-
1
-
-
0036547417
-
Death and anti-death: Tumour resistance to apoptosis
-
Igney F.H., Krammer P.H. Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer. 2:2002;277-288.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
3
-
-
0036515618
-
Cell metabolism in the regulation of programmed cell death
-
Plas D.R., Thompson C.B. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol. Metab. 13:2002;75-78.
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 75-78
-
-
Plas, D.R.1
Thompson, C.B.2
-
4
-
-
0036636095
-
Opinion: Building epithelial architecture: Insights from three-dimensional culture models
-
O'Brien L.E., Zegers M.M., Mostov K.E. Opinion: building epithelial architecture: insights from three-dimensional culture models. Nat. Rev. Mol. Cell. Biol. 3:2002;531-537.
-
(2002)
Nat. Rev. Mol. Cell. Biol.
, vol.3
, pp. 531-537
-
-
O'brien, L.E.1
Zegers, M.M.2
Mostov, K.E.3
-
5
-
-
0036990109
-
The organizing principle: Microenvironmental influences in the normal and malignant breast
-
Bissell M.J., Radisky D.C., Rizki A., Weaver V.M., Petersen O.W. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation. 70:2002;537-546.
-
(2002)
Differentiation
, vol.70
, pp. 537-546
-
-
Bissell, M.J.1
Radisky, D.C.2
Rizki, A.3
Weaver, V.M.4
Petersen, O.W.5
-
6
-
-
0037791921
-
Analysis of microenvironmental factors contributing to basement membrane assembly and normalized epidermal phenotype
-
Andriani F., Margulis A., Lin N., Griffey S., Garlick J.A. Analysis of microenvironmental factors contributing to basement membrane assembly and normalized epidermal phenotype. J. Invest. Dermatol. 120:2003;923-931.
-
(2003)
J. Invest. Dermatol.
, vol.120
, pp. 923-931
-
-
Andriani, F.1
Margulis, A.2
Lin, N.3
Griffey, S.4
Garlick, J.A.5
-
7
-
-
0032956497
-
New perspectives on mechanisms involved in generating epithelial cell polarity
-
Yeaman C., Grindstaff K.K., Nelson W.J. New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol. Rev. 79:1999;73-98.
-
(1999)
Physiol. Rev.
, vol.79
, pp. 73-98
-
-
Yeaman, C.1
Grindstaff, K.K.2
Nelson, W.J.3
-
8
-
-
0036178447
-
Signal transduction by cell adhesion receptors and the cytoskeleton: Functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members
-
Juliano R.L. Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Annu. Rev. Pharmacol. Toxicol. 42:2002;283-323.
-
(2002)
Annu. Rev. Pharmacol. Toxicol.
, vol.42
, pp. 283-323
-
-
Juliano, R.L.1
-
9
-
-
0028818755
-
Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo
-
Coucouvanis E., Martin G.R. Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell. 83:1995;279-287.
-
(1995)
Cell
, vol.83
, pp. 279-287
-
-
Coucouvanis, E.1
Martin, G.R.2
-
10
-
-
0037020196
-
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
-
By studying how lumen formation is maintained in a 3D tissue structure, the authors were able to implicate a role for autophagy in apoptosis regulation. The experiments emphasize the complex nature of 3D tissues and show how resistant tissues can be to malignant transformation. They demonstrate that lumen filling recapitulates an early stage of malignant transformation that requires both enhanced cell survival and increased proliferation. Moreover, although overexpression of an activated ErbB2 could induce a 'premalignant' phenotype, complete malignant transformation and invasion could not be induced.
-
Debnath J., Mills K.R., Collins N.L., Reginato M.J., Muthuswamy S.K., Brugge J.S. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 111:2002;29-40 By studying how lumen formation is maintained in a 3D tissue structure, the authors were able to implicate a role for autophagy in apoptosis regulation. The experiments emphasize the complex nature of 3D tissues and show how resistant tissues can be to malignant transformation. They demonstrate that lumen filling recapitulates an early stage of malignant transformation that requires both enhanced cell survival and increased proliferation. Moreover, although overexpression of an activated ErbB2 could induce a 'premalignant' phenotype, complete malignant transformation and invasion could not be induced.
-
(2002)
Cell
, vol.111
, pp. 29-40
-
-
Debnath, J.1
Mills, K.R.2
Collins, N.L.3
Reginato, M.J.4
Muthuswamy, S.K.5
Brugge, J.S.6
-
11
-
-
0030700763
-
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
-
Goh K.L., Yang J.T., Hynes R.O. Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 124:1997;4309-4319.
-
(1997)
Development
, vol.124
, pp. 4309-4319
-
-
Goh, K.L.1
Yang, J.T.2
Hynes, R.O.3
-
12
-
-
0037052448
-
Stromal effects on mammary gland development and breast cancer
-
Wiseman B.S., Werb Z. Stromal effects on mammary gland development and breast cancer. Science. 296:2002;1046-1049.
-
(2002)
Science
, vol.296
, pp. 1046-1049
-
-
Wiseman, B.S.1
Werb, Z.2
-
13
-
-
0036800344
-
Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells
-
Faraldo M.M., Deugnier M.A., Tlouzeau S., Thiery J.P., Glukhova M.A. Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells. Mol. Biol. Cell. 13:2002;3521-3531.
-
(2002)
Mol. Biol. Cell.
, vol.13
, pp. 3521-3531
-
-
Faraldo, M.M.1
Deugnier, M.A.2
Tlouzeau, S.3
Thiery, J.P.4
Glukhova, M.A.5
-
15
-
-
0034630468
-
Divinations and surprises: Genetic analysis of caspase function in mice
-
Zheng T.S., Flavell R.A. Divinations and surprises: genetic analysis of caspase function in mice. Exp. Cell. Res. 256:2000;67-73.
-
(2000)
Exp. Cell. Res.
, vol.256
, pp. 67-73
-
-
Zheng, T.S.1
Flavell, R.A.2
-
16
-
-
0032217084
-
Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
-
Wang F., Weaver V.M., Petersen O.W., Larabell C.A., Dedhar S., Briand P., Lupu R., Bissell M.J. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc. Natl. Acad. Sci. USA. 95:1998;14821-14826.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14821-14826
-
-
Wang, F.1
Weaver, V.M.2
Petersen, O.W.3
Larabell, C.A.4
Dedhar, S.5
Briand, P.6
Lupu, R.7
Bissell, M.J.8
-
17
-
-
0242266916
-
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
-
This is an interesting study examining the role of AKT in epithelial survival and morphogenesis using a reconstituted ECM assay and immortalized mammary epithelial cells. The data indicate that although AKT does have a modest and significant effect on cell survival it primarily induces cell growth and compromises morphogenesis.
-
Debnath J., Walker S.J., Brugge J.S. Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J. Cell. Biol. 163:2003;315-326 This is an interesting study examining the role of AKT in epithelial survival and morphogenesis using a reconstituted ECM assay and immortalized mammary epithelial cells. The data indicate that although AKT does have a modest and significant effect on cell survival it primarily induces cell growth and compromises morphogenesis.
-
(2003)
J. Cell. Biol.
, vol.163
, pp. 315-326
-
-
Debnath, J.1
Walker, S.J.2
Brugge, J.S.3
-
18
-
-
0347363470
-
-
Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM: Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage independent survival of mammary tumors. J Cell Biol 2003, in press
-
Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM: Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage independent survival of mammary tumors. J Cell Biol 2003, in press.
-
-
-
-
19
-
-
0037009820
-
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts
-
Wang F., Hansen R.K., Radisky D., Yoneda T., Barcellos-Hoff M.H., Petersen O.W., Turley E.A., Bissell M.J. Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J. Natl. Cancer Inst. 94:2002;1494-1503.
-
(2002)
J. Natl. Cancer Inst.
, vol.94
, pp. 1494-1503
-
-
Wang, F.1
Hansen, R.K.2
Radisky, D.3
Yoneda, T.4
Barcellos-Hoff, M.H.5
Petersen, O.W.6
Turley, E.A.7
Bissell, M.J.8
-
20
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
Hutchinson J., Jin J., Cardiff R.D., Woodgett J.R., Muller W.J. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol. Cell. Biol. 21:2001;2203-2212.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
21
-
-
0029916820
-
Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle
-
Boudreau N., Werb Z., Bissell M.J. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc. Natl. Acad. Sci. USA. 93:1996;3509-3513.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3509-3513
-
-
Boudreau, N.1
Werb, Z.2
Bissell, M.J.3
-
22
-
-
0036726312
-
Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
-
Using 3D ECM assays and a unique tumor progression model that could be phenotypically reverted to recapitulate a 'polarized-differentiated' tissue structure, a role for tissue polarity in generating apoptosis resistance in cells was revealed. Tissue polarity and apoptosis resistance were shown to depend upon α6β4 integrin ligation and activation of NFκB, revealing a mechanism whereby the tissue microenvironment can modulate drug responsiveness of primary and metastatic tumors. These data explain why tumors in vivo that express α6β4 integrins and basement membrane proteins often have such an unfavorable prognosis.
-
Weaver V.M., Lelievre S., Lakins J.N., Chrenek M.A., Jones J.C., Giancotti F., Werb Z., Bissell M.J. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2:2002;205-216 Using 3D ECM assays and a unique tumor progression model that could be phenotypically reverted to recapitulate a 'polarized-differentiated' tissue structure, a role for tissue polarity in generating apoptosis resistance in cells was revealed. Tissue polarity and apoptosis resistance were shown to depend upon α6β4 integrin ligation and activation of NFκB, revealing a mechanism whereby the tissue microenvironment can modulate drug responsiveness of primary and metastatic tumors. These data explain why tumors in vivo that express α6β4 integrins and basement membrane proteins often have such an unfavorable prognosis.
-
(2002)
Cancer Cell.
, vol.2
, pp. 205-216
-
-
Weaver, V.M.1
Lelievre, S.2
Lakins, J.N.3
Chrenek, M.A.4
Jones, J.C.5
Giancotti, F.6
Werb, Z.7
Bissell, M.J.8
-
23
-
-
0034854201
-
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly
-
O'Brien L.E., Jou T.S., Pollack A.L., Zhang Q., Hansen S.H., Yurchenco P., Mostov K.E. Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat. Cell. Biol. 3:2001;831-838.
-
(2001)
Nat. Cell. Biol.
, vol.3
, pp. 831-838
-
-
O'brien, L.E.1
Jou, T.S.2
Pollack, A.L.3
Zhang, Q.4
Hansen, S.H.5
Yurchenco, P.6
Mostov, K.E.7
-
24
-
-
0028918891
-
In vivo analysis of cadherin function in the mouse intestinal epithelium: Essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death
-
Hermiston M.L., Gordon J.I. In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J. Cell. Biol. 129:1995;489-506.
-
(1995)
J. Cell. Biol.
, vol.129
, pp. 489-506
-
-
Hermiston, M.L.1
Gordon, J.I.2
-
25
-
-
0028258533
-
Apoptosis induced by inhibition of intercellular contact
-
Bates R.C., Buret A., van Helden D.F., Horton M.A., Burns G.F. Apoptosis induced by inhibition of intercellular contact. J. Cell. Biol. 125:1994;403-415.
-
(1994)
J. Cell. Biol.
, vol.125
, pp. 403-415
-
-
Bates, R.C.1
Buret, A.2
Van Helden, D.F.3
Horton, M.A.4
Burns, G.F.5
-
26
-
-
0037457986
-
CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture
-
A functional role for an immunoglobulin superfamily adhesion molecule was demonstrated during mammary morphogenesis and tumor suppression through regulation of apoptosis induction and lumen formation.
-
Kirshner J., Chen C.J., Liu P., Huang J., Shively J.E. CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Proc. Natl. Acad. Sci. USA. 100:2003;521-526 A functional role for an immunoglobulin superfamily adhesion molecule was demonstrated during mammary morphogenesis and tumor suppression through regulation of apoptosis induction and lumen formation.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 521-526
-
-
Kirshner, J.1
Chen, C.J.2
Liu, P.3
Huang, J.4
Shively, J.E.5
-
27
-
-
12244289602
-
A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance
-
Yu J.L., Coomber B.L., Kerbel R.S. A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance. Differentiation. 70:2002;599-609.
-
(2002)
Differentiation
, vol.70
, pp. 599-609
-
-
Yu, J.L.1
Coomber, B.L.2
Kerbel, R.S.3
-
28
-
-
0038238157
-
Oxygenation and response to irradiation of organotypic multicellular spheroids of human glioma
-
Sminia P., Acker H., Eikesdal H.P., Kaaijk P., Enger P., Slotman B., Bjerkvig R. Oxygenation and response to irradiation of organotypic multicellular spheroids of human glioma. Anticancer Res. 23:2003;1461-1466.
-
(2003)
Anticancer Res.
, vol.23
, pp. 1461-1466
-
-
Sminia, P.1
Acker, H.2
Eikesdal, H.P.3
Kaaijk, P.4
Enger, P.5
Slotman, B.6
Bjerkvig, R.7
-
29
-
-
0033804913
-
Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids
-
Santini M.T., Rainaldi G., Indovina P.L. Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids. Crit. Rev. Oncol. Hematol. 36:2000;75-87.
-
(2000)
Crit. Rev. Oncol. Hematol.
, vol.36
, pp. 75-87
-
-
Santini, M.T.1
Rainaldi, G.2
Indovina, P.L.3
-
30
-
-
0036892112
-
Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: Their prognostic value and role in tumour invasion and progression
-
Ioachim E., Charchanti A., Briasoulis E., Karavasilis V., Tsanou H., Arvanitis D.L., Agnantis N.J., Pavlidis N. Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. Eur. J. Cancer. 38:2002;2362-2370.
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 2362-2370
-
-
Ioachim, E.1
Charchanti, A.2
Briasoulis, E.3
Karavasilis, V.4
Tsanou, H.5
Arvanitis, D.L.6
Agnantis, N.J.7
Pavlidis, N.8
-
31
-
-
0036329807
-
New insights into the role of extracellular matrix during tumor onset and progression
-
Pupa S.M., Menard S., Forti S., Tagliabue E. New insights into the role of extracellular matrix during tumor onset and progression. J. Cell. Physiol. 192:2002;259-267.
-
(2002)
J. Cell. Physiol.
, vol.192
, pp. 259-267
-
-
Pupa, S.M.1
Menard, S.2
Forti, S.3
Tagliabue, E.4
-
32
-
-
0036499140
-
Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines
-
Shain K.H., Landowski T.H., Dalton W.S. Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines. J. Immunol. 168:2002;2544-2553.
-
(2002)
J. Immunol.
, vol.168
, pp. 2544-2553
-
-
Shain, K.H.1
Landowski, T.H.2
Dalton, W.S.3
-
33
-
-
0038528630
-
The tumor microenvironment: Focus on myeloma
-
Dalton W.S. The tumor microenvironment: focus on myeloma. Cancer Treat Rev. 29(Suppl 1):2003;11-19.
-
(2003)
Cancer Treat Rev.
, vol.29
, Issue.SUPPL. 1
, pp. 11-19
-
-
Dalton, W.S.1
-
34
-
-
0034667463
-
Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors
-
Oloumi A., MacPhail S.H., Johnston P.J., Banath J.P., Olive P.L. Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors. Cancer Res. 60:2000;5747-5753.
-
(2000)
Cancer Res.
, vol.60
, pp. 5747-5753
-
-
Oloumi, A.1
Macphail, S.H.2
Johnston, P.J.3
Banath, J.P.4
Olive, P.L.5
-
35
-
-
0033032317
-
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
-
Sethi T., Rintoul R.C., Moore S.M., MacKinnon A.C., Salter D., Choo C., Chilvers E.R., Dransfield I., Donnelly S.C., Strieter R.et al. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat. Med. 5:1999;662-668.
-
(1999)
Nat. Med.
, vol.5
, pp. 662-668
-
-
Sethi, T.1
Rintoul, R.C.2
Moore, S.M.3
Mackinnon, A.C.4
Salter, D.5
Choo, C.6
Chilvers, E.R.7
Dransfield, I.8
Donnelly, S.C.9
Strieter, R.10
-
36
-
-
0034606657
-
Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors
-
Taylor S.T., Hickman J.A., Dive C. Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors. J. Natl. Cancer Inst. 92:2000;18-23.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 18-23
-
-
Taylor, S.T.1
Hickman, J.A.2
Dive, C.3
-
37
-
-
0037302790
-
Prostate carcinoma bone-stroma interaction and its biologic and therapeutic implications
-
Chung L.W. Prostate carcinoma bone-stroma interaction and its biologic and therapeutic implications. Cancer. 97:2003;772-778.
-
(2003)
Cancer
, vol.97
, pp. 772-778
-
-
Chung, L.W.1
-
38
-
-
0037225792
-
The impact of tissue microenvironment on treatment simulation
-
Dasu A., Denekamp J. The impact of tissue microenvironment on treatment simulation. Adv. Exp. Med. Biol. 510:2003;63-67.
-
(2003)
Adv. Exp. Med. Biol.
, vol.510
, pp. 63-67
-
-
Dasu, A.1
Denekamp, J.2
-
39
-
-
0036990103
-
The organ microenvironment and cancer metastasis
-
Fidler I.J. The organ microenvironment and cancer metastasis. Differentiation. 70:2002;498-505.
-
(2002)
Differentiation
, vol.70
, pp. 498-505
-
-
Fidler, I.J.1
-
40
-
-
0032789521
-
Determinants of paclitaxel penetration and accumulation in human solid tumor
-
Kuh H.J., Jang S.H., Wientjes M.G., Weaver J.R., Au J.L. Determinants of paclitaxel penetration and accumulation in human solid tumor. J. Pharmacol. Exp. Ther. 290:1999;871-880.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.290
, pp. 871-880
-
-
Kuh, H.J.1
Jang, S.H.2
Wientjes, M.G.3
Weaver, J.R.4
Au, J.L.5
-
41
-
-
0036307898
-
Limited penetration of anticancer drugs through tumor tissue: A potential cause of resistance of solid tumors to chemotherapy
-
Tannock I.F., Lee C.M., Tunggal J.K., Cowan D.S., Egorin M.J. Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy. Clin. Cancer Res. 8:2002;878-884.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 878-884
-
-
Tannock, I.F.1
Lee, C.M.2
Tunggal, J.K.3
Cowan, D.S.4
Egorin, M.J.5
-
42
-
-
0042337427
-
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
-
Truong T., Sun G., Doorly M., Wang J.Y., Schwartz M.A. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proc. Natl. Acad. Sci. USA. 100:2003;10281-10286.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10281-10286
-
-
Truong, T.1
Sun, G.2
Doorly, M.3
Wang, J.Y.4
Schwartz, M.A.5
-
43
-
-
0036467477
-
Apoptosis and tumourigenesis
-
Hickman J.A. Apoptosis and tumourigenesis. Curr. Opin. Genet. Dev. 12:2002;67-72.
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 67-72
-
-
Hickman, J.A.1
-
44
-
-
0034904776
-
Growth factors can influence cell growth and survival through effects on glucose metabolism
-
Vander Heiden M.G., Plas D.R., Rathmell J.C., Fox C.J., Harris M.H., Thompson C.B. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21:2001;5899-5912.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5899-5912
-
-
Vander Heiden, M.G.1
Plas, D.R.2
Rathmell, J.C.3
Fox, C.J.4
Harris, M.H.5
Thompson, C.B.6
-
45
-
-
0035958902
-
A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription
-
Matter M.L., Ruoslahti E. A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription. J. Biol. Chem. 276:2001;27757-27763.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27757-27763
-
-
Matter, M.L.1
Ruoslahti, E.2
-
46
-
-
0041977046
-
Spatial and temporal changes in Bax subcellular localization during anoikis
-
Valentijn A.J., Metcalfe A.D., Kott J., Streuli C.H., Gilmore A.P. Spatial and temporal changes in Bax subcellular localization during anoikis. J. Cell. Biol. 162:2003;599-612.
-
(2003)
J. Cell. Biol.
, vol.162
, pp. 599-612
-
-
Valentijn, A.J.1
Metcalfe, A.D.2
Kott, J.3
Streuli, C.H.4
Gilmore, A.P.5
-
47
-
-
0033800091
-
Multicellular resistance: A paradigm for clinical resistance?
-
Desoize B., Jardillier J. Multicellular resistance: a paradigm for clinical resistance? Crit. Rev. Oncol. Hematol. 36:2000;193-207.
-
(2000)
Crit. Rev. Oncol. Hematol.
, vol.36
, pp. 193-207
-
-
Desoize, B.1
Jardillier, J.2
-
48
-
-
0030698779
-
Mitochondrial function in oncogene-transfected rat fibroblasts isolated from multicellular spheroids
-
Kunz-Schughart L.A., Habbersett R.C., Freyer J.P. Mitochondrial function in oncogene-transfected rat fibroblasts isolated from multicellular spheroids. Am. J. Physiol. 273:1997;C1487-C1495.
-
(1997)
Am. J. Physiol.
, vol.273
-
-
Kunz-Schughart, L.A.1
Habbersett, R.C.2
Freyer, J.P.3
-
49
-
-
0031837969
-
Decreased mitochondrial function in quiescent cells isolated from multicellular tumor spheroids
-
Freyer J.P. Decreased mitochondrial function in quiescent cells isolated from multicellular tumor spheroids. J. Cell. Physiol. 176:1998;138-149.
-
(1998)
J. Cell. Physiol.
, vol.176
, pp. 138-149
-
-
Freyer, J.P.1
-
50
-
-
0037157824
-
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
-
A comprehensive study showing for the first time that integrin ligation can regulate gene expression by altering mitochondrial redox through activation of RhoGTPases and effects on the actin cytoskeleton.
-
Werner E., Werb Z. Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J. Cell. Biol. 158:2002;357-368 A comprehensive study showing for the first time that integrin ligation can regulate gene expression by altering mitochondrial redox through activation of RhoGTPases and effects on the actin cytoskeleton.
-
(2002)
J. Cell. Biol.
, vol.158
, pp. 357-368
-
-
Werner, E.1
Werb, Z.2
-
51
-
-
0032970945
-
Three-dimensional spheroid model in tumor biology
-
Santini M.T., Rainaldi G. Three-dimensional spheroid model in tumor biology. Pathobiology. 67:1999;148-157.
-
(1999)
Pathobiology
, vol.67
, pp. 148-157
-
-
Santini, M.T.1
Rainaldi, G.2
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