Effect of melatonin in selected populations of sleep-disturbed patients

NeuroSignals

Volumn 8, Issue 1-2, 1999, Pages 126-131

  Brusco, Luis I ^a   Fainstein, Isidoro ^a   Márquez, Miguel ^a   Cardinali, Daniel P ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Aging; Alzheimer disease; Cognitive impairment; Melatonin; Sleep disorders

Indexed keywords

MELATONIN;

ADULT; AGED; AGITATION; ALERTNESS; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; DEMENTIA; DEPRESSION; DRUG EFFICACY; FEMALE; HUMAN; INSOMNIA; MALE; NEUROPSYCHOLOGY; ORAL DRUG ADMINISTRATION; PILOT STUDY; RETROSPECTIVE STUDY; SLEEP DISORDER; SLEEP WAKING CYCLE; TIME; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; DEMENTIA, VASCULAR; DEPRESSION; FEMALE; HUMANS; MALE; MELATONIN; MIDDLE AGED; PSYCHOMOTOR AGITATION; RETROSPECTIVE STUDIES; SLEEP DISORDERS; SLEEP INITIATION AND MAINTENANCE DISORDERS;

EID: 0033037292     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000014580     Document Type: Article

References (18)

1. Vollrath L, Semm P, Gammel G: Sleep induction by intranasal administration of melatonin. Adv Biosci 1981;29:327-329.
2. Waldhauser F, Saletu B, Trinchard Lugan I: Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology 1990; 100:222-226.
3. Garfinkel D, Laudon M, Nof D, Zis-apel N: Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346: 541-554.
4. Haimov I, Lavie P, Laudon M, Her-er P, Vigder C, Zisapel N: Melatonin replacement therapy of elderly insomniacs. Sleep 1995;18:598-603.
5. Attenburrow MEJ, Cowen PJ, Shar-pley AL: Low dose melatonin improves sleep in healthy middle-aged subjects. Psychopharmacology 1996;126:179-181.
6. Iguchi H, Kato KI, Ibasayhi H: Age-dependent reduction in serum melatonin concentration in healthy human subjects. J Clin Endocrinol Me-tab 1982;55:27-29.
7. Skene DJ, Vivien-Roels B, Sparks DL, Hunsaker JC, Pevet P, Ravid D, Swaab DF: Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: Effect of age and Alzheimer disease. Brain Res 1990;528: 170-174.
8. Uchida K, Okamoto N, Ohara K, Morita Y: Daily rhythm of serum melatonin in patients with dementia of the degenerate type. Brain Res 1996;717:154-159.
9. Fainstein I, Bonetto AJ, Brusco LI, Cardinali DP: Effects of melatonin in elderly patients with sleep disturbance. A pilot study. Curr Ther Res 1997;58:990-1000.
10. Jost BC, Grossberg GT: The evolution of the psychiatric symptoms in Alzheimer’s disease: A natural history study. J Am Geriatr Soc 1996;44: 1078-1081.
11. Monti JM, Alvarino F, Cardinali D, Savio I, Pintos A: Effect of melatonin on sleep in elderly patients with chronic primary insomnia. Int Arch Geriatrics Gerontol, in press.
12. McGaffigan S, Bliwise DL: The treatment of sundowning: A selective review of pharmacological and nonpharmacological studies. Drugs Aging 1997;10:10-17.
13. Reiter RJ: Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995;9: 526-533.
14. Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK: Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J Neurosci 1997;17:1683-1690.
15. Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Fran-gione B, Ghiso J: Inhibition of Alzheimer P-fibrillogenesis by melatonin. J Biol Chem 1998;273:7185-7188.
16. Daniels WM, Van Rensburg SJ, Van Zyl JM, Taljaard JJ: Melatonin prevents P amyloid, induced lipid peroxidation. J Pineal Res 1998;24:78-82.
17. Song W, Lahiri K: Melatonin alters the metabolism of the P-amyloid precursor protein in the neuroendocrine cell line PC12. J Mol Neurosci 1997;9:75-92.
18. Brusco LI, Marquez M, Cardinali DP: Monozygotic twins with Alzheimer’s disease treated with melatonin. Case report. J Pineal Res 1998;25:260-263.