Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts

Matrix Biology

Volumn 26, Issue 8, 2007, Pages 625-632

  Shi Wen, Xu ^a   Renzoni, Elisabetta A ^b   Kennedy, Laura ^c   Howat, Sarah ^d   Chen, Yunliang ^a   Pearson, Jeremy D ^d   Bou Gharios, George ^b   Dashwood, Michael R ^a   du Bois, Roland M ^b   Black, Carol M ^a   Denton, Christopher P ^a   Abraham, David J ^a   Leask, Andrew ^c  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c CIHR Group in Skeletal Development and Remodeling   (Canada)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Adhesion; CCN2; Connective tissue; Endothelin; Fibroblast; Fibrosis; Type I collagen

Indexed keywords

BOSENTAN; COLLAGEN TYPE 1; ENDOTHELIN 1; FIBRONECTIN; MATRIX PROTEIN; PROTEIN CCN2; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; DRUG INHIBITION; EXTRACELLULAR MATRIX; FEMALE; FIBROSIS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG BIOPSY; LUNG FIBROBLAST; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCLERODERMA; WESTERN BLOTTING;

BIOPSY; CELL ADHESION; CELLS, CULTURED; COLLAGEN TYPE I; ENDOTHELIN-1; FIBROBLASTS; FIBROSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 36549062970     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2007.06.003     Document Type: Article

References (21)

1. Abraham D.J., Vancheeswaran R., Dashwood M.R., Pantelides P., Shi-Wen X., du Bois R.M., and Black C.M. Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease. Am. J. Pathol. 151 (1997) 831-841
2. Chen Y., Abraham D.J., Shi-Wen X., Pearson J.D., Black C.M., Lyons K.M., and Leask A. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol. Biol. Cell 15 (2004) 5635-5646
3. Chen Y., Shi-Wen X., van Beek J., Kennedy L., McLeod M., Renzoni E.A., Bou-Gharios G., Wilcox-Adelman S., Goetinck P.F., Eastwood M., Black C.M., Abraham D.J., and Leask A. Matrix contraction by dermal fibroblasts requires TGFbeta/ALK5, heparan sulfate containing proteoglycans and MEK/ERK: Insights into pathological scarring in chronic fibrotic disease. Am. J. Pathol. 167 (2005) 1699-1711
4. Chen Y., Shi-Wen X., Eastwood M., Black C.M., Denton C.P., Leask A., and Abraham D.J. ALK5 (TGFβ receptor type I) signaling contributes to the fibrotic phenotype of scleroderma fibroblasts. Arthritis Rheum. 54 (2006) 1309-1316
5. Clozel M., and Salloukh H. Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann. Med. 37 (2005) 2-12
6. Denton C.P., and Black C.M. Pulmonary hypertension in systemic sclerosis. Rheum. Dis. Clin. North Am. 29 (2003) 335-349
7. Desmouliere A. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol. Int. 19 (1995) 471-476
8. Harrison N.K., Argent A.C., McAnulty R.J., Black C.M., Corrin B., and Laurent G.J. Collagen synthesis and degradation by systemic sclerosis lung fibroblasts. Responses to transforming growth factor-beta. Chest 99 3 S (1991) 71S-72S
9. Holmes A., Abraham D.J., Sa S., Shi-wen X., Black C.M., and Leask A. CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J. Biol. Chem. 276 (2001) 10594-10601
10. Holmes A., Abraham D.J., Chen Y., Denton C., Shi-Wen X., Black C.M., and Leask A. Constitutive connective tissue growth factor expression in scleroderma. J. Biol. Chem. 278 (2003) 41728-41733
11. Ivarsson M., McWhirter A., Black C.M., and Rubin K. Impaired regulation of collagen pro-alpha 1(I) mRNA and change in pattern of collagen-binding integrins on scleroderma fibroblasts. J. Invest. Dermatol. 101 (1993) 216-221
12. Kawaguchi Y., Suzuki K., Hara M., Hidaka T., Ishizuka T., Kawagoe M., and Nakamura H. Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis. Ann. Rheum. Dis. 53 (1994) 506-510
13. Leask A., Denton C.P., and Abraham D.J. Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma. J. Invest. Dermatol. 122 (2004) 1-6
14. Miyauchi T., Suzuki N., Yuhara T., Akama T., Suzuki H., and Kashiwagi H. Significance of plasma endothelin-1 levels in patients with systemic sclerosis. J. Rheumatol. 19 (1992) 1566-1571
15. Renzoni E.A., Abraham D.J., Howat S., Shi-Wen X., Sestini P., Bou-Gharios G., Wells A.U., Veeraraghavan S., Nicholson A.G., Denton C.P., Leask A., Pearson J.D., Black C.M., Welsh K.I., and du Bois R.M. Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts. Respir. Res. 5 (2004) 24
16. Shi-Wen X., Denton C.P., McWhirter A., Bou-Gharios G., Abraham D.J., du Bois R.M., and Black C.M. Scleroderma lung fibroblasts exhibit elevated and dysregulated collagen type I biosynthesis. Arthritis Rheum. 40 (1997) 1237-1244
17. Shi-Wen X., Denton C.P., Dashwood M.R., Holmes A.M., Bou-Gharios G., Pearson J.D., Black C.M., and Abraham D.J. Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. J. Invest. Dermatol. 116 (2001) 417-425
18. Shi-Wen X., Chen Y., Denton C.P., Eastwood M., Renzoni E.A., Bou-Gharios G., Pearson J.D., Dashwood M., du Bois R.M., Black C.M., Leask A., and Abraham D.J. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol. Biol. Cell 15 (2004) 2707-2719
19. Shi-Wen X., Howat S.L., Renzoni E.A., Holmes A., Pearson J.D., Dashwood M.R., Bou-Gharios G., Denton C.P., du Bois R.M., Black C.M., Leask A., and Abraham D.J. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J. Biol. Chem. 279 (2004) 23098-23103
20. Shi-Wen X., Rodriguez-Pascual F., Lamas S., Holmes A., Howat S., Pearson J.D., Dashwood M.R., du Bois R.M., Denton C.P., Black C.M., Abraham D.J., and Leask A. Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol. Cell Biol. 26 (2006) 5518-5527
21. Teder P., and Noble P.W. A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis. Am. J. Respir. Cell Mol. Biol. 23 (2000) 7-10