Insulated hsp70B' promoter: Stringent heat-inducible activity in replication-deficient, but not replication-competent adenoviruses

Journal of Gene Medicine

Volumn 10, Issue 4, 2008, Pages 340-354

  Rohmer, Stanimira ^a,b   Mainka, Astrid ^a   Knippertz, Ilka ^a   Hesse, Andrea ^a   Nettelbeck, Dirk M ^a,b  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Adenoviral vector; Heat shock; Hsp70B promoter; Inducible gene expression; Insulator element; Oncolytic adenovirus

Indexed keywords

ADENOVIRUS VECTOR; HEAT SHOCK PROTEIN 70;

ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; HEAT; HUMAN; HUMAN CELL; HYPERTHERMIA; INSULATOR ELEMENT; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; TRANSGENE; VIRAL GENE THERAPY; VIRUS REPLICATION;

ADENOVIRIDAE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEAT; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INSULATOR ELEMENTS; ONCOLYTIC VIRUSES; PLASMIDS; PROMOTER REGIONS (GENETICS); TRANSGENES; VIRUS REPLICATION;

ADENOVIRIDAE;

EID: 42049088577     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1157     Document Type: Article

References (60)

1. Zhang WW. Development and application of adenoviral vectors for gene therapy of cancer. Cancer Gene Ther 1999; 6: 113-138.
2. Glasgow JN, Everts M, Curiel DT. Transductional targeting of adenovirus vectors for gene therapy. Cancer Gene Ther 2006; 13: 830-844.
3. Nettelbeck DM, Jerome V, Muller R. Gene therapy: designer promoters for tumour targeting. Trends Genet 2000; 16: 174-181.
4. Alemany R, Balague C, Curiel DT. Replicative adenoviruses for cancer therapy. Nat Biotechnol 2000; 18: 723-727.
5. O'Shea CC. Viruses - seeking and destroying the tumor program. Oncogene 2005; 24: 7640-7655.
6. Ko D, Hawkins L, Yu DC. Development of transcriptionally regulated oncolytic adenoviruses. Oncogene 2005; 24: 7763-7774.
7. Post DE, Khuri FR, Simons JW, Van Meir EG. Replicative oncolytic adenoviruses in multimodal cancer regimens. Hum Gene Ther 2003; 14: 933-946.
8. Hermiston TW, Kuhn I. Armed therapeutic viruses: strategies and challenges to arming oncolytic viruses with therapeutic genes. Cancer Gene Ther 2002; 9: 1022-1035.
9. Toniatti C, Bujard H, Cortese R, Ciliberto G. Gene therapy progress and prospects: transcription regulatory systems. Gene Ther 2004; 11: 649-657.
10. Rivera AA, Wang M, Suzuki K, et al. Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo. Virology 2004; 320: 121-134.
11. Rome C, Couillaud F, Moonen CT. Spatial and temporal control of expression of therapeutic genes using heat shock protein promoters. Methods 2005; 35: 188-198.
12. Voellmy R. Transduction of the stress signal and mechanisms of transcriptional regulation of heat shock/stress protein gene expression in higher eukaryotes. Crit Rev Eukaryot Gene Expr 1994; 4: 357-401.
13. Baler R, Dahl G, Voellmy R. Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1. Mol Cell Biol 1993; 13: 2486-2496.
14. Blackburn RV, Galoforo SS, Corry PM, Lee YJ. Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells. Cancer Res 1998; 58: 1358-1362.
15. Arai Y, et al. Control of delivered gene expression in chondrocytes using heat shock protein 70B promoter. J Rheumatol 1999; 26: 1769-1774.
16. Huang Q, et al. Heat-induced gene expression as a novel targeted cancer gene therapy strategy. Cancer Res 2000; 60: 3435-3439.
17. Borrelli MJ, et al. Heat-activated transgene expression from adenovirus vectors infected into human prostate cancer cells. Cancer Res 2001; 61: 1113-1121.
18. Lee YJ, et al. Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy. Cancer Gene Ther 2001; 8: 397-404.
19. Smith RC, et al. Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo. Hum Gene Ther 2002; 13: 697-706.
20. Li GC, et al. Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivo. Cancer Res 2003; 63: 3268-3274.
21. Silcox CE, et al. MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate. Ultrasound Med Biol 2005; 31: 965-970.
22. Siddiqui F, et al. Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct. Int J Hyperthermia 2006; 22: 587-606.
23. Lohr F, Huang Q, Hu K, Dewhirst MW, Li CY. Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. Clin Cancer Res 2001; 7: 3625-3628.
24. Brade AM, et al. Heat-directed gene targeting of adenoviral vectors to tumor cells. Cancer Gene Ther 2000; 7: 1566-1574.
25. Plathow C, et al. Focal gene induction in the liver of rats by a heat-inducible promoter using focused ultrasound hyperthermia: preliminary results. Invest Radiol 2005; 40: 729-735.
26. Hurtado Pico A, Wang X, Sipo I, et al. Viral and nonviral factors causing nonspecific replication of tumor- and tissue-specific promoter-dependent oncolytic adenoviruses. Mol Ther 2005; 11: 563-577.
27. Hoffmann D, Jogler C, Wildner O. Effects of the Ad5 upstream El region and gene products on heterologous promoters. J Gene Med 2005; 7: 1356-1366.
28. Chung JH, Whiteley M, Felsenfeld G. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 1993; 74: 505-514.
29. Steinwaerder DS, Lieber A. Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo. Gene Ther 2000; 7: 556-567.
30. Banerjee NS, Rivera AA, Wang M, et al. Analyses of melanoma-targeted oncolytic adenoviruses with tyrosinase enhancer/ promoter-driven E1A, E4, or both in submerged cells and organotypic cultures. Mol Cancer Ther 2004; 3: 437-449.
31. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988; 106: 761-771.
32. Yoshida H, Haze K, Yanagi H, Yura T, Mori K. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J Biol Chem 1998; 273: 33741-33749.
33. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A 1998; 95: 2509-2514.
34. Bell AC, West AG, Felsenfeld G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 1999; 98: 387-396.
35. Zuo J, Rungger D, Voellmy R. Multiple layers of regulation of human heat shock transcription factor 1. Mol Cell Biol 1995, 15: 4319-4330.
36. Alemany R, Curiel DT. CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther 2001; 8: 1347-1353.
37. Krasnykh V, Belousova N, Korokhov N, Mikheeva G, Curiel DT. Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol 2001; 75: 4176-4183.
38. Suzuki K, Alemany R, Yamamoto M, Curiel DT. The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses. Clin Cancer Res 2002; 8: 3348-3359.
39. Leung TK, Rajendran MY, Monfries C, Hall C, Lim L. The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA. Biochem J 1990; 267: 125-132.
40. Parsian AJ, Sheren JF, Tao TY, et al. The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but nonfunctional. Biochim Biophys Acta 2000; 1494: 201-205.
41. Wada K, Taniguchi A, Xu L, Okano T. Rapid and highly sensitive detection of cadmium chloride induced cytotoxicity using the HSP70B' promoter in live cells. Biotechnol Bioeng 2005; 92: 410-415.
42. Williams GT, McClanahan TK and Morimoto RI 1989; Ela transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Mol Cell Biol 9: 2574-2587.
43. Phillips B, Abravaya K, and Morimoto R.I 1991; Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses. J Virol 65: 5680-5692.
44. Lum. L.S, Hsu S, Vaewhongs M, and Wit B. 1992; The hsp70 gene CCAAT-binding factor mediates transcriptional activation by the adenovirus Ela protein. Mol Cell Biol 12: 2599-2605.
45. Buvoli M, Langer SJ, Bialik S, Leinwand LA. Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors. Gene Ther 2002; 9: 227-231.
46. Yamamoto M, Davydova J, Takayama K, Alemany R, Curiel DT. Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with el deleted. J Virol 2003; 77: 1633-1637.
47. Schierer S, Hesse A, Muller I, et al. Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses. Int J Cancer 2008; 122: 219-229.
48. Sassone-Corsi P, Hen R, Borrelli E, Leff T, Chambon P. Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit. Nucleic Acids Res 1983; 11: 8735-8745.
49. Hatfield L, Hearing P. Redundant elements in the adenovirus type 5 inverted terminal repeat promote bidirectional transcription in vitro and are important for virus growth in vivo. Virology 1991; 184: 265-276.
50. Hearing P, Shenk T. The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element. Cell 1983; 33: 695-703.
51. Hearing P, Shenk T. The adenovirus type 5 ELA enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in cis. Cell 1986; 45: 229-236.
52. Leza MA, Hearing P. Cellular transcription factor binds to adenovirus early region promoters and to a cyclic AMP response element. J Virol 1988; 62: 3003-3013.
53. Miralles VJ, Cortes P, Stone N, Reinberg D. The adenovirus inverted terminal repeat functions as an enhancer in a cell-free system. J Biol Chem 1989; 264: 10763-10772.
54. Zhong XP, Krangel MS. An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus. Proc Natl Acad Sci U S A 1997; 94: 5219-5224.
55. Filippova GN, Thienes CP, Perin BH, et al. CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat Genet 2001; 28: 335-343.
56. Martin-Duque P, Jezzard S, Kaftansis L, Vassaux G. Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes. Hum Gene Ther 2004; 15: 995-1002.
57. Majem. M, Cascallo M, Bayo-Puxan N, Mesia R, Germa JR, Alemany R. Control of E1A under an E2F-1 promoter insulated with the myotonic dystrophy locus insulator reduces the toxicity of oncolytic adenovirus Ad-Delta24RGD. Cancer Gene Ther 2006; 13: 696-705.
58. Weichselbaum RR, Kufe DW, Hellman S, et al. Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy. Lancet Oncol 2002; 3: 665-671.
59. Yamini B, Yu X, Gillespie GY, Kufe DW, Weichselbaum RR. Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma. Cancer Res 2004; 64: 6381-6384.
60. Anton M, Gomaa IE, von Lukowicz T, Molls M, Gansbacher B, Wurschmidt F. Optimization of radiation controlled gene expression by adenoviral vectors in vitro. Cancer Gene Ther 2005; 12: 640-646.