Insights into the role of DNA methylation in disease through the use of mouse models

DMM Disease Models and Mechanisms

Volumn 3, Issue 5-6, 2010, Pages 290-297

  Conerly, Melissa ^a   Grady, William M ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARABIDOPSIS; CANCER GENETICS; CELL LINE; CHROMOSOME ABERRATION; CPG ISLAND; DISEASE MODEL; DNA FINGERPRINTING; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; GENE EXPRESSION REGULATION; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HUMAN; KNOCKOUT MOUSE; MOUSE; NEOPLASM; NONHUMAN; NOTE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; DISEASE; DISEASE MODELS, ANIMAL; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; MICE; NEOPLASMS;

ARABIDOPSIS THALIANA;

EID: 77952188471     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.004812     Document Type: Note

References (80)

1. Abdel-Fattah, R., Glick, A., Rehman, I., Maiberger, P. and Hennings, H. (2006). Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol. Int. J. Cancer 118, 527-531. (Pubitemid 43075999)
2. Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U. and Zoghbi, H. Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl- CpG-binding protein 2. Nat. Genet. 23, 185-188. (Pubitemid 29455390)
3. Bai, A. H. C., Tongg, J. H. M., To, K.-F., Chan, M. W. Y., Man, E. P. S., Lo, K.-W., Lee, J. F. Y., Sung, J. J. Y. and Leung, W. K. (2004). Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. Int. J. Cancer 112, 846-853. (Pubitemid 39435270)
4. Bakker, J., Lin, X. and Nelson, W. G. (2002). Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells. J. Biol. Chem. 277, 22573-22580. (Pubitemid 34967234)
5. Belinsky, S. A. (2005). Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis 26, 1481-1487.
6. Bernard, D., Gil, J., Dumont, P., Rizzo, S., Monte, D., Quatannens, B., Hudson, D., Visakorpi, T., Fuks, F. and de Launoit, Y. (2006). The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth. Oncogene 25, 1358-1366. (Pubitemid 43336464)
7. Blanco, D., Vicent, S., Fraga, M. F., Fernandez-Garcia, I., Freire, J., Lujambio, A., Esteller, M., Ortiz-de-Solorzano, C., Pio, R., Lecanda, F. et al. (2007). Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. Neoplasia 9, 840-852. (Pubitemid 47623424)
8. Borinstein, S. C., Conerly, M., Dzieciatkowski, S., Biswas, S., Washington, M. K., Trobridge, P., Henikoff, S. and Grady, W. M. (2010). Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. Mol. Carcinog. 49, 94-103.
9. Cedar, H. and Bergman, Y. (2009). Linking DNA methylation and histone modification: patterns and paradigms. Nat. Rev. Genet. 10, 295-304.
10. Chen, W. D., Han, Z. J., Skoletsky, J., Olson, J., Sah, J., Myeroff, L., Platzer, P., Lu, S., Dawson, D., Willis, J. et al. (2005). Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J. Natl. Cancer Inst. 97, 1124-1132. (Pubitemid 41511211)
11. Collins, A. L., Levenson, J. M., Vilaythong, A. P., Richman, R., Armstrong, D. L., Noebels, J. L., David Sweatt, J. and Zoghbi, H. Y. (2004). Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum. Mol. Genet. 13, 2679-2689. (Pubitemid 39485416)
12. Cui, H., Cruz-Correa, M., Giardiello, F. M., Hutcheon, D. F., Kafonek, D. R., Brandenburg, S., Wu, Y., He, X., Powe, N. R. and Feinberg, A. P. (2003). Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 299, 1753-1755. (Pubitemid 36337205)
13. Eads, C. A., Nickel, A. E. and Laird, P. W. (2002). Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic mice. Cancer Res. 62, 1296-1299.
14. Eckhardt, F., Lewin, J., Cortese, R., Rakyan, V. K., Attwood, J., Burger, M., Burton, J., Cox, T. V., Davies, R., Down, T. A. et al. (2006). DNA methylation profiling of human chromosomes 6, 20 and 22. Nat. Genet. 38, 1378-1385. (Pubitemid 44837559)
15. Eden, A., Gaudet, F., Waghmare, A. and Jaenisch, R. (2003). Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300, 455. (Pubitemid 36444319)
16. Eggermann, T. (2009). Silver-Russell and Beckwith-Wiedemann syndromes: opposite (epi)mutations in 11p15 result in opposite clinical pictures. Horm. Res. 71, 30-35.
17. Fraga, M. F., Herranz, M., Espada, J., Ballestar, E., Paz, M. F., Ropero, S., Erkek, E., Bozdogan, O., Peinado, H., Niveleau, A. et al. (2004). A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res. 64, 5527-5534. (Pubitemid 39095543)
18. Fraga, M. F., Ballestar, E., Villar-Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C., Ropero, S., Petrie, K. et al. (2005). Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 37, 391-400. (Pubitemid 40490489)
19. Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H. and Jaenisch, R. (2003). Induction of tumors in mice by genomic hypomethylation. Science 300, 489-492. (Pubitemid 36444330)
20. Gokul, G., Ramakrishna, G. and Khosla, S. (2009). Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis. Epigenetics 4, 322-329.
21. Guy, J., Hendrich, B., Holmes, M., Martin, J. E. and Bird, A. (2001). A mouse Mecp2- null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27, 322-326. (Pubitemid 32201856)
22. Han, S. Y., Iliopoulos, D., Druck, T., Guler, G., Grubbs, C. J., Pereira, M., Zhang, Z., You, M., Lubet, R. A., Fong, L. Y. et al. (2004). CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Oncogene 23, 3990-3998. (Pubitemid 38747927)
23. Hata, K., Okano, M., Lei, H. and Li, E. (2002). Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129, 1983-1993. (Pubitemid 34874213)
24. Hendrich, B., Guy, J., Ramsahoye, B., Wilson, V. A. and Bird, A. (2001). Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 15, 710-723. (Pubitemid 32244900)
25. Herman, J. G., Umar, A., Polyak, K., Graff, J., Ahuja, N., Issa, J.-P., Markowitz, S., Willson, J. K. V., Hamilton, S., Kinzler, K. et al. (1998). Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95, 6870-6875. (Pubitemid 28278073)
26. Hodges, E., Smith, A. D., Kendall, J., Xuan, Z., Ravi, K., Rooks, M., Zhang, M. Q., Ye, K., Bhattacharjee, A., Brizuela, L. et al. (2009). High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res. 19, 1593-1605.
27. Hong, C., Maunakea, A., Jun, P., Bollen, A. W., Hodgson, J. G., Goldenberg, D. D., Weiss, W. A. and Costello, J. F. (2005). Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 65, 3617-3623. (Pubitemid 40616338)
28. Horsthemke, B. and Wagstaff, J. (2008). Mechanisms of imprinting of the Prader- Willi/Angelman region. Am. J. Med. Genet. A 146A, 2041-2052.
29. Iacobuzio-Donahue, C. A. (2009). Epigenetic changes in cancer. Annu. Rev. Pathol. 4, 229-249.
30. Irizarry, R. A., Ladd-Acosta, C., Carvalho, B., Wu, H., Brandenburg, S. A., Jeddeloh, J. A., Wen, B. and Feinberg, A. P. (2008). Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res. 18, 780-790. (Pubitemid 351645068)
31. Jackson, M., Krassowska, A., Gilbert, N., Chevassut, T., Forrester, L., Ansell, J. and Ramsahoye, B. (2004). Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol. Cell. Biol. 24, 8862-8871. (Pubitemid 39313892)
32. Kane, M., Loda, M., Gaida, G., Lipman, J., Mishra, R., Goldman, H., Jessup, J. M. and Kolodner, R. (1997). Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57, 808-811. (Pubitemid 27097998)
33. Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E. and Sasaki, H. (2004). Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429, 900-903. (Pubitemid 38843304)
34. Kim, D. H., Nelson, H. H., Wiencke, J. K., Christiani, D. C., Wain, J. C., Mark, E. J. and Kelsey, K. T. (2001). Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer. Oncogene 20, 1765-1770. (Pubitemid 32368022)
35. Kim, M., Trinh, B. N., Long, T. I., Oghamian, S. and Laird, P. W. (2004). Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucl. Acids Res. 32, 5742-5749. (Pubitemid 39619157)
36. Kim, S. J., Kang, H. S., Chang, H. L., Jung, Y. C., Sim, H. B., Lee, K. S., Ro, J. and Lee, E. S. (2008). Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer. Oncol. Rep. 19, 663-668. (Pubitemid 351330433)
37. Kim, Y. H., Petko, Z., Dzieciatkowski, S., Lin, L., Ghiassi, M., Stain, S., Chapman, W. C., Washington, M. K., Willis, J., Markowitz, S. D. et al. (2006). CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer 45, 781-789.
38. Kuismanen, S. A., Holmberg, M. T., Salovaara, R., Schweizer, P., Aaltonen, L. A., de la Chapelle, A., Nystrom-Lahti, M. and Peltomaki, P. (1999). Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. Proc. Natl. Acad. Sci. USA 96, 12661-12666. (Pubitemid 29513559)
39. Laird, P. W., Jackson-Grusby, L., Fazeli, A., Dickinson, S. L., Jung, W. E., Li, E., Weinberg, R. A. and Jaenisch, R. (1995). Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81, 197-205.
40. Li, E., Beard, C. and Jaenisch, R. (1993). Role for DNA methylation in genomic imprinting. Nature 366, 362-365. (Pubitemid 23349366)
41. Li, J.-Y., Pu, M.-T., Hirasawa, R., Li, B.-Z., Huang, Y.-N., Zeng, R., Jing, N.-H., Chen, T., Li, E., Sasaki, H. et al. (2007). Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol. Cell. Biol. 27, 8748-8759.
42. Lin, H., Yamada, Y., Nguyen, S., Linhart, H., Jackson-Grusby, L., Meissner, A., Meletis, K., Lo, G. and Jaenisch, R. (2006). Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol. Cell. Biol. 26, 2976-2983.
43. Linhart, H. G., Lin, H., Yamada, Y., Moran, E., Steine, E. J., Gokhale, S., Lo, G., Cantu, E., Ehrich, M., He, T. et al. (2007). Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev. 21, 3110-3122. (Pubitemid 350223528)
44. Lopes, E. C., Valls, E., Figueroa, M. E., Mazur, A., Meng, F.-G., Chiosis, G., Laird, P. W., Schreiber-Agus, N., Greally, J. M., Prokhortchouk, E. et al. (2008). Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res. 68, 7258-7263.
45. Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B. and Sidransky, D. (1995). 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1, 686-692.
46. Millar, C. B., Guy, J., Sansom, O. J., Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P. D., Bishop, S. M., Clarke, A. R. and Bird, A. (2002). Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science 297, 403-405. (Pubitemid 34790770)
47. Mittag, F., Kuester, D., Vieth, M., Peters, B., Stolte, B., Roessner, A. and Schneider- Stock, R. (2006). DAPK promotor methylation is an early event in colorectal carcinogenesis. Cancer Lett. 240, 69-75. (Pubitemid 44037174)
48. Moinova, H. R., Chen, W. D., Shen, L., Smiraglia, D., Olechnowicz, J., Ravi, L., Kasturi, L., Myeroff, L., Plass, C., Parsons, R. et al. (2002). HLTF gene silencing in human colon cancer. Proc. Natl. Acad. Sci. USA 99, 4562-4567. (Pubitemid 34286024)
49. Morey, S. R., Smiraglia, D. J., James, S. R., Yu, J., Moser, M. T., Foster, B. A. and Karpf, A. R. (2006). DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Cancer Res. 66, 11659-11667. (Pubitemid 46094177)
50. Morgan, H. D., Dean, W., Coker, H. A., Reik, W. and Petersen-Mahrt, S. K. (2004). Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J. Biol. Chem. 279, 52353-52360. (Pubitemid 39656611)
51. Nakanishi, H., Suda, T., Katoh, M., Watanabe, A., Igishi, T., Kodani, M., Matsumoto, S., Nakamoto, M., Shigeoka, Y., Okabe, T. et al. (2004). Loss of imprinting of PEG1/MEST in lung cancer cell lines. Oncol. Rep. 12, 1273-1278.
52. Nakata, S., Sugio, K., Uramoto, H., Oyama, T., Hanagiri, T., Morita, M. and Yasumoto, K. (2006). The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance. Cancer 106, 2190-2199. (Pubitemid 43673241)
53. Nan, X., Ng, H. H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N. and Bird, A. (1998). Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389. (Pubitemid 28269714)
54. Okano, M., Bell, D. W., Haber, D. A. and Li, E. (1999). DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257. (Pubitemid 29519904)
55. Opavsky, R., Wang, S. H., Trikha, P., Raval, A., Huang, Y., Wu, Y. Z., Rodriguez, B., Keller, B., Liyanarachchi, S., Wei, G. et al. (2007). CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet. 3, 1757-1769. (Pubitemid 47510267)
56. Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S. and Goff, J. P. (1999). Bone marrow as a potential source of hepatic oval cells. Science 284, 1168-1170. (Pubitemid 29288406)
57. Prokhortchouk, E. and Defossez, P. A. (2008). The cell biology of DNA methylation in mammals. Biochim. Biophys. Acta 1783, 2167-2173.
58. Prokhortchouk, A., Sansom, O., Selfridge, J., Caballero, I. M., Salozhin, S., Aithozhina, D., Cerchietti, L., Meng, F. G., Augenlicht, L. H., Mariadason, J. M. et al. (2006). Kaiso-deficient mice show resistance to intestinal cancer. Mol. Cell. Biol. 26, 199-208.
59. Pulling, L. C., Vuillemenot, B. R., Hutt, J. A., Devereux, T. R. and Belinsky, S. A. (2004). Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens. Cancer Res. 64, 3844-3848.
60. Rhee, I., Jair, K. W., Yen, R. W., Lengauer, C., Herman, J. G., Kinzler, K. W., Vogelstein, B., Baylin, S. B. and Schuebel, K. E. (2000). CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404, 1003-1007. (Pubitemid 30243595)
61. Samuel, M. S., Suzuki, H., Buchert, M., Putoczki, T. L., Tebbutt, N. C., Lundgren- May, T., Christou, A., Inglese, M., Toyota, M., Heath, J. K. et al. (2009). Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling. Gastroenterology 137, 902-913.
62. Sansom, O. J., Berger, J., Bishop, S. M., Hendrich, B., Bird, A. and Clarke, A. R. (2003). Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat. Genet. 34, 145-147. (Pubitemid 36666922)
63. Sato, N., Matsubayashi, H., Abe, T., Fukushima, N. and Goggins, M. (2005). Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms Identified by gene expression profiling. Clin. Cancer Res. 11, 4681-4688. (Pubitemid 41557185)
64. Schreiner, B., Baur, D. M., Fingerle, A. A., Zechner, U., Greten, F. R., Adler, G., Sipos, B., Kloppel, G., Hameister, H. and Schmid, R. M. (2003). Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice. Genes Chromosomes Cancer 38, 240-248. (Pubitemid 37259641)
65. Sherr, C. J. (2001). The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2, 731-737.
66. Shiota, K., Kogo, Y., Ohgane, J., Imamura, T., Urano, A., Nishino, K., Tanaka, S. and Hattori, N. (2002). Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice. Genes Cells 7, 961-969.
67. Tadokoro, Y., Ema, H., Okano, M., Li, E. and Nakauchi, H. (2007). De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J. Exp. Med. 204, 715-722. (Pubitemid 46631602)
68. Tate, P. H. and Bird, A. P. (1993). Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev. 3, 226-231.
69. Tateno, M., Fukunishi, Y., Komatsu, S., Okazaki, Y., Kawai, J., Shibata, K., Itoh, M., Muramatsu, M., Held, W. A. and Hayashizaki, Y. (2001). Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Cancer Res. 61, 1144-1153. (Pubitemid 32174437)
70. Trinh, B. N., Long, T. I., Nickel, A. E., Shibata, D. and Laird, P. W. (2002). DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol. Cell. Biol. 22, 2906-2917. (Pubitemid 34437450)
71. Tsujiuchi, T., Sugata, E., Masaoka, T., Onishi, M., Fujii, H., Shimizu, K. and Honoki, K. (2007). Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. Cancer Sci. 98, 943-948. (Pubitemid 46865375)
72. Uchida, N., Aguila, H. L., Fleming, W. H., Jerabek, L. and Weissman, I. L. (1994). Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells. Blood 83, 3758-3779. (Pubitemid 24175568)
73. Ueda, Y., Okano, M., Williams, C., Chen, T., Georgopoulos, K. and Li, E. (2006). Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development 133, 1183-1192.
74. Watanabe, M., Ogawa, Y., Itoh, K., Koiwa, T., Kadin, M. E., Watanabe, T., Okayasu, I., Higashihara, M. and Horie, R. (2008). Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma. Lab. Invest. 88, 48-57.
75. Weber, M., Davies, J. J., Wittig, D., Oakeley, E. J., Haase, M., Lam, W. L. and Schubeler, D. (2005). Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat. Genet. 37, 853-862. (Pubitemid 41077111)
76. White, H. E., Durston, V. J., Harvey, J. F. and Cross, N. C. P. (2006). Quantitative analysis of SRNPN gene methylation by pyrosequencing as a diagnostic test for Prader-Willi syndrome and Angelman syndrome. Clin. Chem. 52, 1005-1013.
77. Yamada, Y., Jackson-Grusby, L., Linhart, H., Meissner, A., Eden, A., Lin, H. and Jaenisch, R. (2005). Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc. Natl. Acad. Sci. USA 102, 13580-13585. (Pubitemid 41420891)
78. Yu, L., Liu, C., Vandeusen, J., Becknell, B., Dai, Z., Wu, Y. Z., Raval, A., Liu, T. H., Ding, W., Mao, C. et al. (2005). Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Nat. Genet. 37, 265-274. (Pubitemid 41716253)
79. Zhao, X., Ueba, T., Christie, B. R., Barkho, B., McConnell, M. J., Nakashima, K., Lein, E. S., Eadie, B. D., Willhoite, A. R., Muotri, A. R. et al. (2003). Mice lacking methyl- CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl. Acad. Sci. USA 100, 6777-6782. (Pubitemid 36666656)
80. Zilberman, D., Coleman-Derr, D., Ballinger, T. and Henikoff, S. (2008). Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature 456, 125-129.