The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion

Toxicology and Applied Pharmacology

Volumn 233, Issue 2, 2008, Pages 343-352

  Leoni, Claudia ^a   Buratti, Franca M ^a   Testai, Emanuela ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

CYPs; Fenthion; FMO; Hepatic biotransformation; Human liver; Organophosphorothionate pesticides

Indexed keywords

ALDEHYDE OXIDASE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C; CYTOCHROME P450 2C19; CYTOCHROME P450 3A4; DIMETHYLANILINE MONOOXYGENASE; FENTHION; FENTHION OXON; FENTHION SULFOXIDE; INSECTICIDE; ISOENZYME; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; CYTOSOL; ENZYME MECHANISM; HUMAN; HUMAN TISSUE; LIVER MICROSOME; METABOLITE; OXIDATION; PROTEIN FAMILY; REDUCTION; SULFOXIDATION;

ALDEHYDE OXIDASE; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FENTHION; HUMANS; INSECTICIDES; MICROSOMES, LIVER; OXIDATION-REDUCTION; OXYGENASES; PROTEIN ISOFORMS; SULFOXIDES;

EID: 56049096438     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.09.004     Document Type: Article

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