Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice

British Journal of Nutrition

Volumn 103, Issue 10, 2010, Pages 1413-1424

  Cvjetićanin, Tamara ^a   Miljković, Djordje ^a   Stojanović, Ivana ^a   Dekanski, Dragana ^b   Stosic Grujičić, Stanislava ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b R and D Institute   (Serbia)

Author keywords

Cytokines; Nitric oxide; Olea europaea leaves; Type 1 diabetes

Indexed keywords

CYCLOPHOSPHAMIDE; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 17; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OLEA EUROPAEA EXTRACT; PLANT EXTRACT; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL DESTRUCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DOWN REGULATION; HISTOPATHOLOGY; HYPERGLYCEMIA; INHIBITION KINETICS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIVE TREE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PLANT LEAF; PROTEIN EXPRESSION; SPLEEN; STREPTOZOCIN DIABETES; T LYMPHOCYTE; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; CBA MOUSE; CHEMISTRY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; NONOBESE DIABETIC MOUSE;

MUS; OLEA EUROPAEA;

ANIMALS; AUTOIMMUNITY; CYCLOPHOSPHAMIDE; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION REGULATION; INTERFERON-GAMMA; INTERLEUKINS; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED NOD; NITRIC OXIDE; OLEA; PLANT EXTRACTS; PLANT LEAVES;

EID: 77953076333     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509993394     Document Type: Article

References (57)

1. Gianni C, Mohn A & Chiarelli F (2009) Technology and the issue cost/benefit in diabetes. Diabetes Metab Res Rev 25, Suppl. 1, S34-S44.
2. Craig ME, Hattersley A, Donaghue TC, et al. (2009) ISPAD clinical practice consensus guidelines 2009 compendium. Definition, epidemiology and classification of diabetes in children and adolescents. Pediatr Diabetes 10, Suppl. 12, 3-12.
3. Tisch R & McDevitt H (1996) Insulin-dependent diabetes mellitus. Cell 85, 291-297.
4. Daaboul J & Schatz D (2003) Overview of prevention and intervention trials for type 1 diabetes. Rev Endocr Metab Dis 4, 317-323. (Pubitemid 37493647)
5. Watson S & Miller K (2004) Encyclopedia of the Human Body: The Endocrine System. Westport, CT: Greenwood Publishing.
6. Mastrandrea L, Yu J, Behrens T, et al. (2009) Etanercept treatment in children with new-onset type 1 diabetes. Pilot randomized, placebo-controlled, double-blind study. Diabetes Care 32, 1244-1249.
7. Staeva-Vieira T, Peakman M & von Herrath M (2007) Translational mini-review series on type 1 diabetes: immune-based therapeutic approaches for type 1 diabetes. Clin Exp Immunol 148, 17-31. (Pubitemid 46364996)
8. Kawano Y, Irie J, Nakatani H, et al. (2009) Pioglitazone might prevent the progression of slowly progressive type 1 diabetes. Inter Med 48, 1037-1039.
9. Rother KJ, Brown RJ, Morales MM, et al. (2009) Effect of ingested interferon-a on b-cell function in children with new onset type 1 diabetes. Diabetes Care 32, 1250-1255.
10. Shoda LK, Young DL, Ramanujan S, et al. (2005) A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 23, 115-126.
11. Stosic-Grujicic S, Cvetkovic I, Mangano K, et al. (2007) A potent immunomodulatory compound (S,R)-3-phenyl-4, 5-dihydro-5-isoxasole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J Pharmacol Exp Ther 320, 1038-1049.
12. Stosić-Grujicić S, Cvjetićanin T & Stojanović I (2009) Retinoids differentially regulate the progression of autoimmune diabetes in three preclinical models in mice. Mol Immunol 47, 79-86.
13. Perona JS, Cabello-Moruno R & Ruiz-Gutierrez V (2006) The role of virgin olive oil components in the modulation of endothelial function. J Nutr Biochem 17, 429-445.
14. Dekanski D, Janicijevic-Hudomal S, Tadic V, et al. (2009) Phytochemical analysis and gastroprotective activity of an olive leaf extract. J Serb Chem Soc 74, 367-377. Raḿrez-Tortosa MC, Suárez A, Gómez MC, et al. (1999) Effect of extra-virgin olive oil and fish-oil supplementation on plasma lipids and susceptibility of low-density lipoprotein to oxidative alteration in free-living Spanish male patients with peripheral vascular disease. Clin Nutr 18, 167-174.
15. Vissers MN, Zock PL & Katan MB (2004) Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur J Clin Nutr 58, 955-965.
16. Esposito K, Ciotola M & Giugliano D (2007) Mediterranean diet and the metabolic syndrome. Mol Nutr Food Res 51, 1268-1274.
17. Fitó M, de la Torre R, Farré-Albaladejo M, et al. (2007) Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review. Ann Ist Super Sanita 43, 375-381.
18. Panagiotakos DB & Polychronopoulos E (2005) The role of Mediterranean diet in the epidemiology of metabolic syndrome; converting epidemiologyto clinical practice. Lipids Health Dis 4, 7.
19. Visioli F, Bellosta S & Galli C (1998) Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci 62, 541-546.
20. Carluccio MA, Siculella L, Ancora MA, et al. (2003) Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol 23, 622-629.
21. Bitler CM, Viale TM, Damaj B, et al. (2005) Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. J Nutr 135, 1475-1479.
22. Al-Azzawie HF & Alhamdani MS (2006) Hypoglycemic and antioxidant effects of oleuropein in alloxan-diabetic rabbits. Life Sci 78, 1371-1377.
23. Sato H, Genet C, Strehle A, et al. (2007) Anti-hyperglycemic activity of TGR5 agonist isolated from Olea europaea. Biochem Biophys Res Commun 362, 793-798.
24. Said O, Fulder S, Khalil K, et al. (2008) Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional Arab herbal medicine. Evid Based Complement Alternat Med 5, 421-428.
25. Eidi A, Eidi M & Darzi R (2009) Antidiabetic effect of Olea europea L. in normal and diabetic rats. Phytother Res 23, 347-350.
26. Miljkovic DJ, Dekanski D, Miljkovic Z, et al. (2009) Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis. Clin Nutr 28, 346-350.
27. \+ regulatory T cells. J Immunol 177, 6603-6612.
28. Like AA & Rossini AA (1976) Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193, 415-417.
29. Bach JF (1995) Insulin-dependent diabetes mellitus as a beta-cell targeted disease of immunoregulation. J Autoimmun 8, 439-463.
30. Cvetkovic I, Al-Abed Y, Miljkovic D, et al. (2005) Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology 146, 2942-2951.
31. Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, et al. (2008) Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res 22, 1239-1242.
32. Rucker RB (2007) Allometric scaling, metabolic body size and interspecies comparisons of basal nutritional requirements. J Anim Physiol Anim Nutr (Berl) 91, 148-156.
33. Gonzalez M, Zarzuelo A, Gamez MJ, et al. (1992) Hypo-glycemic activity of olive leaf. Planta Med 58, 513-515.
34. Briante R, Patumi M, Terenziani S, et al. (2002) Olea europea L. leaf extract and derivatives: antioxidant properties. J Agric Food Chem 50, 4934-4940.
35. Visioli F, Poli A & Galli C (2002) Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev 22, 65-75. (Pubitemid 34023573)
36. Jemai H, Bouaziz M, Fki I, et al. (2008) Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact 176, 88-98.
37. Bennani-Kabchi N, Fdhil H, Cherrah Y, et al. (2000) Therapeutic effect of Olea europea var. oleaster leaves on carbohydrate and lipid metabolism in obese and prediabetic sand rats (Psammomys obesus). Ann Pharm Fr 58, 271-277.
38. Coskun O, Kanter M, Korkmaz A, et al. (2005) Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and b-cell damage in rat pancreas. Pharmacol Res 51, 117-123.
39. Albina JE, Abate JA & Henry WL Jr (1991) Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway. J Immunol 147, 144-148.
40. Bogdan C (2001) Nitric oxide and the immune response. Nat Immunol 2, 907-916.
41. Lemaire G, Guittet O, Vesin MF, et al. (2009) Glutathione depletion reveals impairment of antigen processing and inhibition of cathepsin activity by nitric oxide in antigen-presenting cells. Mol Immunol 46, 1100-1108.
42. Stassi G, De Maria R, Trucco G, et al. (1997) Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 186, 1193-1200.
43. Pearl-Yafe M, Kaminitz A, Yolcu ES, et al. (2007) Pancreatic islets under attack: cellular and molecular effectors. Curr Pharm Des 13, 749-760.
44. Ischiropoulos H, Zhu L, Chen J, et al. (1992) Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 298, 431-437.
45. Emamaullee JA, Davis J, Merani S, et al. (2009) Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes 58, 1302-1311.
46. Martin-Orozco N, Chung Y, Chang SH, et al. (2009) Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 39, 216-224.
47. Miljkovic D, Cvetkovic I, Momcilovic M, et al. (2005) Inter-leukin-17 stimulates inducible nitric oxide synthase-dependent toxicity in mouse beta cells. Cell Mol Life Sci 62, 2658-2668.
48. Tesmer LA, Lundy SK, Sarkar S, et al. (2008) Th17 cells in human disease. Immunol Rev 223, 87-113.
49. Hartupee J, Liu C, Novotny M, et al. (2009) IL-17 signaling for mRNA stabilization does not require TNF receptor-associated factor 6. J Immunol 182, 1660-1666.
50. Blonska M, Czuba ZP & Krol W (2003) Effect of flavone derivatives on interleukin-1 beta (IL-1 beta) mRNA expression and IL-1 beta protein synthesis in stimulated RAW 264.7 macrophages. Scand J Immunol 57, 162-166.
51. Miles EA, Zoubouli P & Calder PC (2005) Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition 21, 389-394.
52. Zunino SJ, Storms DH & Stephensen CB (2007) Diets rich in polyphenols and vitamin A inhibit the development of type 1 autoimmune diabetes in nonobese diabetic mice. J Nutr 137, 1216-1221.
53. Sanchez-Avila N, Priego-Capote F, Ruiz-Jimenez J, et al. (2009) Fast and selective determination of triterpenoic compounds in olive leaves by liquid chromatography-tandem mass spectrometry with multiple reaction monitoring after microwave-assisted extraction. Talanta 78, 40-48.
54. Jang S-M, Yee S-T, Choi J, et al. (2009) Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin- induced diabetic mice fed a high-fat diet. Int Immunopharmacol 9, 113-119.
55. Liu J, Sun H, Duan W, et al. (2007) Maslinic acid reduces blood glucose in KK-Ay mice. Biol Pharm Bull 30, 2075-2078.
56. Lory D, Incani A, Deiana M, et al. (2009) Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. Toxic Ind Health 25, 301-310.
57. Andrikopoulos NK, Kaliora AC, Assimopoulou AN, et al. (2002) Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. J Med Food 5, 1-7.