Establishment of an in vivo model for pediatric ewing tumors by transplantation into NOD/scid mice

Pediatric Research

Volumn 49, Issue 3, 2001, Pages 332-341

  Vormoor, Josef ^a,b   Baersch, Gudrun ^a   Decker, Stephan ^a   Hotfilder, Marc ^a   Schäfer, Karkl Ludwif ^a   Pelken, Lutz ^a   Rübe, Cristian ^a   Van Valen, Frans ^a   Jürgens, Heribert ^a   Dockhorn Dworniczak, Barbara ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Klin/Poliklin fur Kinderheilkunde   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; COMPLEMENTARY DNA; RNA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER MODEL; CHILDHOOD CANCER; CLONOGENESIS; CYTOLOGY; EWING SARCOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SOLID TUMOR; STEM CELL; TUMOR CELL; TUMOR CELL LINE;

EID: 0035098213     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200103000-00006     Document Type: Article

References (50)

1. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
2. The Ewing family of tumors - A subgroup of small-round-cell tumors defined by specific chimeric transcript
3. Combinatorial generation of variable fusion proteins in the Ewing family of tumours
4. EWS-FLII fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma
5. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?
6. A second Ewing's sarcoma translocation, (21;22), fuses the EWS gene to another ETS-family transciption factor. ERG
7. A variant Ewing's sarcoma translocation (7:22) fuses the EWS gene to the ETS gene ETVI
8. Fusion of an ETS-family gene, EIAF, to EWS by t(17:22)(q12:q12) chromosome translocation in an undifferentiated sarcoma of infancy
9. A new member of the ETS family fused to EWS in Ewing tumors
10. A novel chimera gene between EWS and EIAF. Encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma
11. EWS-FLII-induced manic fringe renders NIH 3T3 cells tumorigenic
12. Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLII oncoprotein
13. A critical appraisal of the human tumour stem-cell assay
14. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
15. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
16. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
17. Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice
18. Significance of the SCID mouse models for the study of normal and leukemic human hemopoiesis and gene therapy
19. A metastatic neuroblastoma model in SCID mice
20. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice
21. Growth of human tumors in immune-deficient scid mice and nude mice
22. Growth characteristics and metastatic properties of human breast cancer xenografts in immunodeficient mice
23. Multiple defects in innate and adaptive immunological function in NOD/LtSz-scid mice
24. Diffuse endothelioma of bone
25. Stem cell homing: Rolling, crawling, and nesting
26. 1 into tumor cells
27. Ewing's sarcoma family of tumors
28. Type I and type II insulin-like growth factor receptors and their function in human Ewing's sarcoma cells
29. Beta-adrenergic agonist- and prostaglandin-mediated regulation of cAMP levels in Ewing's sarcoma cells in culture
30. Chromosome translocation in peripheral neuroepithelioma
31. Differentiation of a Ewing's sarcoma cell line towards neural and mesenchymal cell lineages
32. Good engraftment of B-cell precursor ALL in NOD-SCID mice
33. Diagnostic value of the molecular genetic detection of the 11:22 translocation in Ewing's tumours
34. Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice
35. Flow cytometric identification of candidate normal stem cell populations in CD45-negative B-cell precursor acute lymphoblastic leukaemia
36. Limiting dilution assay for the determination of immunocompetent cell frequencies
37. The role of integrins in tumorigenesis and metastasis
38. VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin
39. Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinoma and epithelial cancers
40. Seeding efficiency of primitive human hematopoietic cells in nonobese diabetic/severe combined immune deficiency mice: Implications for stem cell frequency assessment
41. Identification of human juvenile chronic myelogenous leukemia cells capable of initiating the disease in primary and secondary SCID mice
42. Experimental evidence for a neural origin of Ewing's sarcoma of bone
43. Primitive neuroectodermal tumor and Ewing's sarcoma
44. Multidisciplinary treatment of Ewing's sarcoma of bone. A 6-year experience of a European Cooperative Trial
45. Primitive neuroectodermal tumor (PNET)/Extraosseous Ewing sarcoma of the kidney
46. Primitive neuroectodermal tumor of the kidney - Another enigma: A pathologic, immunohistochemical, and molecular diagnostic study
47. Primitive neuroectodermal tumor of the kidney confirmed by fluorescence in situ hybridization
48. Peripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLI-1 chimeric mRNA
49. Sarcomas metastatic to the ovary: A report of 21 cases
50. Metastatic ovarian tumors in children: A report of 14 cases and review of the literature