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Volumn 1 E, Issue 1, 2009, Pages 115-122

Signaling in fibrosis: Targeting the TGFbeta, endothelin-1 and CCN2 axis in scleroderma

Author keywords

Connective tissue growth factor; Endothelin; Fibrosis; Review; Scarring

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CTGF PROTEIN, HUMAN; ENDOTHELIN 1; TRANSFORMING GROWTH FACTOR BETA;

EID: 77953633610     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (67)

References (72)
  • 1
    • 0034253938 scopus 로고    scopus 로고
    • Fibroblast-matrix interactions in wound healing and fibrosis
    • DOI 10.1016/S0945-053X(00)00077-9, PII S0945053X00000779
    • Eckes B, Zigrino P, Kessler D, Holtkotter O, Shephard P, Mauch C, Krieg T Fibroblast-matrix interactions in wound healing and fibrosis Matrix Biol. 19:325-32 (2000) (Pubitemid 30665656)
    • (2000) Matrix Biology , vol.19 , Issue.4 , pp. 325-332
    • Eckes, B.1    Zigrino, P.2    Kessler, D.3    Holtkotter, O.4    Shephard, P.5    Mauch, C.6    Krieg, T.7
  • 2
    • 0037899249 scopus 로고    scopus 로고
    • The myofibroblast in wound healing and fibrocontractive diseases
    • DOI 10.1002/path.1427
    • Gabbiani G The myofibroblast in wound healing and fibrocontractive diseases J Pathol 200:500-3 (2003) (Pubitemid 36818250)
    • (2003) Journal of Pathology , vol.200 , Issue.4 , pp. 500-503
    • Gabbiani, G.1
  • 3
    • 0037899248 scopus 로고    scopus 로고
    • Liver extracellular matrix in health and disease
    • DOI 10.1002/path.1397
    • Bedossa P, Paradis V. Liver extracellular matrix in health and disease J Pathol. 200:504-15 (2003) (Pubitemid 36818251)
    • (2003) Journal of Pathology , vol.200 , Issue.4 , pp. 504-515
    • Bedossa, P.1    Paradis, V.2
  • 4
    • 0032922445 scopus 로고    scopus 로고
    • Mesangial matrix modulation and glomerulosclerosis
    • Fogo AB. Mesangial matrix modulation and glomerulosclerosis Exp Nephrol. 7:147-59 (1999) (Pubitemid 29210177)
    • (1999) Experimental Nephrology , vol.7 , Issue.2 , pp. 147-159
    • Fogo, A.B.1
  • 7
    • 0025830392 scopus 로고
    • Direct evidence for spatial and temporal regulation of transforming growth factor 1 expression during cutaneous wound healing
    • Kane CJ, Hebda PA, Mansbridge JN, Hanawalt PC Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing Cell Physiol. 148:157-73 (1991) (Pubitemid 21910138)
    • (1991) Journal of Cellular Physiology , vol.148 , Issue.1 , pp. 157-173
    • Kane, C.J.M.1    Hebda, P.A.2    Mansbridge, J.N.3    Hanawalt, P.C.4
  • 9
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J. TGF-beta signal transduction. Annu Rev Biochem. 67:753-91 (1998)
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 10
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask A, Abraham DJ TGF-beta signaling and the fibrotic response FASEB J. 18:816-27 (2004)
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 11
    • 33748551701 scopus 로고    scopus 로고
    • Scar wars: Is TGFbeta the phantom menace in scleroderma?
    • Leask A. Scar wars: Is TGFbeta the phantom menace in scleroderma? Arthritis Res. Ther., 8(4):213 (2006)
    • (2006) Arthritis Res. Ther. , vol.8 , Issue.4 , pp. 213
    • Leask, A.1
  • 12
    • 0033380665 scopus 로고    scopus 로고
    • TGF-beta signaling from receptors to the nucleus
    • Roberts AB. TGF-beta signaling from receptors to the nucleus Microbes Infect. 1:1265-73 (1999)
    • (1999) Microbes Infect , vol.1 , pp. 1265-1273
    • Roberts, A.B.1
  • 14
    • 0032909167 scopus 로고    scopus 로고
    • FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor signals
    • Liu B, Dou CL, Prabhu L, Lai E FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals Mol Cell Biol. 19:424-30 (1999) (Pubitemid 29018444)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.1 , pp. 424-430
    • Liu, B.1    Dou, C.-L.2    Prabhu, L.3    Lai, E.4
  • 16
    • 0034646674 scopus 로고    scopus 로고
    • Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor
    • DOI 10.1074/jbc.275.15.11320
    • von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Bottinger EP. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta. J Biol Chem. 275:11320-6 (2000) (Pubitemid 30212781)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.15 , pp. 11320-11326
    • Von Gersdorff, G.1    Susztak, K.2    Rezvani, F.3    Bitzer, M.4    Liang, D.5    Bottinger, E.P.6
  • 17
    • 0028607541 scopus 로고
    • Collagen type I is not under autocrine control by transforming growth factor-beta 1 in normal and scleroderma fibroblasts
    • McWhirter A, Colosetti P, Rubin K, Miyazono K, Black C Collagen type I is not under autocrine control by transforming growth factor-beta 1 in normal and scleroderma fibroblasts. Lab Invest. 71:885-94 (1994)
    • (1994) Lab Invest , vol.71 , pp. 885-894
    • McWhirter, A.1    Colosetti, P.2    Rubin, K.3    Miyazono, K.4    Black, C.5
  • 18
    • 0023262932 scopus 로고
    • Accelerated healing of incisional wounds in rats induced by transforming growth factor
    • Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta Science 237:1333-6 (1987) (Pubitemid 17125439)
    • (1987) Science , vol.237 , Issue.4820 , pp. 1333-1336
    • Mustoe, T.A.1    Pierce, G.F.2    Thomason, A.3
  • 19
    • 0029135303 scopus 로고
    • Exogenous transforming growth factorbeta amplifies its own expression and induces scar formation in a model of human fetal skin repair
    • Lin RY, Sullivan KM, Argenta PA, Meuli M, Lorenz HP, Adzick NS Exogenous transforming growth factorbeta amplifies its own expression and induces scar formation in a model of human fetal skin repair Ann Surg. 222:146-54 (1995)
    • (1995) Ann Surg , vol.222 , pp. 146-154
    • Lin, R.Y.1    Sullivan, K.M.2    Argenta, P.A.3    Meuli, M.4    Lorenz, H.P.5    Adzick, N.S.6
  • 20
    • 0032873465 scopus 로고    scopus 로고
    • Connective tissue growth factor mediates transforming growth factor induced collagen synthesis: Downregulation by cAMP
    • Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, Huang X, Grotendorst GR. Connective tissue growth factor mediates transforming growth factor betainduced collagen synthesis: down-regulation by cAMP. FASEB J. 13:1774-86 (1999) (Pubitemid 29473339)
    • (1999) FASEB Journal , vol.13 , Issue.13 , pp. 1774-1786
    • Duncan, M.R.1    Frazier, K.S.2    Abramson, S.3    Williams, S.4    Klapper, H.5    Huang, X.6    Grotendorst, G.R.7
  • 21
    • 0032794692 scopus 로고    scopus 로고
    • Role and interaction of connective tissue growth factor with transforming growth factor-in persistent fibrosis: A mouse fibrosis model
    • DOI 10.1002/(SICI)1097-4652(199910) 181:1<153::AID-JCP16>3.0.CO;2-K
    • Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, Takigawa M, Nakanishi T, Takehara K Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol. 181:153-9 (1999) (Pubitemid 29400382)
    • (1999) Journal of Cellular Physiology , vol.181 , Issue.1 , pp. 153-159
    • Mori, T.1    Kawara, S.2    Shinozaki, M.3    Hayashi, N.4    Kakinuma, T.5    Igarashi, A.6    Takigawa, M.7    Nakanishi, T.8    Takehara, K.9
  • 22
    • 0028174630 scopus 로고
    • Neutralising antibody to TGF-beta 1, 2 reduces cutaneous scarring in adult rodents
    • Shah M, Foreman DM, Ferguson MW Neutralising antibody to TGF-beta 1, 2 reduces cutaneous scarring in adult rodents. J Cell Sci. 107:1137-57 (1994)
    • (1994) J Cell Sci , vol.107 , pp. 1137-1157
    • Shah, M.1    Foreman, D.M.2    Ferguson, M.W.3
  • 27
    • 0035815683 scopus 로고    scopus 로고
    • CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling
    • DOI 10.1074/jbc.M010149200
    • Holmes A, Abraham DJ, Sa S, Shiwen X, Black CM, Leask A CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem. 276:10594-601 (2001) (Pubitemid 38089227)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.14 , pp. 10594-10601
    • Holmes, A.1    Abraham, D.J.2    Sa, S.3    Shiwen, X.4    Black, C.M.5    Leask, A.6
  • 29
    • 0035907240 scopus 로고    scopus 로고
    • Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
    • Verrecchia F, Chu ML, Mauviel A Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem. 276:17058-62 (2001)
    • (2001) J Biol Chem , vol.276 , pp. 17058-17062
    • Verrecchia, F.1    Chu, M.L.2    Mauviel, A.3
  • 30
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGF-1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • DOI 10.1172/JCI200319270
    • Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest. 112:1486-94 (2003) (Pubitemid 38056275)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.10 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3    Roberts, A.B.4    Ooshima, A.5
  • 32
    • 0037378403 scopus 로고    scopus 로고
    • Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney
    • DOI 10.1046/j.1523-1755.2003.00874.x
    • Masaki T, Foti R, Hill PA, Ikezumi Y, Atkins RC, Nikolic-Paterson DJ. Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney. Kidney Int. 63:1256-64 (2003) (Pubitemid 36349991)
    • (2003) Kidney International , vol.63 , Issue.4 , pp. 1256-1264
    • Masaki, T.1    Foti, R.2    Hill, P.A.3    Ikezumi, Y.4    Atkins, R.C.5    Nikolic-Paterson, D.J.6
  • 35
    • 33748939751 scopus 로고    scopus 로고
    • IN-1130, a novel transforming growth factor-type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
    • DOI 10.1038/sj.ki.5001775, PII 5001775
    • Moon JA, Kim HT, Cho IS, Sheen YY, Kim DK. IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int. 70:1234-43 (2006) (Pubitemid 44435174)
    • (2006) Kidney International , vol.70 , Issue.7 , pp. 1234-1243
    • Moon, J.-A.1    Kim, H.-T.2    Cho, I.-S.3    Sheen, Y.Y.4    Kim, D.-K.5
  • 38
    • 33847392947 scopus 로고    scopus 로고
    • New developments in fibroblast and myofibroblast biology: Implications for fibrosis and scleroderma
    • DOI 10.1007/s11926-007-0008-z
    • Abraham DJ, Eckes B, Rajkumar V, Krieg T. New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma. Curr Rheumatol Rep. 9:136-43 (2007) (Pubitemid 46932720)
    • (2007) Current Rheumatology Reports , vol.9 , Issue.2 , pp. 136-143
    • Abraham, D.J.1    Eckes, B.2    Rajkumar, V.3    Krieg, T.4
  • 39
    • 33646346588 scopus 로고    scopus 로고
    • ALK5 (TGFß receptor type I) signaling contributes to the fibrotic phenotype of scleroderma fibroblasts
    • Chen, Y., Shi-wen, X., Eastwood, M., Black, C. M., Denton, C. P., Leask, A, Abraham D. J. ALK5 (TGFß receptor type I) signaling contributes to the fibrotic phenotype of scleroderma fibroblasts. Arthr. Rheum. 54:1309-1316 (2006)
    • (2006) Arthr. Rheum , vol.54 , pp. 1309-1316
    • Chen, Y.1    Shi-wen, X.2    Eastwood, M.3    Black, C.M.4    Denton, C.P.5    Leask, A.6    Abraham, D.J.7
  • 40
    • 0038004796 scopus 로고    scopus 로고
    • Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
    • DOI 10.1002/art.11157
    • Mori Y, Chen SJ, Varga J. Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Arthritis Rheum. 48:1964-78 (2003) (Pubitemid 36828692)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.7 , pp. 1964-1978
    • Mori, Y.1    Chen, S.-J.2    Varga, J.3
  • 41
    • 2342547687 scopus 로고    scopus 로고
    • An Increased Transforming Growth Factor Receptor Type I:Type II Ratio Contributes to Elevated Collagen Protein Synthesis That Is Resistant to Inhibition via a Kinase-Deficient Transforming Growth Factor Receptor Type II in Scleroderma
    • DOI 10.1002/art.20225
    • Pannu J, Gore-Hyer E, Yamanaka M, Smith EA, Rubinchik S, Dong JY, Jablonska S, Blaszczyk M, Trojanowska M. An increased transforming growth factor beta receptor type I: type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma. Arthritis Rheum. 50:1566-77 (2004) (Pubitemid 38608079)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.5 , pp. 1566-1577
    • Pannu, J.1    Gore-Hyer, E.2    Yamanaka, M.3    Smith, E.A.4    Rubinchik, S.5    Dong, J.-Y.6    Jablonska, S.7    Blaszczyk, M.8    Trojanowska, M.9
  • 43
    • 34047182621 scopus 로고    scopus 로고
    • TGFbeta in cardiac fibrosis
    • Leask A. TGFbeta in cardiac fibrosis. Cardiovasc. Res. 74:207-12 (2007)
    • (2007) Cardiovasc. Res , vol.74 , pp. 207-212
    • Leask, A.1
  • 44
    • 33744784611 scopus 로고    scopus 로고
    • Betaglycan induces TGF-signaling in a ligand-independent manner, through activation of the p38 pathway
    • DOI 10.1016/j.cellsig.2005.11.011, PII S089865680500327X
    • Santander C, Brandan E. Betaglycan induces TGFbeta signaling in a ligand-independent manner, through activation of the p38 pathway. Cell Signal. 18:1482-91 (2006) (Pubitemid 43832084)
    • (2006) Cellular Signalling , vol.18 , Issue.9 , pp. 1482-1491
    • Santander, C.1    Brandan, E.2
  • 46
    • 0038823614 scopus 로고    scopus 로고
    • Myofibroblast differentiation by transforming growth factor-1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase
    • DOI 10.1074/jbc.M208544200
    • Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase J Biol Chem. 278:12384-9 (2003) (Pubitemid 36800223)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.14 , pp. 12384-12389
    • Thannickal, V.J.1    Lee, D.Y.2    White, E.S.3    Cui, Z.4    Larios, J.M.5    Chacon, R.6    Horowitz, J.C.7    Day, R.M.8    Thomas, P.E.9
  • 47
    • 0036378148 scopus 로고    scopus 로고
    • CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC
    • Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, Leask A. CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int. 62:1149-59 (2002)
    • (2002) Kidney Int , vol.62 , pp. 1149-1159
    • Chen, Y.1    Blom, I.E.2    Sa, S.3    Goldschmeding, R.4    Abraham, D.J.5    Leask, A.6
  • 48
    • 0038644847 scopus 로고    scopus 로고
    • CTGF gene regulation: Requirements for its induction by TGFbeta in fibroblasts
    • Leask, A, Holmes, A., Black, CM, Abraham, D. J. CTGF gene regulation: requirements for its induction by TGFbeta in fibroblasts. J. Biol. Chem. 278, 13008-15 (2003)
    • (2003) J. Biol. Chem , vol.278 , pp. 13008-13015
    • Leask, A.1    Holmes, A.2    Black, C.M.3    Abraham, D.J.4
  • 50
    • 38349011114 scopus 로고    scopus 로고
    • MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397
    • Hayashida T, Wu MH, Pierce A, Poncelet AC, Varga J, Schnaper HW. MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397. J Cell Sci. 120:4230-40 (2007)
    • (2007) J Cell Sci , vol.120 , pp. 4230-4240
    • Hayashida, T.1    Wu, M.H.2    Pierce, A.3    Poncelet, A.C.4    Varga, J.5    Schnaper, H.W.6
  • 52
    • 2542485410 scopus 로고    scopus 로고
    • Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts
    • DOI 10.1091/mbc.E03-12-0902
    • Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, Leask A, Abraham DJ. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts Mol Biol Cell. 15:2707-19 (2004) (Pubitemid 38691860)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.6 , pp. 2707-2719
    • Shi-Wen, X.1    Chen, Y.2    Denton, C.P.3    Eastwood, M.4    Renzoni, E.A.5    Bou-Gharios, G.6    Pearson, J.D.7    Dashwood, M.8    Du Bois, R.M.9    Black, C.M.10    Leask, A.11    Abraham, D.J.12
  • 55
    • 34248183465 scopus 로고    scopus 로고
    • Signaling by ALK5 mediates TGF-induces ET-1 expression in endothelial cells: A role for migration and proliferation
    • DOI 10.1242/jcs.03419
    • Castanares C, Redondo-Horcajo M, Magan-Marchal N, ten Dijke P, Lamas S, Rodriguez-Pascual F. Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation. J Cell Sci. 120:1256-66 (2007) (Pubitemid 46711844)
    • (2007) Journal of Cell Science , vol.120 , Issue.7 , pp. 1256-1266
    • Castanares, C.1    Redondo-Horcajo, M.2    Magan-Marchal, N.3    Ten Dijke, P.4    Lamas, S.5    Rodriguez-Pascual, F.6
  • 57
    • 4444236084 scopus 로고    scopus 로고
    • Dissecting the roles of endothelin, TGF-and GM-CSF on myofibroblast differentiation by keratinocytes
    • Shephard P, Hinz B, Smola-Hess S, Meister JJ, Krieg T, Smola H. Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes. Thromb Haemost. 92:262-74 (2004) (Pubitemid 39172306)
    • (2004) Thrombosis and Haemostasis , vol.92 , Issue.2 , pp. 262-274
    • Shephard, P.1    Hinz, B.2    Smola-Hess, S.3    Meister, J.-J.4    Krieg, T.5    Smola, H.6
  • 58
    • 29144492719 scopus 로고    scopus 로고
    • Signalling and regulation of collagen I synthesis by ET-1 and TGF-1
    • DOI 10.1111/j.1742-4658.2005.05016.x
    • Horstmeyer A, Licht C, Scherr G, Eckes B, Krieg T. Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1 FEBS J. 272:6297-309 (2005) (Pubitemid 41815618)
    • (2005) FEBS Journal , vol.272 , Issue.24 , pp. 6297-6309
    • Horstmeyer, A.1    Licht, C.2    Scherr, G.3    Eckes, B.4    Krieg, T.5
  • 60
    • 33845906843 scopus 로고    scopus 로고
    • All in the CCN family: Essential matricellular signaling modulators emerge from the bunker
    • DOI 10.1242/jcs.03270
    • Leask A Abraham DJ. All in the CCN family: essential signaling mediators emerge from the bunker. J. Cell Sci. 119:4803-10 (2006) (Pubitemid 46017793)
    • (2006) Journal of Cell Science , vol.119 , Issue.23 , pp. 4803-4810
    • Leask, A.1    Abraham, D.J.2
  • 64
    • 1342302941 scopus 로고    scopus 로고
    • Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis
    • Uchio K, Graham M, Dean NM, Rosenbaum J, Desmouliere A. Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis. Wound Repair Regen. 12:60-6 (2004) (Pubitemid 38249137)
    • (2004) Wound Repair and Regeneration , vol.12 , Issue.1 , pp. 60-66
    • Uchio, K.1    Graham, M.2    Dean, N.M.3    Rosenbaum, J.4    Desmouliere, A.5
  • 70
    • 0032913069 scopus 로고    scopus 로고
    • 3, promotes endothelial cell survival, and induces angiogenesis in vivo
    • Babic AM, Chen CC, Lau LF. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol. 19:2958-66 (1999) (Pubitemid 29144541)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.4 , pp. 2958-2966
    • Babic, A.M.1    Chen, C.-C.2    Lau, L.F.3
  • 71
    • 1542305557 scopus 로고    scopus 로고
    • v3 and Heparan Sulfate Proteoglycan
    • DOI 10.1074/jbc.M313204200
    • Gao R, Brigstock DR. Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha (v) beta (3) and heparan sulfate proteoglycan. J Biol Chem. 279:8848-55 (2004) (Pubitemid 38295943)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.10 , pp. 8848-8855
    • Gao, R.1    Brigstock, D.R.2


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