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Volumn 125, Issue 6, 2010, Pages 1237-1247

Defensin-barbed innate immunity: Clinical associations in the pediatric population

Author keywords

Acne; Atopic dermatitis; Cystic fibrosis; Defensin; HIV transmission; Infectious diarrhea; Inflammatory bowel disease; Innate immunity; Necrotizing enterocolitis; Otitis media; Psoriasis

Indexed keywords

ALPHA DEFENSIN; ANTIBIOTIC AGENT; BACTERIAL TOXIN; BETA DEFENSIN; BETA DEFENSIN 2; BETA DEFENSIN 3; BETA DEFENSIN 4; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CHOLERA TOXIN; CYTOLYSIN; DEFENSIN; INTERLEUKIN 17; MESSENGER RNA; PROBIOTIC AGENT; TOLL LIKE RECEPTOR 9; VIRULENCE FACTOR;

EID: 77953072318     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2009-3289     Document Type: Review
Times cited : (39)

References (90)
  • 1
    • 0033044786 scopus 로고    scopus 로고
    • Antimicrobial peptides as mediators of epithelial host defense
    • Huttner KM, Bevins CL. Antimicrobial peptides as mediators of epithelial host defense. Pediatr Res. 1999;45(6):785-794
    • (1999) Pediatr Res , vol.45 , Issue.6 , pp. 785-794
    • Huttner, K.M.1    Bevins, C.L.2
  • 2
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of innate immunity
    • DOI 10.1038/nri1180
    • Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003; 3(9):710-720 (Pubitemid 41070812)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.9 , pp. 710-720
    • Ganz, T.1
  • 3
    • 4444246692 scopus 로고    scopus 로고
    • Primate defensins
    • Lehrer RI. Primate defensins. Nat Rev Microbiol. 2004;2(9):727-738
    • (2004) Nat Rev Microbiol , vol.2 , Issue.9 , pp. 727-738
    • Lehrer, R.I.1
  • 4
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002; 415(6870):389-395
    • (2002) Nature , vol.415 , Issue.6870 , pp. 389-395
    • Zasloff, M.1
  • 5
    • 67349205034 scopus 로고    scopus 로고
    • Membrane order perturbation in the presence of antimicrobial peptides by (2)H solid-state NMR spectroscopy
    • Salnikov ES, Mason AJ, Bechinger B. Membrane order perturbation in the presence of antimicrobial peptides by (2)H solid-state NMR spectroscopy. Biochimie. 2009; 91(6):734-743
    • (2009) Biochimie , vol.91 , Issue.6 , pp. 734-743
    • Salnikov, E.S.1    Mason, A.J.2    Bechinger, B.3
  • 6
    • 34249313567 scopus 로고    scopus 로고
    • Paneth cells, defensins, and the commensal microbiota a hypothesis on intimate interplay at the intestinal mucosa
    • Salzman NH, Underwood MA, Bevins CL. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol. 2007;19(2):70-83
    • (2007) Semin Immunol , vol.19 , Issue.2 , pp. 70-83
    • Salzman, N.H.1    Underwood, M.A.2    Bevins, C.L.3
  • 7
    • 74049122536 scopus 로고    scopus 로고
    • Enteric defensins are essential regulators of intestinal microbial ecology
    • Salzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol. 2010;11(1):76-83
    • (2010) Nat Immunol , vol.11 , Issue.1 , pp. 76-83
    • Salzman, N.H.1    Hung, K.2    Haribhai, D.3
  • 8
    • 69049119234 scopus 로고    scopus 로고
    • Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins
    • Lehrer RI, Jung G, Ruchala P, et al. Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun. 2009;77(9):4028-4040
    • (2009) Infect Immun , vol.77 , Issue.9 , pp. 4028-4040
    • Lehrer, R.I.1    Jung, G.2    Ruchala, P.3
  • 9
    • 16344366178 scopus 로고    scopus 로고
    • Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences
    • Kim C, Gajendran N, Mittrucker HW, et al. Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. Proc Natl Acad Sci USA. 2005;102(13):4830-4835
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.13 , pp. 4830-4835
    • Kim, C.1    Gajendran, N.2    Mittrucker, H.W.3
  • 10
    • 33749989623 scopus 로고    scopus 로고
    • Human alpha-defensins neutralize toxins of the mono-ADP- ribosyltransferase family
    • Kim C, Slavinskaya Z, Merrill AR, Kaufmann SH. Human alpha-defensins neutralize toxins of the mono-ADP-ribosyltransferase family. Biochem J. 2006;399(2):225-229
    • (2006) Biochem J , vol.399 , Issue.2 , pp. 225-229
    • Kim, C.1    Slavinskaya, Z.2    Merrill, A.R.3    Kaufmann, S.H.4
  • 11
    • 44649117522 scopus 로고    scopus 로고
    • Human alpha-defensins inhibit Clostridium difficile toxin B
    • Giesemann T, Guttenberg G, Aktories K. Human alpha-defensins inhibit Clostridium difficile toxin B. Gastroenterology. 2008; 134(7):2049-2058
    • (2008) Gastroenterology , vol.134 , Issue.7 , pp. 2049-2058
    • Giesemann, T.1    Guttenberg, G.2    Aktories, K.3
  • 13
    • 55549113578 scopus 로고    scopus 로고
    • Defensins and the dynamic genome: What we can learn from structural variation at human chromosome band 8p23.1
    • Hollox EJ, Barber JC, Brookes AJ, Armour JA. Defensins and the dynamic genome: what we can learn from structural variation at human chromosome band 8p23.1. Genome Res. 2008;18(11):1686-1697
    • (2008) Genome Res , vol.18 , Issue.11 , pp. 1686-1697
    • Hollox, E.J.1    Barber, J.C.2    Brookes, A.J.3    Armour, J.A.4
  • 14
    • 58849117701 scopus 로고    scopus 로고
    • Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins
    • Abu Bakar S, Hollox EJ, Armour JA. Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins. Proc Natl Acad Sci USA. 2009;106(3):853-858
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.3 , pp. 853-858
    • Abu Bakar, S.1    Hollox, E.J.2    Armour, J.A.3
  • 15
    • 29144457296 scopus 로고    scopus 로고
    • Human defensin gene copy number polymorphisms: Comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23
    • DOI 10.1016/j.ygeno.2005.06.003, PII S0888754305001576
    • Linzmeier RM, Ganz T. Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics. 2005;86(4):423-430 (Pubitemid 43293155)
    • (2005) Genomics , vol.86 , Issue.4 , pp. 423-430
    • Linzmeier, R.M.1    Ganz, T.2
  • 16
    • 0020032180 scopus 로고
    • On the resident aerobic bacterial skin flora in unaffected skin of patients with atopic dermatitis and in healthy controls
    • Gloor M, Peters G, Stoika D. On the resident aerobic bacterial skin flora in unaffected skin of patients with atopic dermatitis and in healthy controls. Dermatologica. 1982; 164(4):258-265 (Pubitemid 12155235)
    • (1982) Dermatologica , vol.164 , Issue.4 , pp. 258-265
    • Gloor, M.1    Peters, G.2    Stoika, D.3
  • 17
    • 37249050911 scopus 로고    scopus 로고
    • Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis
    • DOI 10.1099/jmm.0.47268-0
    • Dekio I, Sakamoto M, Hayashi H, Amagai M, Suematsu M, Benno Y. Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis. J Med Microbiol. 2007;56(pt 12):1675-1683 (Pubitemid 350276519)
    • (2007) Journal of Medical Microbiology , vol.56 , Issue.12 , pp. 1675-1683
    • Dekio, I.1    Sakamoto, M.2    Hayashi, H.3    Amagai, M.4    Suematsu, M.5    Benno, Y.6
  • 19
    • 38149069478 scopus 로고    scopus 로고
    • Reduced diversity in the early fecal microbiota of infants with atopic eczema
    • Wang M, Karlsson C, Olsson C, et al. Reduced diversity in the early fecal microbiota of infants with atopic eczea J Allergy Clin Immunol. 2008;121(1):129-134
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.1 , pp. 129-134
    • Wang, M.1    Karlsson, C.2    Olsson, C.3
  • 20
    • 5444233803 scopus 로고    scopus 로고
    • Dietary modification of atopic disease: Use of probiotics in the prevention of atopic dermatitis
    • Isolauri E. Dietary modification of atopic disease: use of probiotics in the prevention of atopic dermatitis. Curr Allergy Asthma Rep. 2004;4(4):270-275 (Pubitemid 39359528)
    • (2004) Current Allergy and Asthma Reports , vol.4 , Issue.4 , pp. 270-275
    • Isolauri, E.1
  • 21
    • 46149090586 scopus 로고    scopus 로고
    • The effect of UVB radiation on skin microbiota in patients with atopic dermatitis and healthy controls
    • Dotterud LK, Wilsgaard T, Vorland LH, Falk ES. The effect of UVB radiation on skin microbiota in patients with atopic dermatitis and healthy controls. Int J Circumpolar Health. 2008;67(2-3):254-260
    • (2008) Int J Circumpolar Health , vol.67 , Issue.2-3 , pp. 254-260
    • Dotterud, L.K.1    Wilsgaard, T.2    Vorland, L.H.3    Falk, E.S.4
  • 22
    • 0037057645 scopus 로고    scopus 로고
    • Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    • Ong PY, Ohtake T, Brandt C, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002;347(15):1151-1160
    • (2002) N Engl J Med , vol.347 , Issue.15 , pp. 1151-1160
    • Ong, P.Y.1    Ohtake, T.2    Brandt, C.3
  • 23
    • 49549108250 scopus 로고    scopus 로고
    • Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    • Howell MD, Fairchild HR, Kim BE, et al. Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol. 2008;128(9):2248-2258
    • (2008) J Invest Dermatol , vol.128 , Issue.9 , pp. 2248-2258
    • Howell, M.D.1    Fairchild, H.R.2    Kim, B.E.3
  • 25
    • 46049112666 scopus 로고    scopus 로고
    • Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3
    • Kisich KO, Carspecken CW, Fieve S, Boguniewicz M, Leung DY. Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3. J Allergy Clin Immunol. 2008;122(1):62-68
    • (2008) J Allergy Clin Immunol , vol.122 , Issue.1 , pp. 62-68
    • Kisich, K.O.1    Carspecken, C.W.2    Fieve, S.3    Boguniewicz, M.4    Leung, D.Y.5
  • 26
    • 45749134172 scopus 로고    scopus 로고
    • Microanalysis of an antimicrobial peptide, beta-defensin-2, in the stratum corneum from patients with atopic dermatitis
    • DOI 10.1111/j.1365-2133.2008.08613.x
    • Asano S, Ichikawa Y, Kumagai T, Kawashima M, Imokawa G. Microanalysis of an antimicrobial peptide, beta-defensin-2, in the stratum corneum from patients with atopic dermatitis. Br J Dermatol. 2008;159(1):97-104 (Pubitemid 351874497)
    • (2008) British Journal of Dermatology , vol.159 , Issue.1 , pp. 97-104
    • Asano, S.1    Ichikawa, Y.2    Kumagai, T.3    Kawashima, M.4    Imokawa, G.5
  • 27
    • 77951090253 scopus 로고    scopus 로고
    • Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury
    • In press
    • Harder J, Dressel S, Wittersheim M, et al. Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury. J Invest Dermatol. 2010; In press
    • (2010) J Invest Dermatol
    • Harder, J.1    Dressel, S.2    Wittersheim, M.3
  • 28
    • 34250740365 scopus 로고    scopus 로고
    • The role and potential therapeutical applications of antimicrobial proteins in infectious and inflammatory diseases
    • Harder J, Glaser R, Schroder JM. The role and potential therapeutical applications of antimicrobial proteins in infectious and inflammatory diseases. Endocr Metab Immune Disord Drug Targets. 2007;7(2):75-82
    • (2007) Endocr Metab Immune Disord Drug Targets , vol.7 , Issue.2 , pp. 75-82
    • Harder, J.1    Glaser, R.2    Schroder, J.M.3
  • 29
    • 48549088455 scopus 로고    scopus 로고
    • Antimicrobial peptides and self-DNA in autoimmune skin inflammation
    • Gilliet M, Lande R. Antimicrobial peptides and self-DNA in autoimmune skin inflammation. Curr Opin Immunol. 2008;20(4): 401-407
    • (2008) Curr Opin Immunol , vol.20 , Issue.4 , pp. 401-407
    • Gilliet, M.1    Lande, R.2
  • 30
    • 37549033125 scopus 로고    scopus 로고
    • Psoriasis is associated with increased beta-defensin genomic copy number
    • Hollox EJ, Huffmeier U, Zeeuwen PL, et al. Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet. 2008;40(1):23-25
    • (2008) Nat Genet , vol.40 , Issue.1 , pp. 23-25
    • Hollox, E.J.1    Huffmeier, U.2    Zeeuwen, P.L.3
  • 31
    • 62749127946 scopus 로고    scopus 로고
    • Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin
    • Jansen PA, Rodijk-Olthuis D, Hollox EJ, et al. Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS ONE. 2009;4(3): e4725
    • (2009) PLoS ONE , vol.4 , Issue.3
    • Jansen, P.A.1    Rodijk-Olthuis, D.2    Hollox, E.J.3
  • 32
    • 4344665018 scopus 로고    scopus 로고
    • 3 is a direct inducer of antimicrobial peptide gene expression
    • 3 is a direct inducer of antimicrobial peptide gene expression. J Immunol. 2004;173(5): 2909-2912
    • (2004) J Immunol , vol.173 , Issue.5 , pp. 2909-2912
    • Wang, T.T.1    Nestel, F.P.2    Bourdeau, V.3
  • 33
    • 33646127805 scopus 로고    scopus 로고
    • Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling
    • Trivedi NR, Gilliland KL, Zhao W, Liu W, Thiboutot DM. Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. J Invest Dermatol. 2006; 126(5):1071-1079
    • (2006) J Invest Dermatol , vol.126 , Issue.5 , pp. 1071-1079
    • Trivedi, N.R.1    Gilliland, K.L.2    Zhao, W.3    Liu, W.4    Thiboutot, D.M.5
  • 34
    • 0035723428 scopus 로고    scopus 로고
    • Human beta defensin-1 and -2 expression in human pilosebaceous units: Upregulation in acne vulgaris lesions
    • Chronnell CM, Ghali LR, Ali RS, et al. Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. J Invest Dermatol. 2001; 117(5):1120-1125
    • (2001) J Invest Dermatol , vol.117 , Issue.5 , pp. 1120-1125
    • Chronnell, C.M.1    Ghali, L.R.2    Ali, R.S.3
  • 35
    • 18244368957 scopus 로고    scopus 로고
    • Distinct strains of Propionibacterium acnes induce selective human beta-defensin- 2 and interleukin-8 expression in human keratinocytes through toll-like receptors
    • Nagy I, Pivarcsi A, Koreck A, Szell M, Urban E, Kemeny L. Distinct strains of Propionibacterium acnes induce selective human beta-defensin- 2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol. 2005;124(5): 931-938
    • (2005) J Invest Dermatol , vol.124 , Issue.5 , pp. 931-938
    • Nagy, I.1    Pivarcsi, A.2    Koreck, A.3    Szell, M.4    Urban, E.5    Kemeny, L.6
  • 36
    • 33748366355 scopus 로고    scopus 로고
    • Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/ chemokines in human sebocytes
    • Nagy I, Pivarcsi A, Kis K, et al. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/ chemokines in human sebocytes. Microbes Infect. 2006;8(8):2195-2205
    • (2006) Microbes Infect , vol.8 , Issue.8 , pp. 2195-2205
    • Nagy, I.1    Pivarcsi, A.2    Kis, K.3
  • 37
    • 27144556469 scopus 로고    scopus 로고
    • Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions
    • Tollin M, Bergsson G, Kai-Larsen Y, et al. Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions. Cell Mol Life Sci. 2005; 62(19-20):2390-2399
    • (2005) Cell Mol Life Sci , vol.62 , Issue.19-20 , pp. 2390-2399
    • Tollin, M.1    Bergsson, G.2    Kai-Larsen, Y.3
  • 41
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci USA. 2005;102(50):18129-18134
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.50 , pp. 18129-18134
    • Wehkamp, J.1    Salzman, N.H.2    Porter, E.3
  • 42
    • 37349070287 scopus 로고    scopus 로고
    • The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4
    • Wehkamp J, Wang G, Kubler I, et al. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol. 2007;179(5):3109-3118
    • (2007) J Immunol , vol.179 , Issue.5 , pp. 3109-3118
    • Wehkamp, J.1    Wang, G.2    Kubler, I.3
  • 43
    • 77953035136 scopus 로고    scopus 로고
    • Human alpha defensin 5 mRNA levels are decreased in children with untreated, newly diagnosed Crohn disease
    • Kusek K, Punati J, Bevins CL, et al. Human alpha defensin 5 mRNA levels are decreased in children with untreated, newly diagnosed Crohn disease. Gastroenterology. 2009;136(5):A-14
    • (2009) Gastroenterology , vol.136 , Issue.5
    • Kusek, K.1    Punati, J.2    Bevins, C.L.3
  • 44
    • 76349098016 scopus 로고    scopus 로고
    • Defective Paneth cell-mediated host defense in pediatric ileal Crohn's disease
    • Perminow G, Beisner J, Koslowski M, et al. Defective Paneth cell-mediated host defense in pediatric ileal Crohn's disease. Am J Gastroenterol. 2010;105(2):452-459
    • (2010) Am J Gastroenterol , vol.105 , Issue.2 , pp. 452-459
    • Perminow, G.1    Beisner, J.2    Koslowski, M.3
  • 45
    • 34249945094 scopus 로고    scopus 로고
    • Defensins and other antimicrobial peptides in inflammatory bowel disease
    • Wehkamp J, Schmid M, Stange EF. Defensins and other antimicrobial peptides in inflammatory bowel disease. Curr Opin Gastroenterol. 2007;23(4):370-378
    • (2007) Curr Opin Gastroenterol , vol.23 , Issue.4 , pp. 370-378
    • Wehkamp, J.1    Schmid, M.2    Stange, E.F.3
  • 46
    • 33748558056 scopus 로고    scopus 로고
    • A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon
    • Fellermann K, Stange DE, Schaeffeler E, et al. A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet. 2006;79(3): 439-448
    • (2006) Am J Hum Genet , vol.79 , Issue.3 , pp. 439-448
    • Fellermann, K.1    Stange, D.E.2    Schaeffeler, E.3
  • 47
    • 76349096044 scopus 로고    scopus 로고
    • Association of higher DEFB4 genomic copy number with Crohn's disease
    • Bentley RW, Pearson J, Gearry RB, et al. Association of higher DEFB4 genomic copy number with Crohn's disease. Am J Gastroenterol. 2010;105(2):354-359
    • (2010) Am J Gastroenterol , vol.105 , Issue.2 , pp. 354-359
    • Bentley, R.W.1    Pearson, J.2    Gearry, R.B.3
  • 48
    • 7344252456 scopus 로고    scopus 로고
    • Absence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with necrotising enterocolitis
    • Coutinho HB, da Mota HC, Coutinho VB, et al. Absence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with necrotising enterocolitis. J Clin Pathol. 1998;51(7):512-514
    • (1998) J Clin Pathol , vol.51 , Issue.7 , pp. 512-514
    • Coutinho, H.B.1    Da Mota, H.C.2    Coutinho, V.B.3
  • 49
    • 67651012621 scopus 로고    scopus 로고
    • Epithelial functions of the residual bowel after surgery for necrotising enterocolitis in human infants
    • Schaart MW, de Bruijn AC, Bouwman DM, et al. Epithelial functions of the residual bowel after surgery for necrotising enterocolitis in human infants. J Pediatr Gastroenterol Nutr. 2009;49(1):31-41
    • (2009) J Pediatr Gastroenterol Nutr , vol.49 , Issue.1 , pp. 31-41
    • Schaart, M.W.1    De Bruijn, A.C.2    Bouwman, D.M.3
  • 50
    • 0031844367 scopus 로고    scopus 로고
    • Enteric defensin expression in necrotizing enterocolitis
    • Salzman NH, Polin RA, Harris MC, et al. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res. 1998;44(1):20-26
    • (1998) Pediatr Res , vol.44 , Issue.1 , pp. 20-26
    • Salzman, N.H.1    Polin, R.A.2    Harris, M.C.3
  • 51
    • 0037417311 scopus 로고    scopus 로고
    • Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    • Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 2003; 422(6931):522-526
    • (2003) Nature , vol.422 , Issue.6931 , pp. 522-526
    • Salzman, N.H.1    Ghosh, D.2    Huttner, K.M.3    Paterson, Y.4    Bevins, C.L.5
  • 52
    • 34547762705 scopus 로고    scopus 로고
    • MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection
    • Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med. 2007; 204(8):1891-1900
    • (2007) J Exp Med , vol.204 , Issue.8 , pp. 1891-1900
    • Brandl, K.1    Plitas, G.2    Schnabl, B.3    DeMatteo, R.P.4    Pamer, E.G.5
  • 53
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA. 2008; 105(52):20858-20863
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.52 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 54
    • 33646359941 scopus 로고    scopus 로고
    • Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults
    • Kelly P, Bajaj-Elliott M, Katubulushi M, et al. Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults. J Infect Dis. 2006; 193(10):1464-1470
    • (2006) J Infect Dis , vol.193 , Issue.10 , pp. 1464-1470
    • Kelly, P.1    Bajaj-Elliott, M.2    Katubulushi, M.3
  • 55
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    • Wilson CL, Ouellette AJ, Satchell DP, et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 1999; 286(5437):113-117
    • (1999) Science , vol.286 , Issue.5437 , pp. 113-117
    • Wilson, C.L.1    Ouellette, A.J.2    Satchell, D.P.3
  • 56
    • 23944464510 scopus 로고    scopus 로고
    • Paneth cells and antibacterial host defense in neonatal small intestine
    • Sherman MP, Bennett SH, Hwang FF, Sherman J, Bevins CL. Paneth cells and antibacterial host defense in neonatal small intestine. Infect Immun. 2005;73(9):6143-6146
    • (2005) Infect Immun , vol.73 , Issue.9 , pp. 6143-6146
    • Sherman, M.P.1    Bennett, S.H.2    Hwang, F.F.3    Sherman, J.4    Bevins, C.L.5
  • 57
    • 27744564199 scopus 로고    scopus 로고
    • Intestinal innate immunity to Campylobacter jejuni results in induction of bactericidal human beta-defensins 2 and 3
    • Zilbauer M, Dorrell N, Boughan PK, et al. Intestinal innate immunity to Campylobacter jejuni results in induction of bactericidal human beta-defensins 2 and 3. Infect Immun. 2005;73(11):7281-7289
    • (2005) Infect Immun , vol.73 , Issue.11 , pp. 7281-7289
    • Zilbauer, M.1    Dorrell, N.2    Boughan, P.K.3
  • 58
    • 33745217570 scopus 로고    scopus 로고
    • The co-evolution of host cationic antimicrobial peptides and microbial resistance
    • Peschel A, Sahl HG. The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat Rev Microbiol. 2006; 4(7):529-536
    • (2006) Nat Rev Microbiol , vol.4 , Issue.7 , pp. 529-536
    • Peschel, A.1    Sahl, H.G.2
  • 59
    • 31844457136 scopus 로고    scopus 로고
    • Yersinia's stratagem: Targeting innate and adaptive immune defense
    • Heesemann J, Sing A, Trulzsch K. Yersinia's stratagem: targeting innate and adaptive immune defense. Curr Opin Microbiol. 2006; 9(1):55-61
    • (2006) Curr Opin Microbiol , vol.9 , Issue.1 , pp. 55-61
    • Heesemann, J.1    Sing, A.2    Trulzsch, K.3
  • 60
    • 0035126317 scopus 로고    scopus 로고
    • Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator
    • DOI 10.1038/84627
    • Islam D, Bandholtz L, Nilsson J, et al. Down-regulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med. 2001;7(2):180-185 (Pubitemid 32148484)
    • (2001) Nature Medicine , vol.7 , Issue.2 , pp. 180-185
    • Islam, D.1    Bandholtz, L.2    Nilsson, J.3    Wigzell, H.4    Christensson, B.5    Agerberth, B.6    Gudmundsson, G.H.7
  • 62
    • 55749111413 scopus 로고    scopus 로고
    • Bacterial exotoxins downregulate cathelicidin (hCAP-18/LL-37) and human beta-defensin 1 (HBD-1) expression in the intestinal epithelial cells
    • Chakraborty K, Ghosh S, Koley H, et al. Bacterial exotoxins downregulate cathelicidin (hCAP-18/LL-37) and human beta-defensin 1 (HBD-1) expression in the intestinal epithelial cells. Cell Microbiol. 2008;10(12):2520-2537
    • (2008) Cell Microbiol , vol.10 , Issue.12 , pp. 2520-2537
    • Chakraborty, K.1    Ghosh, S.2    Koley, H.3
  • 63
    • 41449100987 scopus 로고    scopus 로고
    • Alpha-defensin expression in the gastric tissue of children with helicobacter pylori-associated chronic gastritis: An immunohistochemical study
    • DOI 10.1097/MPG.0b013e31815a9923, PII 0000517620080400000026
    • Soylu OB, Ozturk Y, Ozer E. Alpha-defensin expression in the gastric tissue of children with Helicobacter pylori-associated chronic gastritis: an immunohistochemical study. J Pediatr Gastroenterol Nutr. 2008;46(4): 474-477 (Pubitemid 351457891)
    • (2008) Journal of Pediatric Gastroenterology and Nutrition , vol.46 , Issue.4 , pp. 474-477
    • Soylu, O.B.1    Ozturk, Y.2    Ozer, E.3
  • 66
    • 0034835879 scopus 로고    scopus 로고
    • Expression of human beta-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: Antibacterial effect of hBD-2 against Helicobacter pylori
    • Hamanaka Y, Nakashima M, Wada A, et al. Expression of human beta-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: antibacterial effect of hBD-2 against Helicobacter pylori. Gut. 2001;49(4):481-487
    • (2001) Gut , vol.49 , Issue.4 , pp. 481-487
    • Hamanaka, Y.1    Nakashima, M.2    Wada, A.3
  • 67
    • 41349117172 scopus 로고    scopus 로고
    • Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity islanddependent manner
    • Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins CL, Solnick JV. Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity islanddependent manner. Gastroenterology. 2008;134(4):1049- 1057
    • (2008) Gastroenterology , vol.134 , Issue.4 , pp. 1049-1057
    • Hornsby, M.J.1    Huff, J.L.2    Kays, R.J.3    Canfield, D.R.4    Bevins, C.L.5    Solnick, J.V.6
  • 68
    • 0037231945 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: High-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls
    • Jurevic RJ, Bai M, Chadwick RB, White TC, Dale BA. Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. J Clin Microbiol. 2003;41(1):90-96
    • (2003) J Clin Microbiol , vol.41 , Issue.1 , pp. 90-96
    • Jurevic, R.J.1    Bai, M.2    Chadwick, R.B.3    White, T.C.4    Dale, B.A.5
  • 70
    • 36349034041 scopus 로고    scopus 로고
    • Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases
    • Komatsuzawa H, Ouhara K, Kawai T, et al. Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases. Curr Pharm Des. 2007;13(30):3084-3095
    • (2007) Curr Pharm des , vol.13 , Issue.30 , pp. 3084-3095
    • Komatsuzawa, H.1    Ouhara, K.2    Kawai, T.3
  • 71
    • 60249087859 scopus 로고    scopus 로고
    • In vitro bactericidal activity of recombinant human beta-defensin- 3 against pathogenic bacterial strains in human tooth root canal
    • Song W, Shi Y, Xiao M, et al. In vitro bactericidal activity of recombinant human beta-defensin- 3 against pathogenic bacterial strains in human tooth root canal. Int J Antimicrob Agents. 2009;33(3):237-243
    • (2009) Int J Antimicrob Agents , vol.33 , Issue.3 , pp. 237-243
    • Song, W.1    Shi, Y.2    Xiao, M.3
  • 72
    • 33845274520 scopus 로고    scopus 로고
    • Kostmann syndrome or infantile genetic agranulocytosis, part one: Celebrating 50 years of clinical and basic research on severe congenital neutropenia
    • Carlsson G, Andersson M, Putsep K, et al. Kostmann syndrome or infantile genetic agranulocytosis, part one: celebrating 50 years of clinical and basic research on severe congenital neutropenia. Acta Paediatr. 2006;95(12):1526-1532
    • (2006) Acta Paediatr , vol.95 , Issue.12 , pp. 1526-1532
    • Carlsson, G.1    Andersson, M.2    Putsep, K.3
  • 73
    • 36348997293 scopus 로고    scopus 로고
    • Oral antimicrobial peptides and biological control of caries
    • Dale BA, Tao R, Kimball JR, Jurevic RJ. Oral antimicrobial peptides and biological control of caries. BMC Oral Health. 2006;6(suppl 1):S13
    • (2006) BMC Oral Health , vol.6 , Issue.SUPPL. 1
    • Dale, B.A.1    Tao, R.2    Kimball, J.R.3    Jurevic, R.J.4
  • 74
    • 76149146689 scopus 로고    scopus 로고
    • Immunopathogenesis of polymicrobial otitis media
    • Bakaletz LO. Immunopathogenesis of polymicrobial otitis media. J Leukoc Biol. 2010;87(2):213-222
    • (2010) J Leukoc Biol , vol.87 , Issue.2 , pp. 213-222
    • Bakaletz, L.O.1
  • 75
    • 10444227185 scopus 로고    scopus 로고
    • Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae
    • Lee HY, Andalibi A, Webster P, et al. Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae. BMC Infect Dis. 2004;4:12
    • (2004) BMC Infect Dis , vol.4 , pp. 12
    • Lee, H.Y.1    Andalibi, A.2    Webster, P.3
  • 77
    • 33144488424 scopus 로고    scopus 로고
    • Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
    • Moon SK, Lee HY, Pan H, et al. Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells. BMC Infect Dis. 2006;6:12
    • (2006) BMC Infect Dis , vol.6 , pp. 12
    • Moon, S.K.1    Lee, H.Y.2    Pan, H.3
  • 78
    • 68049132805 scopus 로고    scopus 로고
    • Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention
    • Bakaletz LO. Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention. Expert Rev Vaccines. 2009;8(8):1063-1082
    • (2009) Expert Rev Vaccines , vol.8 , Issue.8 , pp. 1063-1082
    • Bakaletz, L.O.1
  • 79
    • 70349932460 scopus 로고    scopus 로고
    • RSV-induced dys-regulation of expression of a mucosal beta-defensin augments colonization of the upper airway by nontypeable Haemophilus influenzae
    • McGillivary G, Mason KM, Jurcisek JA, Peeples ME, Bakaletz LO. RSV-induced dys-regulation of expression of a mucosal beta-defensin augments colonization of the upper airway by nontypeable Haemophilus influenzae. Cell Microbiol. 2009;11(9): 1399-1408
    • (2009) Cell Microbiol , vol.11 , Issue.9 , pp. 1399-1408
    • McGillivary, G.1    Mason, K.M.2    Jurcisek, J.A.3    Peeples, M.E.4    Bakaletz, L.O.5
  • 80
    • 38549086390 scopus 로고    scopus 로고
    • Association of beta-defensin-1 gene polymorphisms with Pseudomonas aeruginosa airway colonization in cystic fibrosis
    • Tesse R, Cardinale F, Santostasi T, et al. Association of beta-defensin-1 gene polymorphisms with Pseudomonas aeruginosa airway colonization in cystic fibrosis. Genes Immun. 2008;9(1):57-60
    • (2008) Genes Immun , vol.9 , Issue.1 , pp. 57-60
    • Tesse, R.1    Cardinale, F.2    Santostasi, T.3
  • 81
    • 67650724071 scopus 로고    scopus 로고
    • Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs
    • Voglis S, Quinn K, Tullis E, et al. Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs. Am J Respir Crit Care Med. 2009;180(2):159-166
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.2 , pp. 159-166
    • Voglis, S.1    Quinn, K.2    Tullis, E.3
  • 82
    • 70349650567 scopus 로고    scopus 로고
    • Activity of antimicrobial peptides in the presence of polysaccharides produced by pulmonary pathogens
    • Benincasa M, Mattiuzzo M, Herasimenka Y, Cescutti P, Rizzo R, Gennaro R. Activity of antimicrobial peptides in the presence of polysaccharides produced by pulmonary pathogens. J Pept Sci. 2009;15(9): 595-600
    • (2009) J Pept Sci , vol.15 , Issue.9 , pp. 595-600
    • Benincasa, M.1    Mattiuzzo, M.2    Herasimenka, Y.3    Cescutti, P.4    Rizzo, R.5    Gennaro, R.6
  • 83
    • 34748890084 scopus 로고    scopus 로고
    • The role of cathelicidin and defensins in pulmonary inflammatory diseases
    • Herr C, Shaykhiev R, Bals R. The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther. 2007;7(9):1449-1461
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.9 , pp. 1449-1461
    • Herr, C.1    Shaykhiev, R.2    Bals, R.3
  • 85
    • 4644235588 scopus 로고    scopus 로고
    • Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis
    • Kalfa VC, Spector SL, Ganz T, Cole AM. Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis. Ann Allergy Asthma Immunol. 2004;93(3):288-292 (Pubitemid 39294735)
    • (2004) Annals of Allergy, Asthma and Immunology , vol.93 , Issue.3 , pp. 288-292
    • Kalfa, V.C.1    Spector, S.L.2    Ganz, T.3    Cole, A.M.4
  • 86
    • 39749095910 scopus 로고    scopus 로고
    • Innate immunity in the paranasal sinuses: A review of nasal host defenses
    • Ooi EH, Wormald PJ, Tan LW. Innate immunity in the paranasal sinuses: a review of nasal host defenses. Am J Rhinol. 2008; 22(1):13-19
    • (2008) Am J Rhinol , vol.22 , Issue.1 , pp. 13-19
    • Ooi, E.H.1    Wormald, P.J.2    Tan, L.W.3
  • 90
    • 60549106052 scopus 로고    scopus 로고
    • Probiotic e coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans
    • Möndel M, Schroeder BO, Zimmermann K, et al. Probiotic E coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans. Mucosal Immunol. 2009;2(2):166-172
    • (2009) Mucosal Immunol , vol.2 , Issue.2 , pp. 166-172
    • Möndel, M.1    Schroeder, B.O.2    Zimmermann, K.3


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