The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 17, 2008, Pages 6308-6313

  Doyotte, Aurelie ^a   Mironov, Aleksandr ^a   McKenzie, Edward ^a   Woodman, Philip ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Alix; Endocytosis; ESCRT

Indexed keywords

CARRIER PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN ALIX; PROTEIN BRO1; PROTEIN PTPN23; PROTEIN TYROSINE PHOSPHATASE; SACCHAROMYCES CEREVISIAE PROTEIN; GAG PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE; P6 GAG PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; TRANSFERRIN RECEPTOR;

ARTICLE; CHIMERA; ENDOSOME; MORPHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; UBIQUITINATION; CHEMISTRY; ENDOCYTOSIS; ENZYMOLOGY; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TRANSPORT AT THE CELLULAR LEVEL; TRANSPORT VESICLE; ULTRASTRUCTURE;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

BIOLOGICAL TRANSPORT; ENDOCYTOSIS; ENDOSOMES; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GREEN FLUORESCENT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; TRANSPORT VESICLES;

EID: 44049084101     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0707601105     Document Type: Article

References (25)

1. Hurley JH, Emr SD (2006) The ESCRT complexes: Structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct 35:277-298.
2. Odorizzi G, Katzmann DJ, Babst M, Audhya A, Emr SD (2003) Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J Cell Sci 116:1893-1903.
3. Kim J, et al. (2005) Structural basis for endosomal targeting by the Bro1 domain. Dev Cell 8:937-947.
4. Richter C, West M, Odorizzi G (2007) Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies. EMBO J 26:2454-2464.
5. Morita E, Sundquist WI (2004) Retrovirus budding. Ann Rev Cell Dev Biol 20:395-425.
6. Strack B, Calistri A, Craig S, Popova E, Gottlinger HG (2003) AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell 114:689-699.
7. von Schwedler UK, et al. (2003) The protein network of HIV budding. Cell 114:701-713.
8. Fisher RD, et al. (2007) Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell 128:841-852.
9. Lee S, Joshi A, Nagashima K, Freed EO, Hurley JH (2007) Structural basis for viral late-domain binding to Alix. Nat Struct Mol Biol 14:194-199.
10. Cabezas A, Bache KG, Brech A, Stenmark H (2005) Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci 118:2625-2635.
11. Schmidt MHH, et al. (2004) Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol 24:8981-8993.
12. Bowers K, et al. (2006) Degradation of endocytosed epidermal growth factor and virally-ubiquitinated MHC class I is independent of mammalian ESCRTII. J Biol Chem 281:5094-5105.
13. Welsch S, et al. (2006) Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function. Traffic 7:1551-1566.
14. Benharouga M, Haardt M, Kartner N, Lukacs GL (2001) COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments. J Cell Biol 153:957-970.
15. Mobius W, et al. (2003) Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway. Traffic 4:222-231.
16. White IJ, Bailey LM, Aghakhani MR, Moss SE, Futter CE (2006) EGF stimulates annexin 1-dependent inward vesiculation in a multivesicular endosome subpopulation. EMBO J 25:1-12.
17. Deneka M, Pelchen-Matthews A, Byland R, Ruiz-Mateos E, Marsh M (2007) In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol 177:329-341.
18. Babst M, Wendland B, Estapa EJ, Emr SD (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17:2982-2993.
19. Garrus JE, et al. (2001) Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107:1-20.
20. Strack B, Calistri A, Accola MA, Palu G, Gottlinger HG (2000) A role for ubiquitin ligase recruitment in retrovirus release. PNAS 97:13063-13068.
21. Razi M, Futter CE (2006) Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Mol Biol Cell 3469-3483.
22. Doyotte A, Russell MRG, Hopkins CR, Woodman PG (2005) Depletion of TSG101 forms a mammalian "Class E" compartment: A multicisternal early endosome with multiple sorting defects. J Cell Sci 118:3003-3017.
23. Toyooka S, et al. (2000) HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. Biochem Biophys Res Commun 278:671-678.
24. Ichioka F, et al. (2007) HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions. Arch Biochem Biophys 457:142-149.
25. Bishop N, Horman A, Woodman P (2002) Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol 157:91-102.