A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 3, 2007, Pages 1038-1049

  Stosic Grujicic, Stanislava ^a   Cvetkovic, Ivana ^a   Mangano, Katia ^b   Fresta, Massimo ^c   Maksimovic Ivanic, Danijela ^a   Harhaji, Ljubica ^a   Popadic, Dusan ^d   Momcilovic, Miljana ^a   Miljkovic, Djordje ^a   Kim, Joseph ^e   Al Abed, Yousef ^f   Nicoletti, Ferdinando ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF BELGRADE   (Serbia)

^e VGX Pharmaceuticals Inc   (United States)

^f North Shore Long Island Jewish Health System ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYL 4,5 DIHYDRO 5 ISOXASOLE ACETIC ACID; CYCLOPHOSPHAMIDE; IMMUNOMODULATING AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; MACROPHAGE MIGRATION INHIBITION FACTOR; NITRIC OXIDE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VGX 1027;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL DAMAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; FEMALE; HYPERGLYCEMIA; IMMUNOPHARMACOLOGY; INFLAMMATORY DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SINGLE DRUG DOSE; SPLEEN CELL; STREPTOZOCIN DIABETES;

ACETIC ACIDS; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOPHOSPHAMIDE; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC FACTORS; INFLAMMATION MEDIATORS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED CBA; MICE, INBRED NOD; MOLECULAR STRUCTURE; NITRIC OXIDE; OXAZOLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOZOCIN;

EID: 33847110804     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.109272     Document Type: Article

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