Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: Evidence of an autocrine endothelin loop operating through the endothelin A and B receptors

Molecular and Cellular Biology

Volumn 26, Issue 14, 2006, Pages 5518-5527

  Shi Wen, Xu ^a   Rodríguez Pascual, Fernando ^b   Lamas, Santiago ^b   Holmes, Alan ^a   Howat, Sarah ^c   Pearson, Jeremy D ^c   Dashwood, Michael R ^a   Du Bois, Roland M ^d   Denton, Christopher P ^a   Black, Carol M ^a   Abraham, David J ^a   Leask, Andrew ^e  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ANGIOTENSIN ANTAGONIST; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BOSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; IMATINIB; LOSARTAN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL ISOLATION; CHRONIC LUNG DISEASE; ENZYME REGULATION; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; MYOFIBROBLAST; NONHUMAN; PATHOLOGICAL ANATOMY; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BINDING; SCLERODERMA; SIGNAL TRANSDUCTION; TISSUE REPAIR;

ACTINS; ACTIVIN RECEPTORS, TYPE I; ANIMALS; CELLS, CULTURED; ENDOTHELIN-1; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MODELS, BIOLOGICAL; PULMONARY FIBROSIS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA;

EID: 33745815350     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00625-06     Document Type: Article

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