Ursolic acid enhances the cellular immune system and pancreatic β-cell function in streptozotocin-induced diabetic mice fed a high-fat diet

International Immunopharmacology

Volumn 9, Issue 1, 2009, Pages 113-119

  Jang, Sun Mi ^a   Yee, Sung Tae ^a   Choi, Jina ^a   Choi, Myung Sook ^b   Do, Gyeong Min ^b   Jeon, Seon Min ^b   Yeo, Jiyoung ^b   Kim, Myung Joo ^c   Seo, Kwon Il ^a   Lee, Mi Kyung ^a  

^a Sunchon National University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Daegu Polytechnic College   (South Korea)

Author keywords

High fat; Immune system; Insulin; Type 1 diabetes; Ursolic acid

Indexed keywords

ANTIDIABETIC AGENT; C PEPTIDE; CONCANAVALIN A; GAMMA INTERFERON; GLUCOSE; INTERLEUKIN 2; URSOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES CONTROL; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOREGULATION; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SPLEEN CELL; STATISTICAL SIGNIFICANCE; STREPTOZOCIN DIABETES; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, SURFACE; BLOOD GLUCOSE; C-PEPTIDE; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIET; DIETARY FATS; DIETARY SUPPLEMENTS; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; IMMUNITY, CELLULAR; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; LYMPHOCYTES; MALE; MICE; MICE, INBRED ICR; PANCREAS; PANCREATIC FUNCTION TESTS; TRITERPENES;

EID: 58149464690     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.10.013     Document Type: Article

References (52)

1. Pozzilli P. Infection and diabetes: mechanism and prospects for prevention. Diabet Med 11 (1994) 935-941
2. Geerlings S.E., and Hoepelman A.I. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol 26 (1999) 259-265
3. Chang F.Y., and Shaio M.F. Decreased cell-mediated immunity in patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 528 (1999) 137-146
4. Moutschen M.P., Scheen A.J., and Lefebvre P.J. Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections. Diabet Med 18 (1992) 187-201
5. Plouffe J.R., Silva J., Fekety R., and Allen J.L. Cell-mediated immunity in diabetes mellitus. Infect Immun 21 (1978) 425-429
6. Sakowicz-Burkiewicz M., Kocbuch K., Grden M., Szutowicz A., and Pawelczyk T. Diabetes-induced decrease of adenosine kinase expression impairs the proliferation potential of diabetic rat T lymphocytes. Immunology 118 (2006) 402-412
7. Kawasaki E., Abiru N., and Eguchi K. Prevention of type 1 diabetes: from the view point of β-cell damage. Diabetes Res Clin Pract 66 (2004) S27-S32
8. Leslie R.D., Williams R., and Pozzilli P. Type 1 diabetes and latent autoimmune diabetes in adults: one end or the rainbow. J Clin Endocrinol Metab 91 (2006) 1654-1659
9. Wilkin T.J. The accelerator hypothesis: a unifying explanation for type-1 and type-2 diabetes. Nestle Nutr Workshop Ser Clin Perform Progr 11 (2006) 139-153
10. Liu J. Oleanolic acid and ursolic acid: research perspectives. J Ethnopharmacol 100 (2005) 92-94
11. Green A., and Patterson C.C. Trends in the incidence of childhood-onset diabetes in Europe 1989-1998. Diabetologia 44 (2001) B3-B8
12. Tracey V.V., Dew C., and Harper J.R. Obesity and respiratory infection in infants and young children. Br Met 1 (1971) 17-19
13. Mito N., Hosoda T., Kato C., and Sato K. Change of cytokine balance in diet-induced obese mice. Metabolism 49 (2000) 1295-1300
14. Tanaka S., and Isoda F. Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness. Int J Obes 17 (1993) 631-636
15. Nieman D.C., Henson D.A., and Nehlsen-Cannarella S.L. Influence or obesity on immune function. J Am Diet Assoc 99 (1999) 294-299
16. Sharon F., Elike E., and James M. T-lymphocyte subsets in patients with abnormal body weight: longitudinal studies in anorexia nervosa and obesity. Int J Eat Disord 20 (1996) 295-305
17. Li R.J., Qiu S.D., Chen H.X., Tian H., and Wang H.X. The immunotherapeutic effects of Astragalus polysaccharide in type 1 diabetic mice. Biol Pharm Bull 30 (2007) 470-476
18. Sohn K.H., Lee H.Y., Chung H.Y., Young H.S., Yi S.Y., and Kim K.W. Anti-angiogenic activity of triterpene acids. Cancer Lett 94 (1995) 213-218
19. Balanehru S., and Nagarajan B. Protective effect of oleanolic acid and ursolic acid against lipid peroxidation. Biochem Int 24 (1991) 981-990
20. Ovesna Z., Vachalkova A., Horvathova K., and Tothova D. Pentacyclic triterpenoic acids: new chemoprotective compounds. Minirev Neoplasma 51 (2004) 327-333
21. Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 49 (1995) 57-68
22. Banno N., Akihisa T., Tokuda H., Yasukawa K., Higashihara H., Ukiya M., et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechno Biochem 68 (2004) 85-90
23. Saraswat B., Visen P.K.S., Dayal R., Agarwal D.P., and Patnaik G.K. Protective action of ursolic acid against chemical induced hepatotoxicity in rats. Indian J Pharmacol 28 (1996) 232-239
24. Somova L.O., Nadar A., Rammanan P., and Shode F.O. Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. Phytomedicine 10 (2003) 115-121
25. Raphael T.J., and Kuttan G. Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. Phytomedicine 10 (2003) 483-489
26. Zhang W., Hong D., Zhou Y., Zhang Y., Shen Q., Li J.Y., et al. Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. Biochim Biophys Acta 1760 (2006) 1505-1512
27. Pathak A.K., Bhutani M., Nair A.S., Ahn K.S., Chakraborty A., Kadara H., et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5 (2007) 943-955
28. American Institute of Nutrition. Report of Ad Hoc committee on standards for nutritional studies. J Nutr 110 (1980) 1717-1726
29. American Institute of Nutrition. Report of the American Institute of Nutrition. Ad Hoc committee on standards for nutritional studies. J Nutr 107 (1977) 1340-1348
30. Shima K., Zhu M., Noma Y., Mizuno A., Murakami T., Sano T., et al. Exercise training in Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus: effects on the B-cell mass, insulin content and fibrosis in the pancreas. Diabetes Res Clin Pract 35 (1997) 11-19
31. Pozzilli P., and Buzzetti R. A new expression of diabetes: double diabetes. Trends Endocrinol Metab 18 (2007) 52-57
32. Tracey V.V., De N.C., and Harper J.R. Obesity and respiratory infection in infants and young children. Br Med J 1 (1971) 16-18
33. Lamas O., Martinez J.A., and Marti A. T helper lymphopenia and decreased mitogenic response in cafeteria diet-induced obese rats. Nutr Res 22 (2002) 496-507
34. Yaqoob P., Newsholme E.A., and Calder P.C. The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology 82 (1994) 603-610
35. Erickson K.L., McNeill C.J., Gershwin M.E., and Ossmann J.B. Influence of dietary fat concentration and saturation on immune ontogeny in mice. J Nutr 110 (1980) 1555-1572
36. Erickson K.L., Adams D.A., and McNeill C.J. Dietary lipid modulation of immune responsiveness. Lipids 18 (1983) 468-474
37. Jung S.H., Ha Y.J., Shim E.K., Choi S.Y., Jin J.L., Yun-Choi H.S., et al. Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. Biochem J 403 (2007) 243-250
38. Koziel H., and Koziel M.J. Pulmonary complications of diabetes mellitus. Pneumonia. Infect Dis Clin North Am 9 (1995) 65-96
39. Joshi N., Caputo G.M., Weitekamp M.R., and Karchmer A.W. Infections in patients with diabetes mellitus. N Engl J Med 341 (1999) 1906-1912
40. Baral R., and Chattopadhyay U. Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehlich carcinoma and B16 melanoma. Int Immunopharmacol 4 (2004) 355-366
41. Kim M.J., Kim H.N., Kang K.S., Baek N.I., Kim D.K., and Kim Y.S. Methanol extract of Dioscoreae rhizome inhibits proinflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis. Int Immunopharmacol 4 (2004) 1489-1497
42. Lin B.F., Chiang B.L., and Lin J.Y. Amaranthus spinosus water extract directly stimulates proliferation of B lymphocytes in vitro. Int Immunopharmacol 5 (2005) 711-722
43. Buffington C.K., Ell-Sheikh T., Matteri R., and Kitabchi A.E. Phytohemagglutinin (PHA) activated human T-lymphocytes: insulin binding in T-lymphocytes. Biochem Res Commun 134 (1986) 412-419
44. Liu C.T., Chen K.M., Lee S.H., and Tsai L.J. Effect of supplemental l-arginine on the function of T lymphocytes and the formation of advances glycosylated end products in rats with streptozotocin-induced diabetes. Nutrition 21 (2005) 615-623
45. Doolan D.S., and Hoffman S.L. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J. Immunol 163 (1999) 844-892
46. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 3 (1995) 251-276
47. Crutcher J.M., Stevenson M.M., Sedegah M., and Hoffman S.L. Interleukin-12 and malaria. Res Immunol 146 (1995) 552-559
48. Young H.A., and Hardy K.J. Role of interferon-gamma in immune cell regulation. J Leukoc Biol 58 (1995) 373-381
49. Gottenberg J.E., and Chiocchia G. Dendritic cells and interferon-mediated autoimmunity. Biochimie 89 (2007) 856-871
50. Campbell I.L., Iscaro A., and Harrison L.C. IFN-gamma and tumor necrosis factor-alpha: cytotoxicity to murine islets of Langerhans. J Immunol 141 (1988) 2325-2329
51. Pirot P., Cardozo A.K., and Eizirik D.L. Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. Arg Bras Endrocrinol Metab 52 (2008) 156-165
52. Bilgic S., Aktas E., Salman F., Ersahin G., Erten G., Yilmaz M.T., et al. Intracytoplasmic cytokine levels and neutrophil functions in early clinical stage of type 1 diabetes. Diabet Res Clin Pract 79 (2008) 31-36