee CYF, Rennie PS, Jia WWG. MicroRNA Regulation of Onco-lytic Herpes Simplex Virus-1 for Selective Killing of Prostate Can-cer Cells. Clin Cancer Res 2009; 15(16): 5126-35.
    • (2009) Clin Cancer Res , vol.15 , Issue.16 , pp. 5126-5135
    • Lee, C.Y.F.1    Rennie, P.S.2    Jia, W.W.G.3
  • 54
    • 55549108699 scopus 로고    scopus 로고
    • Generation of aconditionally replicating adenovirus based on targeted destructionof E1A mRNA by a cell type-specific MicroRNA
    • Ylosmaki E, Hakkarainen T, Hemminki A, et al. Generation of aconditionally replicating adenovirus based on targeted destructionof E1A mRNA by a cell type-specific MicroRNA. J Virol 2008;82(22): 11009-15.
    • (2008) J Virol , vol.82 , Issue.22 , pp. 11009-15
    • Ylosmaki, E.1    Hakkarainen, T.2    Hemminki, A.3
  • 55
    • 67249084276 scopus 로고    scopus 로고
    • Use of tissue-specificmicrorna to control pathology of wild-type adenovirus withoutattenuation of its ability to kill cancer cells
    • Cawood R, Chen HH, Carroll F, et al. Use of tissue-specificmicrorna to control pathology of wild-type adenovirus withoutattenuation of its ability to kill cancer cells. PLoS Pathog 2009;5(5): e1000440.
    • (2009) PLoS Pathog , vol.5 , Issue.5
    • Cawood, R.1    Chen, H.H.2    Carroll, F.3
  • 56
    • 0023099280 scopus 로고
    • Adenovirus proteins from both E1B readingframes are required for transformation of rodent cells by viral in-fection and DNA transfection
    • Barker DD, Berk AJ. Adenovirus proteins from both E1B readingframes are required for transformation of rodent cells by viral in-fection and DNA transfection. Virology 1987; 156(1): 107-21.
    • (1987) Virology , vol.156 , Issue.1 , pp. 107-121
    • Barker, D.D.1    Berk, A.J.2
  • 57
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutantthat replicates selectively in p53-deficient human tumor cells
    • Bischoff JR, Kirn DH, Williams A, et al. An adenovirus mutantthat replicates selectively in p53-deficient human tumor cells. Sci-ence 1996; 274(5286): 373-6.
    • (1996) Sci-ence , vol.274 , Issue.5286 , pp. 373-376
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3
  • 58
    • 19944363519 scopus 로고    scopus 로고
    • Late viral RNA export,rather than p53 inactivation, determines ONYX-015 tumor selectiv-ity
    • O'Shea CC, Johnson L, Bagus B, et al. Late viral RNA export,rather than p53 inactivation, determines ONYX-015 tumor selectiv-ity. Cancer Cell 2004; 6(6): 611-23.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 611-623
    • O'Shea, C.C.1    Johnson, L.2    Bagus, B.3
  • 59
    • 0025869428 scopus 로고
    • Adenovirus E1a prevents the retino-blastoma gene product from complexing with a cellular transcrip-tion factor
    • Bandara LR, La Thangue NB. Adenovirus E1a prevents the retino-blastoma gene product from complexing with a cellular transcrip-tion factor. Nature 1991; 351(6326): 494-7.
    • (1991) Nature , vol.351 , Issue.6326 , pp. 494-497
    • Bandara, L.R.1    la Thangue, N.B.2
  • 60
    • 0034610723 scopus 로고    scopus 로고
    • A mutant oncolyticadenovirus targeting the Rb pathway produces anti-glioma effect invivo
    • Fueyo J, Gomez-Manzano C, Alemany R, et al. A mutant oncolyticadenovirus targeting the Rb pathway produces anti-glioma effect invivo. Oncogene 2000; 19(1): 2-12.
    • (2000) Oncogene , vol.19 , Issue.1 , pp. 2-12
    • Fueyo, J.1    Gomez-Manzano, C.2    Alemany, R.3
  • 61
    • 0035138689 scopus 로고    scopus 로고
    • A conditionally replicativeadenovirus with enhanced infectivity shows improved oncolyticpotency
    • Suzuki K, Fueyo J, Krasnykh V, et al. A conditionally replicativeadenovirus with enhanced infectivity shows improved oncolyticpotency. Clin Cancer Res 2001; 7(1): 120-6.
    • (2001) Clin Cancer Res , vol.7 , Issue.1 , pp. 120-126
    • Suzuki, K.1    Fueyo, J.2    Krasnykh, V.3
  • 62
    • 0036494383 scopus 로고    scopus 로고
    • Treatment of ovariancancer with a tropism modified oncolytic adenovirus
    • Bauerschmitz GJ, Lam JT, Kanerva A, et al. Treatment of ovariancancer with a tropism modified oncolytic adenovirus. Cancer Res2002; 62(5): 1266-70.
    • (2002) Cancer Res , vol.62 , Issue.5 , pp. 1266-1270
    • Bauerschmitz, G.J.1    Lam, J.T.2    Kanerva, A.3
  • 63
    • 0033782862 scopus 로고    scopus 로고
    • An adenovirus E1A mutantthat demonstrates potent and selective systemic anti-tumoral effi-cacy
    • Heise C, Hermiston T, Johnson L, et al. An adenovirus E1A mutantthat demonstrates potent and selective systemic anti-tumoral effi-cacy. Nat Med 2000; 6(10): 1134-9.
    • (2000) Nat Med , vol.6 , Issue.10 , pp. 1134-1139
    • Heise, C.1    Hermiston, T.2    Johnson, L.3
  • 64
    • 0025370654 scopus 로고
    • Bayley ST.Retinoblastoma growth suppressor and a 300-kDa protein appear toregulate cellular DNA synthesis
    • Howe JA, Mymryk JS, Egan C, Branton PE, Bayley ST.Retinoblastoma growth suppressor and a 300-kDa protein appear toregulate cellular DNA synthesis. Proc Natl Acad Sci USA 1990;87(15): 5883-7.
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.15 , pp. 5883-5887
    • Howe, J.A.1    Mymryk, J.S.2    Egan, C.3    Branton, P.E.4
  • 65
    • 0022447264 scopus 로고
    • Adenovirus VAI RNAantagonizes the antiviral action of interferon by preventing activa-tion of the interferon-induced eIF-2 alpha kinase
    • Kitajewski J, Schneider RJ, Safer B, et al. Adenovirus VAI RNAantagonizes the antiviral action of interferon by preventing activa-tion of the interferon-induced eIF-2 alpha kinase. Cell 1986; 45(2):195-200.
    • (1986) Cell , vol.45 , Issue.2 , pp. 195-200
    • Kitajewski, J.1    Schneider, R.J.2    Safer, B.3
  • 66
    • 0026481080 scopus 로고
    • Oncogenic ras induces an inhibitorof double-stranded RNA-dependent eukaryotic initiation factor 2alpha-kinase activation
    • Mundschau LJ, Faller DV. Oncogenic ras induces an inhibitorof double-stranded RNA-dependent eukaryotic initiation factor 2alpha-kinase activation. J Biol Chem 1992; 267(32): 23092-8.
    • (1992) J Biol Chem , vol.267 , Issue.32 , pp. 23092-23098
    • Mundschau, L.J.1    Faller, D.V.2
  • 67
    • 0141592775 scopus 로고    scopus 로고
    • Ras-dependent onco-lysis with an adenovirus VAI mutant
    • Cascallo M, Capella G, Mazo A, Alemany R. Ras-dependent onco-lysis with an adenovirus VAI mutant. Cancer Res 2003; 63(17):5544-50.
    • (2003) Cancer Res , vol.63 , Issue.17 , pp. 5544-5550
    • Cascallo, M.1    Capella, G.2    Mazo, A.3    Alemany, R.4
  • 68
    • 33750607468 scopus 로고    scopus 로고
    • Deletion of VAI and VAIIRNA genes in the design of oncolytic adenoviruses
    • Cascallo M, Gros A, Bayo N, et al. Deletion of VAI and VAIIRNA genes in the design of oncolytic adenoviruses. Hum GeneTher 2006; 17(9): 929-40.
    • (2006) Hum GeneTher , vol.17 , Issue.9 , pp. 929-940
    • Cascallo, M.1    Gros, A.2    Bayo, N.3
  • 69
    • 0036303748 scopus 로고    scopus 로고
    • Ras family genes: An interest-ing link between cell cycle and cancer
    • Macaluso M, Russo G, Cinti C, et al. Ras family genes: an interest-ing link between cell cycle and cancer. J Cell Physiol 2002; 192(2):125-30.
    • (2002) J Cell Physiol , vol.192 , Issue.2 , pp. 125-130
    • Macaluso, M.1    Russo, G.2    Cinti, C.3
  • 70
    • 0036990109 scopus 로고    scopus 로고
    • Theorganizing principle: Microenvironmental influences in the normaland malignant breast
    • Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. Theorganizing principle: microenvironmental influences in the normaland malignant breast. Differentiation 2002; 70(9-10): 537-46.
    • (2002) Differentiation , vol.70 , Issue.9-10 , pp. 537-546
    • Bissell, M.J.1    Radisky, D.C.2    Rizki, A.3    Weaver, V.M.4    Petersen, O.W.5
  • 71
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100(1): 57-70.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 72
    • 77949903829 scopus 로고    scopus 로고
    • The biology of cancer
    • New York Taylor & Francis Group, LLC
    • Weinberg R. The biology of cancer. Garland Science. New York Taylor & Francis Group, LLC 2007.
    • (2007) Garland Science
    • Weinberg, R.1
  • 73
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solidtumour
    • Denko NC. Hypoxia, HIF1 and glucose metabolism in the solidtumour. Nat Rev Cancer 2008; 8(9): 705-13.
    • (2008) Nat Rev Cancer , vol.8 , Issue.9 , pp. 705-713
    • Denko, N.C.1
  • 74
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancerand approaches to enforce tumour regression
    • Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancerand approaches to enforce tumour regression. Nature 2006;441(7092): 437-43.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 75
    • 68049105076 scopus 로고    scopus 로고
    • Role of hypoxia in the hallmarks ofhuman cancer
    • Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks ofhuman cancer. J Cell Biochem 2009; 107(6): 1053-62.
    • (2009) J Cell Biochem , vol.107 , Issue.6 , pp. 1053-1062
    • Ruan, K.1    Song, G.2    Ouyang, G.3
  • 76
    • 0036399291 scopus 로고    scopus 로고
    • New onco-lytic adenoviruses with hypoxia- and estrogen receptor-regulatedreplication
    • Hernandez-Alcoceba R, Pihalja M, Qian D, Clarke MF. New onco-lytic adenoviruses with hypoxia- and estrogen receptor-regulatedreplication. Hum Gene Ther 2002; 13(14): 1737-50.
    • (2002) Hum Gene Ther , vol.13 , Issue.14 , pp. 1737-1750
    • Hernandez-Alcoceba, R.1    Pihalja, M.2    Qian, D.3    Clarke, M.F.4
  • 77
    • 0142157670 scopus 로고    scopus 로고
    • Specificoncolytic effect of a new hypoxia-inducible factor-dependentreplicative adenovirus on von Hippel-Lindau-defective renal cellcarcinomas
    • Cuevas Y, Hernandez-Alcoceba R, Aragones J, et al. Specificoncolytic effect of a new hypoxia-inducible factor-dependentreplicative adenovirus on von Hippel-Lindau-defective renal cellcarcinomas. Cancer Res 2003; 63(20): 6877-84.
    • (2003) Cancer Res , vol.63 , Issue.20 , pp. 6877-6884
    • Cuevas, Y.1    Hernandez-Alcoceba, R.2    Aragones, J.3
  • 78
    • 0037509944 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor (HIF)activated oncolytic adenovirus for cancer therapy
    • Post DE, Van Meir EG. A novel hypoxia-inducible factor (HIF)activated oncolytic adenovirus for cancer therapy. Oncogene 2003;22(14): 2065-72.
    • (2003) Oncogene , vol.22 , Issue.14 , pp. 2065-2072
    • Post, D.E.1    van Meir, E.G.2
  • 79
    • 7044233630 scopus 로고    scopus 로고
    • Oncolytic effects of adenovi-rus mutant capable of replicating in hypoxic and normoxic regionsof solid tumor
    • Cho WK, Seong YR, Lee YH, et al. Oncolytic effects of adenovi-rus mutant capable of replicating in hypoxic and normoxic regionsof solid tumor. Mol Ther 2004; 10(5): 938-49.
    • (2004) Mol Ther , vol.10 , Issue.5 , pp. 938-949
    • Cho, W.K.1    Seong, Y.R.2    Lee, Y.H.3
  • 80
    • 1442348829 scopus 로고    scopus 로고
    • Conditionally replicativeadenovirus driven by the human telomerase promoter providesbroad-spectrum antitumor activity without liver toxicity
    • Irving J, Wang Z, Powell S, et al. Conditionally replicativeadenovirus driven by the human telomerase promoter providesbroad-spectrum antitumor activity without liver toxicity. CancerGene Ther 2004; 11(3): 174-85.
    • (2004) CancerGene Ther , vol.11 , Issue.3 , pp. 174-185
    • Irving, J.1    Wang, Z.2    Powell, S.3
  • 81
    • 20044390362 scopus 로고    scopus 로고
    • Inter-patient variationin efficacy of five oncolytic adenovirus candidates for ovariancancer therapy
    • Lam JT, Kanerva A, Bauerschmitz GJ, et al. Inter-patient variationin efficacy of five oncolytic adenovirus candidates for ovariancancer therapy. J Gene Med 2004; 6(12): 1333-42.
    • (2004) J Gene Med , vol.6 , Issue.12 , pp. 1333-1342
    • Lam, J.T.1    Kanerva, A.2    Bauerschmitz, G.J.3
  • 82
    • 33845640114 scopus 로고    scopus 로고
    • Vascular endothelialgrowth factor promoter-based conditionally replicative adenovi-ruses for pan-carcinoma application
    • Takayama K, Reynolds PN, Adachi Y, et al. Vascular endothelialgrowth factor promoter-based conditionally replicative adenovi-ruses for pan-carcinoma application. Cancer Gene Ther 2007;14(1): 105-16.
    • (2007) Cancer Gene Ther , vol.14 , Issue.1 , pp. 105-116
    • Takayama, K.1    Reynolds, P.N.2    Adachi, Y.3
  • 83
    • 49849092967 scopus 로고    scopus 로고
    • A novel triple-regulated oncolyticadenovirus carrying p53 gene exerts potent antitumor efficacy oncommon human solid cancers
    • Wang X, Su C, Cao H, et al. A novel triple-regulated oncolyticadenovirus carrying p53 gene exerts potent antitumor efficacy oncommon human solid cancers. Mol Cancer Ther 2008; 7(6): 1598-603.
    • (2008) Mol Cancer Ther , vol.7 , Issue.6 , pp. 1598-1603
    • Wang, X.1    Su, C.2    Cao, H.3
  • 84
    • 63949083337 scopus 로고    scopus 로고
    • Treatment of PancreaticCancer With an Oncolytic Adenovirus Expressing Interleukin-12 inSyrian Hamsters
    • Bortolanza S, Bunuales M, Otano I, et al. Treatment of PancreaticCancer With an Oncolytic Adenovirus Expressing Interleukin-12 inSyrian Hamsters. Mol Ther 2009; 17(4): 614-22.
    • (2009) Mol Ther , vol.17 , Issue.4 , pp. 614-622
    • Bortolanza, S.1    Bunuales, M.2    Otano, I.3
  • 85
    • 0036325057 scopus 로고    scopus 로고
    • Transcriptionaltargeting of conditionally replicating adenovirus to dividing endo-thelial cells
    • Savontaus MJ, Sauter BV, Huang TG, Woo SL. Transcriptionaltargeting of conditionally replicating adenovirus to dividing endo-thelial cells. Gene Ther 2002; 9(14): 972-9.
    • (2002) Gene Ther , vol.9 , Issue.14 , pp. 972-979
    • Savontaus, M.J.1    Sauter, B.V.2    Huang, T.G.3    Woo, S.L.4
  • 86
    • 0037301795 scopus 로고    scopus 로고
    • A canine conditionallyreplicating adenovirus for evaluating oncolytic virotherapy in asyngeneic animal model
    • Hemminki A, Kanerva A, Kremer EJ, et al. A canine conditionallyreplicating adenovirus for evaluating oncolytic virotherapy in asyngeneic animal model. Mol Ther 2003; 7(2): 163-73.
    • (2003) Mol Ther , vol.7 , Issue.2 , pp. 163-173
    • Hemminki, A.1    Kanerva, A.2    Kremer, E.J.3
  • 87
    • 66849134484 scopus 로고    scopus 로고
    • Tumor associated stromalcells play a critical role on the outcome of the oncolytic efficacy ofconditionally replicative adenoviruses
    • Lopez M, Viale D, Cafferata E, et al. Tumor associated stromalcells play a critical role on the outcome of the oncolytic efficacy ofconditionally replicative adenoviruses. PLoS One 2009; 4(4):e5119.
    • (2009) PLoS One , vol.4 , Issue.4
    • Lopez, M.1    Viale, D.2    Cafferata, E.3
  • 89
    • 14644414207 scopus 로고    scopus 로고
    • Cotargeting tumorand tumor endothelium effectively inhibits the growth of humanprostate cancer in adenovirus-mediated antiangiogenesis andoncolysis combination therapy
    • Jin F, Xie Z, Kuo CJ, Chung LW, Hsieh CL. Cotargeting tumorand tumor endothelium effectively inhibits the growth of humanprostate cancer in adenovirus-mediated antiangiogenesis andoncolysis combination therapy. Cancer Gene Ther 2005; 12(3):257-67.
    • (2005) Cancer Gene Ther , vol.12 , Issue.3 , pp. 257-267
    • Jin, F.1    Xie, Z.2    Kuo, C.J.3    Chung, L.W.4    Hsieh, C.L.5
  • 90
    • 0025769025 scopus 로고
    • Redundant elements in the adenovirus type 5inverted terminal repeat promote bidirectional transcription in vitroand are important for virus growth in vivo
    • Hatfield L, Hearing P. Redundant elements in the adenovirus type 5inverted terminal repeat promote bidirectional transcription in vitroand are important for virus growth in vivo. Virology 1991; 184(1):265-76.
    • (1991) Virology , vol.184 , Issue.1 , pp. 265-276
    • Hatfield, L.1    Hearing, P.2
  • 91
    • 0023758551 scopus 로고
    • Cellular Transcription Factor Binds toAdenovirus Early Region Promoters and to a Cyclic AMPResponse Element
    • Leza MA, Hearing P. Cellular Transcription Factor Binds toAdenovirus Early Region Promoters and to a Cyclic AMPResponse Element. J Virol 1988; 3003-13.
    • (1988) J Virol , pp. 3003-3013
    • Leza, M.A.1    Hearing, P.2
  • 93
    • 0030895597 scopus 로고    scopus 로고
    • Modulation of the specificity and activ-ity of a cellular promoter in an adenoviral vector
    • Shi Q, Wang Y, Worton R. Modulation of the specificity and activ-ity of a cellular promoter in an adenoviral vector. Hum Gene Ther1997; 8(4): 403-10.
    • (1997) Hum Gene Ther , vol.8 , Issue.4 , pp. 403-410
    • Shi, Q.1    Wang, Y.2    Worton, R.3
  • 94
    • 0034068781 scopus 로고    scopus 로고
    • Insulation from viral transcriptionalregulatory elements improves inducible transgene expression fromadenovirus vectors in vitro and in vivo
    • Steinwaerder D, Lieber A. Insulation from viral transcriptionalregulatory elements improves inducible transgene expression fromadenovirus vectors in vitro and in vivo. Gene Ther 2000; 7: 556-67.
    • (2000) Gene Ther , vol.7 , pp. 556-567
    • Steinwaerder, D.1    Lieber, A.2
  • 95
    • 27644535713 scopus 로고    scopus 로고
    • Effects of the Ad5 upstream E1region and gene products on heterologous promoters
    • Hoffmann D, Jogler C, Wildner O. Effects of the Ad5 upstream E1region and gene products on heterologous promoters. J Gene Med2005; 7(10): 1356-66.
    • (2005) J Gene Med , vol.7 , Issue.10 , pp. 1356-1366
    • Hoffmann, D.1    Jogler, C.2    Wildner, O.3
  • 96
    • 35548990188 scopus 로고    scopus 로고
    • We gather together: Insulators andgenome organization
    • Wallace JA, Felsenfeld G. We gather together: insulators andgenome organization. Curr Opin Genet Dev 2007; 15(5): 400-7.
    • (2007) Curr Opin Genet Dev , vol.15 , Issue.5 , pp. 400-407
    • Wallace, J.A.1    Felsenfeld, G.2
  • 97
    • 0037058955 scopus 로고    scopus 로고
    • The insulation ofgenes from external enhancers and silencing chromatin
    • Burgess-Beusse B, Farrell C, Gaszner M, et al. The insulation ofgenes from external enhancers and silencing chromatin. Proc NatlAcad Sci USA 2002; 99(4): 16433-7.
    • (2002) Proc NatlAcad Sci USA , vol.99 , Issue.4 , pp. 16433-16437
    • Burgess-Beusse, B.1    Farrell, C.2    Gaszner, M.3
  • 98
    • 0043072824 scopus 로고    scopus 로고
    • Genomic domains and regula-tory elements operating at the domain level
    • Razin S, Farrell C, Recillas-Targa F. Genomic domains and regula-tory elements operating at the domain level. Int Rev Cytol 2003;226: 63-125.
    • (2003) Int Rev Cytol , vol.226 , pp. 63-125
    • Razin, S.1    Farrell, C.2    Recillas-Targa, F.3
  • 99
    • 0027254748 scopus 로고
    • A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells andprotects against position effect in Drosophila
    • Chung J, Whiteley M, Felsenfeld G. A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells andprotects against position effect in Drosophila. Cell 1993; 74(3): 505-14.
    • (1993) Cell , vol.74 , Issue.3 , pp. 505-514
    • Chung, J.1    Whiteley, M.2    Felsenfeld, G.3
  • 100
    • 0037076316 scopus 로고    scopus 로고
    • Position-effectprotection and enhancer blocking by the chicken -globin insulator areseparable activities
    • Recillas-Targa F, Pikaart MJ, Burgess-Beusse B, et al. Position-effectprotection and enhancer blocking by the chicken -globin insulator areseparable activities. Proc Natl Acad Sci USA 2002; 99: 6883-8.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6883-6888
    • Recillas-Targa, F.1    Pikaart, M.J.2    Burgess-Beusse, B.3
  • 101
    • 0036467996 scopus 로고    scopus 로고
    • Insulators: Many functions,many mechanisms
    • West A, Gaszner M, Felsenfeld G. Insulators: many functions,many mechanisms. Genes Dev 2002; 16(3): 271-88.
    • (2002) Genes Dev , vol.16 , Issue.3 , pp. 271-288
    • West, A.1    Gaszner, M.2    Felsenfeld, G.3
  • 102
    • 33747453473 scopus 로고    scopus 로고
    • Insulators: Exploiting transcriptional andepigenetic mechanisms
    • Gaszner M, Felsenfeld G. Insulators: exploiting transcriptional andepigenetic mechanisms. Nat Rev Genet 2006; 7(9): 703-13.
    • (2006) Nat Rev Genet , vol.7 , Issue.9 , pp. 703-713
    • Gaszner, M.1    Felsenfeld, G.2
  • 104
    • 42249092797 scopus 로고    scopus 로고
    • The role of CTCF in regulating nuclearorganization
    • Williams A, Flavell R. The role of CTCF in regulating nuclearorganization. J Exp Med 2008; 205(4): 747-50.
    • (2008) J Exp Med , vol.205 , Issue.4 , pp. 747-750
    • Williams, A.1    Flavell, R.2
  • 105
    • 0037768685 scopus 로고    scopus 로고
    • Insulation from viral transcriptionalregulatory elements enables improvement to hepatoma-specificgene expression from adenovirus vectors
    • Ye X, Liang M, Meng X, et al. Insulation from viral transcriptionalregulatory elements enables improvement to hepatoma-specificgene expression from adenovirus vectors. Biochem Biophys ResCommun 2003; 307: 759-64.
    • (2003) Biochem Biophys ResCommun , vol.307 , pp. 759-764
    • Ye, X.1    Liang, M.2    Meng, X.3
  • 107
    • 42049088577 scopus 로고    scopus 로고
    • Nettelbeck DM.Insulated hsp70B! promoter: Stringent heat-inducible activity inreplication-deficient, but not replication-competent adenoviruses
    • Rohmer S, Mainka A, Knippertz I, Hesse A, Nettelbeck DM.Insulated hsp70B! promoter: stringent heat-inducible activity inreplication-deficient, but not replication-competent adenoviruses. JGene Med 2008; 10: 340-54.
    • (2008) JGene Med , vol.10 , pp. 340-354
    • Rohmer, S.1    Mainka, A.2    Knippertz, I.3    Hesse, A.4
  • 108
    • 0035138689 scopus 로고    scopus 로고
    • A conditionally replicativeadenovirus with enhanced infectivity shows improved oncolyticpotency
    • Suzuki K, Fueyo J, Krasnykh V, et al. A conditionally replicativeadenovirus with enhanced infectivity shows improved oncolyticpotency. Clin Cancer Res 2001; 7(1): 120-6.
    • (2001) Clin Cancer Res , vol.7 , Issue.1 , pp. 120-126
    • Suzuki, K.1    Fueyo, J.2    Krasnykh, V.3
  • 109
    • 33747600882 scopus 로고    scopus 로고
    • Control of E1A underan E2F-1 promoter insulated with the myotonic dystrophy locusinsulator reduces the toxicity of oncolytic adenovirusAd-Delta24RGD
    • Majem M, Cascallo M, Bayo-Puxan N, et al. Control of E1A underan E2F-1 promoter insulated with the myotonic dystrophy locusinsulator reduces the toxicity of oncolytic adenovirusAd-Delta24RGD. Cancer Gene Ther 2006; 13(7): 696-705.
    • (2006) Cancer Gene Ther , vol.13 , Issue.7 , pp. 696-705
    • Majem, M.1    Cascallo, M.2    Bayo-Puxan, N.3
  • 110
    • 40549092679 scopus 로고    scopus 로고
    • Increased therapeu-tic efficacy of the prostate-specific oncolytic adenovirusAd lsqbI//PPT-E1A rsqb by reduction of the insulator size andintroduction of the full-length E3 region
    • Danielsson A, Dzojic H, Nilsson B, Essand M. Increased therapeu-tic efficacy of the prostate-specific oncolytic adenovirusAd lsqbI//PPT-E1A rsqb by reduction of the insulator size andintroduction of the full-length E3 region. Cancer Gene Ther 2008;15(4): 203-13.
    • (2008) Cancer Gene Ther , vol.15 , Issue.4 , pp. 203-213
    • Danielsson, A.1    Dzojic, H.2    Nilsson, B.3    Essand, M.4
  • 111
    • 0034255145 scopus 로고    scopus 로고
    • A chromatin insulatorprotects retrovirus vectors from chromosomal position effects
    • Emery DW, Yannaki E, Tubbl J, et al. A chromatin insulatorprotects retrovirus vectors from chromosomal position effects. ProcNatl Acad Sci USA 2000; 97(16): 9150-5.
    • (2000) ProcNatl Acad Sci USA , vol.97 , Issue.16 , pp. 9150-9155
    • Emery, D.W.1    Yannaki, E.2    Tubbl, J.3
  • 113
    • 33947245441 scopus 로고    scopus 로고
    • History of oncolytic viruses: Genesis to geneticengineering
    • Kelly E, Russell SJ. History of oncolytic viruses: genesis to geneticengineering. Mol Ther 2007; 15(4): 651-9.
    • (2007) Mol Ther , vol.15 , Issue.4 , pp. 651-659
    • Kelly, E.1    Russell, S.J.2
  • 114
    • 33846531356 scopus 로고    scopus 로고
    • The tumour microenvironment as a target forchemoprevention
    • Albini A, Sporn MB. The tumour microenvironment as a target forchemoprevention. Nat Rev Cancer 2007; 7(2): 139-47.
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 139-147
    • Albini, A.1    Sporn, M.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.