Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function

Nucleic Acids Research

Volumn 31, Issue 8, 2003, Pages 2196-2208

  Zhang, Zhiping ^a   Teng, Christina T ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALPHOSTIN C; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOSINE; DNA; ERYTHROID KRUPPEL LIKE FACTOR; GUANOSINE; HISTONE ACETYLTRANSFERASE; HYBRID PROTEIN; PROTEIN KINASE C; BETA GALACTOSIDASE; CHLORAMPHENICOL ACETYLTRANSFERASE; CREBBP PROTEIN, HUMAN; KLF5 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; NUCLEAR PROTEIN; TRANSACTIVATOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GC RICH SEQUENCE; GENE FUNCTION; GENE MAPPING; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; WILD TYPE; ZINC FINGER MOTIF; ACETYLATION; BINDING SITE; CELL CULTURE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION;

ACETYLATION; BETA-GALACTOSIDASE; BINDING SITES; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CREB-BINDING PROTEIN; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0038137207     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg310     Document Type: Article

References (67)

1. Sogawa,K., Imataka,H., Yamasaki,Y., Kusume,H., Abe,H. and Fujii-Kuriyama,Y. (1993) cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res., 21, 1527-1532.
2. Shi,H., Zhang,Z., Wang,X., Liu,S. and Teng,C.T. (1999) Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. Nucleic Acids Res., 27, 4807-4815.
3. Conkright,M.D., Wani,M.A., Anderson,K.P. and Lingrel,J.B. (1999) A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res., 27, 1263-1270.
4. Turner,J. and Crossley,M. (1999) Mammalian Kruppel-like transcription factors: more than just a pretty finger. Trends Biochem. Sci., 24, 236-240.
5. Philipsen,S. and Suske,G. (1999) A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res., 27, 2991-3000.
6. Dang,D.T., Pevsner,J. and Yang,V.W. (2000) The biology of the mammalian Kruppel-like family of transcription factors. Int. J. Biochem. Cell Biol., 32, 1103-1121.
7. Bieker,J.J. (2001) Kruppel-like factors: three fingers in many pies. J. Biol. Chem., 276, 34355-34358.
8. Shindo,T., Manabe,I., Fukushima,Y., Tobe,K., Aizawa,K., Miyamoto,S., Kawai-Kowase,K., Moriyama,N., Imai,Y., Kawakami,H. et al. (2002) Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nature Med., 8, 856-863.
9. Ohnishi,S., Laub,F., Matsumoto,N., Asaka,M., Ramirez,F., Yoshida,T. and Terada,M. (2000) Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5. Dev. Dyn., 217, 421-429.
10. Sun,R., Chen,X. and Yang,V.W. (2001) Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation. J. Biol. Chem., 276, 6897-6900.
11. Adam,P.J., Regan,C.P., Hautmann,M.B. and Owens,G.K. (2000) Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. J. Biol. Chem., 275, 37798-37806.
12. Watanabe,N., Kurabayashi,M., Shimomura,Y., Kawai-Kowase,K., Hoshino,Y., Manabe,I., Watanabe,M., Aikawa,M., Kuro-o,M., Suzuki,T. et al. (1999) BTEB2, a Kruppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene. Circ. Res., 85, 182-191.
13. Sur,I., Unden,A.B. and Toftgard,R. (2002) Human Kruppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. Eur. J. Cell Biol., 81, 323-334.
14. Giles,R.H. (1998) Update CBP/p300 transgenic mice. Trends Genet., 14, 214.
15. Goodman,R.H. and Smolik,S. (2000) CBP/p300 in cell growth, transformation, and development. Genes Dev., 14, 1553-1577.
16. Janknecht,R. and Nordheim,A. (1996) Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene, 12, 1961-1969.
17. Chrivia,J.C., Kwok,R.P., Lamb,N., Hagiwara,M., Montminy,M.R. and Goodman,R.H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature, 365, 855-859.
18. Abraham,S.E., Lobo,S., Yaciuk,P., Wang,H.G. and Moran,E. (1993) p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes. Oncogene, 8, 1639-1647.
19. Kwok,R.P., Lundblad,J.R., Chrivia,J.C., Richards,J.P., Bachinger,H.P., Brennan,R.G., Roberts,S.G., Green,M.R. and Goodman,R.H. (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature, 370, 223-226.
20. Nakajima,T., Uchida,C., Anderson,S.F., Lee,C.G., Hurwitz,J., Parvin,J.D. and Montminy,M. (1997) RNA helicase A mediates association of CBP with RNA polymerase II. Cell, 90, 1107-1112.
21. Swope,D.L., Mueller,C.L. and Chrivia,J.C. (1996) CREB-binding protein activates transcription through multiple domains. J. Biol. Chem., 271, 28138-28145.
22. Chen,H., Lin,R.J., Schiltz,R.L., Chakravarti,D., Nash,A., Nagy,L., Privalsky,M.L., Nakatani,Y. and Evans,R.M. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell, 90, 569-580.
23. Kamei,Y., Xu,L., Heinzel,T., Torchia,J., Kurokawa,R., Gloss,B., Lin,S.C., Heyman,R.A., Rose,D.W., Glass,C.K. et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell, 85, 403-414.
24. Sheppard,K.A., Rose,D.W., Haque,Z.K., Kurokawa,R., McInerney,E., Westin,S., Thanos,D., Rosenfeld,M.G., Glass,C.K. and Collins,T. (1999) Transcriptional activation by NF-kappaB requires multiple coactivators. Mol. Cell. Biol., 19, 6367-6378.
25. Smith,C.L., Onate,S.A., Tsai,M.J. and O'Malley,B.W. (1996) CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proc. Natl Acad Sci. USA, 93, 8884-8888.
26. Yang,X.J., Ogryzko,V.V., Nishikawa,J., Howard,B.H. and Nakatani,Y. (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature, 382, 319-324.
27. Bannister,A.J. and Kouzarides,T. (1996) The CBP co-activator is a histone acetyltransferase. Nature, 384, 641-643.
28. Ogryzko,V.V., Schiltz,R.L., Russanova,V., Howard,B.H. and Nakatani,Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell, 87, 953-959.
29. Allfrey,V., Faulkner,R.M. and Mirsky,A.E. (1964) Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc. Natl Acad. Sci. USA, 51, 786-794.
30. Turner,B.M. (1998) Histone acetylation as an epigenetic determinant of long-term transcriptional competence. Cell Mol. Life Sci., 54, 21-31.
31. Zhang,W. and Bieker,J.J. (1998) Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc. Natl Acad. Sci. USA, 95, 9855-9860.
32. Hung,H.L., Lau,J., Kim,A.Y., Weiss,M.J. and Blobel,G.A. (1999) CREB-binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol. Cell. Biol., 19, 3496-3505.
33. Imhof,A., Yang,X.J., Ogryzko,V.V., Nakatani,Y., Wolffe,A.P. and Ge,H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol., 7, 689-692.
34. Gu,W. and Roeder,R.G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell, 90, 595-606.
35. Du,K., Asahara,H., Jhala,U.S., Wagner,B.L. and Montminy,M. (2000) Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol. Cell. Biol., 20, 4320-4327.
36. Hunter,T. and Karin,M. (1992) The regulation of transcription by phosphorylation. Cell, 70, 375-387.
37. Lambert,P.F., Kashanchi,F., Radonovich,M.F., Shiekhattar,R. and Brady,J.N. (1998) Phosphorylation of p53 serine 15 increases interaction with CBP. J. Biol. Chem., 273, 33048-33053.
38. Wang,H.G., Rikitake,Y., Carter,M.C., Yaciuk,P., Abraham,S.E., Zerler,B. and Moran,E. (1993) Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. J. Virol., 67, 476-488.
39. Shi,H. and Teng,C. (1996) Promoter-specific activation of mouse lactoferrin gene by epidermal growth factor involves two adjacent regulatory elements. Mol. Endocrinol., 10, 732-741.
40. Dang,D.T., Zhao,W., Mahatan,C.S., Geiman,D.E. and Yang,V.W. (2002) Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene. Nucleic Acids Res., 30, 2736-2741.
41. Kojima,S., Kobayashi,A., Gotoh,O., Ohkuma,Y., Fujii-Kuriyama,Y. and Sogawa,K. (1997) Transcriptional activation domain of human BTEB2, a CTC box-binding factor. J. Biochem., 121, 389-396.
42. Molinari,E., Gilman,M. and Natesan,S. (1999) Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo. EMBO J., 18, 6439-6447.
43. Salghetti,S.E., Muratani,M., Wijnen,H., Futcher,B. and Tansey,W.P. (2000) Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc. Natl Acad. Sci. USA, 97, 3118-3123.
44. Salghetti,S.E., Caudy,A.A., Chenoweth,J.G. and Tansey,W.P. (2001) Regulation of transcriptional activation domain function by ubiquitin. Science, 293, 1651-1653.
45. Tansey,W.P. (2001) Transcriptional activation: risky business. Genes Dev., 15, 1045-1050.
46. Natesan,S., Molinari,E., Rivera,V.M., Rickles,R.J. and Gilman,M. (1999) A general strategy to enhance the potency of chimeric transcriptional activators. Proc. Natl Acad. Sci. USA, 96, 13898-13903.
47. Ottosen,S., Herrera,F.J. and Triezenberg,S.J. (2002) Transcription. Proteasome parts at gene promoters. Science, 296, 479-481.
48. Bannister,A.J. and Kouzarides,T. (1995) CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J., 14, 4758-4762.
49. Kim,T.K., Kim,T.H. and Maniatis,T. (1998) Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. Proc. Natl Acad. Sci. USA, 95, 12191-12196.
50. Kraus,V.B., Moran,E. and Nevins,J.R. (1992) Promoter-specific transactivation by the adenovirus E1A12S product involves separate E1A domains. Mol. Cell. Biol., 12, 4391-4399.
51. Song,C.Z., Loewenstein,P.M., Toth,K. and Green,M. (1995) Transcription factor TFIID is a direct functional target of the adenovirus E1A transcription-repression domain. Proc. Natl Acad. Sci. USA, 92, 10330-10333.
52. Li,Q., Imhof,A., Collingwood,T.N., Urnov,F.D. and Wolffe,A.P. (1999) p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption. EMBO J., 18, 5634-5652.
53. Wolffe,A.P. and Hayes,J.J. (1999) Chromatin disruption and modification. Nucleic Acids Res., 27, 711-720.
54. Korzus,E., Torchia,J., Rose,D.W., Xu,L., Kurokawa,R., McInerney,E.M., Mullen,T.M., Glass,C.K. and Rosenfeld,M.G. (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science, 279, 703-707.
55. Martinez-Balbas,M.A., Bannister,A.J., Martin,K., Haus-Seuffert,P., Meisterernst,M. and Kouzarides,T. (1998) The acetyltransferase activity of CBP stimulates transcription. EMBO J., 17, 2886-2893.
56. Jarvis,W.D., Turner,A.J., Povirk,L.F., Traylor,R.S. and Grant,S. (1994) Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res., 54, 1707-1714.
57. Svetlov,S. and Nigam,S. (1993) Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation. Biochim. Biophys. Acta, 1177, 75-78.
58. Gjertsen,B.T., Mellgren,G., Otten,A., Maronde,E., Genieser,H.G., Jastorff,B., Vintermyr,O.K., McKnight,G.S. and Doskeland,S.O. (1995) Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. J. Biol. Chem., 270, 20599-20607.
59. Wadgaonkar,R., Phelps,K.M., Haque,Z., Williams,A.J., Silverman,E.S. and Collins,T. (1999) CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling. J. Biol. Chem., 274, 1879-1882.
60. Chen,X. and Bieker,J.J. (1996) Erythroid Kruppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J., 15, 5888-5896.
61. Geiman,D.E., Ton-That,H., Johnson,J.M. and Yang,V.W. (2000) Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Nucleic Acids Res., 28, 1106-1113.
62. Pandya,K., Donze,D. and Townes,T.M. (2001) Novel transactivation domain in erythroid Kruppel-like factor (EKLF). J. Biol. Chem., 276, 8239-8243.
63. Blobel,G.A. (2000) CREB-binding protein and p300: molecular integrators of hematopoietic transcription. Blood, 95, 745-755.
64. Parker,D., Ferreri,K., Nakajima,T., LaMorte,V.J., Evans,R., Koerber,S.C., Hoeger,C. and Montminy,M.R. (1996) Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol., 16, 694-703.
65. Cardinaux,J.R., Notis,J.C., Zhang,Q., Vo,N., Craig,J.C., Fass,D.M., Brennan,R.G. and Goodman,R.H. (2000) Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. Mol. Cell. Biol., 20, 1546-1552.
66. Oliner,J.D., Andresen,J.M., Hansen,S.K., Zhou,S. and Tjian,R. (1996) SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev., 10, 2903-2911.
67. Ouyang,L., Chen,X. and Bieker,J.J. (1998) Regulation of erythroid Kruppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain. J. Biol. Chem., 273, 23019-23025.