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Volumn 27, Issue 1 I, 1998, Pages 3-20

Human variability and noncancer risk assessment - An analysis of the default uncertainty factor

Author keywords

Human variability; Interindividual differences; Toxicodynamics; Toxicokinetics; Uncertainty factor

Indexed keywords

ARTICLE; CANCER; CANCER RISK; DATA ANALYSIS; DATA BASE; HEALTH HAZARD; HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0031809917     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1997.1195     Document Type: Article
Times cited : (227)

References (142)
  • 1
    • 0030588234 scopus 로고    scopus 로고
    • Population approaches/sparse data analysis for human variability in kinetics and dynamics
    • Aarons, L. (1996). Population approaches/sparse data analysis for human variability in kinetics and dynamics. Environ. Toxicol. Pharmacol. 2, 197-199.
    • (1996) Environ. Toxicol. Pharmacol. , vol.2 , pp. 197-199
    • Aarons, L.1
  • 5
    • 0020576099 scopus 로고
    • Clinical pharmacokinetics of metoclopramide
    • Bateman, D. N. (1983). Clinical pharmacokinetics of metoclopramide. Clin. Pharmacokinet. 8, 523-529.
    • (1983) Clin. Pharmacokinet. , vol.8 , pp. 523-529
    • Bateman, D.N.1
  • 6
    • 0024580554 scopus 로고
    • Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin but not debrisoquin hydroxylation phenotype
    • Bertilsson, L., Henthorn, T. K, Sanz, E., Tybring, G., Säwe, J., and Viltén, T. (1989). Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin but not debrisoquin hydroxylation phenotype. Clin. Pharmacol. Ther. 45, 348-355.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , pp. 348-355
    • Bertilsson, L.1    Henthorn, T.K.2    Sanz, E.3    Tybring, G.4    Säwe, J.5    Viltén, T.6
  • 10
    • 0026691811 scopus 로고
    • Plasma concentration-effect relationships for felodipine: A meta analysis
    • Blychert, E., Edgar, B., Elmfeldt, D., and Hedner, T. (1992). Plasma concentration-effect relationships for felodipine: A meta analysis. Clin. Pharmacol. Ther. 52, 80-89.
    • (1992) Clin. Pharmacol. Ther. , vol.52 , pp. 80-89
    • Blychert, E.1    Edgar, B.2    Elmfeldt, D.3    Hedner, T.4
  • 11
    • 0026590432 scopus 로고
    • 2-adrenoceptor antagonism in asthmatic patients by pharmacokinetic-pharmacodynamic modelling
    • 2-adrenoceptor antagonism in asthmatic patients by pharmacokinetic-pharmacodynamic modelling. Pulmonary Pharmacol. 5, 31-38.
    • (1992) Pulmonary Pharmacol. , vol.5 , pp. 31-38
    • Braat, M.C.P.1    Jonkers, R.E.2    Van Boxtel, C.J.3
  • 12
    • 0026533885 scopus 로고
    • Quantification of theophylline-induced eosinopenia and hypokalaemia in healthy volunteers
    • Braat, M. C. P., Jonkers, R. E., Bel, E. H., and Van Boxtel, C. J. (1992b). Quantification of theophylline-induced eosinopenia and hypokalaemia in healthy volunteers. Clin. Pharmacokinet. 22, 231-237.
    • (1992) Clin. Pharmacokinet. , vol.22 , pp. 231-237
    • Braat, M.C.P.1    Jonkers, R.E.2    Bel, E.H.3    Van Boxtel, C.J.4
  • 13
    • 0026769059 scopus 로고
    • The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers
    • Buss, N. E., Renwick, A. G., Donaldson, K. M., and George, C. F. (1992). The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers. Toxicol. Appl. Pharmacol. 115, 199-210.
    • (1992) Toxicol. Appl. Pharmacol. , vol.115 , pp. 199-210
    • Buss, N.E.1    Renwick, A.G.2    Donaldson, K.M.3    George, C.F.4
  • 14
    • 0027977106 scopus 로고
    • The teratogenic metabolites of vitamin a in women following supplements and liver
    • Buss, N. E., Tembe, E. A., Prendergast, B. D., Renwick, A. G., and George, C. F. (1994). The teratogenic metabolites of vitamin A in women following supplements and liver. Hum. Exp. Toxicol. 13, 33-43.
    • (1994) Hum. Exp. Toxicol. , vol.13 , pp. 33-43
    • Buss, N.E.1    Tembe, E.A.2    Prendergast, B.D.3    Renwick, A.G.4    George, C.F.5
  • 16
    • 0021808907 scopus 로고
    • Uncertainty factors and interindividual variation
    • Calabrese, E. J. (1985). Uncertainty factors and interindividual variation. Regul. Toxicol. Pharmacol. 5, 190-196.
    • (1985) Regul. Toxicol. Pharmacol. , vol.5 , pp. 190-196
    • Calabrese, E.J.1
  • 17
    • 0026606308 scopus 로고
    • Does the animal to human uncertainty factor incorporate interspecies differences in surface area?
    • Calabrese, E. J., Beck, B. D., and Chappell, W. R. (1992). Does the animal to human uncertainty factor incorporate interspecies differences in surface area? Regul. Toxicol. Pharmacol. 15, 172-179.
    • (1992) Regul. Toxicol. Pharmacol. , vol.15 , pp. 172-179
    • Calabrese, E.J.1    Beck, B.D.2    Chappell, W.R.3
  • 18
    • 0029853347 scopus 로고    scopus 로고
    • The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans
    • Capon, D. A., Bochner, F., Kerry, N., Mikus, G., Danzo, C., and Somogyi, A. A. (1996). The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans. Clin. Pharmacol. Ther. 60, 295-307.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 295-307
    • Capon, D.A.1    Bochner, F.2    Kerry, N.3    Mikus, G.4    Danzo, C.5    Somogyi, A.A.6
  • 20
    • 0025330636 scopus 로고
    • Disposition of pethidine in man under acidic urinary pH. 4. Kinetics after oral dose in Caucasians, Chinese and Indian subjects
    • Chan, K., Tse, J., Jennings, F., and Orme, M. L'E. (1990). Disposition of pethidine in man under acidic urinary pH. 4. Kinetics after oral dose in Caucasians, Chinese and Indian subjects. Methods Find. Exp. Clin. Pharmacol. 12, 61-67.
    • (1990) Methods Find. Exp. Clin. Pharmacol. , vol.12 , pp. 61-67
    • Chan, K.1    Tse, J.2    Jennings, F.3    Orme, M.L'E.4
  • 21
    • 0018833447 scopus 로고
    • Michaelis-Menton pharmacokinetics of diphenylhydantoin and application in the pediatric age patients
    • Chiba, K, Ishizaki, T., Miura, H., and Minagawa, K. (1980). Michaelis-Menton pharmacokinetics of diphenylhydantoin and application in the pediatric age patients. J. Pediatr. 96, 479-484.
    • (1980) J. Pediatr. , vol.96 , pp. 479-484
    • Chiba, K.1    Ishizaki, T.2    Miura, H.3    Minagawa, K.4
  • 22
    • 0026446299 scopus 로고
    • Clarithromycin pharmacokinetics in healthy young and elderly volunteers
    • Chu, S-y., Wilson, D. S., Guay, D. R. P., and Craft, C. (1992). Clarithromycin pharmacokinetics in healthy young and elderly volunteers. J. Clin. Pharmacol. 32, 1045-1049.
    • (1992) J. Clin. Pharmacol. , vol.32 , pp. 1045-1049
    • Chu, S.-Y.1    Wilson, D.S.2    Guay, D.R.P.3    Craft, C.4
  • 27
    • 0027052703 scopus 로고
    • Plasma pharmacokinetics and pharmacodynamics of a new prodrug N-l-leucyldoxorubicin and its metabolites in a phase I clinical trial
    • de Jong, J., Geijssen, G. J., Munniksma, C. N., Vermerken, J. B., and van der Vijgh, W. J. F. (1992). Plasma pharmacokinetics and pharmacodynamics of a new prodrug N-l-leucyldoxorubicin and its metabolites in a phase I clinical trial. J. Clin. Oncol. 10, 1897-1906.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1897-1906
    • De Jong, J.1    Geijssen, G.J.2    Munniksma, C.N.3    Vermerken, J.B.4    Van Der Vijgh, W.J.F.5
  • 28
    • 0026456706 scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous diltiazem in patients with atrial fibrillation or atrial flutter
    • Dias, V. C., Weir, S. J., and Ellenbogen, K. A. (1992). Pharmacokinetics and pharmacodynamics of intravenous diltiazem in patients with atrial fibrillation or atrial flutter. Circulation 86, 1421-1428.
    • (1992) Circulation , vol.86 , pp. 1421-1428
    • Dias, V.C.1    Weir, S.J.2    Ellenbogen, K.A.3
  • 29
    • 0029044201 scopus 로고
    • Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans
    • Dingemanse, J., Jorga, K. M., Schmitt, M., Gieschke, R., Fotteler, B., Zurcher, G., Da Prada, M., and van Brummelen, P. (1995). Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans. Clin. Pharmacol. Ther. 57, 508-517.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 508-517
    • Dingemanse, J.1    Jorga, K.M.2    Schmitt, M.3    Gieschke, R.4    Fotteler, B.5    Zurcher, G.6    Da Prada, M.7    Van Brummelen, P.8
  • 30
    • 0023771513 scopus 로고
    • Nifedipine: Individual responses and concentration-effect relationships
    • Donnelly, R., Elliott, H. L., Meredith, P. A., Kelman, A. W., and Reid, J. L. (1988). Nifedipine: Individual responses and concentration-effect relationships. Hypertension 12, 443-449.
    • (1988) Hypertension , vol.12 , pp. 443-449
    • Donnelly, R.1    Elliott, H.L.2    Meredith, P.A.3    Kelman, A.W.4    Reid, J.L.5
  • 31
    • 0024424074 scopus 로고
    • Concentration-effect relationships and individual responses to doxazosin in essential hypertension
    • Donnelly, R., Elliott, H. L., Meredith, P. A., and Reid, J. L. (1989). Concentration-effect relationships and individual responses to doxazosin in essential hypertension. Br. J. Clin. Pharmacol. 28, 517-526.
    • (1989) Br. J. Clin. Pharmacol. , vol.28 , pp. 517-526
    • Donnelly, R.1    Elliott, H.L.2    Meredith, P.A.3    Reid, J.L.4
  • 32
    • 0025214525 scopus 로고
    • Kinetic-dynamic relations and individual responses to enalapril
    • Donnelly, R., Meredith, P. A., Elliott, H. L., and Reid, J. L. (1990). Kinetic-dynamic relations and individual responses to enalapril. Hypertension 15, 301-309.
    • (1990) Hypertension , vol.15 , pp. 301-309
    • Donnelly, R.1    Meredith, P.A.2    Elliott, H.L.3    Reid, J.L.4
  • 34
    • 0021054771 scopus 로고
    • Regulatory history and experimental support of uncertainty (safety) factors
    • Dourson, M. L., and Stara, J. F. (1983). Regulatory history and experimental support of uncertainty (safety) factors. Regul. Toxicol. Pharmacol. 3, 224-228.
    • (1983) Regul. Toxicol. Pharmacol. , vol.3 , pp. 224-228
    • Dourson, M.L.1    Stara, J.F.2
  • 35
    • 0029803289 scopus 로고    scopus 로고
    • Evolution of science-based uncertainty factors for noncancer risk assessment
    • Dourson, M. L., Felter, S. P., and Robinson, D. (1996). Evolution of science-based uncertainty factors for noncancer risk assessment. Regul. Toxicol. Pharmacol. 24, 108-120.
    • (1996) Regul. Toxicol. Pharmacol. , vol.24 , pp. 108-120
    • Dourson, M.L.1    Felter, S.P.2    Robinson, D.3
  • 36
    • 0027264115 scopus 로고
    • Importance of early blood sampling on vecuronium pharmacokinetic and pharmacodynamic parameters
    • Ducharme, J., Varin, F., Bevan, D. R., and Donati, F. (1993). Importance of early blood sampling on vecuronium pharmacokinetic and pharmacodynamic parameters. Clin. Pharmacokinet. 24, 507-518.
    • (1993) Clin. Pharmacokinet. , vol.24 , pp. 507-518
    • Ducharme, J.1    Varin, F.2    Bevan, D.R.3    Donati, F.4
  • 39
    • 0026647448 scopus 로고
    • Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 AM versus 4 PM
    • Fisher, L. E., Ludwig, E. A., Wald, J. A., Sloan, R. R., Middleton, E., and Jusko, W. J. (1992). Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 AM versus 4 PM. Clin. Pharmacol. Ther. 51, 677-688.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 677-688
    • Fisher, L.E.1    Ludwig, E.A.2    Wald, J.A.3    Sloan, R.R.4    Middleton, E.5    Jusko, W.J.6
  • 40
    • 0025859140 scopus 로고
    • Extent and variability of the first-pass elimination of adinazolam mesylate in healthy male volunteers
    • Fleishaker, J. C., Friedman, H., and Pollock, S. R. (1991a). Extent and variability of the first-pass elimination of adinazolam mesylate in healthy male volunteers. Pharmacol. Res. 8, 162-167.
    • (1991) Pharmacol. Res. , vol.8 , pp. 162-167
    • Fleishaker, J.C.1    Friedman, H.2    Pollock, S.R.3
  • 41
    • 0025739314 scopus 로고
    • N-Desmethyladinazolam pharmacokinetics and behavioral effects following administration of 10-50 mg oral doses in healthy volunteers
    • Fleishaker, J. C., Smith, T. C., Friedman, H., and Phillips, J. P. (1991b). N-Desmethyladinazolam pharmacokinetics and behavioral effects following administration of 10-50 mg oral doses in healthy volunteers. Psychopharmacology 105, 181-185.
    • (1991) Psychopharmacology , vol.105 , pp. 181-185
    • Fleishaker, J.C.1    Smith, T.C.2    Friedman, H.3    Phillips, J.P.4
  • 43
    • 0025881775 scopus 로고
    • Comparative pharmacokinetics of alprazolam and lorazepam in humans and in African green monkeys
    • Friedman, H., Redmond D. E., and Greenblatt, D. J. (1991). Comparative pharmacokinetics of alprazolam and lorazepam in humans and in African green monkeys. Psychopharmacology 104,103-105.
    • (1991) Psychopharmacology , vol.104 , pp. 103-105
    • Friedman, H.1    Redmond, D.E.2    Greenblatt, D.J.3
  • 44
    • 0024544093 scopus 로고
    • An interindividual variability in the sensitivity of atrioventricular node to diltiazem in patients with paroxysmal supraventricular tachycardia
    • Fukuhara, S., Echizen, H., Naito, M., Ishikawa, S., Toyama, M., Nagoshi, H., Honda, M., and Ishizaki, T. (1989). An interindividual variability in the sensitivity of atrioventricular node to diltiazem in patients with paroxysmal supraventricular tachycardia. J. Clin. Pharmacol. 29, 102-106.
    • (1989) J. Clin. Pharmacol. , vol.29 , pp. 102-106
    • Fukuhara, S.1    Echizen, H.2    Naito, M.3    Ishikawa, S.4    Toyama, M.5    Nagoshi, H.6    Honda, M.7    Ishizaki, T.8
  • 46
    • 0027410261 scopus 로고
    • Influence of aging on the pharmacokinetics and pharmacodynamics of doxacurium
    • Gariepy, L. P., Varin, F., Donati, F., Salib, Y., and Bevan, D. R. (1993). Influence of aging on the pharmacokinetics and pharmacodynamics of doxacurium. Clin. Pharmacol. Ther. 53, 340-347.
    • (1993) Clin. Pharmacol. Ther. , vol.53 , pp. 340-347
    • Gariepy, L.P.1    Varin, F.2    Donati, F.3    Salib, Y.4    Bevan, D.R.5
  • 48
    • 0027537286 scopus 로고
    • Pharmacodynamic model of haemodynamic effects of pinacidil in normotensive volunteers
    • Girard, P., Saumet, J. L., Dubois, F., and Boissel, J. P. (1993). Pharmacodynamic model of haemodynamic effects of pinacidil in normotensive volunteers. Eur. J. Clin. Pharmacol. 44, 177-182.
    • (1993) Eur. J. Clin. Pharmacol. , vol.44 , pp. 177-182
    • Girard, P.1    Saumet, J.L.2    Dubois, F.3    Boissel, J.P.4
  • 49
    • 0018599958 scopus 로고
    • Pharmacokinetics of metoclopramide intravenously and orally determined by liquid chromatography
    • Graffner, C., Lagerstrom, P-O., and Lundborg, P. (1979). Pharmacokinetics of metoclopramide intravenously and orally determined by liquid chromatography. Br. J. Clin. Pharmacol. 8, 469-474.
    • (1979) Br. J. Clin. Pharmacol. , vol.8 , pp. 469-474
    • Graffner, C.1    Lagerstrom, P.-O.2    Lundborg, P.3
  • 50
    • 0026011224 scopus 로고
    • Inter- And intraindividual variability in the concentration-effect (sedation) relationship of flunitrazepam
    • Grahnen, A., Wennerlund, P., Dahlstrom, B., and Eckernas, S-A. (1991). Inter- and intraindividual variability in the concentration-effect (sedation) relationship of flunitrazepam. Br. J. Clin. Pharmacol. 31, 89-92.
    • (1991) Br. J. Clin. Pharmacol. , vol.31 , pp. 89-92
    • Grahnen, A.1    Wennerlund, P.2    Dahlstrom, B.3    Eckernas, S.-A.4
  • 51
    • 0029016328 scopus 로고
    • Moclobemide, a substrate for CYP2C19 and an inhibitor of CYP2C19, CYP2D6 and CYP1A2: A panel study
    • Gram, L. F., Guerstert, T. W., Grange, S., Vistisen, K., and Brøsen, K. (1995). Moclobemide, a substrate for CYP2C19 and an inhibitor of CYP2C19, CYP2D6 and CYP1A2: A panel study. Clin. Pharmacol. Ther. 57, 670-677.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 670-677
    • Gram, L.F.1    Guerstert, T.W.2    Grange, S.3    Vistisen, K.4    Brøsen, K.5
  • 55
    • 0029564873 scopus 로고
    • Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes
    • Griensven, J. M. T., Jusko, W. J., Lernkes, H. H. P. J., Kroon, R., Verhorst, C. J., Chiang, S. T., and Cohen, A. F. (1995). Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes. Clin. Pharmacol. Ther. 58, 631-640.
    • (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 631-640
    • Griensven, J.M.T.1    Jusko, W.J.2    Lernkes, H.H.P.J.3    Kroon, R.4    Verhorst, C.J.5    Chiang, S.T.6    Cohen, A.F.7
  • 56
    • 0024339435 scopus 로고
    • Remoxipride - A new potential antipsychotic compound. Tolerability and pharmacokinetics after single oral and intravenous administration in healthy male volunteers
    • Grind, M., Nilsson, M-I., Nilsson, L., Oxenstierna, G., Sedvall, G., and Wahlen, A. (1989). Remoxipride - A new potential antipsychotic compound. Tolerability and pharmacokinetics after single oral and intravenous administration in healthy male volunteers. Psychopharmacology 98, 304-309.
    • (1989) Psychopharmacology , vol.98 , pp. 304-309
    • Grind, M.1    Nilsson, M.-I.2    Nilsson, L.3    Oxenstierna, G.4    Sedvall, G.5    Wahlen, A.6
  • 58
    • 0027238184 scopus 로고
    • The pharmacokinetics of droperidol in anesthetised children
    • Grunwald, Z., Torjman, M., Schieren, H., and Bartkowski, R. R. (1993). The pharmacokinetics of droperidol in anesthetised children. Anaesth. Analg. 76, 1238-1242.
    • (1993) Anaesth. Analg. , vol.76 , pp. 1238-1242
    • Grunwald, Z.1    Torjman, M.2    Schieren, H.3    Bartkowski, R.R.4
  • 59
    • 0026339464 scopus 로고
    • Safety and pharmacokinetics of single dose intravenous ofloxacin in healthy volunteers
    • Guay, D., Tack, K., and Flor, S. (1991). Safety and pharmacokinetics of single dose intravenous ofloxacin in healthy volunteers. Int. J. Clin. Pharm. Res. 11, 203-209.
    • (1991) Int. J. Clin. Pharm. Res. , vol.11 , pp. 203-209
    • Guay, D.1    Tack, K.2    Flor, S.3
  • 60
    • 0024991037 scopus 로고
    • Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. II. Triazolam
    • Gupta, S. K, Ellinwood, E. H., Nikaido, A. M., and Heatherly, D. G. (1990). Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. II. Triazolam. Pharm. Res. 7, 570-575.
    • (1990) Pharm. Res. , vol.7 , pp. 570-575
    • Gupta, S.K.1    Ellinwood, E.H.2    Nikaido, A.M.3    Heatherly, D.G.4
  • 61
    • 0029827303 scopus 로고    scopus 로고
    • The disposition of fluoxetine but not sertraline is altered in poor metabolisers of debrisoquin
    • Hamelin, B. A., Turgeon, J., Vallée, F., Bélanger, P-M., Paguet, F., and LeBel, M. (1996). The disposition of fluoxetine but not sertraline is altered in poor metabolisers of debrisoquin. Clin. Pharmacol. Ther. 60, 512-521.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 512-521
    • Hamelin, B.A.1    Turgeon, J.2    Vallée, F.3    Bélanger, P.-M.4    Paguet, F.5    LeBel, M.6
  • 62
    • 0023601752 scopus 로고
    • Human variability in susceptibility to toxic chemicals: A preliminary analysis of pharmacokinetic data from normal volunteers
    • Haitis, D., Erdreich, L., and Ballew, M. (1987). Human variability in susceptibility to toxic chemicals: A preliminary analysis of pharmacokinetic data from normal volunteers. Risk Anal. 7, 415-426.
    • (1987) Risk Anal. , vol.7 , pp. 415-426
    • Haitis, D.1    Erdreich, L.2    Ballew, M.3
  • 63
    • 0030444901 scopus 로고    scopus 로고
    • Interpatient variability in bioavailability is related to the extent of absorption: Implications for bioavailability and bioequivalence studies
    • Hellriegel, E. T., Bjornsson, T. D., and Hauck, W. W. (1996). Interpatient variability in bioavailability is related to the extent of absorption: Implications for bioavailability and bioequivalence studies. Clin. Pharm. Ther. 60, 601-607.
    • (1996) Clin. Pharm. Ther. , vol.60 , pp. 601-607
    • Hellriegel, E.T.1    Bjornsson, T.D.2    Hauck, W.W.3
  • 64
    • 0025007297 scopus 로고
    • Steady-state infusions of opioids in human. II. Concentration-effect relationships and therapeutic margins
    • Hill, H. F., Chapman, C. R., Saeger, L .S., Bjurstrom, R., Walter, M. H., Schoene, R. B., and Kippes, M. (1990). Steady-state infusions of opioids in human. II. Concentration-effect relationships and therapeutic margins. Pain 43, 69-79.
    • (1990) Pain , vol.43 , pp. 69-79
    • Hill, H.F.1    Chapman, C.R.2    Saeger, L.S.3    Bjurstrom, R.4    Walter, M.H.5    Schoene, R.B.6    Kippes, M.7
  • 65
    • 0027520380 scopus 로고
    • Pharmacokinetics of bromfenac in healthy subjects after single oral administration of 3 different doses
    • Högger, P., and Rohdewald, P. (1993). Pharmacokinetics of bromfenac in healthy subjects after single oral administration of 3 different doses. Arneim-Forsch. /Drug Res. 43, 1114-1118.
    • (1993) Arneim-Forsch. /Drug Res. , vol.43 , pp. 1114-1118
    • Högger, P.1    Rohdewald, P.2
  • 66
    • 0024513853 scopus 로고
    • The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers
    • Hoskin, P. J., Hanks, G. W., Aherne, G. W., Chapman, D., Littleton, P., and Filshie, J. (1989). The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Er. J. Clin. Pharmacol. 27, 499-505.
    • (1989) Er. J. Clin. Pharmacol. , vol.27 , pp. 499-505
    • Hoskin, P.J.1    Hanks, G.W.2    Aherne, G.W.3    Chapman, D.4    Littleton, P.5    Filshie, J.6
  • 68
    • 0022626151 scopus 로고
    • The metabolism of aspirin in man: A population study
    • Hutt, A. J., Caldwell, J., and Smith, R. L. (1986). The metabolism of aspirin in man: A population study. Xenobiotica 16, 239-249.
    • (1986) Xenobiotica , vol.16 , pp. 239-249
    • Hutt, A.J.1    Caldwell, J.2    Smith, R.L.3
  • 69
    • 0025296319 scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain
    • Inturrisi, C. E., Portenoy, R. K, Max, M. B., Colburn, W. A., and Foley, K. M. (1990). Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain. Clin. Pharmacol. Ther. 47, 565-577.
    • (1990) Clin. Pharmacol. Ther. , vol.47 , pp. 565-577
    • Inturrisi, C.E.1    Portenoy, R.K.2    Max, M.B.3    Colburn, W.A.4    Foley, K.M.5
  • 70
    • 0026558361 scopus 로고
    • Disposition kinetics and concentration-effect relationship of metipranolol in patients with cirrhosis and healthy subjects
    • Janku, L, Perlik, F., Tkaczykova, M., and Brodanova, M. (1992). Disposition kinetics and concentration-effect relationship of metipranolol in patients with cirrhosis and healthy subjects. Eur. J. Clin. Pharmacol. 42, 337-340.
    • (1992) Eur. J. Clin. Pharmacol. , vol.42 , pp. 337-340
    • Janku, L.1    Perlik, F.2    Tkaczykova, M.3    Brodanova, M.4
  • 72
    • 0026531962 scopus 로고
    • Racial differences in propranolol pharmacokinetics
    • Johnson, J. A., and Burlew, B. S. (1992). Racial differences in propranolol pharmacokinetics. Clin. Pharmacol. Ther. 51, 495-500.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 495-500
    • Johnson, J.A.1    Burlew, B.S.2
  • 74
    • 0026489914 scopus 로고
    • Effects of age on ibuprofen pharmacokinetics and antipyretic response
    • Kauffman, R. E., and Nelson, M. V. (1992). Effects of age on ibuprofen pharmacokinetics and antipyretic response. J. Pediatr. 121, 969-973.
    • (1992) J. Pediatr. , vol.121 , pp. 969-973
    • Kauffman, R.E.1    Nelson, M.V.2
  • 75
    • 0024835315 scopus 로고
    • Clinical pharmacokinetics in infants and children. a reappraisal
    • Kearns, G. L., and Reed, M. D. (1989). Clinical pharmacokinetics in infants and children. A reappraisal. Clin. Pharmacokinet. 17(S1), 29-67.
    • (1989) Clin. Pharmacokinet. , vol.17 , Issue.1 S , pp. 29-67
    • Kearns, G.L.1    Reed, M.D.2
  • 79
    • 0025611015 scopus 로고
    • Pharmacodynamic action and pharmacokinetics of moxonidine after single oral administration in hypertensive patients
    • Kirch, W., Hutt, H-J., and Plänitz, V. (1990). Pharmacodynamic action and pharmacokinetics of moxonidine after single oral administration in hypertensive patients. J. Clin. Pharmacol. 30, 1088-1095.
    • (1990) J. Clin. Pharmacol. , vol.30 , pp. 1088-1095
    • Kirch, W.1    Hutt, H.-J.2    Plänitz, V.3
  • 81
    • 0023715753 scopus 로고
    • Pharmacokinetic-pharmacodynamic modelling of midazolam effects on the human central nervous system
    • Koopmans, R., Dingemanse, J., Danhof, M., Horsten, G. P. M., and van Boxtel, C. J. (1988). Pharmacokinetic-pharmacodynamic modelling of midazolam effects on the human central nervous system. Clin. Pharmacol. Ther. 44, 14-22.
    • (1988) Clin. Pharmacol. Ther. , vol.44 , pp. 14-22
    • Koopmans, R.1    Dingemanse, J.2    Danhof, M.3    Horsten, G.P.M.4    Van Boxtel, C.J.5
  • 82
    • 0027183414 scopus 로고
    • Workshops on the scientific evaluation of the safety factor for the acceptable daily intake (ADI): Editorial summary
    • Kroes, R., Munro, L, and Poulsen, E. (1993). Workshops on the scientific evaluation of the safety factor for the acceptable daily intake (ADI): Editorial summary. Food Addit. Contam. 10, 269-273.
    • (1993) Food Addit. Contam. , vol.10 , pp. 269-273
    • Kroes, R.1    Munro, L.2    Poulsen, E.3
  • 83
    • 0029034232 scopus 로고
    • Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administration of dofetilide on ventricular repolarisation
    • LeCoz, F., Funck-Brentano, C., Morell, T., Ghadanfar, M. M., and Jaillon, P. (1995). Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administration of dofetilide on ventricular repolarisation. Clin. Pharmacol. Ther. 57, 533-542.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 533-542
    • LeCoz, F.1    Funck-Brentano, C.2    Morell, T.3    Ghadanfar, M.M.4    Jaillon, P.5
  • 86
    • 0027938305 scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil
    • Lemmens, H. J. M., Dyck, J. B., Shafer, S. L., and Stanski, D. R. (1994). Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil. Clin. Pharmacol. Ther. 56, 261-271.
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 261-271
    • Lemmens, H.J.M.1    Dyck, J.B.2    Shafer, S.L.3    Stanski, D.R.4
  • 87
    • 0025092413 scopus 로고
    • A new approach to deriving community exposure guidelines from no-observed-adverse-effect levels
    • Lewis, S. C., Lynch, J. R., and Nikiforov, A. I. (1990). A new approach to deriving community exposure guidelines from no-observed-adverse-effect levels. Regul. Toxicol. Pharmacol. 11, 314-330.
    • (1990) Regul. Toxicol. Pharmacol. , vol.11 , pp. 314-330
    • Lewis, S.C.1    Lynch, J.R.2    Nikiforov, A.I.3
  • 89
    • 0026488174 scopus 로고
    • Demographic factors influencing cyclosporine pharmacokinetic parameters in patients with uremia: Racial differences in bioavailability
    • Lindholm, A., Welsh, M., Alton, C., and Kahan, B. D. (1992). Demographic factors influencing cyclosporine pharmacokinetic parameters in patients with uremia: Racial differences in bioavailability. Clin. Pharmacol. Ther. 52, 359-371.
    • (1992) Clin. Pharmacol. Ther. , vol.52 , pp. 359-371
    • Lindholm, A.1    Welsh, M.2    Alton, C.3    Kahan, B.D.4
  • 90
    • 0023899734 scopus 로고
    • Acceptable daily intake: Inception, evolution, and application
    • Lu, F. C. (1988). Acceptable daily intake: Inception, evolution, and application. Regul. Toxicol. Pharmacol. 8, 45-60.
    • (1988) Regul. Toxicol. Pharmacol. , vol.8 , pp. 45-60
    • Lu, F.C.1
  • 91
    • 0026012431 scopus 로고
    • The effects of age on the pharmacokinetics, antihypertensive efficacy and general tolerability of dilevalol
    • MacPhee, G. J. A., Howie, C. A., Meredith, P. A., and Elliott, H. L. (1991). The effects of age on the pharmacokinetics, antihypertensive efficacy and general tolerability of dilevalol. Br. J. Clin. Pharmacol. 32, 591-597.
    • (1991) Br. J. Clin. Pharmacol. , vol.32 , pp. 591-597
    • MacPhee, G.J.A.1    Howie, C.A.2    Meredith, P.A.3    Elliott, H.L.4
  • 92
    • 0026611310 scopus 로고
    • Pharmacokinetic-pharmacodynamic modelling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers
    • Mandema, J. W., Tuk, B., van Steveninck, A. L., Breimer, D. D., Cohen A. F., and Danhof, M. (1992). Pharmacokinetic-pharmacodynamic modelling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers. Clin. Pharmacol. Ther. 51, 715-728.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 715-728
    • Mandema, J.W.1    Tuk, B.2    Van Steveninck, A.L.3    Breimer, D.D.4    Cohen, A.F.5    Danhof, M.6
  • 93
    • 0025070061 scopus 로고
    • Pharmacokinetics of epanolol in elderly patients with stable angina pectoris
    • Marlier, R., McAinsh, J., and Cockshott, I. D. (1990). Pharmacokinetics of epanolol in elderly patients with stable angina pectoris. Arzneim-Forsch. /Drug Res. 40, 142-144.
    • (1990) Arzneim-Forsch. /Drug Res. , vol.40 , pp. 142-144
    • Marlier, R.1    McAinsh, J.2    Cockshott, I.D.3
  • 94
    • 0027158329 scopus 로고
    • High-performance liquid chromatographic determination of total thiamine in human plasma for oral bioavailability studies
    • Mascher, H., and Kikuta, C. (1993). High-performance liquid chromatographic determination of total thiamine in human plasma for oral bioavailability studies. J. Pharm. Sci. 82, 56-59.
    • (1993) J. Pharm. Sci. , vol.82 , pp. 56-59
    • Mascher, H.1    Kikuta, C.2
  • 95
    • 0022251340 scopus 로고
    • Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin
    • McGourty, J. C., Silas, J. H., Fleming, J. J., McBurney, A., and Ward, J. W. (1985). Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin. Clin. Pharmacol. Ther. 38, 409-413.
    • (1985) Clin. Pharmacol. Ther. , vol.38 , pp. 409-413
    • McGourty, J.C.1    Silas, J.H.2    Fleming, J.J.3    McBurney, A.4    Ward, J.W.5
  • 98
  • 99
    • 0023181109 scopus 로고
    • The effects and dose-response relationship of xamoterol in patients with ischaemic heart disease
    • Molajo, A. O., Bennett, D. H., Marlow, H. F., Snow, H. M., and Bastain, W. (1987). The effects and dose-response relationship of xamoterol in patients with ischaemic heart disease. Br. J. Clin. Pharmacol. 24, 373-379.
    • (1987) Br. J. Clin. Pharmacol. , vol.24 , pp. 373-379
    • Molajo, A.O.1    Bennett, D.H.2    Marlow, H.F.3    Snow, H.M.4    Bastain, W.5
  • 100
    • 21444450325 scopus 로고
    • Scientific basis for uncertainty factors used to establish occupational exposure limits for pharmaceutical active ingredients
    • Naumann, B. D., and Weideman, P. A. (1995). Scientific basis for uncertainty factors used to establish occupational exposure limits for pharmaceutical active ingredients. Hum. Ecol. Risk Assess. 1, 590-613.
    • (1995) Hum. Ecol. Risk Assess. , vol.1 , pp. 590-613
    • Naumann, B.D.1    Weideman, P.A.2
  • 101
    • 0028303496 scopus 로고
    • Single-dose kinetics of clomipramine: Relationship to the sparteine and S-mephenytoin oxidation polymorphisms
    • Nielsen, K. K, Brøsen, K, Hansen, M. G. J., and Gram, L. F. (1994). Single-dose kinetics of clomipramine: Relationship to the sparteine and S-mephenytoin oxidation polymorphisms. Clin. Pharmacol. Ther. 55, 518-527.
    • (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 518-527
    • Nielsen, K.K.1    Brøsen, K.2    Hansen, M.G.J.3    Gram, L.F.4
  • 102
    • 0025874809 scopus 로고
    • A pharmacokinetic-pharmacodynamic model of heart rate during cocaine administration to humans
    • Noe, D. A., and Kumor, K. M. (1991). A pharmacokinetic-pharmacodynamic model of heart rate during cocaine administration to humans. Clin. Pharmacol. Ther. 49, 426-432.
    • (1991) Clin. Pharmacol. Ther. , vol.49 , pp. 426-432
    • Noe, D.A.1    Kumor, K.M.2
  • 103
    • 0025345837 scopus 로고
    • Safety and pharmacokinetics of intravenously administered trospectomycin sulfate
    • Novak, E., Griffith, D. L., Paxton, L. M., Metzler, C. M., and Bye, A. (1990). Safety and pharmacokinetics of intravenously administered trospectomycin sulfate. Clin. Ther. 12, 269-280.
    • (1990) Clin. Ther. , vol.12 , pp. 269-280
    • Novak, E.1    Griffith, D.L.2    Paxton, L.M.3    Metzler, C.M.4    Bye, A.5
  • 104
    • 0024498618 scopus 로고
    • Individual variability in the blood pressure response to intravenous phenylpropanolamine: A pharmacokinetic and pharmacodynamic investigation
    • O'Connell, M. B., Pentel, P. R., and Zimmerman, C. L. (1989). Individual variability in the blood pressure response to intravenous phenylpropanolamine: A pharmacokinetic and pharmacodynamic investigation. Clin. Pharmacol. Ther. 45, 252-259.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , pp. 252-259
    • O'Connell, M.B.1    Pentel, P.R.2    Zimmerman, C.L.3
  • 106
    • 9244260501 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of two dose regimens of befloxatone, a new reversible and selective monoamine oxidase inhibitor, at steady state in healthy volunteers
    • Patat, A., le Coz, F., Dubruc, C., Gandon, J-M., Durrieu, G., Cimarosti, L, Jezequel, S., Curet, O., Zieleniuk, L, Allain, H., and Rosenzweig, P. (1996). Pharmacodynamics and pharmacokinetics of two dose regimens of befloxatone, a new reversible and selective monoamine oxidase inhibitor, at steady state in healthy volunteers. J. Clin. Pharmacol. 36, 216-229.
    • (1996) J. Clin. Pharmacol. , vol.36 , pp. 216-229
    • Patat, A.1    Le Coz, F.2    Dubruc, C.3    Gandon, J.-M.4    Durrieu, G.5    Cimarosti, L.6    Jezequel, S.7    Curet, O.8    Zieleniuk, L.9    Allain, H.10    Rosenzweig, P.11
  • 107
    • 0029115667 scopus 로고
    • Pharmacokinetics and pharmacodynamics of rocuronium on the vocal cords and the adductor pollicis in human
    • Plaud, B., Proost, J. H., Wierda, M. K. H., Barre, J., Debaene, B., and Meistelman, C. (1995). Pharmacokinetics and pharmacodynamics of rocuronium on the vocal cords and the adductor pollicis in human. Clin. Pharmacol. Ther. 58, 185-191.
    • (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 185-191
    • Plaud, B.1    Proost, J.H.2    Wierda, M.K.H.3    Barre, J.4    Debaene, B.5    Meistelman, C.6
  • 108
    • 0030897505 scopus 로고    scopus 로고
    • Grapefruit juice-terfenadine single-dose interaction: Magnitude, mechanism and relevance
    • Rau, S. E., Bend, J. R., Arnold, M. O., Tran, L. T., Spence, J. D., and Bailey, D. G. (1997). Grapefruit juice-terfenadine single-dose interaction: Magnitude, mechanism and relevance. Clin. Pharmacol. Ther. 61, 401-409.
    • (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 401-409
    • Rau, S.E.1    Bend, J.R.2    Arnold, M.O.3    Tran, L.T.4    Spence, J.D.5    Bailey, D.G.6
  • 109
    • 0025849120 scopus 로고
    • Safety factors and establishment of acceptable daily intake
    • Renwick, A. G. (1991). Safety factors and establishment of acceptable daily intake. Food Addit. Contam. 8, 135-150.
    • (1991) Food Addit. Contam. , vol.8 , pp. 135-150
    • Renwick, A.G.1
  • 110
    • 0027171701 scopus 로고
    • Data-derived safety factors for the evaluation of food additives and environmental contaminants
    • Renwick, A. G. (1993). Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Addit. Contam. 10, 275-305.
    • (1993) Food Addit. Contam. , vol.10 , pp. 275-305
    • Renwick, A.G.1
  • 111
    • 0029609107 scopus 로고
    • The use of an additional safety or uncertainty factor for nature of toxicity in the estimation of acceptable daily intake and tolerable daily intake values
    • Renwick, A. G. (1995). The use of an additional safety or uncertainty factor for nature of toxicity in the estimation of acceptable daily intake and tolerable daily intake values. Regul. Toxicol. Pharmacol. 22, 250-261.
    • (1995) Regul. Toxicol. Pharmacol. , vol.22 , pp. 250-261
    • Renwick, A.G.1
  • 112
    • 0030588203 scopus 로고    scopus 로고
    • Inter-ethnic differences in xenobiotic metabolism
    • Renwick, A. G. (1996). Inter-ethnic differences in xenobiotic metabolism. Environ. Toxicol. Pharmacol. 2, 165-170.
    • (1996) Environ. Toxicol. Pharmacol. , vol.2 , pp. 165-170
    • Renwick, A.G.1
  • 113
    • 0031934439 scopus 로고    scopus 로고
    • Toxicokinetics in infants and children in relation to the ADI and TDI
    • Renwick, A. G. (1998). Toxicokinetics in infants and children in relation to the ADI and TDI. Food Addit. Contam. 15, 17-35.
    • (1998) Food Addit. Contam. , vol.15 , pp. 17-35
    • Renwick, A.G.1
  • 115
    • 0022871780 scopus 로고
    • The metabolism of debrisoquine in man: (1) Regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis
    • Ritchie, J. C., Crothers, M. J., Shah, R. R., Idle, J. R., and Smith, R. L. (1986). The metabolism of debrisoquine in man: (1) Regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis. Xenobiotica 16, 503-509.
    • (1986) Xenobiotica , vol.16 , pp. 503-509
    • Ritchie, J.C.1    Crothers, M.J.2    Shah, R.R.3    Idle, J.R.4    Smith, R.L.5
  • 116
    • 0022356746 scopus 로고
    • Metabolism of methoxyphenamine in extensive and poor metabolisers of debrisoquin
    • Roy, S. D., Hawes, E. M., McKay, G., Korchinski, E. D., and Midha, K. K. (1985). Metabolism of methoxyphenamine in extensive and poor metabolisers of debrisoquin. Clin. Pharmacol. Ther. 38, 128-133.
    • (1985) Clin. Pharmacol. Ther. , vol.38 , pp. 128-133
    • Roy, S.D.1    Hawes, E.M.2    McKay, G.3    Korchinski, E.D.4    Midha, K.K.5
  • 118
    • 0024502193 scopus 로고
    • Racial differences in drug response: Isoproterenol effects on heart rate following intravenous metoprolol
    • Rutledge, D. R., Steinberg, J., and Cardozo, L. (1989). Racial differences in drug response: Isoproterenol effects on heart rate following intravenous metoprolol. Clin. Pharmacol. Ther. 45, 380-386.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , pp. 380-386
    • Rutledge, D.R.1    Steinberg, J.2    Cardozo, L.3
  • 119
    • 0027320885 scopus 로고
    • Pharmacokinetics-of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects
    • Sakashita, M., Tamaguchi, T., Miyazaki, H., Sekine, Y., Nomiyama, T., Tanaka, S., Miwa, T., and Harasawa, S. (1993). Pharmacokinetics-of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects. ArzneimForsch./Drug Res. 43, 867-872.
    • (1993) ArzneimForsch./Drug Res. , vol.43 , pp. 867-872
    • Sakashita, M.1    Tamaguchi, T.2    Miyazaki, H.3    Sekine, Y.4    Nomiyama, T.5    Tanaka, S.6    Miwa, T.7    Harasawa, S.8
  • 120
    • 0027484029 scopus 로고
    • Labetalol in hypertension during the third trimester of pregnancy: Its antihypertensive effect and pharmacokinetic-dynamic analysis
    • Saotome, T., Minoura, S., Terashi, K., Sato, T., Echizen, H., and Ishizaki, T. (1993). Labetalol in hypertension during the third trimester of pregnancy: Its antihypertensive effect and pharmacokinetic-dynamic analysis. J. Clin. Pharmacol. 33, 979-988.
    • (1993) J. Clin. Pharmacol. , vol.33 , pp. 979-988
    • Saotome, T.1    Minoura, S.2    Terashi, K.3    Sato, T.4    Echizen, H.5    Ishizaki, T.6
  • 121
    • 0002430750 scopus 로고
    • Analysis of the adequacy of safety factors
    • Sheenan, D. M., and Gaylor, D. W. (1990). Analysis of the adequacy of safety factors. Teratology 41, 590-591.
    • (1990) Teratology , vol.41 , pp. 590-591
    • Sheenan, D.M.1    Gaylor, D.W.2
  • 122
    • 0018394195 scopus 로고
    • Simultaneous modelling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
    • Sheiner, L. B., Stanski, D. R., Vozeh, S., Miller, R. D., and Ham, J. (1979). Simultaneous modelling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin. Pharmacol. Ther. 25, 358-371.
    • (1979) Clin. Pharmacol. Ther. , vol.25 , pp. 358-371
    • Sheiner, L.B.1    Stanski, D.R.2    Vozeh, S.3    Miller, R.D.4    Ham, J.5
  • 123
    • 0030938161 scopus 로고    scopus 로고
    • Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'hydroxylation phenotype status
    • Sohn, D-R., Kwon, J-T., Kirn, H-K, and Ishizaki, T. (1997). Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'hydroxylation phenotype status. Clin. Pharmacol. Ther. 61, 574-582.
    • (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 574-582
    • Sohn, D.-R.1    Kwon, J.-T.2    Kirn, H.-K.3    Ishizaki, T.4
  • 124
    • 0029032224 scopus 로고
    • Racial differences in sensitivity to the negative chronotrophic effects of propranolol in healthy men
    • Sowinski, K. M., Burlew, B. S., and Johnson, J. A. (1995). Racial differences in sensitivity to the negative chronotrophic effects of propranolol in healthy men. Clin. Pharmacol. Ther. 57, 678-683.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 678-683
    • Sowinski, K.M.1    Burlew, B.S.2    Johnson, J.A.3
  • 125
    • 0028793957 scopus 로고
    • Ethnic differences in nifedipine kinetics: Comparisons between Nigerians, Caucasians and South Asians
    • Sowunmi, A., Rashid, T. J., Akinyinka, O. O., and Renwick, A. G. (1995). Ethnic differences in nifedipine kinetics: Comparisons between Nigerians, Caucasians and South Asians. Br. J. Clin. Pharmacol. 40, 489-493.
    • (1995) Br. J. Clin. Pharmacol. , vol.40 , pp. 489-493
    • Sowunmi, A.1    Rashid, T.J.2    Akinyinka, O.O.3    Renwick, A.G.4
  • 127
    • 0027434050 scopus 로고
    • Racial differences in the pharmacokinetics of methylprednisolone in Black and White renal transplant recipients
    • Tornatore, K. M., Reed, K. A., and Venuto, R. C. (1993). Racial differences in the pharmacokinetics of methylprednisolone in Black and White renal transplant recipients. Pharmacotherapy 13, 481-486.
    • (1993) Pharmacotherapy , vol.13 , pp. 481-486
    • Tornatore, K.M.1    Reed, K.A.2    Venuto, R.C.3
  • 128
    • 0025894131 scopus 로고
    • The concept of the acceptable daily intake: An historical review
    • Truhaut, R. (1991). The concept of the acceptable daily intake: An historical review. Food Addit. Contam. 8, 151-162.
    • (1991) Food Addit. Contam. , vol.8 , pp. 151-162
    • Truhaut, R.1
  • 129
    • 0026216517 scopus 로고
    • Pharmacokinetic and pharmacodynamic profiles of vapiprost, a selective, long-lasting thromboxane receptor antagonist, after single and multiple oral administration to healthy volunteers
    • Uematsu, T., Nagashima, S., Mizuno, A., Hirano, K., and Nakashima, M. (1991). Pharmacokinetic and pharmacodynamic profiles of vapiprost, a selective, long-lasting thromboxane receptor antagonist, after single and multiple oral administration to healthy volunteers. J. Clin. Pharmacol. 31, 815-822.
    • (1991) J. Clin. Pharmacol. , vol.31 , pp. 815-822
    • Uematsu, T.1    Nagashima, S.2    Mizuno, A.3    Hirano, K.4    Nakashima, M.5
  • 130
    • 0024346650 scopus 로고
    • Single- And multiple-dose nisoldipine kinetics and effects in the young, the middle-aged and the elderly
    • van Harten, J., Burggraaf, J., Ligthart, G. J., van Brummelen, P., and Breimer, D. D. (1989). Single- and multiple-dose nisoldipine kinetics and effects in the young, the middle-aged and the elderly. Clin. Pharmacol. Ther. 45, 600-607.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , pp. 600-607
    • Van Harten, J.1    Burggraaf, J.2    Ligthart, G.J.3    Van Brummelen, P.4    Breimer, D.D.5
  • 131
    • 0023426325 scopus 로고
    • Advances in the safety evaluation of food additives
    • Vettorazzi, G. (1987). Advances in the safety evaluation of food additives. Food. Addit. Contam. 4, 331-356.
    • (1987) Food. Addit. Contam. , vol.4 , pp. 331-356
    • Vettorazzi, G.1
  • 132
    • 0029857086 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profiles of sumatriptan in migraine patients with headache recurrence or no response
    • Visser, W. H., Burggraaf, J., Muller, L. M., Schoemaker, R. C., Fowler, P. A., Cohen, A. F., and Ferrari, M. D. (1996). Pharmacokinetic and pharmacodynamic profiles of sumatriptan in migraine patients with headache recurrence or no response. Clin. Pharmacol. Ther. 60, 452-460.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 452-460
    • Visser, W.H.1    Burggraaf, J.2    Muller, L.M.3    Schoemaker, R.C.4    Fowler, P.A.5    Cohen, A.F.6    Ferrari, M.D.7
  • 140
    • 0024959582 scopus 로고
    • Racial differences in drug response: Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared to American whites
    • Zhou, H. H., Koshakji, R. P., Silberstein, D. J., Wilkinson, G. R., and Wood, A. J. J. (1989a). Racial differences in drug response: Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared to American whites. New Engl. J. Med. 320, 565-570.
    • (1989) New Engl. J. Med. , vol.320 , pp. 565-570
    • Zhou, H.H.1    Koshakji, R.P.2    Silberstein, D.J.3    Wilkinson, G.R.4    Wood, A.J.J.5
  • 141
    • 0024385802 scopus 로고
    • Interindividual differences in β-receptor density contribute to variability in response to β-adrenoceptor antagonists
    • Zhou, H-H., Silberstein, D. J., Koshakji, R. D., and Wood, A. J. J. (1989b). Interindividual differences in β-receptor density contribute to variability in response to β-adrenoceptor antagonists. Clin. Pharmacol. Ther. 45, 587-592.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , pp. 587-592
    • Zhou, H.-H.1    Silberstein, D.J.2    Koshakji, R.D.3    Wood, A.J.J.4


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