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Volumn 7, Issue 7, 2008, Pages 2233-2240

Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

Author keywords

[No Author keywords available]

Indexed keywords

A33 ANTIBODY; ANTIBODY; CARCINOEMBRYONIC ANTIBODY; CARCINOEMBRYONIC ANTIGEN; UNCLASSIFIED DRUG; CANCER ANTIBODY; TUMOR ANTIGEN;

EID: 51049105989     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0067     Document Type: Article
Times cited : (83)

References (30)
  • 1
    • 33846215917 scopus 로고    scopus 로고
    • Antibody constructs in cancer therapy: Protein engineering strategies to improve exposure in solid tumors
    • Beckman RA, Weiner LM, Davis HM. Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors. Cancer 2007;109:170-9.
    • (2007) Cancer , vol.109 , pp. 170-179
    • Beckman, R.A.1    Weiner, L.M.2    Davis, H.M.3
  • 3
    • 0033302303 scopus 로고    scopus 로고
    • Transport ofmolecules, particles, and cells in solid tumors
    • Jain RK. Transport ofmolecules, particles, and cells in solid tumors. Annu Rev Biomed Eng 1999;1:241-63.
    • (1999) Annu Rev Biomed Eng , vol.1 , pp. 241-263
    • Jain, R.K.1
  • 4
    • 34250380650 scopus 로고    scopus 로고
    • Theoretic criteria for antibody penetration into solid tumors and micrometastases
    • Thurber GM, Zajic SC, Wittrup KD. Theoretic criteria for antibody penetration into solid tumors and micrometastases. J Nucl Med 2007;48:995-9.
    • (2007) J Nucl Med , vol.48 , pp. 995-999
    • Thurber, G.M.1    Zajic, S.C.2    Wittrup, K.D.3
  • 5
    • 0037444270 scopus 로고    scopus 로고
    • Theoretical analysis of antibody targeting of tumor spheroids: Importance of dosage for penetration, and affinity for retention
    • Graff CP, Wittrup KD. Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. Cancer Res 2003;63:1288-96.
    • (2003) Cancer Res , vol.63 , pp. 1288-1296
    • Graff, C.P.1    Wittrup, K.D.2
  • 6
    • 53549106693 scopus 로고    scopus 로고
    • Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance
    • In press
    • Thurber GM, Schmidt MM, Wittrup KD. Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Adv Drug Deliv Rev. In press. 2007.
    • (2007) Adv Drug Deliv Rev
    • Thurber, G.M.1    Schmidt, M.M.2    Wittrup, K.D.3
  • 7
    • 0026425576 scopus 로고
    • An analysis of monoclonal antibody distribution in microscopic tumor nodules: Consequences ofa binding site barrier
    • van Osdol W, Fujimori K, Weinstein JN. An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences ofa "binding site barrier." Cancer Res 1991;51:4776-84.
    • (1991) Cancer Res , vol.51 , pp. 4776-4784
    • van Osdol, W.1    Fujimori, K.2    Weinstein, J.N.3
  • 8
    • 0035874887 scopus 로고    scopus 로고
    • High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules
    • Adams GP, Schier R, McCall AM, et al. High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. Cancer Res 2001;61:4750-5.
    • (2001) Cancer Res , vol.61 , pp. 4750-4755
    • Adams, G.P.1    Schier, R.2    McCall, A.M.3
  • 9
    • 33846404133 scopus 로고    scopus 로고
    • Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent
    • Dennis MS, Jin H, Dugger D, et al. Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent. Cancer Res 2007;67:254-61.
    • (2007) Cancer Res , vol.67 , pp. 254-261
    • Dennis, M.S.1    Jin, H.2    Dugger, D.3
  • 12
    • 0037144397 scopus 로고    scopus 로고
    • Albumin binding as a general strategy for improving the pharmacokinetics of proteins
    • Dennis MS, Zhang M, Meng YG, et al. Albumin binding as a general strategy for improving the pharmacokinetics of proteins. J Biol Chem 2002;277:35035-43.
    • (2002) J Biol Chem , vol.277 , pp. 35035-35043
    • Dennis, M.S.1    Zhang, M.2    Meng, Y.G.3
  • 13
    • 19944430279 scopus 로고    scopus 로고
    • Tailoring the pharmacokinetics and positron emission tomography imaging properties of anticarcinoembryonic antigen single-chain Fv-Fc antibody fragments
    • Kenanova V, Olafsen T, Crow DM, et al. Tailoring the pharmacokinetics and positron emission tomography imaging properties of anticarcinoembryonic antigen single-chain Fv-Fc antibody fragments. Cancer Res 2005;65:622-31.
    • (2005) Cancer Res , vol.65 , pp. 622-631
    • Kenanova, V.1    Olafsen, T.2    Crow, D.M.3
  • 14
    • 0030796064 scopus 로고    scopus 로고
    • Increasing the serum persistence ofan IgG fragment by random mutagenesis
    • Ghetie V, Popov S, Borvak J, et al. Increasing the serum persistence ofan IgG fragment by random mutagenesis. Nat Biotechnol 1997;15:637-40.
    • (1997) Nat Biotechnol , vol.15 , pp. 637-640
    • Ghetie, V.1    Popov, S.2    Borvak, J.3
  • 15
    • 13044292648 scopus 로고    scopus 로고
    • Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
    • Netti PA, Hamberg LM, Babich JW, et al. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc Natl Acad Sci U S A 1999;96:3137-42.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3137-3142
    • Netti, P.A.1    Hamberg, L.M.2    Babich, J.W.3
  • 17
    • 0037701271 scopus 로고    scopus 로고
    • Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety ofcell types
    • Kelm JM, Timmins NE, Brown CJ, Fussenegger M, Nielsen LK. Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety ofcell types. Biotechnol Bioeng 2003;83:173-80.
    • (2003) Biotechnol Bioeng , vol.83 , pp. 173-180
    • Kelm, J.M.1    Timmins, N.E.2    Brown, C.J.3    Fussenegger, M.4    Nielsen, L.K.5
  • 18
    • 0016875214 scopus 로고
    • Radiation response of multicell spheroids-an in vitro tumour model
    • Sutherland RM, Durand RE. Radiation response of multicell spheroids-an in vitro tumour model. Curr Top Radiat Res Q 1976;11:87-139.
    • (1976) Curr Top Radiat Res Q , vol.11 , pp. 87-139
    • Sutherland, R.M.1    Durand, R.E.2
  • 19
    • 0035836641 scopus 로고    scopus 로고
    • Role oftumor- host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors
    • Pluen A, Boucher Y, Ramanujan S, et al. Role oftumor- host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A 2001;98:4628-33.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4628-4633
    • Pluen, A.1    Boucher, Y.2    Ramanujan, S.3
  • 20
    • 0029114671 scopus 로고
    • Targeting cancer micrometastases with monoclonal antibodies: A binding-site barrier
    • Saga T, Neumann RD, Heya T, et al. Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. Proc Natl Acad Sci U S A 1995;92:8999-9003.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 8999-9003
    • Saga, T.1    Neumann, R.D.2    Heya, T.3
  • 21
    • 0025147443 scopus 로고
    • Quantitative analysis of antibody localization in human metastatic colon cancer: A phase I study of monoclonal antibody A33
    • Welt S, Divgi CR, Real FX, et al. Quantitative analysis of antibody localization in human metastatic colon cancer: a phase I study of monoclonal antibody A33. J Clin Oncol 1990;8:1894-906.
    • (1990) J Clin Oncol , vol.8 , pp. 1894-1906
    • Welt, S.1    Divgi, C.R.2    Real, F.X.3
  • 22
    • 27144522470 scopus 로고    scopus 로고
    • A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: Biodistribution, pharmacokinetics, and quantitative tumor uptake
    • Scott AM, Lee FT, Jones R, et al. A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: biodistribution, pharmacokinetics, and quantitative tumor uptake. Clin Cancer Res 2005;11:4810-7.
    • (2005) Clin Cancer Res , vol.11 , pp. 4810-4817
    • Scott, A.M.1    Lee, F.T.2    Jones, R.3
  • 23
    • 34548553392 scopus 로고    scopus 로고
    • Update ofcar cinoembryonic antigen radioimmunotherapy with (131)ilabetuzumab after salvage resection of colorectal liver metastases: Comparison of outcome to a contemporaneous control group
    • Liersch T, Meller J, Bittrich M, Kulle B, Becker H, Goldenberg DM. Update ofcar cinoembryonic antigen radioimmunotherapy with (131)ilabetuzumab after salvage resection of colorectal liver metastases: comparison of outcome to a contemporaneous control group. Ann Surg Oncol 2007;14:2577-90.
    • (2007) Ann Surg Oncol , vol.14 , pp. 2577-2590
    • Liersch, T.1    Meller, J.2    Bittrich, M.3    Kulle, B.4    Becker, H.5    Goldenberg, D.M.6
  • 24
    • 0019814460 scopus 로고
    • Experimental radioimmunotherapy of a xenografted human colonic tumor (GW-39) producing carcinoembryonic antigen
    • Goldenberg DM, Gaffar SA, Bennett SJ, Beach JL. Experimental radioimmunotherapy of a xenografted human colonic tumor (GW-39) producing carcinoembryonic antigen. Cancer Res 1981;41:4354-60.
    • (1981) Cancer Res , vol.41 , pp. 4354-4360
    • Goldenberg, D.M.1    Gaffar, S.A.2    Bennett, S.J.3    Beach, J.L.4
  • 25
    • 9544250404 scopus 로고    scopus 로고
    • Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library
    • Begent RH, Verhaar MJ, Chester KA, et al. Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Nat Med 1996;2:979-84.
    • (1996) Nat Med , vol.2 , pp. 979-984
    • Begent, R.H.1    Verhaar, M.J.2    Chester, K.A.3
  • 26
    • 0035126527 scopus 로고    scopus 로고
    • Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: Effect of treatment schedule
    • Jang SH, Wientjes MG, Au JL. Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J Pharmacol Exp Ther 2001;296:1035-42.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 1035-1042
    • Jang, S.H.1    Wientjes, M.G.2    Au, J.L.3
  • 27
    • 0041836180 scopus 로고    scopus 로고
    • Interferons can upregulate the expression of the tumor associated antigen G250-MN/CA IX, a potential target for (radio)immunotherapy of renal cell carcinoma
    • Brouwers AH, Frielink C, Oosterwijk E, Oyen WJ, Corstens FH, Boerman OC. Interferons can upregulate the expression of the tumor associated antigen G250-MN/CA IX, a potential target for (radio)immunotherapy of renal cell carcinoma. Cancer Biother Radiopharm 2003;18:539-47.
    • (2003) Cancer Biother Radiopharm , vol.18 , pp. 539-547
    • Brouwers, A.H.1    Frielink, C.2    Oosterwijk, E.3    Oyen, W.J.4    Corstens, F.H.5    Boerman, O.C.6
  • 28
    • 23444460271 scopus 로고    scopus 로고
    • Antiangiogenic therapy for cancer: Current and emerging concepts
    • Jain RK. Antiangiogenic therapy for cancer: current and emerging concepts. Oncology (Huntingt) 2005;19:7-16.
    • (2005) Oncology (Huntingt) , vol.19 , pp. 7-16
    • Jain, R.K.1
  • 29
    • 36348930079 scopus 로고    scopus 로고
    • Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus
    • Mok W, Boucher Y, Jain RK. Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus. Cancer Res 2007;67:10664-8.
    • (2007) Cancer Res , vol.67 , pp. 10664-10668
    • Mok, W.1    Boucher, Y.2    Jain, R.K.3
  • 30
    • 33645066093 scopus 로고    scopus 로고
    • Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector
    • McKee TD, Grandi P, Mok W, et al. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Res 2006;66:2509-13.
    • (2006) Cancer Res , vol.66 , pp. 2509-2513
    • McKee, T.D.1    Grandi, P.2    Mok, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.