A preliminary study of melatonin in irritable bowel syndrome

Journal of Clinical Gastroenterology

Volumn 41, Issue 1, 2007, Pages 29-32

  Saha, Lekha ^a,b   Malhotra, Samir ^a   Rana, Surinder ^a   Bhasin, Deepak ^a   Pandhi, Promila ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b H NO 1223   (India)

Author keywords

Clinical trial; Irritable bowel syndrome; Melatonin; Placebo

Indexed keywords

MELATONIN; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; IRRITABLE COLON; LIBIDO DISORDER; MALE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TREATMENT DURATION;

ADOLESCENT; ADULT; AGED; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; FREE RADICAL SCAVENGERS; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; MELATONIN; MIDDLE AGED; TREATMENT OUTCOME;

EID: 33846006939     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e31802df84c     Document Type: Article

References (18)

1. Whorwell PJ, Mc Callum M, Creed FH, et al. Non-colonic features of irritable bowel syndrome. Gut. 1986;27:37-40.
2. Thompson WG. Irritable bowel syndrome: prevention, prognosis and consequences. CMAJ. 1986;134:111-113.
3. Drossman DA, Li Z, Andruzzi E, et al. U.S. householder survey of functional gastrointestinal disorders: prevalence, socio-demography and health impact. Dig Dis Sci. 1993;38:1569-1580.
4. Holmes KM, Salter RH. Irritable bowel syndrome - a safe diagnosis. Br Med J. 1982;285:1533-1534.
5. Talley NJ, Gabriel SE, Harmsen WS, et al. Medical costs in community subjects with irritable bowel syndrome. Gastroenterology. 1995;109:1736-1741.
6. Talley NJ, Spiller R. Irritable bowel syndrome: a little understood organic bowel disease? Lancet. 2002;360:555-564.
7. Mayer EA, Gebbart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology. 1994;107:271-293.
8. Delvaux M. Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome. Gut. 2002;51(suppl 1):167-171.
9. Dunlop SP, Jenkins D, Neal KP, et al. Relative importance of enterochromaffin cell hyperplasia, anxiety and depression in postinfections IBS. Gastroenterology. 2003;125:1651-1659.
10. Brzezinski A. Melatonin in humans. N Engl J Med. 1997;336:186-195.
11. Storr M, Koppitz P, Sibaev A, et al. Melatonin reduces nonadrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents invitro. J Pineal Res. 2002;33:101-108.
12. Harlow HJ, Weekley BL. Effects of melatonin on the force of spontaneous contractions of in vitro rat small and large intestine. J Pineal Res. 1986;3:277-284.
13. Bubenik GA, Dhanvantari S. Influence of serotonin and melatonin on some parameters of gastrointestinal activity. J Pineal Res. 1989;7:333-344.
14. Barajas-Lopez C, Peres AL, Espinosa-Luna R, et al. Melatonin modulates cholinergic transmission by blocking nicotinic channels in the guinea-pig submucous plexus. Eur J Pharmacol. 1996;312:319-325.
15. + channels attenuated melatonin-induced relaxation of serotonin-contracted rat gastric fundus. Can J Physiol Pharmacol. 2000;78:799-806.
16. Roberts-Thomson IC, Knights RE, Kennaway DJ, et al. Circadian rhythms in patients with abdominal pain syndromes. Aust N Z J Med. 1988;18:569-574.
17. Song GH, Leng PH, Gwee KA, et al. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomized, double blind, placebo controlled study. Gut. 2005;54:1402-1407.
18. Chung O. Irritable bowel syndrome. In: Kasper DL, Braunwald E, Fauci AS, et al, eds. Harrison's Principles of Internal Medicine. 16th ed. New York: McGraw Hill; 2005:1789-1793.