Hemagglutinin receptor binding avidity drives influenza a virus antigenic drift

Science

Volumn 326, Issue 5953, 2009, Pages 734-736

  Hensley, Scott E ^a   Das, Suman R ^a   Bailey, Adam L ^a   Schmidt, Loren M ^a   Hickman, Heather D ^a   Jayaraman, Akila ^b   Viswanathan, Karthik ^b   Raman, Rahul ^b   Sasisekharan, Ram ^b   Bennink, Jack R ^a   Yewdell, Jonathan W ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CELL RECEPTOR; HEMAGGLUTININ RECEPTOR; INFLUENZA VACCINE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID; ANTIBODY; ANTIGEN; INFLUENZA; MUTATION; PROTEIN; RODENT; VACCINATION;

AMINO ACID SUBSTITUTION; ANTIGENICITY; ARTICLE; CELL SURFACE; INFLUENZA VIRUS A; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; VACCINATION; WILD TYPE;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENIC VARIATION; CELL LINE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, IMMUNOLOGICAL; MUTATION; RECEPTORS, VIRUS; SERIAL PASSAGE;

INFLUENZA A VIRUS; MUS;

EID: 70350595871     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1178258     Document Type: Article

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20. We thank the staff of the National Institute of Allergy and Infectious Diseases (NIAID) Comparative Medical Branch for assistance with animal studies, G. Reynoso for technical assistance, the Consortium for Functional Glycomics for glycan standards, and S. Epstein (U.S. Food and Drug Administration) for insightful reading of the manuscript. This work was supported by Division of Intramural Research, NIAID (J.R.B. and J.W.Y.), the Singapore-Massachusetts Institute of Technology Alliance for Research and Technology (R.S.), and the National Institute of General Medical Sciences (GM 57073 and U54 GM62116) (R.S.).