Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo

Gene Therapy

Volumn 16, Issue 2, 2009, Pages 262-278

  Tyler, M A ^a   Ulasov, I V ^a   Sonabend, A M ^a   Nandi, S ^a   Han, Y ^a   Marler, S ^a   Roth, J ^b   Lesniak, M S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CELL SURFACE RECEPTOR; LUCIFERASE; ONCOLYTIC ADENOVIRUS; SURVIVIN; BIRC5 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CXCR4; CXCR4 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; ONCOLYTIC VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER GENE THERAPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; FLUORESCENCE ACTIVATED CELL SORTING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEURAL STEM CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; ONCOLYTIC VIROTHERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARGET CELL; VIRAL GENE DELIVERY SYSTEM; VIRUS REPLICATION; ADENOVIRIDAE; ANIMAL; BIOSYNTHESIS; BRAIN NEOPLASMS; CANCER TRANSPLANTATION; CELL MOTION; EVALUATION STUDY; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSCRIPTION; GENETICS; GLIOMA; NERVE CELL; NUDE MOUSE; PHARMACOKINETICS; PHYSIOLOGY; PROCEDURES; STEM CELL; STEM CELL TRANSPLANTATION; TUMOR CELL CULTURE; VIROLOGY;

ADENOVIRIDAE; ANIMALS; BRAIN NEOPLASMS; CELL MOVEMENT; GENE EXPRESSION; GENETIC VECTORS; GLIOMA; HUMANS; MALE; MICE; MICE, NUDE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM TRANSPLANTATION; NEURONS; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; RECEPTORS, CXCR4; RNA, MESSENGER; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VIRUS REPLICATION; INHIBITOR OF APOPTOSIS PROTEINS;

ADENOVIRIDAE;

EID: 60449099546     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2008.165     Document Type: Article

References (43)

1. Tyler MA, Sonabend AM, Ulasov IV, Lesniak MS. Vector therapies for malignant glioma: Shifting the clinical paradigm. Expert Opin Drug Deliv 2008; 5: 445-458.
2. Borovjagin AV, Krendelchtchikov A, Ramesh N, Yu DC, Douglas JT, Curiel DT. Complex mosaicism is a novel approach to infectivity enhancement of adenovirus type 5-based vectors. Cancer Gene Ther 2005; 12: 475-486.
3. Brouwer E, Havenga MJ, Ophorst O, de Leeuw B, Gijsbers L, Gillissen G et al. Human adenovirus type 35 vector for gene therapy of brain cancer: Improved transduction and bypass of pre-existing anti-vector immunity in cancer patients. Cancer Gene Ther 2007; 14: 211-219.
4. Miura Y, Yoshida K, Nishimoto T, Hatanaka K, Ohnami S, Asaka M et al Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob. Gene Therapy 2007; 14: 1448-1460.
5. Paul CP, Everts M, Dent P, Fisher PB, Ulasov IV, Lesniak MS et al. Characterization of infectivity of Knob-modified adenoviral vectors in glioma. Cancer Biol Ther 2008; 7: 786-793.
6. Tyler MA, Ulasov IV, Borovjagin A, Sonabend AM, Khramtsov A, Han Y et al. Enhanced transduction of malignant glioma with a double targeted Ad5/3-RGD fiber-modified adenovirus. Mol Cancer Ther 2006; 5 2408-2416.
7. Ulasov IV, Tyler MA, Han Y, Glasgow JN, Lesniak MS. Novel recombinant adenoviral vector that targets the interleukin-13 receptor alpha2 chain permits effective gene transfer to malignant glioma. Hum Gene Ther 2007; 18: 118-129.
8. Ulasov IV, Tyler MA, Zheng S, Han Y, Lesniak MS. CD46 represents a target for adenoviral gene therapy of malignant glioma. Hum Gene Ther 2006; 17: 556-564.
9. Ulasov IV, Zhu ZB, Tyler MA, Han Y, Rivera AA, Khramtsov A et al. Survivin-driven and fiber-modified oncolytic adenovirus exhibits potent antitumor activity in established intracranial glioma. Hum Gene Ther 2007; 18: 589-602.
10. Aboody KS, Najbauer J, Danks MK. Stem and progenitor cell-mediated tumor selective gene therapy. Gene Therapy 2008; 15: 739-752.
11. Sonabend AM, Ulasov IV, Tyler MA, Rivera AA, Mathis JM, LesniakMS.Mesenchymal stemcells effectively deliver an oncolytic adenovirus to intracranial glioma. Stem Cells 2008; 26: 831-841.
12. Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997; 275: 1320-1323.
13. Gaggar A, Shayakhmetov DM, Lieber A. CD46 is a cellular receptor for group B adenoviruses. Nat Med 2003; 9: 1408-1412.
14. Wickham TJ, Tzeng E, Shears II LL, Roelvink PW, Li Y, Lee GM et al Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins. J Virol 1997; 71: 8221-8229.
15. Ulasov IV, Rivera AA, Sonabend AM, Rivera LB, Wang M, Zhu ZB et al Comparative evaluation of survivin, midkine and CXCR4 promoters for transcriptional targeting of glioma gene therapy. Cancer Biol Ther 2007; 6: 679-685.
16. Lesniak MS. Targeted therapy for malignant glioma: Neural stem cells. Expert Rev Neurother 2006; 6: 1-3.
17. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W et al. Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proc Natl Acad Sci USA 2000; 97: 12846-12851.
18. Brown AB, Yang W, Schmidt NO, Carroll R, Leishear KK, Rainov NG et al Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin. Hum Gene Ther 2003; 14: 1777-1785.
19. Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC et al. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin Cancer Res 2006; 12: 5550-5556.
20. Ourednik V, Ourednik J, Park KI, Teng YD, Aboody KA, Auguste KI et al Neural stem cells are uniquely suited for cell replacement and gene therapy in the CNS. Novartis Found Symp 2000; 231: 242-262; discussion 262-269, 302-306.
21. Ziu M, Schmidt NO, Cargioli TG, Aboody KS, Black PM, Carroll RS. Glioma-produced extracellular matrix influences brain tumor tropism of human neural stem cells. J Neurooncol 2006; 79: 125-133.
22. Modo M, Rezaie P, Heuschling P, Patel S, Male DK, Hodges H. Transplantation of neural stem cells in a rat model of stroke: assessment of short-term graft survival and acute host immunological response. Brain Res 2002; 958: 70-82.
23. Benedetti S, Pirola B, Pollo B, Magrassi L, Bruzzone MG, Rigamonti D et al. Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 2000; 6: 447-450.
24. Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L et al. Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma. Cancer Res 2007; 67: 22-25.
25. Dickson PV, Hamner JB, Burger RA, Garcia E, Ouma AA, Kim SU et al. Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma. J Pediatr Surg 2007; 42: 48-53.
26. Ehtesham M, Kabos P, Gutierrez MA, Chung NH, Griffith TS, Black KL et al. Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 2002; 62: 7170-7174.
27. Ehtesham M, Kabos P, Kabosova A, Neuman T, Black KL, Yu JS. The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res 2002; 62: 5657-5663.
28. Ehtesham M, Stevenson CB, Thompson RC. Stem cell therapies for malignant glioma. Neurosurg Focus 2005; 19: E5.
29. Ehtesham M, Yuan X, Kabos P, Chung NH, Liu G, Akasaki Y et al. Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4. Neoplasia 2004; 6: 287-293.
30. Kabos P, Ehtesham M, Black KL, Yu JS. Neural stem cells as delivery vehicles. Expert Opin Biol Ther 2003; 3: 759-770.
31. Kabos P, Ehtesham M, Kabosova A, Black KL, Yu JS. Generation of neural progenitor cells from whole adult bone marrow. Exp Neurol 2002; 178: 288-293.
32. Herrlinger U, Woiciechowski C, Sena-Esteves M, Aboody KS, Jacobs AH, Rainov NG et al. Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas. Mol Ther 2000; 1: 347-357.
33. Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A et al. Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. J Neurosci 2008; 28: 4406-4413.
34. Chu K, Kim M, Park KI, Jeong SW, Park HK, Jung KH et al. Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia. Brain Res 2004; 1016: 145-153.
35. Jeong SW, Chu K, Jung KH, Kim SU, Kim M, Roh JK. Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage. Stroke 2003; 34: 2258-2263.
36. Kim SU. Human neural stem cells genetically modified for brain repair in neurological disorders. Neuropathology 2004; 24: 159-171.
37. Meng XL, Shen JS, Ohashi T, Maeda H, Kim SU, Eto Y. Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse. J Neurosci Res 2003; 74: 266-277.
38. Coskun V, Wu H, Blanchi B, Tsao S, Kim K, Zhao J et al. CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proc Natl Acad Sci USA 2008; 105: 1026-1031.
39. Duan X, Kang E, Liu CY, Ming GL, Song H. Development of neural stem cell in the adult brain. Curr Opin Neurobiol 2008; 18: 108-115.
40. Sims Jr TL, Hamner JB, Bush RA, Williams RF, Zhou J, Kim SU et al. Neural progenitor cell-mediated delivery of interferon beta improves neuroblastoma response to cyclophosphamide. Ann Surg Oncol 2008; 15: 3259-3267.
41. Staflin K, Honeth G, Kalliomaki S, Kjellman C, Edvardsen K, Lindvall M. Neural progenitor cell lines inhibit rat tumor growth in vivo. Cancer Res 2004; 64: 5347-5354.
42. Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 2004; 22: 1567-1572.
43. Deregowski V, Canalis E. Gene delivery by retroviruses. Methods Mol Biol 2008; 455: 157-162.