Expression of β-defensins in the tubotympanum of experimental otitis media

Acta Oto-Laryngologica

Volumn 126, Issue 10, 2006, Pages 1040-1045

  Shin, Dong Jin ^a   Gan Undram, Semeibsuren ^a   Kim, Seo Jin ^a   Jun, Young Joon ^a   Im, Gi Jung ^a   Jung, Hak Hyun ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Gene; Mouse; Otitis media; Pathogenesis

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; BETA DEFENSIN 4; CRYPTDIN; CRYPTDIN RELATED SEQUENCE 1 C; CRYPTDIN RELATED SEQUENCE 4 C; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY TUBE; CONTROLLED STUDY; EARDRUM; INNATE IMMUNITY; MALE; MIDDLE EAR MUCOSA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OTITIS MEDIA; PATHOGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BETA-DEFENSINS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; EAR, MIDDLE; ENDOTOXINS; EUSTACHIAN TUBE; GENE EXPRESSION; MALE; MICE; MICE, INBRED BALB C; OTITIS MEDIA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, PROTEIN; UP-REGULATION;

EID: 33747727656     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480600672626     Document Type: Article

References (18)

1. Lim DJ, Chun YM, Moon SK, Chang KH, Li JD, Chang JD, et al. Cell biology of tubotympanum in relation to pathogenesis of otitis media - a review. Vaccine 2000;19(Suppl 1):S17-25.
2. Hanamure Y, Lim DJ. Normal distribution of lysozyme- and lactoferrin-secreting cells in the chinchilla tubotympanum. Am J Otolaryngol 1986;7:410-25.
3. Park K, Lim DJ. Development of secretory elements in murine tubotympanum: lysozyme and lactoferrin immunohistochemistry. Ann Otol Rhinol Laryngol 1993;102:385-95.
4. Paananen R, Glumoff V, Hallman M. Surfactant protein A and D expression in the porcine Eustachian tube. FEBS Lett 1999;452:141-4.
5. Ichimiya I, Kawauchi H, Mogi G. Analysis of immunocompetent cells in the middle ear mucosa. Arch Otolaryngol Head Neck Surg 1990;116:324-30.
6. Sakamoto N, Mukae H, Fujii T, Ishii H, Yoshioka S, Kakugawa T, et al. Differential effects of alpha- and beta-defensin on cytokine production by cultured human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2005;288:508-13.
7. Eckmann L. Defence molecules in intestinal innate immunity against bacterial infections. Curr Opin Gastroenterol 2005;21:147-51.
8. Jung HH, Kim MW, Lee JH, Kim YT, Kim NH, Chang BA, et al. Expression of vascular endothelial growth factor in otitis media. Acta Otolaryngol 1999;119:801-8.
9. Com E, Bourgeon F, Evrard B, Ganz T, Colleu D, Jegou B, et al. Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod 2003;68:95-104.
10. Patil A, Hughes AL, Zhang G. Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes. Physiol Genomics 2004;20:1-11.
11. Hornef MW, Putsep K, Karlsson J, Refai E, Andersson M. Increased diversity of intestinal antimicrobial peptides by covalent dimer formation. Nat Immunol 2004;5:836-43.
12. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB Jr, Ganz T. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 1998;101:1633-42.
13. Aarbiou J, Rabe KF, Hiemstra PS. Role of defensins in inflammatory lung disease. Ann Med 2002;34:96-101.
14. Mathews M, Jia HP, Guthmiller JM, Losh G, Graham S, Johnson GK, et al. Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 1999;67:2740-5.
15. Garcia JR, Krause A, Schulz S, Rodriguez-Jimenez FJ, Kluver E, Adermann K, et al. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 2001;15:1819-21.
16. Harder J, Meyer-Hoffert U, Teran LM, Schwichtenberg L, Bartels J, Maune S, et al. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 2000;22:714-21.
17. Fahlgren A, Hammarstrom S, Danielsson A, Hammarstrom ML. Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis. Clin Exp Immunol 2004;137:379-85.
18. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001;276:5707-13.