Mimicking vernix caseosa-Preparation and characterization of synthetic biofilms

International Journal of Pharmaceutics

Volumn 372, Issue 1-2, 2009, Pages 59-65

  Rissmann, Robert ^a   Oudshoorn, Marion H M ^b   Zwier, Raphaël ^c   Ponec, Maria ^a   Bouwstra, Joke A ^a   Hennink, Wim E ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Biophysical properties; Dehydration; Synthetic biofilms; Vernix caseosa

Indexed keywords

BIOMIMETIC MATERIAL; LANOLIN;

ARTICLE; BIOFILM; DRUG FORMULATION; DRUG MIXTURE; DRUG STABILITY; DRUG SYNTHESIS; ELASTICITY; ENTHALPY; FETUS (ANATOMY); FLOW KINETICS; IN VITRO STUDY; PRIORITY JOURNAL; VISCOSITY;

BIOFILMS; BIOMIMETIC MATERIALS; BIOMIMETICS; MEMBRANES, ARTIFICIAL; VERNIX CASEOSA;

EID: 64149107352     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.01.013     Document Type: Article

References (21)

1. Akinbi H.T., Narendran V., Pass A.K., Markart P., and Hoath S.B. Host defense proteins in vernix caseosa and amniotic fluid. Am. J. Obstet. Gynecol. 191 (2004) 2090-2096
2. Candi E., Schmidt R., and Melino G. The cornified envelope: a model of cell death in the skin. Nat. Rev. Mol. Cell Biol. 6 (2005) 328-340
3. De Geest B.G., Stubbe B.G., Jonas A.M., Van Thienen T., Hinrichs W.L., Demeester J., and De Smedt S.C. Self-exploding lipid-coated microgels. Biomacromolecules 7 (2006) 373-379
4. Haubrich K.A. Role of Vernix caseosa in the neonate: potential application in the adult population. AACN Clin. Issues 14 (2003) 457-464
5. Hoeger P.H., Schreiner V., Klaassen I.A., Enzmann C.C., Friedrichs K., and Bleck O. Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern in vernix and fetal skin. Br. J. Dermatol. 146 (2002) 194-201
6. Kaerkkaeinen J., Nikkari T., Ruponen S., and Haahti E. Lipids Of vernix caseosa. J. Invest. Dermatol. 44 (1965) 333-338
7. Kainthan R.K., Janzen J., Levin E., Devine D.V., and Brooks D.E. Biocompatibility testing of branched and linear polyglycidol. Biomacromolecules 7 (2006) 703-709
8. Moraille R., Pickens W.L., Visscher M.O., and Hoath S.B. A novel role for vernix caseosa as a skin cleanser. Biol. Neonate 87 (2005) 8-14
9. Oudshoorn M.H., Penterman R., Rissmann R., Bouwstra J.A., Broer D.J., and Hennink W.E. Preparation and characterization of structured hydrogel microparticles based on cross-linked hyperbranched polyglycerol. Langmuir 23 (2007) 11819-11825
10. Oudshoorn M.H., Rissmann R., Bouwstra J.A., and Hennink W.E. Synthesis and characterization of hyperbranched polyglycerol hydrogels. Biomaterials 27 (2006) 5471-5479
11. Oudshoorn M.H., Rissmann R., van der Coelen D., Hennink W.E., Ponec M., and Bouwstra J.A. Development of a Murine model to evaluate the effect of vernix caseosa on skin barrier recovery. Exp. Dermatol. 18 (2009) 178-184
12. Pickens W.L., Warner R.R., Boissy Y.L., Boissy R.E., and Hoath S.B. Characterization of vernix caseosa: water content, morphology, and elemental analysis. J. Invest. Dermatol. 115 (2000) 875-881
13. Pickens W.L., Zhou Y., Wickett R.R., Visscher M.Q., and Hoath S.B. Antioxidant defense mechanisms in vernix caseosa: potential role of endogenous vitamin E. Pediatr. Res. 47 (2000) 425A-1425A
14. Rissmann R., Groenink H.W., Gooris G.S., Oudshoorn M.H., Hennink W.E., Ponec M., and Bouwstra J.A. Temperature-induced changes in structural and physicochemical properties of vernix caseosa. J. Invest. Dermatol. 128 (2008) 292-299
15. Rissmann R., Groenink H.W., Weerheim A.M., Hoath S.B., Ponec M., and Bouwstra J.A. New insights into ultrastructure, lipid composition and organization of vernix caseosa. J. Invest. Dermatol. 126 (2006) 1823-1833
16. Rissmann R., Oudshoorn M.H., Kocks E., Hennink W.E., Ponec M., and Bouwstra J. Lanolin-derived lipid mixtures mimic closely the lipid composition and organization of vernix caseosa lipids. Biochim. Biophys. Acta 1778 (2008) 2350-2360
17. Tansirikongkol A., Hoath S.B., Pickens W.L., Visscher M.O., and Wickett R.R. Equilibrium water content in native vernix and its cellular component. J. Pharm. Sci. 97 (2008) 972-981
18. Tansirikongkol A., Wickett R.R., Visscher M.O., and Hoath S.B. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr. Res. 62 (2007) 49-53
19. Tollin M., Bergsson G., Kai-Larsen Y., Lengqvist J., Sjovall J., Griffiths W., Skuladottir G.V., et al. Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions. Cell. Mol. Life Sci. 62 (2005) 2390-2399
20. Tollin M., Jagerbrink T., Haraldsson A., Agerberth B., and Jornvall H. Proteome analysis of vernix caseosa. Pediatr. Res. (2006) 60
21. Visscher M.O., Narendran V., Pickens W.L., LaRuffa A.A., Meinzen-Derr J., Allen K., and Hoath S.B. Vernix caseosa in neonatal adaptation. J. Perinatol. 25 (2005) 440-446