Estrogen-signaling pathway: A link between breast cancer and melatonin oncostatic actions

Cancer Detection and Prevention

Volumn 30, Issue 2, 2006, Pages 118-128

  Cos, Samuel ^a   González, Alicia ^a   Martínez Campa, Carlos ^a   Mediavilla, Maria Dolores ^a   Alonso González, Carolina ^a   Sánchez Barceló, Emilio J ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Antioxidant; Antiproliferative effect; Aromatase; Aromatases; Breast cancer; Cadmodulin; Carcinogenic effects; Cell proliferation; Cytochrome P 450; E cadherin expression; Estradiol; Estradiol receptor; Gap junction; Hypothalmus; Immunomodulator; Indolamine; Mammary carcinogen; MCF 7; Melatonin; Metastasis; Oncostatic actions; Ovarian function; Oxidative damage; Pineal function; Pineal gland; Postmenopausal women; Prolactic; Signaling pathways; Steroid hormones

Indexed keywords

AROMATASE; CYCLIC AMP; ESTRADIOL; ESTROGEN RECEPTOR; MELATONIN; MEMBRANE RECEPTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER INCIDENCE; CANCER INHIBITION; CARCINOGENIC ACTIVITY; CELL PROLIFERATION; DOWN REGULATION; DRUG MECHANISM; HORMONE ACTION; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; AROMATASE INHIBITORS; BREAST NEOPLASMS; ESTROGEN ANTAGONISTS; ESTROGENS; HUMANS; MAMMARY GLANDS, HUMAN; MELATONIN; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SIGNAL TRANSDUCTION;

EID: 33646787132     PISSN: 0361090X     EISSN: 15251500     Source Type: Journal    
DOI: 10.1016/j.cdp.2006.03.002     Document Type: Short Survey

References (73)

1. Cos S., and Sánchez-Barceló E.J. Melatonin and mammary pathological growth. Front Neuroendocrinol 21 (2000) 133-170
2. Cos S., and Sánchez-Barceló E.J. Melatonin, experimental basis for a possible application in breast cancer prevention and treatment. Histol Histopathol 15 (2000) 637-647
3. Blask D.E., Sauer L.A., and Dauchy R.T. Melatonin as a chronobiotic/anticancer agent: cellular, biochemical and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr Top Med Chem 2 (2002) 113-132
4. Sánchez-Barceló E.J., Cos S., Fernández R., and Mediavilla M.D. Melatonin and mammary cancer: a short review. Endocr Relat Cancer 10 (2003) 153-159
5. Reiter R.J. The pineal and its hormones in the control of reproduction in mammals. Endocr Rev 1 (1980) 109-131
6. Molis T.M., Spriggs L.L., and Hill S.M. Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Mol Endocrinol 8 (1994) 1681-1690
7. Cos S., Blask D.E., Lemus-Wilson A., and Hill S.M. Effects of melatonin on the cell cycle kinetics and estrogen rescue of MCF-7 human breast cancer cells in culture. J Pineal Res 10 (1991) 36-42
8. Fraschini F., Demartini G., Esposti D., and Scaglione F. Melatonin involvement in immunity and cancer. Biol Signals Recept 7 (1998) 61-72
9. Allegra M., Reiter R.J., Tan D.X., Gentile C., Tesoriere L., and Livrea M.A. The chemistry of melatonin's interaction with reactive species. J Pineal Res 34 (2003) 1-10
10. Leon-Blanco M.M., Guerrero J.M., Reiter R.J., Calvo J.R., and Pozo D. Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro. J Pineal Res 35 (2003) 204-211
11. Dumitrescu R.G., and Cotarla I. Understanding breast cancer risk-where do we stand in 2005?. J Cell Mol Med 9 1 (2005) 208-221
12. Russo I.H., and Russo J. Role of hormones in mammary cancer initiation and progression. J Mammary Gland Biol Neoplasia 3 (1998) 49-61
13. Howell A., Clarke R.B., and Anderson E. Oestrogens, Beatson and endocrine therapy. Endocr Relat Cancer 4 (1997) 371-380
14. Preston-Martin S., Pike M.C., Ross R.K., Jones P.A., and Henderson B.E. Increased cell division as a cause of human cancer. Cancer Res 50 (1990) 7415-7421
15. Yue W., Santen R.J., Wang J.P., Li Y., Verderame M.F., Bocchinfuso W.P., et al. Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis. J Steroid Biochem Mol Biol 86 (2003) 477-486
16. Landeghem A.A., Poortman J., Nabuurs M., and Thijssen J.H. Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res 45 (1985) 2900-2906
17. Yue W., Wang J.P., Hamilton C.J., Demers L.M., and Santen R.J. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res 58 (1998) 927-932
18. Wong Z.W., and Ellis M.J. First-line endocrine treatment of breast cancer: aromatase inhibitor or antiestrogen?. Br J Cancer 90 (2004) 20-25
19. Lerner A.B., Case J.D., Takahashi Y., Lee T.H., and Mori W. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc 80 (1958) 2587
20. Vanecek J. Cellular mechanisms of melatonin action. Physiol Rev 78 (1998) 687-721
21. Becker-Andre M., Wiesenberg I., Schaeren-Wiemers N., Andre E., Missbach M., Saurat J.H., et al. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem 269 (1994) 28531-28534
22. Anton-Tay F., Martínez I., Tovar R., and Benitez-King G. Modulation of the subcellular distribution of calmodulin by melatonin in MDCK cells. J Pineal Res 24 (1998) 35-42
23. Arendt J. Role of the pineal gland and melatonin in seasonal reproductive function in mammals. Oxf Rev Reprod Biol 8 (1986) 266-320
24. Malpaux B., Migaud M., Tricoire H., and Chemineau P. Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin. J Biol Rhythms 16 (2001) 336-347
25. Dubocovich M.L., Rivera-Bermudez M.A., Gerdin M.J., and Masana M.I. Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci 8 (2003) 1093-1108
26. Yellon S.M., and Foster D.L. Melatonin rhythms time photoperiod-induced puberty in the female lamb. Endocrinology 119 (1986) 44-49
27. Kauppila A., Kivela A., Pakarinen A., and Vakkuri O. Inverse seasonal relationship between melatonin and ovarian activity in humans in a region with a strong seasonal contrast in luminosity. J Clin Endocrinol Metab 65 (1987) 823-828
28. Luboshitzky R., and Lavie P. Melatonin and sex hormone interrelationships-a review. J Pediatr Endocrinol Metab 12 (1999) 355-362
29. Woo M.M., Tai C.J., Kang S.K., Nathwani P.S., Pang S.F., and Leung P.C. Direct action of melatonin in human granulosa-luteal cells. J Clin Endocrinol Metab 86 (2001) 4789-4797
30. Webley G.E., and Luck M.R. Melatonin directly stimulates the secretion of progesterone by human and bovine granulosa cells in vitro. J Reprod Fertil 78 (1986) 711-717
31. Cohen M., Lippman M., and Chabner B. Role of pineal gland in aetiology and treatment of breast cancer. Lancet 2 (1978) 814-816
32. Tamarkin L., Danforth D.N., Lichter A., Demoss E., Cohen M., Chabner B., et al. Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer. Science 216 (1982) 1003-1005
33. Maestroni J.M., and Conti A. Melatonin in human breast cancer tissue: association with nuclear grade and estrogen receptor status. Lab Invest 75 (1996) 557-561
34. Bartsch C., Bartsch H., Jain A.K., Laumas K.R., and Wetterberg L. Urinary melatonin levels in human breast cancer patients. J Neural Transm 52 (1981) 281-294
35. Brzezinski A. Melatonin in humans. N Engl J Med 336 (1997) 186-195
36. Soule H.D., Vazquez J., Long A., Albert S., and Brennan M.J. A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst 51 (1973) 1409-1412
37. Brooks S.C., Locke E.R., and Soule H.D. Estrogen receptor in a human breast tumor cell line (MCF-7) from breast carcinoma. J Biol Chem 248 (1973) 6251-6256
38. Lippman M.E., Bolan G., and Huff K. The effects of estrogen and antiestrogen on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res 36 (1976) 4595-4601
39. Adams D.J., Edwards D.P., and McGuire W.L. Hormone action in human breast cancer. In: McKems K.W. (Ed). Regulation of gene expression by hormones (1983), Plenum Press, New York 1-25
40. Yuan L., Collins A.R., Dai J., Dubocovich M.L., and Hill S.M. MT-1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells. Mol Cell Endocrinol 192 (2002) 147-156
41. Ram P.T., Dai J., Yuan L., Dong C., Kiefer T.L., Lai L., et al. Involvement of the MT-1 melatonin receptor in human breast cancer. Cancer Lett 179 (2002) 141-150
42. Blask D.E., and Hill S.M. Effects of melatonin on cancer: studies on MCF-7 human breast cancer cells in culture. J Neural Transm 21 Suppl. (1986) 433-449
43. Hill S.M., Spriggs L.L., Simon M.A., Muraoka H., and Blask D.E. The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system. Cancer Lett 64 (1992) 249-256
44. Cos S., Fernández F., and Sánchez-Barceló E.J. Melatonin inhibits DNA synthesis in MCF-7 human breast cancer cells in vitro. Life Sci 58 (1996) 2447-2453
45. Cos S., and Blask D.E. Melatonin modulates growth factor activity in MCF-7 human breast cancer cells. J Pineal Res 17 (1994) 25-32
46. Molis T.M., Walters M.R., and Hill S.M. Melatonin modulation of estrogen receptor expression in MCF-7 human breast cancer cells. Int J Oncol 3 (1993) 687-694
47. Molis T.M., Spriggs L.L., Jupiter Y., and Hill S.M. Melatonin modulation of estrogen-regulated proteins, growth factors and proto-oncogenes in human breast cancer. J Pineal Res 18 (1995) 93-103
48. Osborne C.K. Effects of estrogens and antiestrogens on human breast cancer cell proliferation: in vitro studies in tissue culture and in vivo studies in athymic mice. In: Hollander V.P. (Ed). Hormonally responsive tumors (1985), Academic Press, Orlando 93-113
49. Cos S., Recio J., and Sánchez-Barceló E.J. Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatonin. Life Sci 58 (1996) 811-816
50. Mediavilla M.D., Cos S., and Sánchez-Barceló E.J. Melatonin increases p53 and p21waf1 expression in MCF-7 human breast cancer cells in vitro. Life Sci 65 (1999) 415-420
51. Malamud D. In: Baserga R. (Ed). The cell cycle and cancer (1971), Cold Spring Harbor, New York 132-141
52. Crespo D., Fernández-Viadero C., Verduga R., Ovejero V., and Cos S. Interaction between melatonin and estradiol on morphological and morphometric features of MCF-7 human breast cancer cells. J Pineal Res 16 (1994) 215-222
53. Albini A., Graf J., Kitten G.T., Kleinman H.K., Martin G.R., Veillette A., et al. 17β-Estradiol regulates and v-Ha-ras transfection constitutively enhances MCF-7 breast cancer cell interactions with basement membrane. Proc Natl Acad Sci USA 83 (1986) 8182-8186
54. Cos S., Fernández R., Güezmes A., and Sánchez-Barceló E.J. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res 58 (1998) 4383-4390
55. Gui G.P.H., Puddefoot J.R., Vinson G.P., Wells C.A., and Carpenter R. Altered cell-matrix contact: a prerequisite for breast cancer metastasis?. Br J Cancer 75 (1997) 623-633
56. Trosko J.E., Chang C.C., Madhukar B.V., and Klaunig J.E. Chemical, oncogene and growth factor inhibition of gap junctional intercellular communication: an integrative hypothesis of carcinogenesis. Pathobiology 58 (1990) 265-278
57. Cos S., and Fernández R. Melatonin effects on intercellular junctional communication in MCF-7 human breast cancer cells. J Pineal Res 29 (2000) 166-171
58. Nicolson G.L., Dulski K.M., and Trosko J.E. Loss of intercellular junctional communication correlates with metastatic potential in mammary adenocarcinoma cells. Proc Natl Acad Sci USA 85 (1988) 473-476
59. Mediavilla M.D., San Martín M., and Sánchez-Barceló E.J. Melatonin inhibits mammary gland development in female mice. J Pineal Res 13 (1992) 13-19
60. Mediavilla M.D., Güezmes A., Ramos S., Kothari L., Garijo F., and Sánchez-Barceló E.J. Effects of melatonin on mammary gland lesions in transgenic mice overexpressing N-ras proto-oncogene. J Pineal Res 22 (1997) 86-94
61. Rato A.G., Pedrero J.G., Martinez M.A., del Rio B., Lazo P.S., and Ramos S. Melatonin blocks the activation of estrogen receptor for DNA binding. FASEB J 13 (1999) 857-868
62. Aronika S.M., Kraus W.L., and Katzenellenbogen B.S. Estrogen action via the cAMP signalling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci USA 91 (1994) 8517-8521
63. Godson C., and Reppert S.M. The mel1a melatonin receptor is coupled to parallel signal transduction pathways. Endocrinology 138 (1997) 397-404
64. Kiefer T., Ram P.T., Yuan L., and Hill S.M. Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells. Breast Cancer Res Treat 71 (2002) 37-45
65. García-Pedrero J.M., del Rio B., Martínez-Campa C., Muramatsu M., Lazo P.S., and Ramos S. Calmodulin is a selective modulator of estrogen receptors. Mol Endocrinol 16 (2002) 947-960
66. Dai J., Inscho E.W., Yuan L., and Hill S.M. Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells. J Pineal Res 32 (2002) 112-119
67. Del Rio B., García-Pedrero J.M., Martínez-Campa C., Zuazua P., Lazo P.S., and Ramos S. Melatonin: an endogenous specific inhibitor of estrogen receptor α via calmodulin. J Biol Chem 279 (2004) 38294-38302
68. Conley A., and Hinshelwood M. Mammalian aromatases. Reproduction 121 (2001) 685-695
69. Santen R.J., and Harvey H.A. Use of aromatase inhibitors in breast carcinoma. Endocr Relat Cancer 6 (1999) 75-92
70. Cos S., Martínez-Campa C., Mediavilla M.D., and Sänchez-Barceló E.J. Melatonin modulates aromatase activity in MCF-7 human breast cancer cells. J Pineal Res 38 (2005) 136-142
71. Cos S., González A., Güezmes A., Mediavilla M.D., Martínez-Campa C., Alonso-González C., et al. Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity. Int J Cancer 118 (2006) 274-278
72. Bulun S.E., Sebastian S., Takayama K., Suzuki T., Sasano H., and Shozu M. The human CYP 19 (aromatase p450) gene: update on physiologic roles and genomic organization of promoters. J Steroid Biochem Mol Biol 86 (2003) 219-224
73. Cardinali D.P., Bonanni Rey R.A., Mediavilla M.D., and Sánchez-Barceló E.J. Diurnal changes in cyclic nucleotide response to pineal indoles in murine mammary glands. J Pineal Res 13 (1992) 111-116