Melatonin and Zopiclone as Facilitators of Early Circadian Sleep in Operational Air Transport Crews

Aviation Space and Environmental Medicine

Volumn 75, Issue 5, 2004, Pages 439-443

  Paul, Michel A ^a   Gray, Gary ^a   Sardana, Tarek M ^a   Pigeau, Ross A ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

Author keywords

Early circadian sleep; Military operations; Sleep induction

Indexed keywords

MELATONIN; PLACEBO; STARNOC; TEMAZEPAM; ZALEPLON; ZOPICLONE;

ACTIMETRY; ADULT; AIRPLANE CREW; AROUSAL; ARTICLE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; DRUG SCREENING; DRUG UTILIZATION; FEMALE; HUMAN; LOW DRUG DOSE; MALE; MILITARY PHENOMENA; PSYCHOMOTOR PERFORMANCE; QUESTIONNAIRE; SINGLE DRUG DOSE; SLEEP INDUCTION; SLEEP PARAMETERS; SLEEP TIME; SLEEP WAKING CYCLE; SUSTAINED RELEASE PREPARATION;

ADULT; AEROSPACE MEDICINE; ANALYSIS OF VARIANCE; CANADA; CIRCADIAN RHYTHM; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MELATONIN; MIDDLE AGED; MILITARY MEDICINE; PIPERAZINES; QUESTIONNAIRES; SLEEP; TASK PERFORMANCE AND ANALYSIS;

EID: 2142711667     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Arendt J, Aldhous M, English J, et al. Some effects of jet-lag and their alleviation by melatonin. Ergonomics 1987; 30:1379-93.
2. Billiard M, Besset A, de Lustrac C, et al. Effets de la zopiclone sur le sommeil, la somnolence diurne et les performances nocturnes et diurnes chez le volontaire sain. Neurophysiol Clin 1989; 19:131-43.
3. Brown GM. Melatonin in pyschiatric and sleep disorders: Therapeutic implications. Pharmacology and Pathophysiology 1995; 3:209-26.
4. Repchinsky C, ed. Compendium of pharmaceuticals, and specialties. The Canadian drug reference for health professionals. Ottawa, Canada: Canadian Pharmacists Association; 2003:783.
5. Dollins AB, Lynch HJ, Wurtman RJ, et al. Effect of pharmacological daytime doses of melatonin on human mood and performance. Pyschopharmacol 1993; 112:490-6.
6. Gaillot J, Heusse D, Houghton GW, et al. Pharmacokinetics and metabolism of zopiclone. Pharmacology 1983; 27(Suppl 2):76-91.
7. Ladner M, Denny SC. A double-blind study to establish the residual effects of zopiclone on performance in healthy man. In: Nicholson AN, Scholsberg A, Dreyfus JF, eds. Zopiclone: A third generation of hypnotics. Basel, Switzerland: Karger; 1983: 98-108.
8. Lieberman HR, Waldhauser F, Garfield G, et al. Effects of melatonin on human mood and performance. Brain Res 1984; 323: 201-7.
9. Paul MA, Brown G, Buguet A, et al. Melatonin and zopiclone as pharmacologic aids to facilitate crew rest. Aviat Space Environ Med 2001; 72:974-84.
10. Paul MA, Gray G, Kenny G, Pigeau R. Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance. Aviat Space Environ Med 2003; 74:1263-70.
11. Paul MA, Gray GW, Sardana TM, Pigeau RA. Fatigue counter-measures in support of cf CC-130 air transport operations: From the operation to the laboratory and back to the operation. Ontario, Canada: Defence Research and Development Canada-Toronto; 2003. Report No. TR 2003-106.
12. Paul MA, Pigeau RA, Weinberg H. Human factors of CC-130 operations. Volume 6: Fatigue in long-haul resupply missions. Toronto, Canada: Defence and Civil Institute of Environmental Medicine; 1998. DCIEM Report No.98-R-19.
13. Paul MA, Pigeau RA, Weinberg H. CC-130 pilot fatigue during resupply missions to former Yugoslavia. Aviat Space Environ Med 2001; 72:965-73.
14. Tafti M, Besset A, Billiard M. Effects of zopiclone on subjective evaluation of sleep and daytime alertness and on psychomotor and physical performance tests in athletes. Prog Neuropsychopharmacol Biol Psychiatry 1992; 16:55-63.