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Volumn 191, Issue 2, 2008, Pages 235-245

MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats

Author keywords

Antagonist; Exploration; Maze learning; mGlu5 receptor; MPEP; Object recognition; Prelimbic cortex; Rat

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR 5;

EID: 43849090366     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.03.032     Document Type: Article
Times cited : (42)

References (49)
  • 1
    • 0036882079 scopus 로고    scopus 로고
    • [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo charaterization
    • Anderson J.J., Rao S.P., Rowe B., Giracello D.R., Holtz G., Chapman D.F., et al. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo charaterization. J Pharmacol Exp Therapeutics 303 (2002) 1044-1051
    • (2002) J Pharmacol Exp Therapeutics , vol.303 , pp. 1044-1051
    • Anderson, J.J.1    Rao, S.P.2    Rowe, B.3    Giracello, D.R.4    Holtz, G.5    Chapman, D.F.6
  • 2
    • 0032907608 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: electrophysiological properties and role in plasticity
    • Anwyl R. Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res Rev 29 (1999) 83-120
    • (1999) Brain Res Rev , vol.29 , pp. 83-120
    • Anwyl, R.1
  • 3
    • 17744373871 scopus 로고    scopus 로고
    • The effect of the mGluR5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison
    • Ballard T.M., Woolley M.L., Prinssen E., Huwyler J., Porter R., and Spooren W. The effect of the mGluR5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison. Psychopharmacology 179 (2005) 218-229
    • (2005) Psychopharmacology , vol.179 , pp. 218-229
    • Ballard, T.M.1    Woolley, M.L.2    Prinssen, E.3    Huwyler, J.4    Porter, R.5    Spooren, W.6
  • 4
    • 0032890608 scopus 로고    scopus 로고
    • A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning
    • Balschun D., Manahan-Vaughan D., Wagner T., Behnish T., Reymann K.G., and Wetzel W. A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning. Learn Mem 6 (1999) 138-152
    • (1999) Learn Mem , vol.6 , pp. 138-152
    • Balschun, D.1    Manahan-Vaughan, D.2    Wagner, T.3    Behnish, T.4    Reymann, K.G.5    Wetzel, W.6
  • 5
    • 0035996371 scopus 로고    scopus 로고
    • Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats
    • Balschun D., and Wetzel W. Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol Biochem Behav 73 (2002) 375-380
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 375-380
    • Balschun, D.1    Wetzel, W.2
  • 6
    • 33749245129 scopus 로고    scopus 로고
    • Allosteric enhacement of metabotropic glutamate receptor 5 function promotes spatial memory
    • Balschun D., Zuschratter W., and Wetzel W. Allosteric enhacement of metabotropic glutamate receptor 5 function promotes spatial memory. Neuroscience 142 (2006) 691-702
    • (2006) Neuroscience , vol.142 , pp. 691-702
    • Balschun, D.1    Zuschratter, W.2    Wetzel, W.3
  • 7
    • 11144308408 scopus 로고    scopus 로고
    • Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversion
    • Bills C., Schachtman T.R., Spooren W.P.J.M., Gasparini F., and Simonyi A. Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversion. Behav Brain Res 157 (2005) 71-78
    • (2005) Behav Brain Res , vol.157 , pp. 71-78
    • Bills, C.1    Schachtman, T.R.2    Spooren, W.P.J.M.3    Gasparini, F.4    Simonyi, A.5
  • 9
    • 0035996363 scopus 로고    scopus 로고
    • Anxiolytic-like activity of the mGluR5 antagonist MPEP. A comparison with diazepam and buspirone
    • Brodkin J., Busse C., Sukoff S.J., and Varney M.A. Anxiolytic-like activity of the mGluR5 antagonist MPEP. A comparison with diazepam and buspirone. Pharmacol Biochem Behav 73 (2002) 359-366
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 359-366
    • Brodkin, J.1    Busse, C.2    Sukoff, S.J.3    Varney, M.A.4
  • 10
    • 5544228283 scopus 로고    scopus 로고
    • The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats
    • Campbell U.C., Lalwani K., Hernandez L., Kinney G.G., Conn P.J., and Bristow L.J. The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology 175 (2004) 310-318
    • (2004) Psychopharmacology , vol.175 , pp. 310-318
    • Campbell, U.C.1    Lalwani, K.2    Hernandez, L.3    Kinney, G.G.4    Conn, P.J.5    Bristow, L.J.6
  • 11
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Ann Rev Pharmacol Toxicol 37 (1997) 205-237
    • (1997) Ann Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 12
    • 0037330358 scopus 로고    scopus 로고
    • [3H]-Methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor
    • Cosford N.D., Roppe J., Tehrani L., Schweiger E.J., Seiders T.J., Chaudhary A., et al. [3H]-Methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett 10 (2003) 351-354
    • (2003) Bioorg Med Chem Lett , vol.10 , pp. 351-354
    • Cosford, N.D.1    Roppe, J.2    Tehrani, L.3    Schweiger, E.J.4    Seiders, T.J.5    Chaudhary, A.6
  • 14
    • 0023691166 scopus 로고
    • A new one-trial test for neurobiological studies of memory in rats. 1. Behavioural data
    • Ennaceur A., and Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1. Behavioural data. Behav Brain Res 31 (1988) 47-59
    • (1988) Behav Brain Res , vol.31 , pp. 47-59
    • Ennaceur, A.1    Delacour, J.2
  • 15
    • 0032853255 scopus 로고    scopus 로고
    • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
    • Gasparini F., Lingenhöhl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38 (1999) 1493-1503
    • (1999) Neuropharmacology , vol.38 , pp. 1493-1503
    • Gasparini, F.1    Lingenhöhl, K.2    Stoehr, N.3    Flor, P.J.4    Heinrich, M.5    Vranesic, I.6
  • 16
    • 33750802463 scopus 로고    scopus 로고
    • The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats-a comparison
    • Gravius A., Barberi C., Schäfer D., Schmidt W.J., and Danysz W. The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats-a comparison. Neuropharmacology 51 (2006) 1146-1155
    • (2006) Neuropharmacology , vol.51 , pp. 1146-1155
    • Gravius, A.1    Barberi, C.2    Schäfer, D.3    Schmidt, W.J.4    Danysz, W.5
  • 17
    • 16444361969 scopus 로고    scopus 로고
    • Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning
    • Gravius A., Pietraszek M., Schäfer D., Schmidt W.J., and Danysz W. Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning. Behav Pharmacol 16 (2005) 113-121
    • (2005) Behav Pharmacol , vol.16 , pp. 113-121
    • Gravius, A.1    Pietraszek, M.2    Schäfer, D.3    Schmidt, W.J.4    Danysz, W.5
  • 18
    • 0036945935 scopus 로고    scopus 로고
    • The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    • Henry S.A., Lehmann-Masten V., Gasparini F., Geyer M.A., and Markou A. The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology 43 (2002) 1199-1209
    • (2002) Neuropharmacology , vol.43 , pp. 1199-1209
    • Henry, S.A.1    Lehmann-Masten, V.2    Gasparini, F.3    Geyer, M.A.4    Markou, A.5
  • 19
    • 0035504328 scopus 로고    scopus 로고
    • Structural, signaling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein coupled receptors
    • Hermans E., and Challiss R.A.J. Structural, signaling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein coupled receptors. Biochem J 359 (2001) 465-484
    • (2001) Biochem J , vol.359 , pp. 465-484
    • Hermans, E.1    Challiss, R.A.J.2
  • 20
    • 2942650911 scopus 로고    scopus 로고
    • Functional interactions between NMDA and mGluR5 receptors: effects on working memory, instrumental learning, motor behaviours, and dopamine release
    • Homayoun H., Stefani M.R., Adams B.W., Tamagan G.D., and Moghaddam B. Functional interactions between NMDA and mGluR5 receptors: effects on working memory, instrumental learning, motor behaviours, and dopamine release. Neuropsychopharmacology 29 (2004) 1259-1269
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1259-1269
    • Homayoun, H.1    Stefani, M.R.2    Adams, B.W.3    Tamagan, G.D.4    Moghaddam, B.5
  • 21
    • 0029982969 scopus 로고    scopus 로고
    • Effects of purine analogues on spontaneous alternation in mice
    • Hooper N., Fraser C., and Stone T.V. Effects of purine analogues on spontaneous alternation in mice. Psychopharmacology 123 (1996) 250-257
    • (1996) Psychopharmacology , vol.123 , pp. 250-257
    • Hooper, N.1    Fraser, C.2    Stone, T.V.3
  • 22
    • 0027093913 scopus 로고
    • Excitatory amino acid pathway from hippocampus to the prefrontal cortex. Contribution of AMPA receptors in hippocampo-prefrontal cortex transmission
    • Jay T.M., Thierry A.-M., Wiklund L., and Glowinski J. Excitatory amino acid pathway from hippocampus to the prefrontal cortex. Contribution of AMPA receptors in hippocampo-prefrontal cortex transmission. Eur J Neurosci 4 (1992) 1285-1295
    • (1992) Eur J Neurosci , vol.4 , pp. 1285-1295
    • Jay, T.M.1    Thierry, A.-M.2    Wiklund, L.3    Glowinski, J.4
  • 23
    • 0026066215 scopus 로고
    • Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin
    • Jay T.M., and Witter M.P. Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin. J Comp Neurol 313 (1991) 574-586
    • (1991) J Comp Neurol , vol.313 , pp. 574-586
    • Jay, T.M.1    Witter, M.P.2
  • 25
    • 0034502492 scopus 로고    scopus 로고
    • Anxiolytic-like effects of a group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats
    • Klodzinska A., Tatarczynska E., Chojnacka-Wojcik E., and Pilc A. Anxiolytic-like effects of a group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Pol J Pharmacol 52 (2000) 463-466
    • (2000) Pol J Pharmacol , vol.52 , pp. 463-466
    • Klodzinska, A.1    Tatarczynska, E.2    Chojnacka-Wojcik, E.3    Pilc, A.4
  • 26
    • 33847026476 scopus 로고    scopus 로고
    • The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats
    • Koros E., Rosenbrock H., Birk G., Weiss C., and Sams-Dodd F. The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats. Neuropsychopharmacology 32 (2007) 562-576
    • (2007) Neuropsychopharmacology , vol.32 , pp. 562-576
    • Koros, E.1    Rosenbrock, H.2    Birk, G.3    Weiss, C.4    Sams-Dodd, F.5
  • 27
    • 0033812520 scopus 로고    scopus 로고
    • Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation
    • Laroche S., Davis S., and Jay T.M. Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation. Hippocampus 10 (2000) 438-446
    • (2000) Hippocampus , vol.10 , pp. 438-446
    • Laroche, S.1    Davis, S.2    Jay, T.M.3
  • 28
    • 26844466906 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity
    • Manahan-Vaughan D., and Braunewell D. The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. Cerebral cortex 11 (2005) 1703-1713
    • (2005) Cerebral cortex , vol.11 , pp. 1703-1713
    • Manahan-Vaughan, D.1    Braunewell, D.2
  • 29
    • 3142737454 scopus 로고    scopus 로고
    • Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice
    • McGeehan A.J., Janak P.H., and Olive M.F. Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. Psychopharmacology 174 (2004) 266-273
    • (2004) Psychopharmacology , vol.174 , pp. 266-273
    • McGeehan, A.J.1    Janak, P.H.2    Olive, M.F.3
  • 30
    • 0942290621 scopus 로고    scopus 로고
    • Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation
    • Naie K., and Manahan-Vaughan D. Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. Cerebral cortex 14 (2004) 189-198
    • (2004) Cerebral cortex , vol.14 , pp. 189-198
    • Naie, K.1    Manahan-Vaughan, D.2
  • 31
    • 34648831985 scopus 로고    scopus 로고
    • Defensive-like behaviors induced by ultrasound: further pharmacological characterization in Lister-hooded rats
    • Nicolas L.B., Klein S., and Prinssen E.P. Defensive-like behaviors induced by ultrasound: further pharmacological characterization in Lister-hooded rats. Psychopharmacology 194 (2007) 243-252
    • (2007) Psychopharmacology , vol.194 , pp. 243-252
    • Nicolas, L.B.1    Klein, S.2    Prinssen, E.P.3
  • 34
    • 21344470129 scopus 로고    scopus 로고
    • MGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition
    • Pietraszek M., Gravius A., Schäfer D., Weil T., Trifanova D., and Danysz W. MGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition. Neuropharmacology 49 (2005) 73-85
    • (2005) Neuropharmacology , vol.49 , pp. 73-85
    • Pietraszek, M.1    Gravius, A.2    Schäfer, D.3    Weil, T.4    Trifanova, D.5    Danysz, W.6
  • 35
    • 0036669731 scopus 로고    scopus 로고
    • Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats
    • Pilc A., Klodzinska A., Branski P., Nowak G., Palucha A., Szewczyk B., et al. Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats. Neuropharmacology 43 (2002) 181-187
    • (2002) Neuropharmacology , vol.43 , pp. 181-187
    • Pilc, A.1    Klodzinska, A.2    Branski, P.3    Nowak, G.4    Palucha, A.5    Szewczyk, B.6
  • 36
    • 0036951025 scopus 로고    scopus 로고
    • Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist
    • Popik P., and Wrobel M. Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology 43 (2002) 1210-1217
    • (2002) Neuropharmacology , vol.43 , pp. 1210-1217
    • Popik, P.1    Wrobel, M.2
  • 37
    • 0030044017 scopus 로고    scopus 로고
    • Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose
    • Ragozzino M.E., Unick K.E., and Gold P.E. Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose. Proc Natl Acad Sci USA 93 (1996) 4693-4698
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4693-4698
    • Ragozzino, M.E.1    Unick, K.E.2    Gold, P.E.3
  • 38
    • 0037452854 scopus 로고    scopus 로고
    • Glutamate receptor function in learning and memory
    • Riedel G., Platt B., and Micheau J. Glutamate receptor function in learning and memory. Behav Brain Res 140 (2003) 1-47
    • (2003) Behav Brain Res , vol.140 , pp. 1-47
    • Riedel, G.1    Platt, B.2    Micheau, J.3
  • 39
    • 0038418020 scopus 로고    scopus 로고
    • MPEP, a selective glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats
    • Schachtman T.R., Bills C., Ghinescu R., Murch K., Serfozo P., and Simonyi A. MPEP, a selective glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. Behav Brain Res 141 (2003) 177-182
    • (2003) Behav Brain Res , vol.141 , pp. 177-182
    • Schachtman, T.R.1    Bills, C.2    Ghinescu, R.3    Murch, K.4    Serfozo, P.5    Simonyi, A.6
  • 40
    • 0034968969 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethyl)-pyridine (MPEP) blocks fear conditioning in rats
    • Schulz B., Fendt M., Gasparini F., Lingenhöhl K., Kuhn R., and Koch M. The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethyl)-pyridine (MPEP) blocks fear conditioning in rats. Neuropharmacology 41 (2001) 1-7
    • (2001) Neuropharmacology , vol.41 , pp. 1-7
    • Schulz, B.1    Fendt, M.2    Gasparini, F.3    Lingenhöhl, K.4    Kuhn, R.5    Koch, M.6
  • 41
    • 30444460573 scopus 로고    scopus 로고
    • The role of metabotropic glutamate receptor 5 in learning and memory processes
    • Simonyi A., Schachtman T.R., and Christoffersen G.R.J. The role of metabotropic glutamate receptor 5 in learning and memory processes. Drug News Perspect 18 (2005) 353-361
    • (2005) Drug News Perspect , vol.18 , pp. 353-361
    • Simonyi, A.1    Schachtman, T.R.2    Christoffersen, G.R.J.3
  • 42
  • 43
    • 0033680311 scopus 로고    scopus 로고
    • Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl) pyridine in rodents
    • Spooren W.P., Vassout A., Neijt H.C., Kuhn R., Gasparini F., Roux S., et al. Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl) pyridine in rodents. J Pharmacol Exp Therapeutics 295 (2001) 1267-1275
    • (2001) J Pharmacol Exp Therapeutics , vol.295 , pp. 1267-1275
    • Spooren, W.P.1    Vassout, A.2    Neijt, H.C.3    Kuhn, R.4    Gasparini, F.5    Roux, S.6
  • 44
    • 0034693328 scopus 로고    scopus 로고
    • Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
    • Spooren W.P.J.M., Gasparini F., Bergmann R., and Kuhn R. Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats. Eur J Pharmacol 406 (2000) 403-410
    • (2000) Eur J Pharmacol , vol.406 , pp. 403-410
    • Spooren, W.P.J.M.1    Gasparini, F.2    Bergmann, R.3    Kuhn, R.4
  • 45
  • 46
    • 0035069188 scopus 로고    scopus 로고
    • Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    • Tatarczynska E., Klodzinska A., Chojnacka-Wojcik E., Palucha A., Gasparini F., Kuhn R., et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol 132 (2001) 1423-1430
    • (2001) Br J Pharmacol , vol.132 , pp. 1423-1430
    • Tatarczynska, E.1    Klodzinska, A.2    Chojnacka-Wojcik, E.3    Palucha, A.4    Gasparini, F.5    Kuhn, R.6
  • 47
    • 20944438126 scopus 로고    scopus 로고
    • The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles
    • Varty G.B., Grilli M., Forlani A., Fredduzzi S., Grzelak M.E., Guthrie D.H., et al. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology 179 (2005) 207-217
    • (2005) Psychopharmacology , vol.179 , pp. 207-217
    • Varty, G.B.1    Grilli, M.2    Forlani, A.3    Fredduzzi, S.4    Grzelak, M.E.5    Guthrie, D.H.6
  • 48
    • 12144289648 scopus 로고    scopus 로고
    • In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling
    • Wieronska J.M., Smialowska M., Branski P., Gasparini F., Klodzinska A., Szewczyk B., et al. In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling. Neuropsychopharmacology 29 (2004) 514-521
    • (2004) Neuropsychopharmacology , vol.29 , pp. 514-521
    • Wieronska, J.M.1    Smialowska, M.2    Branski, P.3    Gasparini, F.4    Klodzinska, A.5    Szewczyk, B.6
  • 49
    • 0033832030 scopus 로고    scopus 로고
    • Behavioural activity of S-(3,5)-DHPG, a selective agonist of group 1 metabotropic glutamate receptors
    • Zalewska-Winska A., and Wisniewski K. Behavioural activity of S-(3,5)-DHPG, a selective agonist of group 1 metabotropic glutamate receptors. Pharmacol Res 42 (2000) 239-245
    • (2000) Pharmacol Res , vol.42 , pp. 239-245
    • Zalewska-Winska, A.1    Wisniewski, K.2


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