Carbofuran-induced endocrine disruption in adult male rats

Toxicology Mechanisms and Methods

Volumn 14, Issue 4, 2004, Pages 233-239

  Goad, Ryan T ^a   Goad, John T ^a   Atieh, Bassam H ^a   Gupta, Ramesh C ^a  

^a MURRAY STATE UNIVERSITY   (United States)

Author keywords

Carbamate; Cortisol; Endocrine Disruption; Estradiol; Hormones; Hypothermia; Progesterone; Testosterone

Indexed keywords

CARBAMATE INSECTICIDE; CARBOFURAN; CORTISONE; ESTRADIOL; GLUCOSE; LIOTHYRONINE; PROGESTERONE; TESTOSTERONE; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CHEMOLUMINESCENCE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; CONVULSION; ENDOCRINE DISEASE; FASCICULATION; IMMUNOASSAY; MALE; MASTICATION; NONHUMAN; PRIORITY JOURNAL; RAT; SALIVATION DISORDER; SERUM; TREMOR;

ANIMALIA;

EID: 3542990909     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376520490434476     Document Type: Article

References (42)

1. Chen, H., Xiao, J., Hu, G., Zhou, J., Xio, H., and Wang, X. 2002. Estrogenicity of organophosphorus and pyrethroid pesticides. J. Toxicol. Environ. Health, Part A. 65:1419-1435.
2. Clement, J. G. 1985. Hormonal consequences of organophosphate poisoning. Fund. Appl. Toxicol. 5:S61-S77.
3. Coleman, A. M., Smith, A., and Watson, L. 1990. Occupational carbamate pesticide intoxication in three farm workers. Implications and significance for occupational health in Jamaica. West Ind. Med J. 39:109-113.
4. Fletcher, H. P., Akbar, W. J., Peoples, R. W., and Spratto, G. R. 1988. Effect of acute soman on selected endocrine parameters and blood glucose in rats. Fund. Appl. Toxicol. 11:580-586.
5. Goes, E. H., Savage, E. P., and Gibbons, G. 1980. Suspected food borne carbamate pesticide intoxications associated with ingestion of hydroponic cucumbers. Am. J. Epidemiol. 111:254-259.
6. Goldman, L. R., Beller, M., and Jackson, R. J. 1990. Aldicarb food poisoning, 1985-1988. Toxicity estimates for humans. Arch. Environ. Health 45:141-147.
7. Gupta, R. C., and Kadel, W. L. 1989a. Concerted role of carboxylesterases in the potentiation of carbofuran toxicity by iso-OMPA pretreatment. J. Toxicol. Environ. Health 26:447-457.
8. Gupta, R. C., and Kadel, W. L. 1989b. Prevention and antagonism of acute carbofuran intoxication by memantine and atropine. J. Toxicol. Environ. Health 28:111-122.
9. Gupta, R. C., Goad, J. T., and Kadel, W. L. 1991a. Carbofuran-induced alterations (in vivo) in high-energy phosphates, creatine kinase (CK) and CKisoenzymes. Arch. Toxicol. 65:304-310.
10. Gupta, R. C., Goad, J. T., and Kadel, W. L. 1991b. In vivo alterations in lactate dehydrogenase (LDH) and LDH isoenzymes patterns by acute carbofuran intoxication. Arch. Environ. Contam. Toxicol. 21:263-269.
11. Gupta, R. C., Goad, J. T., and Kadel, W. L. 1993. Protection and reversal by memantine and atropine of carbofuran-induced changes in biomarkers. Drug Dev. Res. 28:153-160.
12. Gupta, R. C. 1994. Carbofuran toxicity. J. Toxicol. Environ. Health 43:383-418.
13. Gupta, R. C., Goad, J. T., and Kadel, W. L. 1994a. Cholinergic and noncholinergic changes in skeletal muscles by carbofuran and methyl parathion. J. Toxicol. Environ. Health 43:291-304.
14. Gupta, R. C., Goad, J. T., and Kadel, W. L. 1994b. Energy related metabolic alterations in diaphragm muscle resulting from acute methomyl toxicity. Neurotoxicol. 15:321-330.
15. Gupta, R. C., and Goad, J. T. 2000. Role of high-energy phosphates and their metabolites in protection of carbofuran-induced biochemical changes in diaphragm muscle by memantine. Arch. Toxicol. 74:13-20.
16. Gupta, R. C., Goad, J. T., Milatovic, D., and Dettbarn, W.-D. 2000. Cholinergic and noncholinergic brain biomarkers of insecticide exposure and effects. Hum. Exp. Toxicol. 19:297-308.
17. Güven, M., Bayram, F., Ünlühizarci, K., and Kelestimur, F. 1999. Endocrine changes in patients with acute organophosphate poisoning. Hum. Exp. Toxicol. 18:598-601.
18. Hussain, M., Yoshida, K., and Atiemo, M. 1990. Occupational exposure of grain farmers to carbofuran. Arch. Environ. Contam. Toxicol. 19:197-204.
19. Kacew, S., and Singhal, R. L. 1973. The influence of p,p′-DDT, alpha-chlordane, heptachlor and endrin on hepatic and adrenal carbohydrate metabolism and cyclic AMP-adenyl cyclase system. Life Sci. 13:1363-1371.
20. Kitamura, S., Yoshida, M., Sugihara, K., Ohta, S., and Hara, A. 1999. Effect of fenthion on the level of vitellogenin in goldfish, Corassius auratus. J. Health Sci. 45:262-265.
21. Kokka, N., Lee, R., and Lomax, P. 1985. Effects of organophosphate inhibitors on pituitary adrenal activity and thermoregulation. Fifth Ann. Chem. Defense Biosci. Rev. 60.
22. Kokka, N., Clemons, G. K., and Lomax, P. 1987. Relationship between the temperature and endocrine changes by cholinesterase inhibitors. Pharmacol. 34:74-79.
23. Kuhr, R. J., and Dorough, H. W. 1976. Carbamate insecticides: Chemistry, biochemistry, and toxicology (pp. 133-134). CRC Press: Cleveland, OH.
24. Lee, M. H., and Ransdell, J. F. 1984. A farmworker death due to pesticide toxicity. A case report. J. Toxicol. Environ. Health 14:239-246.
25. Mills, L. J., Gutjahr-Gobell, R. E., Haebler, R. A., Borsay, H. D. J., Jayaraman, S., Pruell, R. J., McKinney, R. A., Gardner, G. R., and Zaroogian, G. E. 2001. Effects of estrogenic (o,p′-DDT) and anti-androgenic (p,p′-DDE) chemicals on indicators of endocrine status in juvenile male summer flounder (Paralichthys dentatus). Aquatic Toxicol. 52:157-176.
26. Murphy, S. D. 1969. Some relationships between effects of insecticides and other stress conditions. An. N.Y. Acad. Sci. 160:366-377.
27. O'Brien, R. D. 1967. Insecticides, Action and Metabolism (pp. 86-106). Academic Press: New York.
28. Osicka-Koprowska, A., Lipska, M., and Wysocka-Paruszewska, B. 1984. Effects of chlorfenvinphos on plasma corticosterone and aldosterone levels in rats. Arch. Toxicol. 55:68-69.
29. Pant, N., Prasad, A. K., Srivastava, S. C., Shankar, R., and Srivastava, S. P. 1995. Effect of oral administration of carbofuran on male reproductive system of rat. Hum. Exp. Toxicol. 14:889-894.
30. Parks, P., Lipman, J., and Eidelman, J. 1987. Carbamate toxicity. A case report. South African Med. J. 72:222.
31. Peoples, R. W., Spratto, G. R., Akbar, W. J., and Fletcher, H. P. 1988. Effect of repeated administration of soman on selected endocrine parameters and blood glucose in rats. Fund. Appl. Toxicol. 11:587-593.
32. Prakash N., Narayana, K., Mathy, G. S., and Moudal, N. R. 1992. The effect of malathion, an organophosphate, on the plasma FSH, 17-beta-estradiol and progesterone concentrations and acetylcholinesterase activity and conception in dairy cattle. Vet. Hum. Toxicol. 34:116-119.
33. Rawlings, N. C., Cook, S. J., and Waldbillig, D. 1998. Effects of the pesticides carbofuran, chlorpyriphos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes. J. Toxicol. Environ. Health 54:21-36.
34. Rhouma, B. K., Tébourbi, O., Krichah, R., and Sakly, M. 2001. Reproductive toxicity of DDT in adult male rats. Hum. Exp. Toxicol. 20:393-397.
35. Saito, K., Tomigahara, Y., Ohe, N., Isobe, N., Nakatsuka, I., and Kaneko, H. 2000. Lack of significant estrogenic or antiestrogenic activity of pyrethroids insecticides in three in vitro assays based on classic estrogen receptor α-mediated mechanisms. Toxicol. Sci. 57:54-60.
36. Sugawara, T., Nakajima, A., and Nomura, E. 2002. Development of a simple screening system for endocrine system. Med. Sci. Monit. 8:BR431-438.
37. U.S. EPA. 1997. EPA special report on endocrine disruption. Fact sheet. Office of Research and Development, Washington, D.C.
38. You, L., and Heck, H. A. 1998. Endocrine toxicity of p,p′-DDE administered by gavage. Chem. Industry Institute of Toxicol. CIIT Activities 18:11-12.
39. Yu, C., Metcalf, R. L., and Booth, G. M. 1972. Inhibition of acetylcholinesterase from mammals and insects by carbofuran and its related compounds and their toxicities toward these animals. J. Ag. Food Chem. 20:921-926.
40. Witorsch, R. J. 2003. Physiological role and toxicological effects of glucocorticoids on reproduction. Soc. Toxicol. C.E. Course Man. pp. 3.1-3.20.
41. Zaidi, S. S. A., Bhatnagar, V. K., Gandhi, S. J., Shah, M. P., Kulkarni, P. K., and Saiyed H.N. 2000. Assessment of thyroid function in pesticide formulators. Hum. Exp. Toxicol. 19:497-501.
42. Zweigner, R. J., and Ginsburg, C. M. 1988. Organophosphate and carbamate poisoning in infants and children. Ped. 81:121-126.