Controlling influenza by cytotoxic T-cells: Calling for help from destroyers

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  Schotsaert, Michael ^a,b   Ibaez, Lorena Itatí ^a,b   Fiers, Walter ^a,b   Saelens, Xavier ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; HLA ANTIGEN; INFLUENZA VACCINE;

ANTIBODY RESPONSE; ANTIGEN PRESENTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; COMPUTER PREDICTION; CROSS PRESENTATION; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ENZYME LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; HEMAGGLUTINATION INHIBITION TEST; HUMAN; HUMORAL IMMUNITY; IMMUNOPROPHYLAXIS; INFECTION CONTROL; INFLUENZA VACCINATION; INFLUENZA VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; PANDEMIC INFLUENZA; PRACTICE GUIDELINE; REFERENCE DATABASE; REVIEW; SEASONAL INFLUENZA; T LYMPHOCYTE ACTIVATION; VACCINE PRODUCTION;

ORTHOMYXOVIRIDAE;

EID: 77953517626     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/863985     Document Type: Review

References (131)

1. Kresse H., Rovini H., Influenza vaccine market dynamics Nature Reviews Drug Discovery 2009 8 11 841 842
2. Fiore A. E., Bridges C. B., Cox N. J., Seasonal influenza vaccines Current Topics in Microbiology and Immunology 2009 333 43 82
3. Hensley S. E., Das S. R., Bailey A. L., Hemagglutinin receptor binding avidity drives influenza a virus antigenic drift Science 2009 326 5953 734 736
4. Banzhoff A., Pellegrini M., Del Giudice G., Fragapane E., Groth N., Podda A., MF59-adjuvanted vaccines for seasonal and pandemic influenza prophylaxis Influenza and Other Respiratory Viruses 2008 2 6 243 249
5. Leroux-Roels I., Roman F., Forgus S., Priming with AS03A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: an open non-randomised extension of a double-blind randomised primary study Vaccine 2010 28 3 849 857
6. Morein B., Sundquist B., Hoglund S., Dalsgaard K., Osterhaus A., Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses Nature 1984 308 5958 457 460
7. Rimmelzwaan G. F., Nieuwkoop N., Brandenburg A., A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOMTM vaccines and conventional vaccines Vaccine 2000 19 9-10 1180 1187
8. Mullbacher A., Ada G. L., Hla R., Gamma-irradiated influenza A virus can prime for a cross-reactive and cross-protective immune response against influenza A viruses Immunology and Cell Biology 1988 66 2 153 157
9. Mullbacher A., Lobigs M., Alsharifi M., Regner M., Cytotoxic T-cell immunity as a target for influenza vaccines The Lancet Infectious Diseases 2006 6 5 255 256
10. Heiny A. T., Miotto O., Srinivasan K. N., Evolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targets PLoS ONE 2007 2 11, article e1190
11. Neirynck S., Deroo T., Saelens X., Vanlandschoot P., Jou W. M., Fiers W., A universal influenza A vaccine based on the extracellular domain of the M2 protein Nature Medicine 1999 5 10 1157 1163
12. Matsui M., Kohyama S., Suda T., A CTL-based liposomal vaccine capable of inducing protection against heterosubtypic influenza viruses in HLA- A 0201 transgenic mice Biochemical and Biophysical Research Communications 2010 391 3 1494 1499
13. Mozdzanowska K., Feng J., Eid M., Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2 Vaccine 2003 21 19-20 2616 2626
14. Frace A. M., Klimov A. I., Rowe T., Black R. A., Katz J. M., Modified M2 proteins produce heterotypic immunity against influenza A virus Vaccine 1999 17 18 2237 2244
15. Tompkins S. M., Zhao Z.-S., Lo C.-Y., Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1 Emerging Infectious Diseases 2007 13 3 426 435
16. Ulmer J. B., Donnelly J. J., Parker S. E., Heterologous protection against influenza by injection of DNA encoding a viral protein Science 1993 259 5102 1745 1749
17. Fu T.-M., Guan L., Friedman A., Dose dependence of CTL precursor frequency induced by a DNA vaccine and correlation with protective immunity against influenza virus challenge Journal of Immunology 1999 162 7 4163 4170
18. Bennink J. R., Yewdell J. W., Smith G. L., Moss B., Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a nonstructural protein: responsiveness to individual viral antigens is major histocompatibility complex controlled Journal of Virology 1987 61 4 1098 1102
19. Fiers W., De Filette M., Bakkouri K. E., M2e-based universal influenza A vaccine Vaccine 2009 27 45 6280 6283
20. Brown D. M., Dilzer A. M., Meents D. L., Swain S. L., CD4 T cell-mediated protection from lethal influenza: perform and antibody-mediated mechanisms give a one-two punch Journal of Immunology 2006 177 5 2888 2898
21. Norton S. D., Zuckerman L., Urdahl K. B., Shefner R., Miller J., Jenkins M. K., The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells Journal of Immunology 1992 149 5 1556 1561
22. Belshe R. B., Current status of live attenuated influenza virus vaccine in the US Virus Research 2004 103 1-2 177 185
23. Powell T. J., Strutt T., Reome J., Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus Journal of Immunology 2007 178 2 1030 1038
24. Shen L., Rock K. L., Priming of T cells by exogenous antigen cross-presented on MHC class I molecules Current Opinion in Immunology 2006 18 1 85 91
25. Sawai T., Itoh Y., Ozaki H., Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin Immunology 2008 124 2 155 165
26. Sette A., Sidney J., Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism Immunogenetics 1999 50 3-4 201 212
27. La Gruta N. L., Kedzierska K., Pang K., A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies Proceedings of the National Academy of Sciences of the United States of America 2006 103 4 994 999
28. van der Most R. G., Murali-Krishna K., Lanier J. G., Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation Virology 2003 315 1 93 102
29. Liu J., Ewald B. A., Lynch D. M., Nanda A., Sumida S. M., Barouch D. H., Modulation of DNA vaccine-elicited CD8+ T-lymphocyte epitope immunodominance hierarchies Journal of Virology 2006 80 24 11991 11997
30. Kreijtz J. H. C. M., Bodewes R., van Amerongen G., Primary influenza A virus infection induces cross-protective immunity against a lethal infection with a heterosubtypic virus strain in mice Vaccine 2007 25 4 612 620 (Pubitemid 44856111)
31. Bodewes R., Kreijtz J. H. C. M., Baas C., Vaccination against human influenza A/H3N2 virus prevents the induction of heterosubtypic immunity against lethal infection with avian influenza A/H5N1 virus PLoS ONE 2009 4 5, article e5538
32. Tschernig T., Pabst R., Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases Pathobiology 2000 68 1 1 8
33. Moyron-Quiroz J. E., Rangel-Moreno J., Kusser K., Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity Nature Medicine 2004 10 9 927 934
34. Geurtsvankessel C. H., Willart M. A. M., Bergen I. M., Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice Journal of Experimental Medicine 2009 206 11 2339 2349
35. Vujanic A., Wee J. L. K., Snibson K. J., Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIXTM adjuvanted recombinant antigens Vaccine 2010 28 14 2593 2597
36. Lowin B., Hahne M., Mattmann C., Tschopp J., Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways Nature 1994 370 6491 650 652
37. Topham D. J., Tripp R. A., Doherty P. C., CD 8 + T cells clear influenza virus by perform or Fas-dependent processes Journal of Immunology 1997 159 11 5197 5200
38. Zinkernagel R. M., On natural and artificial vaccinations Annual Review of Immunology 2003 21 515 546
39. Seder R. A., Boulay J.-L., Finkelman F., CD 8 + T cells can be primed in vitro to produce IL-4 Journal of Immunology 1992 148 6 1652 1656
40. Croft M., Carter L., Swain S. L., Dutton R. W., Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles Journal of Experimental Medicine 1994 180 5 1715 1728
41. Hamada H., Garcia-Hernandez M. D. L. L., Reome J. B., Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge Journal of Immunology 2009 182 6 3469 3481
42. Oran A. E., Robinson H. L., DNA vaccines: influenza virus challenge of a Th2/Tc2 immune response results in a Th2/Tc1 response in the lung Journal of Virology 2004 78 8 4376 4380
43. Sun J., Madan R., Karp C. L., Braciale T. J., Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10 Nature Medicine 2009 15 3 277 284
44. McKinstry K. K., Strutt T. M., Buck A., IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge Journal of Immunology 2009 182 12 7353 7363
45. Castellino F., Boucher P. E., Eichelberg K., Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways Journal of Experimental Medicine 2000 191 11 1957 1964
46. Tobian A. A. R., Harding C. V., Canaday D. H., Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytes Journal of Immunology 2005 174 9 5209 5214
47. Ikonomidis G., Paterson Y., Kos F. J., Portnoy D. A., Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes Journal of Experimental Medicine 1994 180 6 2209 2218
48. Hu P. Q., Tuma-Warrino R. J., Bryan M. A., Escherichia coli expressing recombinant antigen and listeriolysin O stimulate class I-restricted CD8+ T cells following uptake by human APC Journal of Immunology 2004 172 3 1595 1601
49. De Koker S., De Geest B. G., Singh S. K., Polyelectrolyte microcapsules as antigen delivery vehicles to dendritic cells: uptake, processing, and cross-presentation of encapsulated antigens Angewandte Chemie International Edition 2009 48 45 8485 8489
50. Shen H., Ackerman A. L., Cody V., Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles Immunology 2006 117 1 78 88
51. Heit A., Schmitz F., O'Keeffe M., Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines Journal of Immunology 2005 174 7 4373 4380
52. Shedlock D. J., Shen H., Requirement for CD4 T cell help in generating functional CD8 T cell memory Science 2003 300 5617 337 339
53. Harty J. T., Badovinac V. P., Shaping and reshaping CD8+ T-cell memory Nature Reviews Immunology 2008 8 2 107 119
54. Mullbacher A., The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen Journal of Experimental Medicine 1994 179 1 317 321
55. Murali-Krishna K., Lau L. L., Sambhara S., Lemonnier F., Altman J., Ahmed R., Persistence of memory CD8 T cells in MHC class I-deficient mice Science 1999 286 5443 1377 1381
56. Sallusto F., Geginat J., Lanzavecchia A., Central memory and effector memory T cell subsets: function, generation, and maintenance Annual Review of Immunology 2004 22 745 763
57. Sallusto F., Lenig D., Forster R., Lipp M., Lanzavecchia A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 1999 401 6754 708 712
58. Sambhara S., Woods S., Arpino R., Heterotypic protection against influenza by immunostimulating complexes is associated with the induction of cross-reactive cytotoxic T lymphocytes Journal of Infectious Diseases 1998 177 5 1266 1274
59. Rimmelzwaan G. F., Sutter G., Candidate influenza vaccines based on recombinant modified vaccinia virus Ankara Expert Review of Vaccines 2009 8 4 447 454
60. Sutter G., Moss B., Nonreplicating vaccinia vector efficiently expresses recombinant genes Proceedings of the National Academy of Sciences of the United States of America 1992 89 22 10847 10851
61. Wolff J. A., Malone R. W., Williams P., Direct gene transfer into mouse muscle in vivo Science 1990 247 4949, part 1 1465 1468
62. Donnelly J. J., Ulmer J. B., Shiver J. W., Liu M. A., DNA vaccines Annual Review of Immunology 1997 15 617 648
63. Temin H. W., Overview of biological effects of addition of DNA molecules to cells Journal of Medical Virology 1990 31 1 13 17
64. Wolff J. A., Ludtke J. J., Acsadi G., Williams P., Jani A., Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle Human Molecular Genetics 1992 1 6 363 369
65. Smith H. A., Regulatory considerations for nucleic acid vaccines Vaccine 1994 12 16 1515 1519
66. Robertson J. S., Safety considerations for nucleic acid vaccinese Vaccine 1994 12 16 1526 1528
67. Openshaw P. J. M., Tregoning J. S., Immune responses and disease enhancement during respiratory syncytial virus infection Clinical Microbiology Reviews 2005 18 3 541 555
68. Huisman W., Martina B. E. E., Rimmelzwaan G. F., Gruters R. A., Osterhaus A. D. M. E., Vaccine-induced enhancement of viral infections Vaccine 2009 27 4 505 512
69. Mealey R. H., Leib S. R., Littke M. H., Wagner B., Horohov D. W., McGuire T. C., Viral load and clinical disease enhancement associated with a lentivirus cytotoxic T lymphocyte vaccine regimen Vaccine 2009 27 18 2453 2468
70. Simeckova-Rosenberg J., Yun Z., Wyde P. R., Zouhair Atassi M., Protection of mice against lethal viral infection by synthetic peptides corresponding to B- and T-cell recognition sites of influenza A hemagglutinin Vaccine 1995 13 10 927 932
71. Moskophidis D., Kioussis D., Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model Journal of Experimental Medicine 1998 188 2 223 232
72. Haring J. S., Badovinac V. P., Harty J. T., Inflaming the CD8+ T cell response Immunity 2006 25 1 19 29
73. Grebe K. M., Hickman H. D., Irvine K. R., Takeda K., Bennink J. R., Yewdell J. W., Sympathetic nervous system control of anti-influenza CD8+ T cell responses Proceedings of the National Academy of Sciences of the United States of America 2009 106 13 5300 5305
74. Moffat J. M., Gebhardt T., Doherty P. C., Turner S. J., Mintern J. D., Granzyme a expression reveals distinct cytolytic CTL subsets following influenza A virus infection European Journal of Immunology 2009 39 5 1203 1210
75. Metkar S. S., Menaa C., Pardo J., Human and mouse granzyme A induce a proinflammatory cytokine response Immunity 2008 29 5 720 733
76. La Gruta N. L., Kedzierska K., Stambas J., Doherty P. C., A question of self-preservation: immunopathology in influenza virus infection Immunology and Cell Biology 2007 85 2 85 92
77. Rimmelzwaan G. F., Boon A. C. M., Voeten J. T. M., Berkhoff E. G. M., Fouchier R. A. M., Osterhaus A. D. M. E., Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes Virus Research 2004 103 1-2 97 100
78. Berkhoff E. G. M., Geelhoed-Mieras M. M., Jonges M., An amino acid substitution in the influenza A virus hemagglutinin associated with escape from recognition by human virus-specific CD4+ T-cells Virus Research 2007 126 1-2 282 287
79. Korber B., LaBute M., Yusim K., Immunoinformatics comes of age PLoS Computational Biology 2006 2 6, article e71
80. Peters B., Sidney J., Bourne P., The immune epitope database and analysis resource: from vision to blueprint PLoS Biology 2005 3 3, article e91
81. Vita R., Zarebski L., Greenbaum J. A., The immune epitope database 2.0 Nucleic Acids Research 2009 38 supplement 1 D854 D862
82. Salimi N., Vita R., The biocurator: connecting and enhancing scientific data PLoS Computational Biology 2006 2 10, article e125
83. Vita R., Vaughan K., Zarebski L., Curation of complex, context-dependent immunological data BMC Bioinformatics 2006 7, article 341
84. Peters B., Sette A., Integrating epitope data into the emerging web of biomedical knowledge resources Nature Reviews Immunology 2007 7 6 485 490
85. Bui H.-H., Peters B., Assarsson E., Mbawuike I., Sette A., Ab and T cell epitopes of influenza A virus, knowledge and opportunities Proceedings of the National Academy of Sciences of the United States of America 2007 104 1 246 251
86. Greenbaum J. A., Kotturi M. F., Kim Y., Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population Proceedings of the National Academy of Sciences of the United States of America 2010 106 48 20365 20370
87. Stevanovic S., Antigen processing is predictable: from genes to T cell epitopes Transplant Immunology 2005 14 3-4 171 174
88. Tong J. C., Tan T. W., Ranganathan S., Methods and protocols for prediction of immunogenic epitopes Briefings in Bioinformatics 2007 8 2 96 108
89. Brusic V., Bajic V. B., Petrovsky N., Computational methods for prediction of T-cell epitopesa framework for modelling, testing, and applications Methods 2004 34 4 436 443
90. Lundegaard C., Lund O., Kesmir C., Brunak S., Nielsen M., Modeling the adaptive immune system: predictions and simulations Bioinformatics 2007 23 24 3265 3275
91. Lin H. H., Ray S., Tongchusak S., Reinherz E. L., Brusic V., Evaluation of MHC class I peptide binding prediction servers: applications for vaccine research BMC Immunology 2008 9, article 8
92. Moise L., De Groot A. S., Putting immunoinformatics to the test Nature Biotechnology 2006 24 7 791 792
93. Moutaftsi M., Peters B., Pasquetto V., A consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus Nature Biotechnology 2006 24 7 817 819
94. Lundegaard C., Nielsen M., Lund O., The validity of predicted T-cell epitopes Trends in Biotechnology 2006 24 12 537 538
95. De Groot A. S., Ardito M., McClaine E. M., Moise L., Martin W. D., Immunoinformatic comparison of T-cell epitopes contained in novel swine-origin influenza A (H1N1) virus with epitopes in 2008-2009 conventional influenza vaccine Vaccine 2009 27 42 5740 5747
96. Doytchinova I. A., Flower D. R., Class I T-cell epitope prediction: improvements using a combination of proteasome cleavage, TAP affinity, and MHC binding Molecular Immunology 2006 43 13 2037 2044
97. Zhang G. L., Petrovsky N., Kwoh C. K., August J. T., Brusic V., PRED(TAP): a system for prediction of peptide binding to the human transporter associated with antigen processing Immunome Research 2006 2, article 3
98. Brusic V., August J. T., Petrovsky N., Information technologies for vaccine research Expert Review of Vaccines 2005 4 3 407 417
99. Tong J. C., Ren E. C., Immunoinformatics: current trends and future directions Drug Discovery Today 2009 14 13-14 684 689
100. McElhaney J. E., Xie D., Hager W. D., T cell responses are better correlates of vaccine protection in the elderly Journal of Immunology 2006 176 10 6333 6339
101. McElhaney J. E., Ewen C., Zhou X., Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults Vaccine 2009 27 18 2418 2425
102. Carragher D. M., Kaminski D. A., Moquin A., Hartson L., Randall T. D., A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus Journal of Immunology 2008 181 6 4168 4176
103. Rimmelzwaan G. F., Fouchier R. A., Osterhaus A. D., Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development Current Opinion in Biotechnology 2007 18 6 529 536
104. Rimmelzwaan G. F., McElhaney J. E., Correlates of protection: novel generations of influenza vaccines Vaccine 2008 26 supplement 4 D41 D44
105. McMichael A. J., Gotch F. M., Noble G. R., Beare P. A. S., Cytotoxic T-cell immunity to influenza New England Journal of Medicine 1983 309 1 13 17
106. Sonoguchi T., Naito H., Hara M., Cross-subtype protection in humans during sequential, overlapping, and/or concurrent epidemics caused by H3N2 and H1N1 influenza viruses Journal of Infectious Diseases 1985 151 1 81 88
107. Epstein S. L., Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature Journal of Infectious Diseases 2006 193 1 49 53
108. Jameson J., Cruz J., Terajima M., Ennis F. A., Human CD8+ and CD4+ T lymphocyte memory to influenza a viruses of swine and avian species Journal of Immunology 1999 162 12 7578 7583
109. Boon A. C. M., De Mutsert G., Van Baarle D., Recognition of homo- and heterosubtypic variants of influenza A viruses by human CD8+ T lymphocytes Journal of Immunology 2004 172 4 2453 2460
110. Kreijtz J. H. C. M., De Mutsert G., Van Baalen C. A., Fouchier R. A. M., Osterhaus A. D. M. E., Rimmelzwaan G. F., Cross-recognition of avian H5N1 influenza virus by human cytotoxic T-lymphocyte populations directed to human influenza A virus Journal of Virology 2008 82 11 5161 5166
111. Rimmelzwaan G. F., Kreijtz J. H. C. M., Bodewes R., Fouchier R. A. M., Osterhaus A. D. M. E., Influenza virus CTL epitopes, remarkably conserved and remarkably variable Vaccine 2009 27 45 6363 6365
112. Bolton D. L., Roederer M., Flow cytometry and the future of vaccine development Expert Review of Vaccines 2009 8 6 779 789
113. McElhaney J. E., Gravenstein S., Upshaw C. M., Granzyme B: a marker of risk for influenza in institutionalized older adults Vaccine 2001 19 27 3744 3751
114. Ewen C., Kane K. P., Shostak I., A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B Journal of Immunological Methods 2003 276 1-2 89 101
115. Packard B. Z., Komoriya A., Intracellular protease activation in apoptosis and cell-mediated cytotoxicity characterized by cell-permeable fluorogenic protease substrates Cell Research 2008 18 2 238 247
116. Brunner K. T., Mauel J., Cerottini J. C., Chapuis B., Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs Immunology 1968 14 2 181 196
117. Chahroudi A., Silvestri G., Feinberg M. B., Measuring T cell-mediated cytotoxicity using fluorogenic caspase substrates Methods 2003 31 2 120 126
118. Jerome K. R., Sloan D. D., Aubert M., Measurement of CTL-induced cytotoxicity: the caspase 3 assay Apoptosis 2003 8 6 563 571
119. van Baalen C. A., Gruters R. A., Berkhoff E. G. M., Osterhaus A. D. M. E., Rimmelzwaan G. F., FATT-CTL assay for detection of antigen-specific cell-mediated cytotoxicity Cytometry Part A 2008 73 11 1058 1065
120. Chen K., Chen L., Zhao P., FL-CTL assay: fluorolysometric determination of cell-mediated cytotoxicity using green fluorescent protein and red fluorescent protein expressing target cells Journal of Immunological Methods 2005 300 1-2 100 114
121. Barber D. L., Wherry E. J., Ahmed R., Cutting edge: rapid in vivo killing by memory CD8 T cells Journal of Immunology 2003 171 1 27 31
122. Grebe K. M., Yewdell J. W., Bennink J. R., Heterosubtypic immunity to influenza A virus: where do we stand? Microbes and Infection 2008 10 9 1024 1029
123. Bodewes R., Kreijtz J. H., Rimmelzwaan G. F., Yearly influenza vaccinations: a double-edged sword? The Lancet Infectious Diseases 2009 9 12 784 788
124. Corbeel L., Should healthy children be vaccinated against influenza? Comments about this query European Journal of Pediatrics 2007 166 6 629 631
125. Heikkinen T., Booy R., Campins M., Should healthy children be vaccinated against influenza? A consensus report of the Summits of Independent European Vaccination Experts European Journal of Pediatrics 2006 165 4 223 228
126. Moral L., Rubio E. M., We will have to vaccinate healthy children against influenza when we know that it is helpful European Journal of Pediatrics 2006 165 11 817
127. Heikkinen T., Peltola V., Influenza vaccination of children The Lancet Infectious Diseases 2009 9 12 720 721
128. De Groot A. S., Immunomics: discovering new targets for vaccines and therapeutics Drug Discovery Today 2006 11 5-6 203 209
129. Sette A., Peters B., Immune epitope mapping in the post-genomic era: lessons for vaccine development Current Opinion in Immunology 2007 19 1 106 110
130. Stern E., Steenblock E. R., Reed M. A., Fahmy T. M., Label-free electronic detection of the antigen-specific T-cell immune response Nano Letters 2008 8 10 3310 3314
131. Soen Y., Chen D. S., Kraft D. L., Davis M. M., Brown P. O., Detection and characterization of cellular immune responses using peptide-MHC microarrays PLoS Biology 2003 1 3, article E65