메뉴 건너뛰기




Volumn 15, Issue 9, 2009, Pages 3037-3049

A novel A33 promoter-based conditionally replicative adenovirus suppresses tumor growth and eradicates hepatic metastases in human colon cancer models

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; AV22EL; FLUOROURACIL; MEMBRANE PROTEIN; PROTEIN A33; UNCLASSIFIED DRUG;

EID: 65649142589     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-1161     Document Type: Article
Times cited : (24)

References (50)
  • 1
    • 26244466645 scopus 로고    scopus 로고
    • Hepatic and extrahepatic colorectal metastases: When resectable, their localization does not matter, but their total number has a prognostic effect
    • Elias D, Liberale G, Vernerey D, et al. Hepatic and extrahepatic colorectal metastases: when resectable, their localization does not matter, but their total number has a prognostic effect. Ann Surg Oncol 2005;12: 900-909
    • (2005) Ann Surg Oncol , vol.12 , pp. 900-909
    • Elias, D.1    Liberale, G.2    Vernerey, D.3
  • 2
    • 0033786941 scopus 로고    scopus 로고
    • Surgical resection of liver metastases of colorectal carcinoma: Short and long-term results
    • Lorenz M, Staib-Sebler E, Hochmuth K, et al. Surgical resection of liver metastases of colorectal carcinoma: short and long-term results. Semin Oncol 2000; 27:112-119
    • (2000) Semin Oncol , vol.27 , pp. 112-119
    • Lorenz, M.1    Staib-Sebler, E.2    Hochmuth, K.3
  • 3
    • 13744251436 scopus 로고    scopus 로고
    • Systemic therapy for colorectal cancer
    • Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med 2005;352:476-487
    • (2005) N Engl J Med , vol.352 , pp. 476-487
    • Meyerhardt, J.A.1    Mayer, R.J.2
  • 5
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P, Bugat R, Douillard JY, et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 1997;15:251-260
    • (1997) J Clin Oncol , vol.15 , pp. 251-260
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3
  • 6
    • 0032585197 scopus 로고    scopus 로고
    • Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • Rougier P, Van Cutsem E, Bajetta E, et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 1998;352:1407-1412
    • (1998) Lancet , vol.352 , pp. 1407-1412
    • Rougier, P.1    Van Cutsem, E.2    Bajetta, E.3
  • 7
    • 0037509944 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy
    • DOI 10.1038/sj.onc.1206464
    • Post DE, Van Meir EG. A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy. Oncogene 2003;22:2065-2072 (Pubitemid 36539557)
    • (2003) Oncogene , vol.22 , Issue.14 , pp. 2065-2072
    • Post, D.E.1    Van Meir, E.G.2
  • 9
    • 33745658913 scopus 로고    scopus 로고
    • Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells
    • Bauerschmitz GJ, Guse K, Kanerva A, et al. Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells. Mol Ther 2006;14:164-174
    • (2006) Mol Ther , vol.14 , pp. 164-174
    • Bauerschmitz, G.J.1    Guse, K.2    Kanerva, A.3
  • 10
    • 2442660335 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-producing cell-specific oncolytic adenovirus, OV798, for colorectal cancer therapy
    • Li Y, Chen Y, Dilley J, et al. Carcinoembryonic antigen-producing cell-specific oncolytic adenovirus, OV798, for colorectal cancer therapy. Mol Cancer Ther 2003;2:1003-1009
    • (2003) Mol Cancer Ther , vol.2 , pp. 1003-1009
    • Li, Y.1    Chen, Y.2    Dilley, J.3
  • 11
    • 4644287822 scopus 로고    scopus 로고
    • CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase/5-fluorocytosine therapy directed by the carcinoembryonic antigen promoter
    • Dabrowska A, Szary J, Kowalczuk M, Szala S, Ugorski M. CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase/5- fluorocytosine therapy directed by the carcinoembryonic antigen promoter. Acta Biochim Pol 2004;51:723-732
    • (2004) Acta Biochim Pol , vol.51 , pp. 723-732
    • Dabrowska, A.1    Szary, J.2    Kowalczuk, M.3    Szala, S.4    Ugorski, M.5
  • 12
    • 0036187890 scopus 로고    scopus 로고
    • Tumor-specific transcriptional targeting of suicide gene therapy
    • Qiao J, Doubrovin M, Sauter BV, et al. Tumor-specific transcriptional targeting of suicide gene therapy. Gene Ther 2002;9:168-175
    • (2002) Gene Ther , vol.9 , pp. 168-175
    • Qiao, J.1    Doubrovin, M.2    Sauter, B.V.3
  • 13
    • 0141483028 scopus 로고    scopus 로고
    • Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer
    • Yamamoto M, Davydova J, Wang M, et al. Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology 2003;125:1203-1218
    • (2003) Gastroenterology , vol.125 , pp. 1203-1218
    • Yamamoto, M.1    Davydova, J.2    Wang, M.3
  • 14
    • 1442348829 scopus 로고    scopus 로고
    • Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity
    • Irving J, Wang Z, Powell S, et al. Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity. Cancer Gene Ther 2004;11: 174-185
    • (2004) Cancer Gene Ther , vol.11 , pp. 174-185
    • Irving, J.1    Wang, Z.2    Powell, S.3
  • 15
    • 3042734847 scopus 로고    scopus 로고
    • A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells
    • Shirakawa T, Hamada K, Zhang Z, et al. A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells. Clin Cancer Res 2004;10:4342-4348
    • (2004) Clin Cancer Res , vol.10 , pp. 4342-4348
    • Shirakawa, T.1    Hamada, K.2    Zhang, Z.3
  • 16
    • 23044439544 scopus 로고    scopus 로고
    • RAD001 (everolimus) improves the efficacy of replicating adenoviruses that target colon cancer
    • DOI 10.1158/0008-5472.CAN-05-0309
    • Homicsko K, Lukashev A, Iggo RD. RAD001 (everolimus) improves the efficacy of replicating adenoviruses that target colon cancer. Cancer Res 2005;65: 6882-6890 (Pubitemid 41060727)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6882-6890
    • Homicsko, K.1    Lukashev, A.2    Iggo, R.D.3
  • 17
    • 33747888987 scopus 로고    scopus 로고
    • Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and11p
    • Lu ZZ, Ni F, Hu ZB, et al. Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and11p. Exp Hematol 2006;34:1171-1182
    • (2006) Exp Hematol , vol.34 , pp. 1171-1182
    • Lu, Z.Z.1    Ni, F.2    Hu, Z.B.3
  • 18
    • 33749117374 scopus 로고    scopus 로고
    • Strategies to enhance transductional efficiency of adenoviral-based gene transfer to primary human fibroblasts and keratinocytes as a platform in dermal wounds
    • Stoff A, Rivera AA, Banerjee NS, et al. Strategies to enhance transductional efficiency of adenoviral-based gene transfer to primary human fibroblasts and keratinocytes as a platform in dermal wounds. Wound Repair Regen 2006;14:608-617
    • (2006) Wound Repair Regen , vol.14 , pp. 608-617
    • Stoff, A.1    Rivera, A.A.2    Banerjee, N.S.3
  • 19
    • 12644268234 scopus 로고    scopus 로고
    • The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily
    • Heath JK, White SJ, Johnstone CN, et al. The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. Proc Natl Acad Sci U S A 1997;94:469-474
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 469-474
    • Heath, J.K.1    White, S.J.2    Johnstone, C.N.3
  • 20
    • 0033768442 scopus 로고    scopus 로고
    • Organ-specific expression of the intestinal epithelium-related antigen A33, a cell surface target for antibody-based imaging and treatment in gastrointestinal cancer
    • Sakamoto J, Kojima H, Kato J, Hamashima H, Suzuki H. Organ-specific expression of the intestinal epithelium-related antigen A33, a cell surface target for antibody-based imaging and treatment in gastrointestinal cancer. Cancer Chemother Pharmacol 2000; 46 Suppl:S27-32.
    • (2000) Cancer Chemother Pharmacol , vol.46 , Issue.SUPPL.
    • Sakamoto, J.1    Kojima, H.2    Kato, J.3    Hamashima, H.4    Suzuki, H.5
  • 21
    • 34548525518 scopus 로고    scopus 로고
    • In silico promoter analysis can predict genes of functional relevance in cell proliferation: Validation in a colon cancer model
    • Moss A, Doran P, MacMathuna P. In silico promoter analysis can predict genes of functional relevance in cell proliferation: validation in a colon cancer model. Translational Oncogenomics 2007;2:1-16.
    • (2007) Translational Oncogenomics , vol.2 , pp. 1-16
    • Moss, A.1    Doran, P.2    MacMathuna, P.3
  • 23
    • 0029587051 scopus 로고
    • Preparation and preclinical evaluation of humanised A33 immuno-conjugates for radioimmunotherapy
    • King DJ, Antoniw P, Owens RJ, et al. Preparation and preclinical evaluation of humanised A33 immuno-conjugates for radioimmunotherapy. Br J Cancer 1995; 72:1364-1372
    • (1995) Br J Cancer , vol.72 , pp. 1364-1372
    • King, D.J.1    Antoniw, P.2    Owens, R.J.3
  • 24
    • 27144522470 scopus 로고    scopus 로고
    • A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: Biodistribution, pharmacokinetics, and quantitative tumor uptake
    • Scott AM, Lee FT, Jones R, et al. A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: biodistribution, pharmacokinetics, and quantitative tumor uptake. Clin Cancer Res 2005;11:4810-4817
    • (2005) Clin Cancer Res , vol.11 , pp. 4810-4817
    • Scott, A.M.1    Lee, F.T.2    Jones, R.3
  • 25
    • 0025147443 scopus 로고
    • Quantitative analysis of antibody localization in human metastatic colon cancer: A phase I study of monoclonal antibody A33
    • Welt S, Divgi CR, Real FX, et al. Quantitative analysis of antibody localization in human metastatic colon cancer: a phase I study of monoclonal antibody A33. J Clin Oncol 1990;8:1894-1906
    • (1990) J Clin Oncol , vol.8 , pp. 1894-1906
    • Welt, S.1    Divgi, C.R.2    Real, F.X.3
  • 26
    • 0037390263 scopus 로고    scopus 로고
    • Phase I study of anticolon cancer humanized antibody A33
    • Welt S, Ritter G, Williams C Jr, et al. Phase I study of anticolon cancer humanized antibody A33. Clin Cancer Res 2003;9:1338-1346
    • (2003) Clin Cancer Res , vol.9 , pp. 1338-1346
    • Welt, S.1    Ritter, G.2    Williams Jr., C.3
  • 27
    • 14844320868 scopus 로고    scopus 로고
    • Adenoviruses for treatment of cancer
    • DOI 10.1080/07853890410018934
    • Kanerva A, Hemminki A. Adenoviruses for treatment of cancer. Ann Med 2005;37:33-43. (Pubitemid 40342423)
    • (2005) Annals of Medicine , vol.37 , Issue.1 , pp. 33-43
    • Kanerva, A.1    Hemminki, A.2
  • 28
    • 0037379880 scopus 로고    scopus 로고
    • An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: Dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy
    • Jakubczak JL, Ryan P, Gorziglia M, et al. An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy. Cancer Res 2003;63: 1490-1499
    • (2003) Cancer Res , vol.63 , pp. 1490-1499
    • Jakubczak, J.L.1    Ryan, P.2    Gorziglia, M.3
  • 29
    • 1842717937 scopus 로고    scopus 로고
    • Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes
    • DOI 10.1089/hum.2004.15.995
    • Martin-Duque P, Jezzard S, Kaftansis L, Vassaux G. Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes. Hum Gene Ther 2004;15:995-1002. (Pubitemid 39372576)
    • (2004) Human Gene Therapy , vol.15 , Issue.10 , pp. 995-1002
    • Martin-Duque, P.1    Jezzard, S.2    Kaftansis, L.3    Vassaux, G.4
  • 30
    • 0028559768 scopus 로고
    • An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
    • Bett AJ, Haddara W, Prevec L, Graham FL. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci U S A 1994;91:8802-8806
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8802-8806
    • Bett, A.J.1    Haddara, W.2    Prevec, L.3    Graham, F.L.4
  • 31
    • 0029861452 scopus 로고    scopus 로고
    • Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo
    • Lieber A, He CY, Kirillova I, Kay MA. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 1996;70:8944-8960 (Pubitemid 26378479)
    • (1996) Journal of Virology , vol.70 , Issue.12 , pp. 8944-8960
    • Lieber, A.1    He, C.-Y.2    Kirillova, I.3    Kay, M.A.4
  • 32
    • 0028403236 scopus 로고
    • Butyrateinducible and tumor-restricted gene expression by adenovirus vectors
    • Tang DC, Johnston SA, Carbone DP. Butyrateinducible and tumor-restricted gene expression by adenovirus vectors. Cancer GeneTher 1994;1:15-20.
    • (1994) Cancer GeneTher , vol.1 , pp. 15-20
    • Tang, D.C.1    Johnston, S.A.2    Carbone, D.P.3
  • 33
    • 40149100649 scopus 로고    scopus 로고
    • Isolation of primary human hepatocytes after partial hepatectomy: Criteria for identification of the most promising liver specimen
    • Vondran FW, Katenz E, Schwartlander R, et al. Isolation of primary human hepatocytes after partial hepatectomy: criteria for identification of the most promising liver specimen. Artif Organs 2008;32: 205-213
    • (2008) Artif Organs , vol.32 , pp. 205-213
    • Vondran, F.W.1    Katenz, E.2    Schwartlander, R.3
  • 34
    • 33750454736 scopus 로고    scopus 로고
    • Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth
    • Lopez MV, Blanco P, Viale DL, et al. Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth. Mol Cancer Ther 2006;5:2503-2511
    • (2006) Mol Cancer Ther , vol.5 , pp. 2503-2511
    • Lopez, M.V.1    Blanco, P.2    Viale, D.L.3
  • 35
    • 0035417931 scopus 로고    scopus 로고
    • A hepatocellular carcinoma-specific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin
    • Li Y, Yu DC, Chen Y, et al. A hepatocellular carcinoma-specific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin. Cancer Res 2001;61:6428-6436
    • (2001) Cancer Res , vol.61 , pp. 6428-6436
    • Li, Y.1    Yu, D.C.2    Chen, Y.3
  • 36
    • 51849100695 scopus 로고    scopus 로고
    • Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus
    • Bazan-Peregrino M, Carlisle RC, Hernandez-Alcoceba R, et al. Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus. Hum Gene Ther 2008;19:873-886
    • (2008) Hum Gene Ther , vol.19 , pp. 873-886
    • Bazan-Peregrino, M.1    Carlisle, R.C.2    Hernandez-Alcoceba, R.3
  • 37
    • 42149141692 scopus 로고    scopus 로고
    • Factors influencing retention of adenovirus within tumours following direct intratumoural injection
    • Bazan-Peregrino M, Carlisle RC, Purdie L, Seymour LW. Factors influencing retention of adenovirus within tumours following direct intratumoural injection. Gene Ther 2008;15:688-694
    • (2008) Gene Ther , vol.15 , pp. 688-694
    • Bazan-Peregrino, M.1    Carlisle, R.C.2    Purdie, L.3    Seymour, L.W.4
  • 38
    • 33748201193 scopus 로고    scopus 로고
    • Efficient generation of double heterologous promoter controlled oncolytic adenovirus vectors by a single homologous recombination step in Escherichia coli
    • DOI 10.1186/1472-6750-6-36
    • Hoffmann D, Wildner O. Efficient generation of double heterologous promoter controlled oncolytic adenovirus vectors by a single homologous recombination step in Escherichia coli. BMC Biotechnol 2006;6:36. (Pubitemid 44314520)
    • (2006) BMC Biotechnology , vol.6 , pp. 36
    • Hoffmann, D.1    Wildner, O.2
  • 39
    • 2342453303 scopus 로고    scopus 로고
    • A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases
    • Sova P, Ren XW, Ni S, et al. A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. Mol Ther 2004;9:496-509.
    • (2004) Mol Ther , vol.9 , pp. 496-509
    • Sova, P.1    Ren, X.W.2    Ni, S.3
  • 40
    • 0023883716 scopus 로고
    • A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5
    • DOI 10.1016/0042-6822(88)90302-9
    • McGrory WJ, Bautista DS, Graham FL. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology 1988; 163:614-617 (Pubitemid 18115467)
    • (1988) Virology , vol.163 , Issue.2 , pp. 614-617
    • McGrory, W.J.1    Bautista, D.S.2    Graham, F.L.3
  • 41
    • 0028070360 scopus 로고
    • Down-regulation of human adenovirus E1a by E3 gene products: Evidence for translational control of E1a by E3 14.5K and/or E3 10.4K products
    • Zhang X, Bellett AJ, Hla RT, Voss T, Mullbacher A, Braithwaite AW. Down-regulation of human adenovirus E1a by E3 gene products: evidence for translational control of E1a by E3 14.5K and/or E3 10.4K products. J Gen Virol 1994;75:1943-1951. (Pubitemid 24243074)
    • (1994) Journal of General Virology , vol.75 , Issue.8 , pp. 1943-1951
    • Zhang, X.1    Bellett, A.J.D.2    Tha Hla, R.3    Voss, T.4    Mullbacher, A.5    Braithwaite, A.W.6
  • 42
    • 40549092679 scopus 로고    scopus 로고
    • Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad(I/PPT-E1A) by reduction of the insulator size and introduction of the full-length E3 region
    • Danielsson A, Dzojic H, Nilsson B, Essand M. Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad(I/PPT-E1A) by reduction of the insulator size and introduction of the full-length E3 region. Cancer Gene Ther 2008;15:203-213
    • (2008) Cancer Gene Ther , vol.15 , pp. 203-213
    • Danielsson, A.1    Dzojic, H.2    Nilsson, B.3    Essand, M.4
  • 43
    • 38349019847 scopus 로고    scopus 로고
    • Anticancer activity of oncolytic adenovirus vector armed with IFN-α and ADP is enhanced by pharmacologically controlled expression of TRAIL
    • Shashkova EV, Kuppuswamy MN, Wold WS, Doronin K. Anticancer activity of oncolytic adenovirus vector armed with IFN-α and ADP is enhanced by pharmacologically controlled expression of TRAIL. Cancer Gene Ther 2008;15:61-72.
    • (2008) Cancer Gene Ther , vol.15 , pp. 61-72
    • Shashkova, E.V.1    Kuppuswamy, M.N.2    Wold, W.S.3    Doronin, K.4
  • 44
    • 10844281217 scopus 로고    scopus 로고
    • ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis
    • DOI 10.1038/sj.cgt.7700769
    • Yun CO, Kim E, Koo T, Kim H, Lee YS, Kim JH. ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis. Cancer Gene Ther 2005;12:61-71. (Pubitemid 39665244)
    • (2005) Cancer Gene Therapy , vol.12 , Issue.1 , pp. 61-71
    • Yun, C.-O.1    Kim, E.2    Koo, T.3    Kim, H.4    Lee, Y.-S.5    Kim, J.-H.6
  • 45
    • 0035105560 scopus 로고    scopus 로고
    • The results of colorectal cancer treatment by p53 status: Treatment-specific overview
    • Petersen S, Thames HD, Nieder C, Petersen C, Baumann M. The results of colorectal cancer treatment by p53 status: treatment-specific overview. Dis Colon Rectum 2001;44:322-33; discussion 333-334 (Pubitemid 32226320)
    • (2001) Diseases of the Colon and Rectum , vol.44 , Issue.3 , pp. 322-334
    • Petersen, S.1    Thames, H.D.2    Nieder, C.3    Petersen, C.4    Baumann, M.5
  • 46
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1b gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • DOI 10.1038/nm0697-639
    • Heise C, Sampson-Johannes A, Williams A, McCormick F, Von Hoff DD, Kirn DH. ONYX-015, an E1B gene-attenuated adenovirus, causes tumorspecific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 1997;3:639-645 (Pubitemid 27264973)
    • (1997) Nature Medicine , vol.3 , Issue.6 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3    McCormick, F.4    Von Hoff, D.D.5    Kirn, D.H.6
  • 47
    • 33846198764 scopus 로고    scopus 로고
    • Minimal hepatic toxicity of Onyx-015: Spatial restriction of coxsackie-adenoviral receptor in normal liver
    • DOI 10.1038/sj.cgt.7700988, PII 7700988
    • Au T, Thorne S, Korn WM, Sze D, Kirn D, Reid TR. Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. Cancer GeneTher 2007;14:139-150 (Pubitemid 46106958)
    • (2007) Cancer Gene Therapy , vol.14 , Issue.2 , pp. 139-150
    • Au, T.1    Thorne, S.2    Korn, W.M.3    Sze, D.4    Kirn, D.5    Reid, T.R.6
  • 48
    • 34447251868 scopus 로고    scopus 로고
    • Cloning and characterization of an adenoviral vector for highly efficient and doxycycline-suppressible expression of bioactive human single-chain interleukin 12 in colon cancer
    • Wulff H, Krieger T, Kruger K, et al. Cloning and characterization of an adenoviral vector for highly efficient and doxycycline-suppressible expression of bioactive human single-chain interleukin 12 in colon cancer. BMC Biotechnol 2007;7:35.
    • (2007) BMC Biotechnol , vol.7 , pp. 35
    • Wulff, H.1    Krieger, T.2    Kruger, K.3
  • 49
    • 0035884115 scopus 로고    scopus 로고
    • Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33
    • Ritter G, Cohen LS, Williams C, Jr. Richards EC, Old LJ, Welt S. Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33. Cancer Res 2001;61: 6851-6859 (Pubitemid 32896510)
    • (2001) Cancer Research , vol.61 , Issue.18 , pp. 6851-6859
    • Ritter, G.1    Cohen, L.S.2    Williams Jr., C.3    Richards, E.C.4    Old, L.J.5    Welt, S.6
  • 50
    • 0037386871 scopus 로고    scopus 로고
    • Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer
    • Welt S, Ritter G, Williams C Jr, et al. Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer. Clin Cancer Res 2003;9:1347-1353
    • (2003) Clin Cancer Res , vol.9 , pp. 1347-1353
    • Welt, S.1    Ritter, G.2    Williams Jr., C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.