Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved

Chemico-Biological Interactions

Volumn 185, Issue 3, 2010, Pages 163-173

  Abass, Khaled ^a   Reponen, Petri ^a   Mattila, Sampo ^a   Pelkonen, Olavi ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

In vitro metabolism; LC MS; P450; Pesticides; Risk assessment; Xenobiotic

Indexed keywords

AMFEBUTAMONE; AMODIAQUINE; CARBOSULFAN; CHLORZOXAZONE; COMPLEMENTARY DNA; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DEXTROMETHORPHAN; ETHOXYRESORUFIN; KETOCONAZOLE; MIDAZOLAM; OMEPRAZOLE; PENTOXYRESORUFIN; TOLBUTAMIDE; CARBAMIC ACID DERIVATIVE; ISOENZYME;

ARTICLE; BIOTRANSFORMATION; CHEMICAL STRUCTURE; DEALKYLATION; DISULFIDE BOND; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HYDROXYLATION; IN VITRO STUDY; INDIVIDUALITY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SULFOXIDATION; ADULT; CHEMISTRY; ENZYMOLOGY; FEMALE; LIVER; MALE; METABOLISM; MIDDLE AGED;

ADULT; BIOTRANSFORMATION; CARBAMATES; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; ISOENZYMES; LIVER; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MIDDLE AGED; MOLECULAR STRUCTURE;

EID: 77952297444     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.024     Document Type: Article

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