메뉴 건너뛰기




Volumn 17, Issue 14, 2008, Pages 1199-1202

Progress in research of pregnane X receptor and its effect on drug metabolism

Author keywords

CytochromeP450 3A; Drug metabolism; Pregnane X receptor (PXR)

Indexed keywords

ANTIBIOTIC AGENT; BILE ACID; CYTOCHROME P450 3A; HETERODIMER; PREGNANE X RECEPTOR; RETINOIC ACID RECEPTOR; STEROID; UNSPECIFIC MONOOXYGENASE; XENOBIOTIC AGENT;

EID: 77953461521     PISSN: 10033734     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (31)
  • 1
    • 77953371961 scopus 로고    scopus 로고
    • Chinese source
  • 3
    • 0036138199 scopus 로고    scopus 로고
    • Induction profile of rat organic anion transporting polypoptide 2 (oatp2 ) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways [J]
    • GUO GL,CHOUDHURI S,KIAASSEN CD. Induction profile of rat organic anion transporting polypoptide 2 (oatp2 ) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways [J]. J Pharmacol Exp Ther,2002,300(1) :206-212.
    • (2002) J Pharmacol Exp Ther , vol.300 , Issue.1 , pp. 206-212
    • Guo, G.L.1    Choudhuri, S.2    Kiaassen, C.D.3
  • 4
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor[J]
    • KAST HR, GOODWIN B, TARR PT, et al. Regulation of multidrug resistance associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor[J]. J Biol Chem,2002,277 (4) : 2908-2915.
    • (2002) J Biol Chem , vol.277 , Issue.4 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3
  • 5
    • 0036171965 scopus 로고    scopus 로고
    • Regulation of cyp3 a gene transcription by the pregnane x receptor [J]
    • GOODWIN B, REDINBO MR, KLIEWER SA. Regulation of cyp3 a gene transcription by the pregnane x receptor [J]. Annu Rev Pharmacol Toxicol, 2002,42(1) :1-23.
    • (2002) Annu Rev Pharmacol Toxicol , vol.42 , Issue.1 , pp. 1-23
    • Goodwin, B.1    Redinbo, M.R.2    Kliewer, S.A.3
  • 6
    • 0032498303 scopus 로고    scopus 로고
    • An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway[J]
    • KLIEWER SA, MOORE JT, WADE L, et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway[J]. Cell,1998,92(1) :73-82.
    • (1998) Cell , vol.92 , Issue.1 , pp. 73-82
    • Kliewer, S.A.1    Moore, J.T.2    Wade, L.3
  • 7
    • 0038210248 scopus 로고    scopus 로고
    • Nuclear receptors and the control of metabolism[J]
    • FRANCIS GA, fa YARD E.PICARD F, et al. Nuclear receptors and the control of metabolism[J]. Annu Rev Physiol, 2003,65 : 261-311.
    • (2003) Annu Rev Physiol , vol.65 , pp. 261-311
    • Francis, G.A.1    Fayard, E.2    Picard, F.3
  • 8
    • 17844396881 scopus 로고    scopus 로고
    • Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin[J]
    • CHRENCIK JE, ORANS J, LINDA B, et al. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin[J]. Mol Endocrinol,2005,19(5) : 1125-1134.
    • (2005) Mol Endocrinol , vol.19 , Issue.5 , pp. 1125-1134
    • Chrencik, J.E.1    Orans, J.2    Linda, B.3
  • 9
    • 0035933511 scopus 로고    scopus 로고
    • The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity[J]
    • WATKHINS RE, WISELY GB, MOORE LB, et al. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity[J]. Science, 2001,292(5525) :2329-2333.
    • (2001) Science , vol.292 , Issue.5525 , pp. 2329-2333
    • Watkhins, R.E.1    Wisely, G.B.2    Moore, L.B.3
  • 10
    • 0036136534 scopus 로고    scopus 로고
    • A pharmacophore for human pregnane X receptor ligands[J]
    • EKINS S, ERICKSON JA. A pharmacophore for human pregnane X receptor ligands[J]. Drug Metab Dispos, 2002,30(1) :96-99.
    • (2002) Drug Metab Dispos , vol.30 , Issue.1 , pp. 96-99
    • Ekins, S.1    Erickson, J.A.2
  • 11
    • 77953449646 scopus 로고    scopus 로고
    • Chinese source
  • 12
    • 77953473763 scopus 로고    scopus 로고
    • Chinese source
  • 13
    • 0037417994 scopus 로고    scopus 로고
    • Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance[J]
    • DUSSAULT I, YOO HD, LIN M, et al. Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance[J]. PNAS,2003,100 (3) :833-838.
    • (2003) PNAS , vol.100 , Issue.3 , pp. 833-838
    • Dussault, I.1    Yoo, H.D.2    Lin, M.3
  • 14
    • 0034685779 scopus 로고    scopus 로고
    • Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands[J]
    • MOORE LB, PARKS DJ, JONES SA, et al. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands[J]. J Biol Chem, 2000,275 (20) :15122-15127.
    • (2000) J Biol Chem , vol.275 , Issue.20 , pp. 15122-15127
    • Moore, L.B.1    Parks, D.J.2    Jones, S.A.3
  • 15
    • 0033638960 scopus 로고    scopus 로고
    • Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR[J]
    • XIE W, BARWICK JL, SIMON CM, et al. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR[J]. Genes Dev, 2000,14(23) :3014-3023
    • (2000) Genes Dev , vol.14 , Issue.23 , pp. 3014-3023
    • Xie, W.1    Barwick, J.L.2    Simon, C.M.3
  • 16
    • 33745830106 scopus 로고    scopus 로고
    • Pregnane X receptor is a target of farnesoid X receptor [J]
    • JUNG D, MANGELSDORF DJ, MEYER UA. Pregnane X receptor is a target of farnesoid X receptor [J]. J Biol Chem, 2006, 281(28) :19081-19091.
    • (2006) J Biol Chem , vol.281 , Issue.28 , pp. 19081-19091
    • Jung, D.1    Mangelsdorf, D.J.2    Meyer, U.A.3
  • 17
    • 0032807743 scopus 로고    scopus 로고
    • The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue [J]
    • DOTZLAW H, LEYGUE E, WATSON P, et al. The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue [J]. Clin Cancer Res, 1999,5(8) : 2103-2107.
    • (1999) Clin Cancer Res , vol.5 , Issue.8 , pp. 2103-2107
    • Dotzlaw, H.1    Leygue, E.2    Watson, P.3
  • 18
    • 33845970888 scopus 로고    scopus 로고
    • Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis [J]
    • ZHAI YG, PAI HV, ZHOU J, et al. Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis [J]. Mol Endocrinol, 2007,21 (1) : 138-147.
    • (2007) Mol Endocrinol , vol.21 , Issue.1 , pp. 138-147
    • Zhai, Y.G.1    Pai, H.V.2    Zhou, J.3
  • 19
    • 33744948052 scopus 로고    scopus 로고
    • A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway [J]
    • ZHOU J, ZHAI YG, MU Y, et al. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway [J]. J Biol Chem, 2006, 281 (21 ) : 15013-15020.
    • (2006) J Biol Chem , vol.281 , Issue.21 , pp. 15013-15020
    • Zhou, J.1    Zhai, Y.G.2    Mu, Y.3
  • 20
    • 24044526873 scopus 로고    scopus 로고
    • Perinatal lipopolysaccha-ride exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver [J]
    • XU DX,CHEN YH, WANG JP, et al. Perinatal lipopolysaccha-ride exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver [J]. Toxicol Sci, 2005, 87 (1) : 38-45.
    • (2005) Toxicol Sci , vol.87 , Issue.1 , pp. 38-45
    • Xu Dxchen, Y.H.1    Wang, J.P.2
  • 21
    • 0038650987 scopus 로고    scopus 로고
    • Nuclear receptor, pregname X receptor, is required for induction of UDP-glu-curonosyltranferases in mouse liver by pregnenolone-16 alpha-car-bonitrile [J]
    • CHEN C, STAUDINGER JL, KLAASSEN CD. Nuclear receptor, pregname X receptor, is required for induction of UDP-glu-curonosyltranferases in mouse liver by pregnenolone-16 alpha-car-bonitrile [J]. Drug Metab Dispos, 2003,31 (7) : 908-915.
    • (2003) Drug Metab Dispos , vol.31 , Issue.7 , pp. 908-915
    • Chen, C.1    Staudinger, J.L.2    Klaassen, C.D.3
  • 22
    • 77953367221 scopus 로고    scopus 로고
    • Chinese source
  • 23
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin [J]
    • GEICK A, EICHELBAUM M, BURK O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin [J].J Biol Chem, 2001,276(18) :14581-14587.
    • (2001) J Biol Chem , vol.276 , Issue.18 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 24
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux [J]
    • SYNOLD TW, DUSSAULT I, FORMAN BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux [J]. Nat Med, 2001,7(5):584-590.
    • (2001) Nat Med , vol.7 , Issue.5 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 25
    • 8844286879 scopus 로고    scopus 로고
    • CYP3A4 induction by xenobiotics: Biochemistry, experimental methods and impact on drug discovery and development [J]
    • LUO G, GUENTHNER T, GAN LS, et al. CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development [J]. Curr Drug Metab, 2004, 5 (6) :483-505.
    • (2004) Curr Drug Metab , vol.5 , Issue.6 , pp. 483-505
    • Luo, G.1    Guenthner, T.2    Gan, L.S.3
  • 26
    • 0035851148 scopus 로고    scopus 로고
    • Orphan nudear receptor;the exotics of xeno-biotics[J]
    • XIE W,EVANS RM. Orphan nudear receptor;the exotics of xeno-biotics[J]. J Biol Chem,2001,276(41) :37739-37742.
    • (2001) J Biol Chem , vol.276 , Issue.41 , pp. 37739-37742
    • Xie Wevans, R.M.1
  • 27
    • 0037303706 scopus 로고    scopus 로고
    • A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection [J]
    • SONODA J, ROSENFELD JM, XU L, et al. A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection [J]. Curr Drug Metab, 2003, 4 (1 ) : 59-72.
    • (2003) Curr Drug Metab , vol.4 , Issue.1 , pp. 59-72
    • Sonoda, J.1    Rosenfeld, J.M.2    Xu, L.3
  • 28
    • 0034676513 scopus 로고    scopus 로고
    • Use of the nuclear receptor PXR to predict drug interaction [J]
    • MOORE JT, KLIEWER SA. Use of the nuclear receptor PXR to predict drug interaction [J]. Toxicology, 2000, 153 (1/3) : 1-10.
    • (2000) Toxicology , vol.153 , Issue.1-3 , pp. 1-10
    • Moore, J.T.1    Kliewer, S.A.2
  • 29
    • 0035987895 scopus 로고    scopus 로고
    • CYP3A4 induction by drugs: Correlation between a pregnane X receptor reporter gene assay and CYP3A4 expressing in human hepatocytes [J]
    • [ 29] LUO G, CUNNINGHAM M, KIM S, et al. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expressing in human hepatocytes [J]. Drug Metab Dispos, 2002, 30(7) :795-804.
    • (2002) Drug Metab Dispos , vol.30 , Issue.7 , pp. 795-804
    • Luo, G.1    Cunningham, M.2    Kim, S.3
  • 30
    • 0036558204 scopus 로고    scopus 로고
    • Pharmaceutical use of mouse models humanized for the xenobiotic receptor [J]
    • XIE W, EVANS RM. Pharmaceutical use of mouse models humanized for the xenobiotic receptor [J]. Drug Discov Today, 2002, 7(9) :509-515.
    • (2002) Drug Discov Today , vol.7 , Issue.9 , pp. 509-515
    • Xie, W.1    Evans, R.M.2
  • 31
    • 77953417855 scopus 로고    scopus 로고
    • Chinese source


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.