Metabolism of chlorpyrifos by human cytochrome p450 isoforms and human, mouse, and rat liver microsomes

Drug Metabolism and Disposition

Volumn 29, Issue 9, 2001, Pages 1201-1204

  Tang, J ^a   Cao, Y ^a   Rose, R L ^a   Brimfield, A A ^a   Dai, D ^a   Goldstein, J A ^a   Hodgson, E ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPYRIFOS; CHOLINESTERASE INHIBITOR; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; ORGANOPHOSPHATE INSECTICIDE;

ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; DESULFURIZATION; DETOXIFICATION; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; LYMPHOBLASTOMA; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHLORPYRIFOS; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; INSECTICIDES; MALE; MICE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; RATS; RATS, LONG-EVANS;

EID: 0034861252     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Biotransformation of parathion in human liver: Participation of CYP3A4 and its inactivation during microsomal parathion oxidation
2. Noncatalytic detoxication of six organophosphorus compounds by rat liver homogenates
3. Organophosphorus compounds: An overview
4. Oxidative desulfuration of chlorpyrifos, chlorpyrifos-methyl, and leptophos by rat brain and liver
5. Induction of cytochrome P-450 by methylenedioxyphenyl compounds: Importance of the methylene carbon
6. Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats
7. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
8. Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver
9. Identification of residues 286 and 289 as critical for conferring substrate specificity of Human CYP2C9 for diclofenac and ibuprofen
10. Differences in oxidative dearylation and desulfuration of fenitruthion by cytochrome P-450 isozymes and in the subsequent inhibition of monooxygenase activity
11. Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid
12. A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats
13. The effect of carboxylesterase inhibition on interspecies differences in soman toxicity
14. The role of metabolism in determining susceptibility to parathion toxicity in man
15. Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes
16. Biochemical Calculations
17. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
18. Metabolic-activation of the organophosphorus insecticides chlorpyrifos and fenitrothion by perfused-rat-liver
19. Kinetic analysis of the microsomal biotransformation of the phosphorothioate insecticides chlorpyrifos and parathion