Practical application of kinetic data in risk assessment - An IPCS initiative

Toxicology Letters

Volumn 138, Issue 1-2, 2003, Pages 151-160

  Meek, Bette ^a   Renwick, Andrew ^b   Sonich Mullin, Cindy ^c  

^a HEALTH CANADA   (Canada)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c IPCS H A A of R from E to C   (United States)

Author keywords

Chemical specific adjustment factors; Human variability; Interspecies differences; Toxicokinetics; Uncertainty factor

Indexed keywords

ARTICLE; CANCER RISK; CASE STUDY; CHEMICAL ANALYSIS; DATA ANALYSIS; DOSE RESPONSE; DRUG TOLERABILITY; EXPERIMENTAL MODEL; GENETIC VARIABILITY; GOVERNMENT; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; NONHUMAN; ORGANIZATION; PARAMETER; PLANNING; POPULATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SAMPLE; SPECIES COMPARISON; TOXICOKINETICS; WORKSHOP;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERNATIONAL COOPERATION; PRACTICE GUIDELINES; RISK ASSESSMENT; SPECIES SPECIFICITY; UNCERTAINTY; XENOBIOTICS;

EID: 0037452438     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00371-5     Document Type: Article

References (7)

1. IPCS, 1994. Assessing human health risks of chemicals: derivation of guidance values for health-based exposure limits. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland (Environmental Health Criteria No. 170).
2. IPCS, 1999. Principles for the assessment of risks to human health from exposure to chemicals. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland (Environmental Health Criteria No. 210).
3. IPCS, 2001. Guidance document for the use of data in development of chemical-specific adjustment factors (CSAFs) for interspecies differences and human variability in dose/concentration-response assessment. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland. http://www.ipcsharmonize.org .
4. Meek M.E. Categorical default uncertainty factors - interspecies variation and adequacy of database. Hum. Ecol. Risk Assess. 7:2001;157-163.
5. Meek M.E., Ohanian E., Renwick A., Naumann B., Lake B., Vu V., Dourson M. Guidelines for application of compound-specific adjustment factors (CSAF) in dose/concentration-response assessment. Comment Toxicol. 7:2001;575-590.
6. Renwick A.G. Data-derived safety (uncertainty) factors for the evaluation of food additives and environmental contaminants. Food Addit. Contam. 10:(3):1993;275-305.
7. Renwick A.G., Lazarus N.R. Human variability and noncancer risk assessment - an analysis of the default uncertainty factor. Regul. Toxicol. Pharmacol., Part 2. 27:(1):1998;3-20.