-
2
-
-
0038825269
-
In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [H-3]3-methoxy-5-(pyridin-2-ylethynyl)pyridine)
-
Anderson J.J., Bradbury M.J., Giracello D.R., Chapman D.F., Holtz G., Roppe J., King C., Cosford N.D.P., Varney M.A. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [H-3]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur. J. Pharmacol. 2003, 473:35-40.
-
(2003)
Eur. J. Pharmacol.
, vol.473
, pp. 35-40
-
-
Anderson, J.J.1
Bradbury, M.J.2
Giracello, D.R.3
Chapman, D.F.4
Holtz, G.5
Roppe, J.6
King, C.7
Cosford, N.D.P.8
Varney, M.A.9
-
3
-
-
17744373871
-
The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison
-
Ballard T.M., Woolley M.L., Prinssen E., Huwyler J., Porter R., Spooren W. The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison. Psychopharmacology (Berlin) 2005, 1791:218-229.
-
(2005)
Psychopharmacology (Berlin)
, vol.1791
, pp. 218-229
-
-
Ballard, T.M.1
Woolley, M.L.2
Prinssen, E.3
Huwyler, J.4
Porter, R.5
Spooren, W.6
-
4
-
-
0035996371
-
Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats
-
Balschun D., Wetzel W. Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol. Biochem. Behav. 2002, 73:375-380.
-
(2002)
Pharmacol. Biochem. Behav.
, vol.73
, pp. 375-380
-
-
Balschun, D.1
Wetzel, W.2
-
5
-
-
33749245129
-
Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory
-
Balschun D., Zuschratter W., Wetzel W. Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory. Neurosci 2006, 142:691-702.
-
(2006)
Neurosci
, vol.142
, pp. 691-702
-
-
Balschun, D.1
Zuschratter, W.2
Wetzel, W.3
-
6
-
-
33645508765
-
A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory
-
Barker G.R., Bashir Z.I., Brown M.W., Warburton E.C. A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory. Learn. Mem. 2006, 13:178-186.
-
(2006)
Learn. Mem.
, vol.13
, pp. 178-186
-
-
Barker, G.R.1
Bashir, Z.I.2
Brown, M.W.3
Warburton, E.C.4
-
7
-
-
33751190762
-
Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and mouse tail suspension tests
-
Belozertseva I.V., Kos T., Popik P., Danysz W., Bespalov A.Y. Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and mouse tail suspension tests. Eur. Neuropsychopharmacol. 2007, 17:172-179.
-
(2007)
Eur. Neuropsychopharmacol.
, vol.17
, pp. 172-179
-
-
Belozertseva, I.V.1
Kos, T.2
Popik, P.3
Danysz, W.4
Bespalov, A.Y.5
-
8
-
-
0032993405
-
Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia
-
Biber K., Laurie D.J., Berthele A., Sommer B., Tolle T.R., Gebicke-Harter P.J., van Calker D., Boddeke H.W. Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. J. Neurochem 1999, 72:1671-1680.
-
(1999)
J. Neurochem
, vol.72
, pp. 1671-1680
-
-
Biber, K.1
Laurie, D.J.2
Berthele, A.3
Sommer, B.4
Tolle, T.R.5
Gebicke-Harter, P.J.6
van Calker, D.7
Boddeke, H.W.8
-
9
-
-
11144308408
-
Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversion
-
Bills C., Schachtman T.R., Serfozo P., Spooren W.P.J.M., Gasparini F., Simonyi A. Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversion. Behav. Brain Res. 2005, 157:71-78.
-
(2005)
Behav. Brain Res.
, vol.157
, pp. 71-78
-
-
Bills, C.1
Schachtman, T.R.2
Serfozo, P.3
Spooren, W.P.J.M.4
Gasparini, F.5
Simonyi, A.6
-
10
-
-
20144364615
-
Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice
-
Bradbury M.J., Campbell U., Giracello D., Chapman D., King C., Tehrani L., Cosford N.D., Anderson J., Varney M.A., Strack A.M. Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J. Pharmacol. Exp. Ther 2005, 313:395-402.
-
(2005)
J. Pharmacol. Exp. Ther
, vol.313
, pp. 395-402
-
-
Bradbury, M.J.1
Campbell, U.2
Giracello, D.3
Chapman, D.4
King, C.5
Tehrani, L.6
Cosford, N.D.7
Anderson, J.8
Varney, M.A.9
Strack, A.M.10
-
11
-
-
0035996363
-
Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone
-
Brodkin J., Busse C., Sukoff S.J., Varney M.A. Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone. Pharmacol. Biochem. Behav. 2002, 73:359-366.
-
(2002)
Pharmacol. Biochem. Behav.
, vol.73
, pp. 359-366
-
-
Brodkin, J.1
Busse, C.2
Sukoff, S.J.3
Varney, M.A.4
-
13
-
-
3042685523
-
The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[2-methyl-1, 3-thiazol-4yl)ethynyl]pyridine, (MTEP) in rodent models of anxiety
-
Busse C.S., Brodkin J., Tattersall D., Anderson J.J., Warren N., Tehrani L., Bristow L.J., Varney M.A., Cosford N.D. The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[2-methyl-1, 3-thiazol-4yl)ethynyl]pyridine, (MTEP) in rodent models of anxiety. Neuropsychopharmacology 2004, 29:1971-1979.
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 1971-1979
-
-
Busse, C.S.1
Brodkin, J.2
Tattersall, D.3
Anderson, J.J.4
Warren, N.5
Tehrani, L.6
Bristow, L.J.7
Varney, M.A.8
Cosford, N.D.9
-
14
-
-
5544228283
-
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats
-
Campbell U.C., Lalwani K., Hernandez L., Kinney G.G., Conn P.J., Bristow L.J. The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology 2004, 175:310-318.
-
(2004)
Psychopharmacology
, vol.175
, pp. 310-318
-
-
Campbell, U.C.1
Lalwani, K.2
Hernandez, L.3
Kinney, G.G.4
Conn, P.J.5
Bristow, L.J.6
-
15
-
-
43849090366
-
MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats
-
Christoffersen G.R.J., Simonyi A., Schachtman T.R., Clausen B., Clement D., Bjerre V.K., Mark L.T., Reinholdt M., Schmith-Rasmussen K., Zink L.V.B. MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats. Behav. Brain Res. 2008, 191:235-245.
-
(2008)
Behav. Brain Res.
, vol.191
, pp. 235-245
-
-
Christoffersen, G.R.J.1
Simonyi, A.2
Schachtman, T.R.3
Clausen, B.4
Clement, D.5
Bjerre, V.K.6
Mark, L.T.7
Reinholdt, M.8
Schmith-Rasmussen, K.9
Zink, L.V.B.10
-
16
-
-
0031539216
-
Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture
-
Ciccarelli R., Sureda F.X., Casabona G., Di Iorio P., Caruso A., Spinella F., Condorelli D.F., Nicoletti F., Caciagli F. Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture. Glia 1997, 21:390-398.
-
(1997)
Glia
, vol.21
, pp. 390-398
-
-
Ciccarelli, R.1
Sureda, F.X.2
Casabona, G.3
Di Iorio, P.4
Caruso, A.5
Spinella, F.6
Condorelli, D.F.7
Nicoletti, F.8
Caciagli, F.9
-
17
-
-
27944470972
-
Metabotropic glutamate receptors in the basal ganglia motor circuit
-
Conn P.J., Battaglia G., Marino M.J., Nicoletti F. Metabotropic glutamate receptors in the basal ganglia motor circuit. Nat. Rev. Neurosci 2005, 6:787-798.
-
(2005)
Nat. Rev. Neurosci
, vol.6
, pp. 787-798
-
-
Conn, P.J.1
Battaglia, G.2
Marino, M.J.3
Nicoletti, F.4
-
18
-
-
0037448394
-
3-[2-Methyl-1, 3-thiazol-4yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity
-
Cosford N.D.P., Tehrani L., Roppe J., Schweiger E., Smith N.D., Anderson J., Bristow L., Brodkin J., Jiang X.H., McDonald I., Rao S., Washburn M., Varney M.A. 3-[2-Methyl-1, 3-thiazol-4yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J. Med. Chem 2003, 46:204-206.
-
(2003)
J. Med. Chem
, vol.46
, pp. 204-206
-
-
Cosford, N.D.P.1
Tehrani, L.2
Roppe, J.3
Schweiger, E.4
Smith, N.D.5
Anderson, J.6
Bristow, L.7
Brodkin, J.8
Jiang, X.H.9
McDonald, I.10
Rao, S.11
Washburn, M.12
Varney, M.A.13
-
19
-
-
58149462237
-
Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease
-
De Leonibus E., Managò F., Giordani F., Petrosino F., Lopez S., Oliverio A., Amalric M., Mele A. Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease. Neuropsychopharmacology 2009, 34:729-738.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 729-738
-
-
De Leonibus, E.1
Managò, F.2
Giordani, F.3
Petrosino, F.4
Lopez, S.5
Oliverio, A.6
Amalric, M.7
Mele, A.8
-
20
-
-
49949085152
-
Role of metabotropic glutamate receptors in the control of neuroendocrine function
-
Durand D., Pampillo M., Caruso C., Lasaga M. Role of metabotropic glutamate receptors in the control of neuroendocrine function. Neuropharmacology 2008, 55:577-583.
-
(2008)
Neuropharmacology
, vol.55
, pp. 577-583
-
-
Durand, D.1
Pampillo, M.2
Caruso, C.3
Lasaga, M.4
-
21
-
-
2342470026
-
Identification and functional roles of metabotropic glutamate receptor-interacting proteins
-
Fagni L., Ango F., Perroy J., Bockaert J. Identification and functional roles of metabotropic glutamate receptor-interacting proteins. Semin. Cell Dev. Biol. 2004, 15:289-298.
-
(2004)
Semin. Cell Dev. Biol.
, vol.15
, pp. 289-298
-
-
Fagni, L.1
Ango, F.2
Perroy, J.3
Bockaert, J.4
-
22
-
-
0036460427
-
Metabotropic glutamate receptors are involved in amygdaloid plasticity
-
Fendt M., Schmid S. Metabotropic glutamate receptors are involved in amygdaloid plasticity. Eur. J. NeuroSci. 2002, 15:1535-1541.
-
(2002)
Eur. J. NeuroSci.
, vol.15
, pp. 1535-1541
-
-
Fendt, M.1
Schmid, S.2
-
24
-
-
0032853255
-
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
-
Gasparini F., Lingenhöhl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., Biollaz M., Allgeier H., Heckendorn R., Urwyler S., Varney M.A., Johnson E.C., Hess S.D., Rao S.P., Sacaan A.I., Santori E.M., Veliçelebi G., Kuhn R. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 1999, 38:1493-1503.
-
(1999)
Neuropharmacology
, vol.38
, pp. 1493-1503
-
-
Gasparini, F.1
Lingenhöhl, K.2
Stoehr, N.3
Flor, P.J.4
Heinrich, M.5
Vranesic, I.6
Biollaz, M.7
Allgeier, H.8
Heckendorn, R.9
Urwyler, S.10
Varney, M.A.11
Johnson, E.C.12
Hess, S.D.13
Rao, S.P.14
Sacaan, A.I.15
Santori, E.M.16
Veliçelebi, G.17
Kuhn, R.18
-
25
-
-
50249155962
-
MGluR5 antagonists: discovery, characterization and drug development
-
Gasparini F., Bilbe G., Gomez-Mancilla B., Spooren W. mGluR5 antagonists: discovery, characterization and drug development. Curr. Opin. Drug Discov. Dev. 2008, 11:655-665.
-
(2008)
Curr. Opin. Drug Discov. Dev.
, vol.11
, pp. 655-665
-
-
Gasparini, F.1
Bilbe, G.2
Gomez-Mancilla, B.3
Spooren, W.4
-
26
-
-
34250331599
-
Effects of MPEP on avoidance learning in rats
-
Genkova-Papazova M., Petkova B., Stankova I., Ossowska K., Lazarova-Bakarova M. Effects of MPEP on avoidance learning in rats. Methods Find. Exp. Clin. Pharmacol. 2007, 29:205-209.
-
(2007)
Methods Find. Exp. Clin. Pharmacol.
, vol.29
, pp. 205-209
-
-
Genkova-Papazova, M.1
Petkova, B.2
Stankova, I.3
Ossowska, K.4
Lazarova-Bakarova, M.5
-
27
-
-
37549047960
-
Metabotropic glutamate receptor: intracellular signaling pathways
-
Gerber U., Gee C.E., Benquet P. Metabotropic glutamate receptor: intracellular signaling pathways. Curr. Opin. Pharmacol. 2006, 6:1-6.
-
(2006)
Curr. Opin. Pharmacol.
, vol.6
, pp. 1-6
-
-
Gerber, U.1
Gee, C.E.2
Benquet, P.3
-
28
-
-
0002167507
-
Psychobiology of memory: towards a model of memory formation
-
Gibbs M.E., Ng K.T. Psychobiology of memory: towards a model of memory formation. Biobehav. Rev. 1977, 1:113-136.
-
(1977)
Biobehav. Rev.
, vol.1
, pp. 113-136
-
-
Gibbs, M.E.1
Ng, K.T.2
-
29
-
-
0022743596
-
The use of avoidance training in studies of modulation of memory storage
-
Gold P.E. The use of avoidance training in studies of modulation of memory storage. Behav. Neural. Biol. 1986, 46:87-98.
-
(1986)
Behav. Neural. Biol.
, vol.46
, pp. 87-98
-
-
Gold, P.E.1
-
30
-
-
16444361969
-
Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning
-
Gravius A., Pietraszek M., Schäfer D., Schmidt W.J., Danysz W. Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning. Behav. Pharmacol. 2005, 16:113-121.
-
(2005)
Behav. Pharmacol.
, vol.16
, pp. 113-121
-
-
Gravius, A.1
Pietraszek, M.2
Schäfer, D.3
Schmidt, W.J.4
Danysz, W.5
-
31
-
-
33344467243
-
Functional interaction of NMDA and group I metabotropic glutamate receptors in negatively reinforced learning in rats
-
Gravius A., Pietraszek M., Schmidt W.J., Danysz W. Functional interaction of NMDA and group I metabotropic glutamate receptors in negatively reinforced learning in rats. Psychopharmacology 2006, 185:58-65.
-
(2006)
Psychopharmacology
, vol.185
, pp. 58-65
-
-
Gravius, A.1
Pietraszek, M.2
Schmidt, W.J.3
Danysz, W.4
-
32
-
-
33750802463
-
The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats-a comparison
-
Gravius A., Barberi C., Schäfer D., Schmidt W.J., Danysz W. The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats-a comparison. Neuropharmacology 2006, 51:1146-1155.
-
(2006)
Neuropharmacology
, vol.51
, pp. 1146-1155
-
-
Gravius, A.1
Barberi, C.2
Schäfer, D.3
Schmidt, W.J.4
Danysz, W.5
-
33
-
-
57049084065
-
Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats
-
Gravius A., Dekundy A., Nagel J., Morè L., Pietraszek M., Danysz W. Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. J. Neural Transm. 2008, 115:1609-1619.
-
(2008)
J. Neural Transm.
, vol.115
, pp. 1609-1619
-
-
Gravius, A.1
Dekundy, A.2
Nagel, J.3
Morè, L.4
Pietraszek, M.5
Danysz, W.6
-
34
-
-
0242653836
-
In vivo evidence that the metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) acts as an inhibitor of the norepinephrine transporter in vitro and in vivo
-
Heidbreder C.A., Bianchi M., Lacroix L.P., Faedo S., Perdona E., Remelli R. In vivo evidence that the metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) acts as an inhibitor of the norepinephrine transporter in vitro and in vivo. Synapse 2003, 50:269-276.
-
(2003)
Synapse
, vol.50
, pp. 269-276
-
-
Heidbreder, C.A.1
Bianchi, M.2
Lacroix, L.P.3
Faedo, S.4
Perdona, E.5
Remelli, R.6
-
35
-
-
0036945935
-
The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
-
Henry S.A., Lehmann-Masten V., Gasparini F., Geyer M.A., Markou A. The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology 2002, 43:1199-1209.
-
(2002)
Neuropharmacology
, vol.43
, pp. 1199-1209
-
-
Henry, S.A.1
Lehmann-Masten, V.2
Gasparini, F.3
Geyer, M.A.4
Markou, A.5
-
36
-
-
0035504328
-
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein coupled receptors
-
Hermans E., Challis R.A.J. Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein coupled receptors. Biochem. J. 2001, 359:465-484.
-
(2001)
Biochem. J.
, vol.359
, pp. 465-484
-
-
Hermans, E.1
Challis, R.A.J.2
-
37
-
-
2942650911
-
Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release
-
Homayoun H., Stefani M.R., Adams B.W., Tamagan G.D., Moghaddam B. Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology 2004, 29:1259-1269.
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 1259-1269
-
-
Homayoun, H.1
Stefani, M.R.2
Adams, B.W.3
Tamagan, G.D.4
Moghaddam, B.5
-
38
-
-
0033638624
-
Behavioural pharmacology and its contribution to the molecular basis of memory consolidation
-
Izquierdo I., McGaugh J.L. Behavioural pharmacology and its contribution to the molecular basis of memory consolidation. Behav. Pharmacol. 2000, 11:517-534.
-
(2000)
Behav. Pharmacol.
, vol.11
, pp. 517-534
-
-
Izquierdo, I.1
McGaugh, J.L.2
-
39
-
-
67650455900
-
The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning
-
Jacob W., Gravius A., Pietraszek M., Nagel J., Belozertseva I., Shekunova E., Malyshkin A., Greco S., Barberi C., Danysz W. The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning. Neuropharmacology 2009, 57:97-108.
-
(2009)
Neuropharmacology
, vol.57
, pp. 97-108
-
-
Jacob, W.1
Gravius, A.2
Pietraszek, M.3
Nagel, J.4
Belozertseva, I.5
Shekunova, E.6
Malyshkin, A.7
Greco, S.8
Barberi, C.9
Danysz, W.10
-
40
-
-
40749139454
-
MGlu5 receptor antagonists and their therapeutic potential
-
Jaeshke G., Wettstein J.G., Nordquist R.E., Spooren W. mGlu5 receptor antagonists and their therapeutic potential. Expert Opin. Ther. Pat. 2008, 18:123-142.
-
(2008)
Expert Opin. Ther. Pat.
, vol.18
, pp. 123-142
-
-
Jaeshke, G.1
Wettstein, J.G.2
Nordquist, R.E.3
Spooren, W.4
-
41
-
-
0029043591
-
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1
-
Joly C., Gomeza J., Brabet I., Curry K., Bockaert J., Pin J.-P. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. J. Neurosci 1995, 15:3970-3981.
-
(1995)
J. Neurosci
, vol.15
, pp. 3970-3981
-
-
Joly, C.1
Gomeza, J.2
Brabet, I.3
Curry, K.4
Bockaert, J.5
Pin, J.-P.6
-
42
-
-
0026514823
-
Modality-specific retrograde amnesia of fear
-
Kim J.J., Fanselow M.S. Modality-specific retrograde amnesia of fear. Science 1992, 256:675-677.
-
(1992)
Science
, vol.256
, pp. 675-677
-
-
Kim, J.J.1
Fanselow, M.S.2
-
43
-
-
0037665283
-
Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents
-
Kinney G.G., Burno M., Campbell U.C., Hernandez L.M., Rodriguez D., Bristow L.J., Conn P.J. Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J. Pharmacol. Exp. Ther 2003, 306:116-123.
-
(2003)
J. Pharmacol. Exp. Ther
, vol.306
, pp. 116-123
-
-
Kinney, G.G.1
Burno, M.2
Campbell, U.C.3
Hernandez, L.M.4
Rodriguez, D.5
Bristow, L.J.6
Conn, P.J.7
-
44
-
-
33847026476
-
The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats
-
Koros E., Rosenbrock H., Birk G., Weiss C., Sams-Dodd F. The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats. Neuropsychopharmacology 2007, 32:62-76.
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 62-76
-
-
Koros, E.1
Rosenbrock, H.2
Birk, G.3
Weiss, C.4
Sams-Dodd, F.5
-
45
-
-
0001792065
-
The amygdala in conditioned taste aversion: it's there but where?
-
Oxford University Press, New York, NY, J. Aggleton (Ed.)
-
Lamprecht R., Dudai Y. The amygdala in conditioned taste aversion: it's there but where?. The amygdala 2000, 310-331. Oxford University Press, New York, NY. J. Aggleton (Ed.).
-
(2000)
The amygdala
, pp. 310-331
-
-
Lamprecht, R.1
Dudai, Y.2
-
46
-
-
33748999574
-
Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice
-
Li X., Need A.B., Baez M., Witkin J.M. Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice. J. Pharmacol. Exp. Ther 2006, 319:254-259.
-
(2006)
J. Pharmacol. Exp. Ther
, vol.319
, pp. 254-259
-
-
Li, X.1
Need, A.B.2
Baez, M.3
Witkin, J.M.4
-
47
-
-
33646937725
-
MGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy
-
Loscher W., Dekundy A., Nagel J., Danysz W., Parsons C.G., Potschka H. mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy. Neuropharmacology 2006, 50:1006-1015.
-
(2006)
Neuropharmacology
, vol.50
, pp. 1006-1015
-
-
Loscher, W.1
Dekundy, A.2
Nagel, J.3
Danysz, W.4
Parsons, C.G.5
Potschka, H.6
-
48
-
-
0030954048
-
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
-
Lu Y.-M., Jia Z., Janus C., Henderson J.T., Gerlai R., Wojtowicz J.M., Roder J.C. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 1997, 17:5196-5205.
-
(1997)
J. Neurosci.
, vol.17
, pp. 5196-5205
-
-
Lu, Y.-M.1
Jia, Z.2
Janus, C.3
Henderson, J.T.4
Gerlai, R.5
Wojtowicz, J.M.6
Roder, J.C.7
-
49
-
-
0030704241
-
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites
-
Lujan R., Roberts J.D., Shigemoto R., Ohishi H., Somogyi P. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J. Chem. Neuroanat. 1997, 13:219-241.
-
(1997)
J. Chem. Neuroanat.
, vol.13
, pp. 219-241
-
-
Lujan, R.1
Roberts, J.D.2
Shigemoto, R.3
Ohishi, H.4
Somogyi, P.5
-
50
-
-
0142164892
-
Hippocampal mGluR1 and consolidation of contextual fear conditioning
-
Maciejak P., Taracha E., Lehner M., Szyndler J., Bidzióski A., Skórzewska A., Wislowska A., Zienowicz M., Plaźnik A. Hippocampal mGluR1 and consolidation of contextual fear conditioning. Brain Res. Bull. 2003, 62:39-45.
-
(2003)
Brain Res. Bull.
, vol.62
, pp. 39-45
-
-
Maciejak, P.1
Taracha, E.2
Lehner, M.3
Szyndler, J.4
Bidzióski, A.5
Skórzewska, A.6
Wislowska, A.7
Zienowicz, M.8
Plaźnik, A.9
-
51
-
-
33746484507
-
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP
-
Malherbe P., Kratochwil N., Mühlemann A., Zenner M.T., Fischer C., Stahl M., Gerber P.R., Jaeschke G., Porter R.H. Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP. J. Neurochem. 2006, 98:601-615.
-
(2006)
J. Neurochem.
, vol.98
, pp. 601-615
-
-
Malherbe, P.1
Kratochwil, N.2
Mühlemann, A.3
Zenner, M.T.4
Fischer, C.5
Stahl, M.6
Gerber, P.R.7
Jaeschke, G.8
Porter, R.H.9
-
52
-
-
26844466906
-
The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal plasticity
-
Manahan-Vaughan D., Braunewell K.-H. The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal plasticity. Cereb. Cortex 2005, 15:1703-1713.
-
(2005)
Cereb. Cortex
, vol.15
, pp. 1703-1713
-
-
Manahan-Vaughan, D.1
Braunewell, K.-H.2
-
53
-
-
0037363728
-
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (HmGluR4) by SIB-1893 and MPEP
-
Mathiesen J.M., Svendsen N., Brauner-Osborne H., Thomsen C., Ramirez M.T. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (HmGluR4) by SIB-1893 and MPEP. British J. Pharmacol 2003, 138:1026-1030.
-
(2003)
British J. Pharmacol
, vol.138
, pp. 1026-1030
-
-
Mathiesen, J.M.1
Svendsen, N.2
Brauner-Osborne, H.3
Thomsen, C.4
Ramirez, M.T.5
-
54
-
-
0038613122
-
The mind through chick eyes: memory, cognition and anticipation
-
Matsushima T., Izawa E.-I., Aoki N., Yanagihara S. The mind through chick eyes: memory, cognition and anticipation. Zool. Sci. 2003, 20:395-408.
-
(2003)
Zool. Sci.
, vol.20
, pp. 395-408
-
-
Matsushima, T.1
Izawa, E.-I.2
Aoki, N.3
Yanagihara, S.4
-
55
-
-
3142737454
-
Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice
-
McGeehan A.J., Janak P.H., Olive M.F. Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. Psychopharmacology (Berlin) 2004, 174:266-273.
-
(2004)
Psychopharmacology (Berlin)
, vol.174
, pp. 266-273
-
-
McGeehan, A.J.1
Janak, P.H.2
Olive, M.F.3
-
56
-
-
0029133369
-
The expression of two splice variants of metabotropic glutamate receptor subtype 5 in the rat brain and neuronal cells during development
-
Minakami R., Iida K., Hirakawa N., Sugiyama H. The expression of two splice variants of metabotropic glutamate receptor subtype 5 in the rat brain and neuronal cells during development. J. Neurochem. 1995, 65:1536-1542.
-
(1995)
J. Neurochem.
, vol.65
, pp. 1536-1542
-
-
Minakami, R.1
Iida, K.2
Hirakawa, N.3
Sugiyama, H.4
-
57
-
-
70349260680
-
The mGlu5 antagonist fenobam is analgesic and has improved in vivo selectivity as compared to the prototypical antagonist MPEP
-
Montana M.C., Cavallone L.F., Stubbert K.K., Stefanescu A.D., Kharasch E.D., Gereau R.W. The mGlu5 antagonist fenobam is analgesic and has improved in vivo selectivity as compared to the prototypical antagonist MPEP. J. Pharmacol. Exp. Ther. 2009, 330:834-843.
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.330
, pp. 834-843
-
-
Montana, M.C.1
Cavallone, L.F.2
Stubbert, K.K.3
Stefanescu, A.D.4
Kharasch, E.D.5
Gereau, R.W.6
-
58
-
-
0942290621
-
Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation
-
Naie K., Manahan-Vaughan D. Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. Cereb. Cortex 2004, 14:189-198.
-
(2004)
Cereb. Cortex
, vol.14
, pp. 189-198
-
-
Naie, K.1
Manahan-Vaughan, D.2
-
59
-
-
33750432533
-
Antiaggressive effects of MPEP, a selective antagonist of mGlu5 receptors, in agonistic interactions between male mice
-
Navarro J.F., Postigo D., Martín M., Burón E. Antiaggressive effects of MPEP, a selective antagonist of mGlu5 receptors, in agonistic interactions between male mice. Eur. J. Pharmacol. 2006, 551:67-70.
-
(2006)
Eur. J. Pharmacol.
, vol.551
, pp. 67-70
-
-
Navarro, J.F.1
Postigo, D.2
Martín, M.3
Burón, E.4
-
60
-
-
34648831985
-
Defensive-like behaviors induced by ultrasound: further pharmacological characterization in Lister-hooded rats
-
Nicolas L.B., Klein S., Prinssen E.P. Defensive-like behaviors induced by ultrasound: further pharmacological characterization in Lister-hooded rats. Psychopharmacology 2007, 194:243-252.
-
(2007)
Psychopharmacology
, vol.194
, pp. 243-252
-
-
Nicolas, L.B.1
Klein, S.2
Prinssen, E.P.3
-
61
-
-
0033638723
-
Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
-
O'Leary D.M., Movsesyan V., Vicini S., Faden A.I. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br. J. Pharmacol. 2000, 131:1429-1437.
-
(2000)
Br. J. Pharmacol.
, vol.131
, pp. 1429-1437
-
-
O'Leary, D.M.1
Movsesyan, V.2
Vicini, S.3
Faden, A.I.4
-
62
-
-
34347241277
-
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
-
Palucha A., Pilc A. Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs. Pharmacol. Ther. 2007, 115:116-147.
-
(2007)
Pharmacol. Ther.
, vol.115
, pp. 116-147
-
-
Palucha, A.1
Pilc, A.2
-
63
-
-
0035996499
-
Differential effects of mGluR1 and mGluR5 antagonism on spatial learning in rats
-
Petersen S., Bomme C., Baastrup C., Kemp A., Christoffersen G.R.J. Differential effects of mGluR1 and mGluR5 antagonism on spatial learning in rats. Pharmacol. Biochem. Behav. 2002, 73:381-389.
-
(2002)
Pharmacol. Biochem. Behav.
, vol.73
, pp. 381-389
-
-
Petersen, S.1
Bomme, C.2
Baastrup, C.3
Kemp, A.4
Christoffersen, G.R.J.5
-
64
-
-
0026635574
-
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning
-
Philips A.G., LeDoux J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 1992, 106:274-285.
-
(1992)
Behav. Neurosci.
, vol.106
, pp. 274-285
-
-
Philips, A.G.1
LeDoux, J.E.2
-
65
-
-
21344470129
-
MGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition
-
Pietraszek M., Gravius A., Schäfer D., Weil T., Trifanova D., Danysz W. mGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition. Neuropharmacol 2005, 49:73-85.
-
(2005)
Neuropharmacol
, vol.49
, pp. 73-85
-
-
Pietraszek, M.1
Gravius, A.2
Schäfer, D.3
Weil, T.4
Trifanova, D.5
Danysz, W.6
-
66
-
-
18844364756
-
Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats
-
Pietraszek M., Sukhanov I., Maciejak P., Szyndler J., Gravius A., Wisłowska A., Płaźnik A., Bespalov A.Y., Danysz W. Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats. Eur. J. Pharmacol. 2005, 514:25-34.
-
(2005)
Eur. J. Pharmacol.
, vol.514
, pp. 25-34
-
-
Pietraszek, M.1
Sukhanov, I.2
Maciejak, P.3
Szyndler, J.4
Gravius, A.5
Wisłowska, A.6
Płaźnik, A.7
Bespalov, A.Y.8
Danysz, W.9
-
67
-
-
0036669731
-
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats
-
Pilc A., Klodzińska A., Brański P., Nowak G., Palucha A., Szewczyk B., Tatarczyńska E., Chojnacka-Wójcik E., Wierońska J.M. Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats. Neuropharmacol 2002, 43:181-187.
-
(2002)
Neuropharmacol
, vol.43
, pp. 181-187
-
-
Pilc, A.1
Klodzińska, A.2
Brański, P.3
Nowak, G.4
Palucha, A.5
Szewczyk, B.6
Tatarczyńska, E.7
Chojnacka-Wójcik, E.8
Wierońska, J.M.9
-
68
-
-
0001050066
-
The metabotropic glutamate receptors: structure, activation mechanism and pharmacology
-
Pin J.P., Acher F. The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr. Drug Targets CNS Neurol. Disord 2002, 1:297-317.
-
(2002)
Curr. Drug Targets CNS Neurol. Disord
, vol.1
, pp. 297-317
-
-
Pin, J.P.1
Acher, F.2
-
69
-
-
27144537834
-
Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity
-
Porter R.H., Jaeschke G., Spooren W., Ballard T.M., Büttelmann B., Kolczewski S., Peters J.U., Prinssen E., Wichmann J., Vieira E., Mühlemann A., Gatti S., Mutel V., Malherbe P. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J. Pharmacol. Exp. Ther 2005, 315:711-721.
-
(2005)
J. Pharmacol. Exp. Ther
, vol.315
, pp. 711-721
-
-
Porter, R.H.1
Jaeschke, G.2
Spooren, W.3
Ballard, T.M.4
Büttelmann, B.5
Kolczewski, S.6
Peters, J.U.7
Prinssen, E.8
Wichmann, J.9
Vieira, E.10
Mühlemann, A.11
Gatti, S.12
Mutel, V.13
Malherbe, P.14
-
71
-
-
0033846281
-
Fear conditioning-induced time- and subregion-specific increase in expression of mGlu5 receptor protein in rat hippocampus
-
Riedel G., Casabona G., Platt B., Macphail E.M., Nicoletti F. Fear conditioning-induced time- and subregion-specific increase in expression of mGlu5 receptor protein in rat hippocampus. Neuropharmacol 2000, 39:1943-1951.
-
(2000)
Neuropharmacol
, vol.39
, pp. 1943-1951
-
-
Riedel, G.1
Casabona, G.2
Platt, B.3
Macphail, E.M.4
Nicoletti, F.5
-
72
-
-
0037096244
-
The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala
-
Rodrigues S.M., Bauer E.P., Farb C.R., Schafe G.E., LeDoux J.E. The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala. J. Neurosci 2002, 22:5219-5229.
-
(2002)
J. Neurosci
, vol.22
, pp. 5219-5229
-
-
Rodrigues, S.M.1
Bauer, E.P.2
Farb, C.R.3
Schafe, G.E.4
LeDoux, J.E.5
-
73
-
-
5344245987
-
Molecular mechanisms underlying emotional learning and memory in the lateral amygdala
-
Rodrigues S.M., Schafe G.E., LeDoux J.E. Molecular mechanisms underlying emotional learning and memory in the lateral amygdala. Neuron 2004, 44:75-91.
-
(2004)
Neuron
, vol.44
, pp. 75-91
-
-
Rodrigues, S.M.1
Schafe, G.E.2
LeDoux, J.E.3
-
74
-
-
0029872230
-
Enhanced early development expression of the metabotropic glutamate receptor mGluR5 in rat: protein, mRNA splice variants, and regional distribution
-
Romano C., Van Den Pol A.N., O'Malley K.L. Enhanced early development expression of the metabotropic glutamate receptor mGluR5 in rat: protein, mRNA splice variants, and regional distribution. J. Comp. Neurol 1996, 367:403-412.
-
(1996)
J. Comp. Neurol
, vol.367
, pp. 403-412
-
-
Romano, C.1
Van Den Pol, A.N.2
O'Malley, K.L.3
-
75
-
-
0029903640
-
Metabotropic glutamate receptor 5 is a disulfide-linked dimer
-
Romano C., Yang W.L., O'Malley K.L. Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J. Biol. Chem 1996, 271:28612-28616.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 28612-28616
-
-
Romano, C.1
Yang, W.L.2
O'Malley, K.L.3
-
76
-
-
33645850140
-
The role of group I metabotropic glutamate receptors in memory consolidation and reconsolidation in the passive avoidance task in 1-day-old chicks
-
Salinska E. The role of group I metabotropic glutamate receptors in memory consolidation and reconsolidation in the passive avoidance task in 1-day-old chicks. Neurochem. Int. 2006, 48:447-452.
-
(2006)
Neurochem. Int.
, vol.48
, pp. 447-452
-
-
Salinska, E.1
-
77
-
-
0038418020
-
MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats
-
Schachtman T.R., Bills C., Ghinescu R., Murch K., Serfozo P., Simonyi A. MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. Behav. Brain Res. 2003, 141:177-182.
-
(2003)
Behav. Brain Res.
, vol.141
, pp. 177-182
-
-
Schachtman, T.R.1
Bills, C.2
Ghinescu, R.3
Murch, K.4
Serfozo, P.5
Simonyi, A.6
-
78
-
-
0034968969
-
The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats
-
Schulz B., Fendt M., Gasparini F., Lingenhöhl K., Kuhn R., Koch M. The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats. Neuropharmacol 2001, 41:1-7.
-
(2001)
Neuropharmacol
, vol.41
, pp. 1-7
-
-
Schulz, B.1
Fendt, M.2
Gasparini, F.3
Lingenhöhl, K.4
Kuhn, R.5
Koch, M.6
-
79
-
-
33846862930
-
The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task
-
Semenova S., Markou A. The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task. Neuropharmacol 2007, 52:863-872.
-
(2007)
Neuropharmacol
, vol.52
, pp. 863-872
-
-
Semenova, S.1
Markou, A.2
-
80
-
-
0002897958
-
Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses
-
Elsevier Science, Amsterdam, O.P. Ottersen, J. Storm-Mathisen (Eds.) Handbook of Chemical Neuroanatomy
-
Shigemoto R., Mizuno N. Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses. Glutamate, chapter III 2000, vol. 18:63-98. Elsevier Science, Amsterdam. O.P. Ottersen, J. Storm-Mathisen (Eds.).
-
(2000)
Glutamate, chapter III
, vol.18
, pp. 63-98
-
-
Shigemoto, R.1
Mizuno, N.2
-
81
-
-
0030821474
-
Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus
-
Shigemoto R., Kinoshita A., Wada E., Nomura S., Ohishi H., Takada M., Flor P.J., Neki A., Abe T., Nakanishi S., Mizuno N. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci 1997, 17:7503-7522.
-
(1997)
J. Neurosci
, vol.17
, pp. 7503-7522
-
-
Shigemoto, R.1
Kinoshita, A.2
Wada, E.3
Nomura, S.4
Ohishi, H.5
Takada, M.6
Flor, P.J.7
Neki, A.8
Abe, T.9
Nakanishi, S.10
Mizuno, N.11
-
83
-
-
34548226500
-
Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning
-
Simonyi A., Serfozo P., Shelat P.B., Dopheide M.M., Coulibaly A.P., Schachtman T.R. Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning. Neurobiol. Learn. Mem. 2007, 88:305-311.
-
(2007)
Neurobiol. Learn. Mem.
, vol.88
, pp. 305-311
-
-
Simonyi, A.1
Serfozo, P.2
Shelat, P.B.3
Dopheide, M.M.4
Coulibaly, A.P.5
Schachtman, T.R.6
-
84
-
-
69249210980
-
Metabotropic glutamate receptor 5 in conditioned taste aversion learning
-
Simonyi A., Serfozo P., Parker K.E., Ramsey A.K., Schachtman T.R. Metabotropic glutamate receptor 5 in conditioned taste aversion learning. Neurobiol. Learn. Mem. 2009, 92:460-463.
-
(2009)
Neurobiol. Learn. Mem.
, vol.92
, pp. 460-463
-
-
Simonyi, A.1
Serfozo, P.2
Parker, K.E.3
Ramsey, A.K.4
Schachtman, T.R.5
-
85
-
-
0034693328
-
Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
-
Spooren W.P., Gasparini F., Bergmann R., Kuhn R. Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats. Eur. J. Pharmacol. 2000, 406:403-410.
-
(2000)
Eur. J. Pharmacol.
, vol.406
, pp. 403-410
-
-
Spooren, W.P.1
Gasparini, F.2
Bergmann, R.3
Kuhn, R.4
-
86
-
-
0033680311
-
Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents
-
Spooren W.P., Vassout A., Neijt H.C., Kuhn R., Gasparini F., Roux S., Porsolt R.D., Gentsch C. Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents. J. Pharmacol. Exp. Ther 2000, 295:1267-1275.
-
(2000)
J. Pharmacol. Exp. Ther
, vol.295
, pp. 1267-1275
-
-
Spooren, W.P.1
Vassout, A.2
Neijt, H.C.3
Kuhn, R.4
Gasparini, F.5
Roux, S.6
Porsolt, R.D.7
Gentsch, C.8
-
87
-
-
0042868860
-
Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders
-
Spooren W., Ballard T., Gasparini F., Amalric M., Mutel V., Schreiber R. Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders. Behav. Pharmacol. 2003, 14:257-277.
-
(2003)
Behav. Pharmacol.
, vol.14
, pp. 257-277
-
-
Spooren, W.1
Ballard, T.2
Gasparini, F.3
Amalric, M.4
Mutel, V.5
Schreiber, R.6
-
88
-
-
24344483151
-
Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task
-
Steckler T., Oliveira A.F.M., Van Dyck C., Van Craenendock H., Mateus A.M.A., Langlois X., Lesage A.S.J., Prickaerts J. Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task. Behav. Brain Res. 2006, 164:52-60.
-
(2006)
Behav. Brain Res.
, vol.164
, pp. 52-60
-
-
Steckler, T.1
Oliveira, A.F.M.2
Van Dyck, C.3
Van Craenendock, H.4
Mateus, A.M.A.5
Langlois, X.6
Lesage, A.S.J.7
Prickaerts, J.8
-
89
-
-
0035069188
-
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
-
Tatarczyńska E., Klodzińska A., Chojnacka-Wójcik E., Palucha A., Gasparini F., Kuhn R., Pilc A. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br. J. Pharmacol. 2001, 132:1423-1430.
-
(2001)
Br. J. Pharmacol.
, vol.132
, pp. 1423-1430
-
-
Tatarczyńska, E.1
Klodzińska, A.2
Chojnacka-Wójcik, E.3
Palucha, A.4
Gasparini, F.5
Kuhn, R.6
Pilc, A.7
-
90
-
-
0033004276
-
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
-
Varney M.A., Cosford N.D.P., Jachec C., Rao S.P., Sacaan A., Lin F.-F., Bleicher L., Santori E., Flor P.-J., Allgeier H., Gasparini F., Kuhn R., Hess S.D., Velicelebi G., Johnson E.C. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J. Pharm. Exp. Ther 1999, 290:170-181.
-
(1999)
J. Pharm. Exp. Ther
, vol.290
, pp. 170-181
-
-
Varney, M.A.1
Cosford, N.D.P.2
Jachec, C.3
Rao, S.P.4
Sacaan, A.5
Lin, F.-F.6
Bleicher, L.7
Santori, E.8
Flor, P.-J.9
Allgeier, H.10
Gasparini, F.11
Kuhn, R.12
Hess, S.D.13
Velicelebi, G.14
Johnson, E.C.15
-
91
-
-
20944438126
-
The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles
-
Varty G.B., Grilli M., Forlani A., Fredduzzi S., Grzelak M.E., Guthrie D.H., Hodgson R.A., Lu S.X., Nicolussi E., Pond A.J., Parker E.M., Hunter J.C., Higgins G.A., Reggiani A., Bertorelli R. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology (Berlin) 2005, 179:207-217.
-
(2005)
Psychopharmacology (Berlin)
, vol.179
, pp. 207-217
-
-
Varty, G.B.1
Grilli, M.2
Forlani, A.3
Fredduzzi, S.4
Grzelak, M.E.5
Guthrie, D.H.6
Hodgson, R.A.7
Lu, S.X.8
Nicolussi, E.9
Pond, A.J.10
Parker, E.M.11
Hunter, J.C.12
Higgins, G.A.13
Reggiani, A.14
Bertorelli, R.15
-
92
-
-
64849110971
-
MGluR5 has a critical role in inhibitory learning
-
Xu J., Zhu Y., Contractor A., Heinemann S.F. MGluR5 has a critical role in inhibitory learning. J. Neurosci. 2009, 29:3676-3684.
-
(2009)
J. Neurosci.
, vol.29
, pp. 3676-3684
-
-
Xu, J.1
Zhu, Y.2
Contractor, A.3
Heinemann, S.F.4
-
93
-
-
0028560338
-
Neural substrates for conditioned taste aversion in the rat
-
Yamamoto T., Shimura T., Sako N., Yasoshima Y., Sakai N. Neural substrates for conditioned taste aversion in the rat. Behav. Brain Res. 1994, 65:123-137.
-
(1994)
Behav. Brain Res.
, vol.65
, pp. 123-137
-
-
Yamamoto, T.1
Shimura, T.2
Sako, N.3
Yasoshima, Y.4
Sakai, N.5
-
94
-
-
9944223305
-
Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities
-
Zhu C.Z., Wilson S.G., Mikusa J.P., Wismer C.T., Gauvin D.M., Lynch J.J., Wade C.L., Decker M.W., Honore P. Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. Eur. J. Pharmacol. 2004, 506:107-118.
-
(2004)
Eur. J. Pharmacol.
, vol.506
, pp. 107-118
-
-
Zhu, C.Z.1
Wilson, S.G.2
Mikusa, J.P.3
Wismer, C.T.4
Gauvin, D.M.5
Lynch, J.J.6
Wade, C.L.7
Decker, M.W.8
Honore, P.9
|