ESCRT & Co

Biology of the Cell

Volumn 102, Issue 5, 2010, Pages 293-318

  Roxrud, Ingrid ^a,b   Stenmark, Harald ^a,b   Malerød, Lene ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cell signalling; Cytokinesis; ESCRT; MVE biogenesis; Virus budding

Indexed keywords

MEMBRANE PROTEIN; PROTEIN ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT; UBIQUITIN; UNCLASSIFIED DRUG; ESCRT PROTEIN; FUNGAL PROTEIN; PROTEIN SUBUNIT; VESICULAR TRANSPORT PROTEIN;

CELL FUNCTION; CELL MOTILITY; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOKINESIS; CYTOSOL; ENDOSOME; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BIOLOGICAL TRANSPORT; CYTOKINESIS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; ENDOSOMES; FUNGAL PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; PROTEIN SUBUNITS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UBIQUITIN; VESICULAR TRANSPORT PROTEINS; VIRUSES;

EID: 77953101780     PISSN: 02484900     EISSN: 1768322X     Source Type: Journal    
DOI: 10.1042/BC20090161     Document Type: Review

References (255)

1. Abbas, T. and Dutta, A. (2009) p21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer 9, 400-414
2. Agromayor, M. and Martin-Serrano, J. (2006) Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo. J. Biol. Chem. 281, 23083-23091
3. Agromayor, M., Carlton, J.G., Phelan, J.P., Matthews, D.R., Carlin, L.M., Ameer-Beg, S., Bowers, K. and Martin-Serrano, J. (2009) Essential role of hIST1 in cytokinesis. Mol. Biol. Cell 20, 1374-1387
4. Alwan, H.A., van Zoelen, E.J. and van Leeuwen, J.E. (2003) Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasome-dependent EGFR de-ubiquitination. J. Biol. Chem. 278, 35781-35790
5. Amerik, A.Y., Nowak, J., Swaminathan, S. and Hochstrasser, M. (2000) The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways. Mol. Biol. Cell 11, 3365-3380
6. Amerik, A., Sindhi, N. and Hochstrasser, M. (2006) A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J. Cell Biol. 175, 825-835 (Pubitemid 44878514)
7. Amit, I., Yakir, L., Katz, M., Zwang, Y., Marmor, M.D., Citri, A., Shtiegman, K., Alroy, I., Tuvia, S., Reiss, Y., Roubini, E., Cohen, M., Wides, R., Bacharach, E., Schubert, U. and Yarden, Y. (2004) Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding. Genes Dev. 18, 1737-1752
8. Aniento, F., Emans, N., Griffiths, G. and Gruenberg, J. (1993) Cytoplasmic dynein-dependent vesicular transport from early to late endosomes. J. Cell Biol. 123, 1373-1387 (Pubitemid 24012018)
9. Aoh, Q.L., Castle, A.M., Hubbard, C.H., Katsumata, O. and Castle, J.D. (2009) SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. Mol. Biol. Cell 20, 1816-1832
10. Azmi, I., Davies, B., Dimaano, C., Payne, J., Eckert, D., Babst, M. and Katzmann, D.J. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J. Cell Biol. 172, 705-717
11. Azmi, I.F., Davies, B.A., Xiao, J., Babst, M., Xu, Z. and Katzmann, D.J. (2008) ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1. Dev. Cell 14, 50-61
12. *Babst, M., Katzmann, D.J., Estepa-Sabal, E.J., Meerloo, T. and Emr, S.D. (2002) ESCRT-III: an endosome-associated heterooligomeric protein complex required for MVB sorting. Dev. Cell 3, 271-282
13. Bache, K.G., Stuffers, S., Malerod, L., Slagsvold, T., Raiborg, C., Lechardeur, D., Walchli, S., Lukacs, G.L., Brech, A. and Stenmark, H. (2006) The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol. Biol. Cell 17, 2513-2523
14. Bajorek, M., Morita, E., Skalicky, J.J., Morham, S.G., Babst, M. and Sundquist, W.I. (2009) Biochemical analyses of human IST1 and its function in cytokinesis. Mol. Biol. Cell 20, 1360-1373
15. Batonick, M., Favre, M., Boge, M., Spearman, P., Honing, S. and Thali, M. (2005) Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2. Virology 342, 2, 190-200 (Pubitemid 41566652)
16. *Bieniasz, P.D. (2009) The cell biology of HIV-1 virion genesis. Cell Host Microbe 5, 550-558
17. Blot, V., Perugi, F., Gay, B., Prevost, M.C., Briant, L., Tangy, F., Abriel, H., Staub, O., Dokhelar, M.C. and Pique, C. (2004) Nedd4.1- mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. J. Cell Sci. 117, 2357-2367
18. Bouamr, F., Melillo, J.A., Wang, M.Q., Nagashima, K., de Los Santos, M., Rein, A. and Goff, S.P. (2003) PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. J. Virol. 77, 11882-11895 (Pubitemid 37339842)
19. Bowers, K., Lottridge, J., Helliwell, S.B., Goldthwaite, L.M., Luzio, J.P. and Stevens, T.H. (2004) Protein - protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae. Traffic 5, 194-210 (Pubitemid 38379938)
20. Bowers, K., Piper, S.C., Edeling, M.A., Gray, S.R., Owen, D.J., Lehner, P.J. and Luzio, J.P. (2006) Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. J. Biol. Chem. 281, 5094-5105
21. Boysen, J.H. and Mitchell, A.P. (2006) Control of Bro1-domain protein Rim20 localization by external pH, ESCRT machinery, and the Saccharomyces cerevisiae Rim101 pathway. Mol. Biol. Cell 17, 1344-1353
22. Bruce, E.A., Medcalf, L., Crump, C.M., Noton, S.L., Stuart, A.D., Wise, H.M., Elton, D., Bowers, K. and Digard, P. (2009) Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway. Virology 390, 268-278
23. Burgdorf, S., Leister, P. and Scheidtmann, K.H. (2004) TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination. J. Biol. Chem. 279, 17524-17534
24. Camus, G., Segura-Morales, C., Molle, D., Lopez-Verges, S., Begon-Pescia, C., Cazevieille, C., Schu, P., Bertrand, E., Berlioz-Torrent, C. and Basyuk, E. (2007) The clathrin adaptor complex AP-1 binds HIV-1 and MLV Gag and facilitates their budding. Mol. Biol. Cell 18, 3193-3203
25. Cantalupo, G., Alifano, P., Roberti, V., Bruni, C.B. and Bucci, C. (2001) Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J. 20, 683-693 (Pubitemid 32167633)
26. *Carlton, J.G. and Martin-Serrano, J. (2007) Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science 316, 1908-1912
27. Carlton, J., Bujny, M., Peter, B.J., Oorschot, V.M., Rutherford, A., Mellor, H., Klumperman, J., McMahon, H.T. and Cullen, P.J. (2004) Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides. Curr. Biol. 14, 1791-1800
28. Carlton, J.G., Agromayor, M. and Martin-Serrano, J. (2008) Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release. Proc. Natl. Acad. Sci. U.S.A. 105, 10541-10546
29. Carstens, M.J., Krempler, A., Triplett, A.A., Van Lohuizen, M. and Wagner, K.U. (2004) Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J. Biol. Chem 279, 35984-35994 (Pubitemid 39100606)
30. Chang, H.C., Newmyer, S.L., Hull, M.J., Ebersold, M., Schmid, S.L. and Mellman, I. (2002) Hsc70 is required for endocytosis and clathrin function in Drosophila. J. Cell Biol. 159, 477-487 (Pubitemid 35332834)
31. Chen, B.J. and Lamb, R.A. (2008) Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? Virology 372, 221-232
32. Chen, B.J., Leser, G.P., Morita, E. and Lamb, R.A. (2007) Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles. J. Virol. 81, 7111-7123 (Pubitemid 46986647)
33. Cheng, T.H. and Cohen, S.N. (2007) Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops. Mol. Cell. Biol. 27, 111-119
34. Chin, L.S., Raynor, M.C., Wei, X., Chen, H.Q. and Li, L. (2001) Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J. Biol. Chem. 276, 7069-7078
35. Chung, H.Y., Morita, E., von Schwedler, U., Muller, B., Krausslich, H.G. and Sundquist, W.I. (2008) NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type1 constructs lacking PTAP and YPXL late domains. J. Virol. 82, 4884-4897 (Pubitemid 351657050)
36. Corless, L., Crump, C., Griffin, S.D. and Harris, M. (2009) Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles. J. Gen. Virol. 91, 362-372
37. Coutts, A.S., Adams, C.J. and La Thangue, N.B. (2009) p53 ubiquitination by Mdm2: a never ending tail? DNA Repair 8, 483-490
38. de Melker, A.A., van der Horst, G., Calafat, J., Jansen, H. and Borst, J. (2001) c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. J. Cell Sci. 114, 2167-2178 (Pubitemid 32586641)
39. Dimaano, C., Jones, C.B., Hanono, A., Curtiss, M. and Babst, M. (2008) Ist1 regulates Vps4 localization and assembly. Mol. Biol. Cell 19, 465-474
40. Dong, X., Li, H., Derdowski, A., Ding, L., Burnett, A., Chen, X., Peters, T.R., Dermody, T.S., Woodruff, E., Wang, J.J. and Spearman, P. (2005) AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell 120, 663-674
41. Doyotte, A., Mironov, A., McKenzie, E. and Woodman, P. (2008) The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 105, 6308-6313
42. Driskell, O.J., Mironov, A., Allan, V.J. and Woodman, P.G. (2007) Dynein is required for receptor sorting and the morphogenesis of early endosomes. Nat. Cell Biol. 9, 113-120
43. Dukes, J.D., Richardson, J.D., Simmons, R. and Whitley, P. (2008) A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes. Biochem. J. 411, 233-239 (Pubitemid 351580175)
44. Dupre, S. and Haguenauer-Tsapis, R. (2001) Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase. Mol. Cell. Biol. 21, 4482-4494
45. Endo, K., Takeshita, T., Kasai, H., Sasaki, Y., Tanaka, N., Asao, H., Kikuchi, K., Yamada, M., Chenb, M., O'Shea, J.J. and Sugamura, K. (2000) STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Lett. 477, 55-61
46. Errico, A., Claudiani, P., D'Addio, M. and Rugarli, E.I. (2004) Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon. Hum. Mol. Genet. 13, 2121-2132
47. Fabbro, M., Zhou, B.B., Takahashi, M., Sarcevic, B., Lal, P., Graham, M.E., Gabrielli, B.G., Robinson, P.J., Nigg, E.A., Ono, Y. and Khanna, K.K. (2005) Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev. Cell 9, 477-488
48. Falguieres, T., Luyet, P.P. and Gruenberg, J. (2009) Molecular assemblies and membrane domains in multivesicular endosome dynamics. Exp. Cell Res. 315, 1567-1573
49. Feng, G.H., Lih, C.J. and Cohen, S.N. (2000) TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence. Cancer Res. 60, 1736-1741
50. Filimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerod, L., Fisher, E.M., Isaacs, A., Brech, A., Stenmark, H. and Simonsen, A. (2007) Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J. Cell Biol. 179, 485-500
51. Fujii, K., Hurley, J.H. and Freed, E.O. (2007) Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1. Nat. Rev. Microbiol. 5, 912-916
52. Fujita, H., Umezuki, Y., Imamura, K., Ishikawa, D., Uchimura, S., Nara, A., Yoshimori, T., Hayashizaki, Y., Kawai, J., Ishidoh, K., Tanaka, Y. and Himeno, M. (2004) Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. J. Cell Sci. 117, 2997-3009
53. Galindo, A., Hervas-Aguilar, A., Rodriguez-Galan, O., Vincent, O., Arst, Jr, H.N., Tilburn, J. and Penalva, M.A. (2007) PalC, one of two Bro1 domain proteins in the fungal pH signalling pathway, localizes to cortical structures and binds Vps32. Traffic 8, 1346-1364 (Pubitemid 47394240)
54. Garrus, J.E., von Schwedler, U.K., Pornillos, O.W., Morham, S.G., Zavitz, K.H., Wang, H.E., Wettstein, D.A., Stray, K.M., Cote, M., Rich, R.L., Myszka, D.G. and Sundquist, W.I. (2001) Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107, 55-65
55. Gruenberg, J. and Stenmark, H. (2004) The biogenesis of multivesicular endosomes. Nat. Rev. Mol. Cell Biol. 5, 317-323
56. Gullapalli, A., Garrett, T.A., Paing, M.M., Griffin, C.T., Yang, Y. and Trejo, J. (2004) A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol. Biol. Cell 15, 2143-2155
57. Gullapalli, A., Wolfe, B.L., Griffin, C.T., Magnuson, T. and Trejo, J. (2006) An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol. Biol. Cell 17, 1228-1238
58. Gurer, C., Berthoux, L. and Luban, J. (2005) Covalent modification of human immunodeficiency virus type1 p6 by SUMO-1. J. Virol. 79, 910-917 (Pubitemid 40053874)
59. Haglund, K. and Dikic, I. (2005) Ubiquitylation and cell signalling. EMBO J. 24, 19, 3353-9
60. Hanson, P.I., Shim, S. and Merrill, S.A. (2009) Cell biology of the ESCRT machinery. Curr. Opin. Cell Biol. 21, 568-574
61. Hanyaloglu, A.C., McCullagh, E. and von Zastrow, M. (2005) Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signalling. EMBO J. 24, 2265-2283 (Pubitemid 41032580)
62. Hasdemir, B., Bunnett, N.W. and Cottrell, G.S. (2007) Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor. J. Biol. Chem. 282, 29646-29657
63. Hayes, S., Chawla, A. and Corvera, S. (2002) TGF β receptor internalization into EEA1-enriched early endosomes: role in signalling to Smad2. J. Cell Biol. 158, 1239-1249
64. Herrador, A., Herranz, S., Lara, D. and Vincent, O. (2009) Recruitment of the ESCRT machinery to a putative seven-transmembranedomain receptor is mediated by an arrestin-related protein. Mol. Cell Biol. 30, 897-907
65. Hirano, S., Kawasaki, M., Ura, H., Kato, R., Raiborg, C., Stenmark, H. and Wakatsuki, S. (2006) Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat. Struct. Mol. Biol. 13, 272-277
66. Hislop, J.N., Marley, A. and Von Zastrow, M. (2004) Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes. J. Biol. Chem. 279, 22522-22531
67. Hittelman, A.B., Burakov, D., Iniguez-Lluhi, J.A., Freedman, L.P. and Garabedian, M.J. (1999) Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J. 18, 5380-5388 (Pubitemid 29465587)
68. Hoeller, D., Crosetto, N., Blagoev, B., Raiborg, C., Tikkanen, R., Wagner, S., Kowanetz, K., Breitling, R., Mann, M., Stenmark, H. and Dikic, I. (2006) Regulation of ubiquitin-binding proteins by monoubiquitination. Nat. Cell Biol. 8, 163-169
69. Hoepfner, S., Severin, F., Cabezas, A., Habermann, B., Runge, A., Gillooly, D., Stenmark, H. and Zerial, M. (2005) Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell 121, 437-450
70. Hofmann, K. and Falquet, L. (2001) A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem. Sci. 26, 347-350
71. Huang, S.H., Zhao, L., Sun, Z.P., Li, X.Z., Geng, Z., Zhang, K.D., Chao, M.V. and Chen, Z.Y. (2009) Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1. J. Biol. Chem. 284, 15126-15136
72. Hurley, J.H., Im, Y.J., Lee, H.H., Ren, X., Wollert, T. and Yang, D. (2009) Piecing together the ESCRTs. Biochem. Soc. Trans. 37, 161-166
73. Ichioka, F., Takaya, E., Suzuki, H., Kajigaya, S., Buchman, V.L., Shibata, H. and Maki, M. (2007) HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions. Arch. Biochem. Biophys. 457, 142-149
74. Irion, U. and St Johnston, D. (2007) bicoid RNA localization requires specific binding of an endosomal sorting complex. Nature 445, 554-558
75. Ismaili, N., Blind, R. and Garabedian, M.J. (2005) Stabilization of the unliganded glucocorticoid receptor by TSG101. J. Biol. Chem. 280, 11120-11126
76. Itoh, F., Divecha, N., Brocks, L., Oomen, L., Janssen, H., Calafat, J., Itoh, S. and Dijke Pt, P. (2002) The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-β/Smad signalling. Genes Cells 7, 321-331
77. Jiao, J., Sun, K., Walker, W.P., Bagher, P., Cota, C.D. and Gunn, T.M. (2009) Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. Biochim. Biophys. Acta 1792, 1027-1035
78. Jin, Y., Mancuso, J.J., Uzawa, S., Cronembold, D. and Cande, W.Z. (2005) The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification. Dev. Cell 9, 63-73
79. Johnstone, R.W., Gerber, M., Landewe, T., Tollefson, A., Wold, W.S. and Shilatifard, A. (2001) Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survival. Mol. Cell. Biol. 21, 1672-1681
80. Jordens, I., Fernandez-Borja, M., Marsman, M., Dusseljee, S., Janssen, L., Calafat, J., Janssen, H., Wubbolts, R. and Neefjes, J. (2001) The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein - dynactin motors. Curr. Biol. 11, 1680-1685
81. Joshi, A., Ablan, S.D., Soheilian, F., Nagashima, K. and Freed, E.O. (2009) Evidence that productive human immunodeficiency virus type1 assembly can occur in an intracellular compartment. J. Virol. 83, 5375-5387
82. Kamura, T., Burian, D., Khalili, H., Schmidt, S.L., Sato, S., Liu, W.J., Conrad, M.N., Conaway, R.C., Conaway, J.W. and Shilatifard, A. (2001) Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. J. Biol. Chem. 276, 16528-16533
83. Kantamneni, S., Holman, D., Wilkinson, K.A., Correa, S.A., Feligioni, M., Ogden, S., Fraser, W., Nishimune, A. and Henley, J.M. (2008) GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation. J. Neurochem. 107, 86-95
84. Kantamneni, S., Holman, D., Wilkinson, K.A., Nishimune, A. and Henley, J.M. (2009) GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation. Neurosci. Lett. 452, 106-110
85. Kato, M., Miyazawa, K. and Kitamura, N. (2000) A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. J. Biol. Chem. 275, 37481-37487
86. 2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B. Biochem. J. 391, 677-685
87. Katz, M., Shtiegman, K., Tal-Or, P., Yakir, L., Mosesson, Y., Harari, D., Machluf, Y., Asao, H., Jovin, T., Sugamura, K. and Yarden, Y. (2002) Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4. Traffic 3, 740-751
88. Kikonyogo, A., Bouamr, F., Vana, M.L., Xiang, Y., Aiyar, A., Carter, C. and Leis, J. (2001) Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells. Proc. Natl. Acad. Sci. U.S.A. 98, 11199-11204
89. Kim, J., Sitaraman, S., Hierro, A., Beach, B.M., Odorizzi, G. and Hurley, J.H. (2005) Structural basis for endosomal targeting by the Bro1 domain. Dev. Cell 8, 937-947
90. Kim, G.H., Park, E., Kong, Y.Y. and Han, J.K. (2006) Novel function of POSH, a JNK scaffold, as an E3 ubiquitin ligase for the Hrs stability on early endosomes. Cell. Signal. 18, 553-563
91. Kim, B.Y., Olzmann, J.A., Barsh, G.S., Chin, L.S. and Li, L. (2007a) Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol. Biol. Cell 18, 1129-1142
92. Kim, H.J., Taylor, L.J. and Bar-Sagi, D. (2007b) Spatial regulation of EGFR signalling by Sprouty2. Curr. Biol. 17, 455-461
93. Kirk, E., Chin, L.S. and Li, L. (2006) GRIF1 binds Hrs and is a new regulator of endosomal trafficking. J. Cell Sci. 119, 4689-4701
94. Kong, C., Su, X., Chen, P.I. and Stahl, P.D. (2007) Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. J. Biol. Chem. 282, 15294-15301
95. Kostelansky, M.S., Schluter, C., Tam, Y.Y., Lee, S., Ghirlando, R., Beach, B., Conibear, E. and Hurley, J.H. (2007) Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell 129, 485-498
96. Krempler, A., Henry, M.D., Triplett, A.A. and Wagner, K.U. (2002) Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death. J. Biol. Chem. 277, 43216-43223
97. Kunda, P. and Baum, B. (2009) The actin cytoskeleton in spindle assembly and positioning. Trends Cell Biol. 19, 174-179
98. Kurten, R.C., Cadena, D.L. and Gill, G.N. (1996) Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science 272, 1008-1010
99. 2+-dependent exocytosis. J. Cell Sci. 113, 2273-2284
100. Langelier, C., von Schwedler, U.K., Fisher, R.D., De Domenico, I., White, P.L., Hill, C.P., Kaplan, J., Ward, D. and Sundquist, W.I. (2006) Human ESCRT-II complex and its role in human immunodeficiency virus type1 release. J. Virol. 80, 9465-9480
101. Lee, J.A. (2009) Autophagy in neurodegeneration: two sides of the same coin. BMB Rep. 42, 324-330
102. Lee, J.A., Beigneux, A., Ahmad, S.T., Young, S.G. and Gao, F.B. (2007) ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr. Biol. 17, 1561-1567
103. Lee, H.H., Elia, N., Ghirlando, R., Lippincott-Schwartz, J. and Hurley, J.H. (2008) Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science 322, 576-580
104. *Li, L. and Cohen, S.N. (1996) Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell 85, 319-329
105. Li, L., Liao, J., Ruland, J., Mak, T.W. and Cohen, S.N. (2001) A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Proc. Natl. Acad. Sci. U.S.A. 98, 1619-1624
106. Li, Y., Chin, L.S., Levey, A.I. and Li, L. (2002) Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J. Biol. Chem. 277, 28212-28221
107. Longva, K.E., Blystad, F.D., Stang, E., Larsen, A.M., Johannessen, L.E. and Madshus, I.H. (2002) Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies. J. Cell Biol. 156, 843-854
108. Lottridge, J.M., Flannery, A.R., Vincelli, J.L. and Stevens, T.H. (2006) Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc. Natl. Acad. Sci. U.S.A. 103, 6202-6207
109. Lu, Q., Hope, L.W., Brasch, M., Reinhard, C. and Cohen, S.N. (2003) TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. Proc. Natl. Acad. Sci. U.S.A. 100, 7626-7631
110. Luhtala, N. and Odorizzi, G. (2004) Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes. J. Cell Biol. 166, 717-729
111. Magnifico, A., Ettenberg, S., Yang, C., Mariano, J., Tiwari, S., Fang, S., Lipkowitz, S. and Weissman, A.M. (2003) WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J. Biol. Chem. 278, 43169-43177
112. Mahul-Mellier, A.L., Hemming, F.J., Blot, B., Fraboulet, S. and Sadoul, R. (2006) Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. J. Neurosci. 26, 542-549
113. Mahul-Mellier, A.L., Strappazzon, F., Chatellard-Causse, C., Blot, B., Beal, D., Torch, S., Hemming, F., Petiot, A., Verna, J.M., Fraboulet, S. and Sadoul, R. (2009) Alix and ALG-2 make a link between endosomes and neuronal death. Biochem. Soc. Trans. 37, 200-203
114. Malerod, L., Stuffers, S., Brech, A. and Stenmark, H. (2007) Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. Traffic 8, 1617-1629
115. Marchese, A. and Benovic, J.L. (2001) Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J. Biol. Chem. 276, 45509-45512
116. Marchese, A., Raiborg, C., Santini, F., Keen, J.H., Stenmark, H. and Benovic, J.L. (2003) The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev. Cell 5, 709-722
117. Martinez-Garay, I., Rustom, A., Gerdes, H.H. and Kutsche, K. (2006) The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. Genomics 87, 243-253
118. Mathews, A., Holland, L. and Yankulov, K. (2009) The interaction between EAP30 and ELL is modulated by MCM2. FEBS Lett. 583, 3431-3436
119. Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Faure, J., Blanc, N.S., Matile, S., Dubochet, J., Sadoul, R., Parton, R.G., Vilbois, F. and Gruenberg, J. (2004) Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 303, 4531-534
120. McCullough, J., Clague, M.J. and Urbe, S. (2004) AMSH is an endosome-associated ubiquitin isopeptidase. J. Cell Biol. 166, 487-492
121. McCullough, J., Row, P.E., Lorenzo, O., Doherty, M., Beynon, R., Clague, M.J. and Urbe, S. (2006) Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr. Biol. 16, 160-165
122. McDonald, B. and Martin-Serrano, J. (2008) Regulation of Tsg101 expression by the steadiness box: a role of Tsg101-associated ligase. Mol. Biol. Cell 19, 754-763
123. Missotten, M., Nichols, A., Rieger, K. and Sadoul, R. (1999) Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. Cell Death Differ. 6, 124-129 (Pubitemid 29082300)
124. Mitani, K., Yamagata, T., Iida, C., Oda, H., Maki, K., Ichikawa, M., Asai, T., Honda, H., Kurokawa, M. and Hirai, H. (2000) Nonredundant roles of the elongation factor MEN in postimplantation development. Biochem. Biophys. Res. Commun. 279, 563-567
125. Miura, S., Takeshita, T., Asao, H., Kimura, Y., Murata, K., Sasaki, Y., Hanai, J.I., Beppu, H., Tsukazaki, T., Wrana, J.L., Miyazono, K. and Sugamura, K. (2000) Hgs (Hrs), a FYVE domain protein, is involved in Smad signalling through cooperation with SARA. Mol. Cell. Biol. 20, 9346-9355
126. Mizuno, E., Kawahata, K., Kato, M., Kitamura, N. and Komada, M. (2003) STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mol. Biol. Cell 14, 3675-3689
127. Mizuno, E., Kobayashi, K., Yamamoto, A., Kitamura, N. and Komada, M. (2006) A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Traffic 7, 1017-1031
128. Moberg, K.H., Schelble, S., Burdick, S.K. and Hariharan, I.K. (2005) Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev. Cell 9, 699-710 (Pubitemid 41555151)
129. *Morita, E., Sandrin, V., Chung, H.Y., Morham, S.G., Gygi, S.P., Rodesch, C.K. and Sundquist, W.I. (2007) Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 26, 4215-4227
130. Morvan, J., Froissard, M., Haguenauer-Tsapis, R. and Urban-Grimal, D. (2004) The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodies. Traffic 5, 383-392 (Pubitemid 38660204)
131. Mullins, J.M. and Biesele, J.J. (1977) Terminal phase of cytokinesis in D-98s cells. J. Cell Biol. 73, 672-684
132. Murdaca, J., Treins, C., Monthouel-Kartmann, M.N., Pontier-Bres, R., Kumar, S., Van Obberghen, E. and Giorgetti-Peraldi, S. (2004) Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J. Biol. Chem. 279, 26754-26761
133. Muromoto, R., Sugiyama, K., Takachi, A., Imoto, S., Sato, N., Yamamoto, T., Oritani, K., Shimoda, K. and Matsuda, T. (2004a) Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. J. Immunol. 172, 2985-2993
134. Muromoto, R., Sugiyama, K., Yamamoto, T., Oritani, K., Shimoda, K. and Matsuda, T. (2004b) Physical and functional interactions between Daxx and TSG101. Biochem. Biophys. Res. Commun. 316, 827-833
135. Nair, S.S., Mishra, S.K., Yang, Z., Balasenthil, S., Kumar, R. and Vadlamudi, R.K. (2004) Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells. Cancer Res. 64, 6416-6423 (Pubitemid 39297895)
136. Nakamura, M., Tanaka, N., Kitamura, N. and Komada, M. (2006) Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. Genes Cells 11, 593-606 (Pubitemid 43744810)
137. Newmyer, S.L. and Schmid, S.L. (2001) Dominant-interfering Hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo. J. Cell Biol. 152, 607-620
138. Nickerson, D.P., West, M. and Odorizzi, G. (2006) Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes. J. Cell Biol. 175, 715-720 (Pubitemid 44878504)
139. Nikko, E. and Andre, B. (2007) Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway. Traffic 8, 566-581 (Pubitemid 46646205)
140. Obsilova, V., Silhan, J., Boura, E., Teisinger, J. and Obsil, T. (2008) 14-3-3 proteins: a family of versatile molecular regulators. Physiol. Res. 57, (Suppl. 3), S11-S21
141. Odorizzi, G., Katzmann, D.J., Babst, M., Audhya, A. and Emr, S.D. (2003) Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J. Cell Sci. 116, 1893-1903 (Pubitemid 36622288)
142. Cip1/WAF1. Proc. Natl. Acad. Sci. U.S.A. 99, 5430-5435
143. 2+-dependent adaptor that bridges Alix and TSG101. Biochem. Biophys. Res. Commun. 386, 237-241
144. Gag protein of Moloney murine leukemia virus. J. Virol. 72, 2962-2968
145. Ott, D.E., Coren, L.V., Chertova, E.N., Gagliardi, T.D. and Schubert, U. (2000) Ubiquitination of HIV-1 and MuLV Gag. Virology 278, 111-121
146. Panopoulou, E., Gillooly, D.J., Wrana, J.L., Zerial, M., Stenmark, H., Murphy, C. and Fotsis, T. (2002) Early endosomal regulation of Smad-dependent signalling in endothelial cells. J. Biol. Chem. 277, 18046-18052
147. Papa, F.R. and Hochstrasser, M. (1993) The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature 366, 313-319
148. Pascual-Le Tallec, L., Simone, F., Viengchareun, S., Meduri, G., Thirman, M.J. and Lombes, M. (2005) The elongation factor ELL (eleven-nineteen lysine-rich leukemia) is a selective coregulator for steroid receptor functions. Mol. Endocrinol. 19, 1158-1169
149. Passananti, C., Floridi, A. and Fanciulli, M. (2007) Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Biochem. Cell Biol. 85, 477-483
150. Patnaik, A., Chau, V. and Wills, J.W. (2000) Ubiquitin is part of the retrovirus budding machinery. Proc. Natl. Acad. Sci. U.S.A. 97, 3069-3074
151. Pawliczek, T. and Crump, C.M. (2009) Herpes simplex virus type-1 production requires a functional ESCRT-III complex, but is independent of TSG101 and/or ALIX expression. J. Virol. 83, 11254-11264
152. Penalva, M.A., Tilburn, J., Bignell, E. and Arst, Jr, H.N. (2008) Ambient pH gene regulation in fungi: making connections. Trends Microbiol. 16, 291-300
153. Petiot, A., Strappazzon, F., Chatellard-Causse, C., Blot, B., Torch, S., Verna, J.M. and Sadoul, R. (2008) Alix differs from ESCRT proteins in the control of autophagy. Biochem. Biophys. Res. Commun. 375, 63-68
154. Pincetic, A., Medina, G., Carter, C. and Leis, J. (2008) Avian sarcoma virus and human immunodeficiency virus, type1 use different subsets of ESCRT proteins to facilitate the budding process. J. Biol. Chem. 283, 29822-29830
155. Polo, S., Sigismund, S., Faretta, M., Guidi, M., Capua, M.R., Bossi, G., Chen, H., De Camilli, P. and Di Fiore, P.P. (2002) A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416, 451-455
156. Pornillos, O., Alam, S.L., Rich, R.L., Myszka, D.G., Davis, D.R. and Sundquist, W.I. (2002) Structure and functional interactions of the Tsg101 UEV domain. EMBO J. 21, 2397-2406 (Pubitemid 34546712)
157. Pridgeon, J.W., Webber, E.A., Sha, D., Li, L. and Chin, L.S. (2009) Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signalling in multiple cellular processes. FEBS J. 276, 118-131
158. Progida, C., Spinosa, M.R., De Luca, A. and Bucci, C. (2006) RILP interacts with the VPS22 component of the ESCRT-II complex. Biochem. Biophys. Res. Commun. 347, 1074-1079
159. Progida, C.,Malerod, L., Stuffers, S., Brech, A., Bucci, C. and Stenmark, H. (2007) RILP is required for the proper morphology and function of late endosomes. J. Cell Sci. 120, 3729-3737 (Pubitemid 350187355)
160. Puffer, B.A., Watkins, S.C. and Montelaro, R.C. (1998) Equine infectious anemia virus Gag polyprotein late domain specifically recruits cellular AP-2 adapter protein complexes during virion assembly. J. Virol. 72, 10218-10221
161. Putterman, D., Pepinsky, R.B. and Vogt, V.M. (1990) Ubiquitin in avian leukosis virus particles. Virology 176, 633-637 (Pubitemid 20177055)
162. *Raiborg, C. and Stenmark, H. (2009) The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458, 445-452
163. Raiborg, C., Bache, K.G., Mehlum, A., Stang, E. and Stenmark, H. (2001) Hrs recruits clathrin to early endosomes. EMBO J. 20, 5008-5021
164. *Raiborg, C., Bache, K.G., Gillooly, D.J., Madshus, I.H., Stang, E. and Stenmark, H. (2002) Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat. Cell Biol. 4, 394-398
165. Raiborg, C., Wesche, J., Malerod, L. and Stenmark, H. (2006) Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains. J. Cell Sci. 119, 2414-2424
166. Raiborg, C., Malerod, L., Pedersen, N.M. and Stenmark, H. (2008) Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Exp. Cell Res. 314, 801-813
167. Rayala, S.K., Hollander, P., Balasenthil, S., Molli, P.R., Bean, A.J., Vadlamudi, R.K., Wang, R.A. and Kumar, R. (2006) Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK. J. Biol. Chem., 281, 4395-4403
168. Razi, M. and Futter, C.E. (2006) Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Mol. Biol. Cell 17, 3469-3483
169. Reid, E., Connell, J., Edwards, T.L., Duley, S., Brown, S.E. and Sanderson, C.M. (2005) The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. Hum. Mol. Genet. 14, 19-38
170. Ren, J., Kee, Y., Huibregtse, J.M. and Piper, R.C. (2007) Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. Mol. Biol. Cell 18, 324-335
171. Ren, J., Pashkova, N., Winistorfer, S. and Piper, R.C. (2008) DOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies. J. Biol. Chem., 283, 21599-21611
172. Reynwar, B.J., Illya, G., Harmandaris, V.A., Muller, M.M., Kremer, K. and Deserno, M. (2007) Aggregation and vesiculation of membrane proteins by curvature-mediated interactions. Nature 447, 461-464
173. Richter, C., West, M. and Odorizzi, G. (2007) Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies. EMBO J. 26, 2454-2464
174. Rismanchi, N., Puertollano, R. and Blackstone, C. (2009) STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. Traffic 10, 201-217
175. Rodriguez-Galan, O., Galindo, A., Hervas-Aguilar, A., Arst, Jr, H.N. and Penalva, M.A. (2009) Physiological involvement in pH signalling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III. J. Biol. Chem., 284, 4404-4412
176. Ross, J.L., Ali, M.Y. and Warshaw, D.M. (2008) Cargo transport: molecular motors navigate a complex cytoskeleton. Curr. Opin. Cell Biol., 20, 41-47
177. Rotin, D. and Kumar, S. (2009) Physiological functions of the HECT family of ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 10, 398-409
178. Rountree, M.R., Bachman, K.E. and Baylin, S.B. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet., 25, 269-277
179. Row, P.E., Prior, I.A., McCullough, J., Clague, M.J. and Urbe, S. (2006) The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. J. Biol. Chem., 281, 12618-12624
180. Row, P.E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., Clague, M.J., Sanderson, C.M. and Urbe, S. (2007) The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J. Biol. Chem., 282, 30929-30937
181. Roxrud, I., Raiborg, C., Pedersen, N.M., Stang, E. and Stenmark, H. (2008) An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor. J. Cell Biol. 180, 1205-1218
182. Rue, S.M., Mattei, S., Saksena, S. and Emr, S.D. (2008) Novel Ist1 - Did2 complex functions at a late step in multivesicular body sorting. Mol. Biol. Cell 19, 475-484
183. Ruland, J., Sirard, C., Elia, A., MacPherson, D., Wakeham, A., Li, L., de la Pompa, J.L., Cohen, S.N. and Mak, T.W. (2001) p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc. Natl. Acad. Sci. U.S.A. 98, 1859-1864
184. Rusten, T.E. and Simonsen, A. (2008) ESCRT functions in autophagy and associated disease. Cell Cycle 7, 1166-1172
185. Rusten, T.E. and Stenmark, H. (2009) How do ESCRT proteins control autophagy? J. Cell Sci. 122, 2179-2183
186. Sachse, M., Urbe, S., Oorschot, V., Strous, G.J. and Klumperman, J. (2002) Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes. Mol. Biol. Cell 13, 1313-1328
187. Saifi, G.M., Szigeti, K., Wiszniewski, W., Shy, M.E., Krajewski, K., Hausmanowa-Petrusewicz, I., Kochanski, A., Reeser, S., Mancias, P., Butler, I. and Lupski, J.R. (2005) SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. Hum. Mutat. 25, 372-383
188. *Saksena, S., Wahlman, J., Teis, D., Johnson, A.E and and Emr, S. (2009) Functional Reconstitution of ESCRT-III Assembly and Disassembly. Cell 136, 97-109
189. Salinas, S., Carazo-Salas, R.E., Proukakis, C., Schiavo, G. and Warner, T.T. (2007) Spastin and microtubules: functions in health and disease. J. Neurosci. Res. 85, 12, 2778-82
190. Salomoni, P. and Khelifi, A.F. (2006) Daxx: death or survival protein? Trends. Cell Biol. 16, 97-104
191. Sasaki, Y. and Sugamura, K. (2001) Involvement of Hgs/Hrs in signalling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1. J. Biol. Chem., 276, 29943-29952
192. Satoh, J., Nanri, Y. and Yamamura, T. (2006) Rapid identification of 14-3-3-binding proteins by protein microarray analysis. J. Neurosci. Methods 152, 278-288
193. Schmidt, A.E., Miller, T., Schmidt, S.L., Shiekhattar, R. and Shilatifard, A. (1999) Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II. J. Biol. Chem., 274, 21981-21985
194. Scoles, D.R., Huynh, D.P., Chen, M.S., Burke, S.P., Gutmann, D.H. and Pulst, S.M. (2000) The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. Hum. Mol. Genet. 9, 1567-1574
195. Scoles, D.R., Qin, Y., Nguyen, V., Gutmann, D.H. and Pulst, S.M. (2005) HRS inhibits EGF receptor signalling in the RT4 rat schwannoma cell line. Biochem. Biophys. Res. Commun. 335, 385-392
196. Scott, A., Chung, H.Y., Gonciarz-Swiatek, M., Hill, G.C., Whitby, F.G., Gaspar, J., Holton, J.M., Viswanathan, R., Ghaffarian, S., Hill, C.P. and Sundquist, W.I. (2005a) Structural and mechanistic studies of VPS4 proteins. EMBO J., 24, 3658-3669
197. Scott, A., Gaspar, J., Stuchell-Brereton, M.D., Alam, S.L., Skalicky, J.J. and Sundquist, W.I. (2005b) Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. Proc. Natl. Acad. Sci. U.S.A. 102, 13813-13818
198. Shields, S.B., Oestreich, A.J., Winistorfer, S., Nguyen, D., Payne, J.A., Katzmann, D.J. and Piper, R. (2009) ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting. J. Cell Biol. 185, 213-224
199. Shiflett, S.L., Ward, D.M., Huynh, D., Vaughn, M.B., Simmons, J.C. and Kaplan, J. (2004) Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J. Biol. Chem., 279, 10982-10990
200. Shih, S.C., Katzmann, D.J., Schnell, J.D., Sutanto, M., Emr, S.D. and Hicke, L. (2002) Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat. Cell Biol. 4, 389-393
201. Shirk, A.J., Anderson, S.K., Hashemi, S.H., Chance, P.F. and Bennett, C.L. (2005) SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J. Neurosci. Res. 82, 43-50
202. *Shilatifard, A. (1998) Identification and Purification of the HOLO-ELL Complex. J. Biol. Chem. 273, 11212-11217
203. Singleton, D.R., Wu, T.T. and Castle, J.D. (1997) Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. J. Cell Sci. 110, 2099-2107
204. Slagsvold, T., Aasland, R., Hirano, S., Bache, K.G., Raiborg, C., Trambaiano, D., Wakatsuki, S. and Stenmark, H. (2005) Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J. Biol. Chem., 280, 19600-19606
205. Slagsvold, T., Pattni, K., Malerod, L. and Stenmark, H. (2006) Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol. 16, 317-326
206. Spitzer, C., Schellmann, S., Sabovljevic, A., Shahriari, M., Keshavaiah, C., Bechtold, N., Herzog, M., Muller, S., Hanisch, F.G. and Hulskamp, M. (2006) The Arabidopsis elch mutant reveals functions of an ESCRT component in cytokinesis. Development 133, 4679-4689
207. Stasyk, T., Schiefermeier, N., Skvortsov, S., Zwierzina, H., Peranen, J., Bonn, G.K. and Huber, L.A. (2007) Identification of endosomal epidermal growth factor receptor signalling targets by functional organelle proteomics. Mol. Cell Proteomics 6, 908-922
208. Strack, B., Calistri, A., Accola, M.A., Palu, G. and Gottlinger, H.G. (2000) A role for ubiquitin ligase recruitment in retrovirus release. Proc. Natl. Acad. Sci. U.S.A. 97, 13063-13068
209. Strack, B., Calistri, A., Craig, S., Popova, E. and Gottlinger, H.G. (2003) AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell 114, 689-699 (Pubitemid 37186765)
210. *Stuffers, S., Brech, A. and Stenmark, H. (2009) ESCRT proteins in physiology and disease. Exp. Cell Res. 315, 1619-1626
211. Sun, Z., Pan, J., Hope, W.X., Cohen, S.N. and Balk, S.P. (1999) Tumor susceptibility gene 101 protein represses androgenreceptor transactivation and interacts with p300. Cancer 86, 689-696 (Pubitemid 29379416)
212. Sun, W., Yan, Q., Vida, T.A. and Bean, A.J. (2003) Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex. J. Cell Biol. 162, 125-137 (Pubitemid 36859540)
213. Svedruzic, Z.M. (2008) Mammalian cytosine DNA methyltransferase Dnmt1: enzymatic mechanism, novel mechanism-based inhibitors, and RNA-directed DNA methylation. Curr. Med. Chem. 15, 92-106
214. Takeshita, T., Arita, T., Asao, H., Tanaka, N., Higuchi, M., Kuroda, H., Kaneko, K., Munakata, H., Endo, Y., Fujita, T. and Sugamura, K. (1996) Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. Biochem. Biophys. Res. Commun., 225, 1035-1039
215. Takeshita, T., Arita, T., Higuchi, M., Asao, H., Endo, K., Kuroda, H., Tanaka, N., Murata, K., Ishii, N. and Sugamura, K. (1997) STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signalling for cell growth and c-myc induction. Immunity 6, 449-457
216. Tamai, K., Toyoshima, M., Tanaka, N., Yamamoto, N., Owada, Y., Kiyonari, H., Murata, K., Ueno, Y., Ono, M., Shimosegawa, T., Yaegashi, N., Watanabe, M. and Sugamura, K. (2008) Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration. Am. J. Pathol. 173, 1806-1817
217. Tanaka, N., Kaneko, K., Asao, H., Kasai, H., Endo, Y., Fujita, T., Takeshita, T. and Sugamura, K. (1999) Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. J. Biol. Chem., 274, 19129-19135
218. Tarabykina, S., Mollerup, J., Winding, P. and Berchtold, M.W. (2004) ALG-2, a multifunctional calcium binding protein? Front. Biosci. 9, 1817-1832
219. Thompson, B.J., Mathieu, J., Sung, H.H., Loeser, E., Rorth, P. and Cohen, S.M. (2005) Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell 9, 711-720 (Pubitemid 41555152)
220. Toyooka, S., Ouchida, M., Jitsumori, Y., Tsukuda, K., Sakai, A., Nakamura, A., Shimizu, N. and Shimizu, K. (2000) HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. Biochem. Biophys. Res. Commun., 278, 671-678
221. Tsang, H.T., Connell, J.W., Brown, S.E., Thompson, A., Reid, E. and Sanderson, C.M. (2006) A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Genomics 88, 333-346 (Pubitemid 44278530)
222. Tsukazaki, T., Chiang, T.A., Davison, A.F., Attisano, L. and Wrana, J.L. (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGF β receptor. Cell 95, 779-791 (Pubitemid 29014458)
223. Usami, Y., Popov, S., Popova, E., Inoue,M., Weissenhorn, W. and Göttlinger, H.G. (2009) The ESCRT pathway and HIV-1 budding. Biochem. Soc. Trans. 37, 181-184
224. Utley, T.J., Ducharme, N.A., Varthakavi, V., Shepherd, B.E., Santangelo, P.J., Lindquist, M.E., Goldenring, J.R. and Crowe, Jr, J.E. (2008) Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2. Proc. Natl. Acad. Sci. U.S.A. 105, 10209-10214
225. Vaccari, T. and Bilder, D. (2005) The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev. Cell 9, 687-698 (Pubitemid 41555150)
226. Vaccari, T., Rusten, T.E., Menut, L., Nezis, I.P., Brech, A., Stenmark, H. and Bilder, D. (2009) Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J. Cell Sci. 122, 2413-2423
227. Vadlamudi, R.K., Wang, R.A., Mazumdar, A., Kim, Y., Shin, J., Sahin, A. and Kumar, R. (2001) Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor α. J. Biol. Chem., 276, 38272-38279
228. Vadlamudi, R.K., Manavathi, B., Balasenthil, S., Nair, S.S., Yang, Z., Sahin, A.A. and Kumar, R. (2005) Functional implications of altered subcellular localization of PELP1 in breast cancer cells. Cancer Res. 65, 7724-7732 (Pubitemid 41297247)
229. Vajjhala, P.R., Catchpoole, E., Nguyen, C.H., Kistler, C. and Munn, A.L. (2007) Vps4 regulates a subset of protein interactions at the multivesicular endosome. FEBS J. 274, 1894-1907 (Pubitemid 46587992)
230. Gag. Proc. Natl. Acad. Sci. U.S.A. 98, 7724-7729
231. Vincent, O., Rainbow, L., Tilburn, J., Arst, Jr, H.N. and Penalva, M.A. (2003) YPXL/I is a protein interaction motif recognized by Aspergillus PalA and its human homologue, AIP1/Alix. Mol. Cell. Biol. 23, 1647-1655
232. 2+-dependent reaction. J. Biol. Chem., 274, 1533-1540
233. Wagner, K.U., Krempler, A., Qi, Y., Park, K., Henry, M.D., Triplett, A.A., Riedlinger, G., Rucker, I.E. and Hennighausen, L. (2003) Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol. Cell. Biol. 23, 150-162
234. Walczak, C.E. and Heald, R. (2008) Mechanisms of mitotic spindle assembly and function. Int. Rev. Cytol. 265, 111-158
235. Wang, T. and Hong, W. (2006) RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. Biochem. Biophys. Res. Commun. 350, 413-423
236. Webber, E., Li, L. and Chin, L.S. (2008) Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. J. Mol. Biol. 382, 638-651
237. Wong, C.W., McNally, C., Nickbarg, E., Komm, B.S. and Cheskis, B.J. (2002) Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc. Natl. Acad. Sci. U.S.A. 99, 14783-14788
238. Xiao, J., Xia, H., Yoshino-Koh, K., Zhou, J. and Xu, Z. (2007) Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J. Mol. Biol. 374, 655-670
239. Xiao, J., Xia, H., Zhou, J., Azmi, I.F., Davies, B.A., Katzmann, D.J. and Xu, Z. (2008) Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev. Cell 14, 37-49
240. Xie, W., Li, L. and Cohen, S.N. (1998) Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency. Proc. Natl. Acad. Sci. U.S.A. 95, 1595-1600
241. Xin, H., Yoon, H.G., Singh, P.B., Wong, J. and Qin, J. (2004) Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in mammalian cells. J. Biol. Chem., 279, 9539-9546
242. Xu, W., Smith, Jr, F.J., Subaran, R. and Mitchell, A.P. (2004) Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans. Mol. Biol. Cell 15, 5528-5537
243. Yamashita, Y., Kojima, K., Tsukahara, T., Agawa, H., Yamada, K., Amano, Y., Kurotori, N., Tanaka, N., Sugamura, K. and Takeshita, T. (2008) Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor β-chain. J. Cell Sci. 121, 1727-1738
244. 2+ and N-ethylmaleimide-sensitive factor differentially regulate disassembly of SNARE complexes on early endosomes. J. Biol. Chem. 279, 18270-1876
245. Yan, Q., Sun,W., Kujala, P., Lotfi, Y., Vida, T.A. and Bean, A.J. (2005) CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. Mol. Biol. Cell 16, 2470-2482
246. Yang, D., Rismanchi, N., Renvoise, B., Lippincott-Schwartz, J., Blackstone, C. and Hurley, J.H. (2008) Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat. Struct. Mol. Biol. 15, 1278-1286
247. Yeo, S.C., Xu, L., Ren, J., Boulton, V.J., Wagle, M.D., Liu, C., Ren, G., Wong, P., Zahn, R., Sasajala, P., Yang, H., Piper, R.C. and Munn, A.L. (2003) Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J. Cell Sci. 116, 3957-3970
248. Yorikawa, C., Takaya, E., Osako, Y., Tanaka, R., Terasawa, Y., Hamakubo, T., Mochizuki, Y., Iwanari, H., Kodama, T., Maeda, T., Hitomi, K., Shibata, H. and Maki, M. (2008) Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments. J. Biochem. 143, 731-745
249. Young, T.W., Rosen, D.G., Mei, F.C., Li, N., Liu, J., Wang, X.F. and Cheng, X. (2007) Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. Clin. Cancer Res. 13, 3848-3854
250. Zhao, W.M., Seki, A. and Fang, G. (2006) Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis. Mol. Biol. Cell 17, 3881-3896
251. Zheng, B., Lavoie, C., Tang, T.D., Ma, P., Meerloo, T., Beas, A. and Farquhar, M.G. (2004) Regulation of epidermal growth factor receptor degradation by heterotrimeric Gαs protein. Mol. Biol. Cell 15, 5538-5550
252. Zheng, B., Tang, T., Tang, N., Kudlicka, K., Ohtsubo, K., Ma, P., Marth, J.D., Farquhar, M.G. and Lehtonen, E. (2006) Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc. Natl. Acad. Sci. U.S.A. 103, 16776-16781
253. Zhong, Q., Chen, Y., Jones, D. and Lee, W.H. (1998) Perturbation of TSG101 protein affects cell cycle progression. Cancer Res. 58, 2699-2702
254. Zhong, Q., Lazar, C.S., Tronchere, H., Sato, T., Meerloo, T., Yeo, M., Songyang, Z., Emr, S.D. and Gill, G.N. (2002) Endosomal localization and function of sorting nexin 1. Proc. Natl. Acad. Sci. U.S.A. 99, 6767-6772
255. Zhou, X., Pan, S., Sun, L., Corvera, J., Lee, Y.C., Lin, S.H. and Kuang, J. (2009) The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix. Biochem. J. 418, 277-284