메뉴 건너뛰기




Volumn 137, Issue 3, 2009, Pages

Elevated Dnmt3a Activity Promotes Polyposis in ApcMin Mice by Relaxing Extracellular Restraints on Wnt Signaling

Author keywords

[No Author keywords available]

Indexed keywords

A33 GLYCOPROTEIN; APC PROTEIN; BETA CATENIN; DNA METHYLTRANSFERASE 3A; GLYCOPROTEIN; SECRETED FRIZZLED RELATED PROTEIN 1; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 69249091869     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.05.042     Document Type: Article
Times cited : (34)

References (49)
  • 1
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones P.A., and Baylin S.B. The fundamental role of epigenetic events in cancer. Nat Rev Genet 3 (2002) 415-428
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 2
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones P.A., and Laird P.W. Cancer epigenetics comes of age. Nat Genet 21 (1999) 163-167
    • (1999) Nat Genet , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 3
    • 0026317881 scopus 로고
    • High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
    • el-Deiry W.S., Nelkin B.D., Celano P., et al. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci U S A 88 (1991) 3470-3474
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 3470-3474
    • el-Deiry, W.S.1    Nelkin, B.D.2    Celano, P.3
  • 4
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg A.P., and Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301 (1983) 89-92
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 5
    • 0034015438 scopus 로고    scopus 로고
    • CpG-island methylation in aging and cancer
    • Issa J.P. CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249 (2000) 101-118
    • (2000) Curr Top Microbiol Immunol , vol.249 , pp. 101-118
    • Issa, J.P.1
  • 6
    • 0022495317 scopus 로고
    • DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas
    • Baylin S.B., Hoppener J.W., de Bustros A., et al. DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas. Cancer Res 46 (1986) 2917-2922
    • (1986) Cancer Res , vol.46 , pp. 2917-2922
    • Baylin, S.B.1    Hoppener, J.W.2    de Bustros, A.3
  • 7
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman J.G., and Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349 (2003) 2042-2054
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 8
    • 33645825196 scopus 로고    scopus 로고
    • Suppression of intestinal neoplasia by deletion of Dnmt3b
    • Lin H., Yamada Y., Nguyen S., et al. Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol 26 (2006) 2976-2983
    • (2006) Mol Cell Biol , vol.26 , pp. 2976-2983
    • Lin, H.1    Yamada, Y.2    Nguyen, S.3
  • 9
    • 0027504621 scopus 로고
    • Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells
    • Wu J., Issa J.P., Herman J., et al. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. Proc Natl Acad Sci U S A 90 (1993) 8891-8895
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8891-8895
    • Wu, J.1    Issa, J.P.2    Herman, J.3
  • 10
    • 33744813317 scopus 로고    scopus 로고
    • CpG island methylation in precursors of gastrointestinal malignancies
    • Chan A.O., and Rashid A. CpG island methylation in precursors of gastrointestinal malignancies. Curr Mol Med 6 (2006) 401-408
    • (2006) Curr Mol Med , vol.6 , pp. 401-408
    • Chan, A.O.1    Rashid, A.2
  • 11
    • 0036613250 scopus 로고    scopus 로고
    • A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    • Suzuki H., Gabrielson E., Chen W., et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 31 (2002) 141-149
    • (2002) Nat Genet , vol.31 , pp. 141-149
    • Suzuki, H.1    Gabrielson, E.2    Chen, W.3
  • 12
    • 34548746357 scopus 로고    scopus 로고
    • Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence
    • Schmidt W.M., Sedivy R., Forstner B., et al. Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence. Mol Carcinog 46 (2007) 766-772
    • (2007) Mol Carcinog , vol.46 , pp. 766-772
    • Schmidt, W.M.1    Sedivy, R.2    Forstner, B.3
  • 13
    • 0037355506 scopus 로고    scopus 로고
    • Unanswered questions about the role of promoter methylation in carcinogenesis
    • Bestor T.H. Unanswered questions about the role of promoter methylation in carcinogenesis. Ann N Y Acad Sci 983 (2003) 22-27
    • (2003) Ann N Y Acad Sci , vol.983 , pp. 22-27
    • Bestor, T.H.1
  • 14
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61 (1990) 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 15
    • 8444220513 scopus 로고    scopus 로고
    • Signaling pathways in intestinal development and cancer
    • Sancho E., Batlle E., and Clevers H. Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol 20 (2004) 695-723
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 695-723
    • Sancho, E.1    Batlle, E.2    Clevers, H.3
  • 16
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler K.W., and Vogelstein B. Lessons from hereditary colorectal cancer. Cell 87 (1996) 159-170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 17
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano Y., and Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116 (2003) 2627-2634
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 18
    • 29744465560 scopus 로고    scopus 로고
    • Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified
    • Ward R.L., Turner J., Williams R., et al. Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. J Pathol 207 (2005) 377-384
    • (2005) J Pathol , vol.207 , pp. 377-384
    • Ward, R.L.1    Turner, J.2    Williams, R.3
  • 19
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M., McDonald L.E., Millar D.S., et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 89 (1992) 1827-1831
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 20
    • 0033835810 scopus 로고    scopus 로고
    • Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells
    • Johnstone C.N., Tebbutt N.C., Abud H.E., et al. Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Am J Physiol GastrointestLiver Physiol 279 (2000) G500-G510
    • (2000) Am J Physiol GastrointestLiver Physiol , vol.279
    • Johnstone, C.N.1    Tebbutt, N.C.2    Abud, H.E.3
  • 21
    • 0030008349 scopus 로고    scopus 로고
    • Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
    • Lakso M., Pichel J.G., Gorman J.R., et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93 (1996) 5860-5865
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5860-5865
    • Lakso, M.1    Pichel, J.G.2    Gorman, J.R.3
  • 22
    • 0025147443 scopus 로고
    • Quantitative analysis of antibody localization in human metastatic colon cancer: a phase I study of monoclonal antibody A33
    • Welt S., Divgi C.R., Real F.X., et al. Quantitative analysis of antibody localization in human metastatic colon cancer: a phase I study of monoclonal antibody A33. J Clin Oncol 8 (1990) 1894-1906
    • (1990) J Clin Oncol , vol.8 , pp. 1894-1906
    • Welt, S.1    Divgi, C.R.2    Real, F.X.3
  • 23
    • 0034662626 scopus 로고    scopus 로고
    • Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
    • Esteller M., Sparks A., Toyota M., et al. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 60 (2000) 4366-4371
    • (2000) Cancer Res , vol.60 , pp. 4366-4371
    • Esteller, M.1    Sparks, A.2    Toyota, M.3
  • 24
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    • Suzuki H., Watkins D.N., Jair K.W., et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36 (2004) 417-422
    • (2004) Nat Genet , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3
  • 25
    • 0029982877 scopus 로고    scopus 로고
    • The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
    • Nathke I.S., Adams C.L., Polakis P., et al. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 134 (1996) 165-179
    • (1996) J Cell Biol , vol.134 , pp. 165-179
    • Nathke, I.S.1    Adams, C.L.2    Polakis, P.3
  • 26
    • 34247187543 scopus 로고    scopus 로고
    • Myc deletion rescues Apc deficiency in the small intestine
    • Sansom O.J., Meniel V.S., et al. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (2007) 676-679
    • (2007) Nature , vol.446 , pp. 676-679
    • Sansom, O.J.1    Meniel, V.S.2
  • 27
    • 0037068351 scopus 로고    scopus 로고
    • Gene silencing in mammalian cells and the spread of DNA methylation
    • Turker M.S. Gene silencing in mammalian cells and the spread of DNA methylation. Oncogene 21 (2002) 5388-5393
    • (2002) Oncogene , vol.21 , pp. 5388-5393
    • Turker, M.S.1
  • 28
    • 40149088485 scopus 로고    scopus 로고
    • Differential expression of secretory phospholipases A2 in normal and malignant prostate cell lines: regulation by cytokines, cell signaling pathways, and epigenetic mechanisms
    • Menschikowski M., Hagelgans A., Gussakovsky E., et al. Differential expression of secretory phospholipases A2 in normal and malignant prostate cell lines: regulation by cytokines, cell signaling pathways, and epigenetic mechanisms. Neoplasia 10 (2008) 279-286
    • (2008) Neoplasia , vol.10 , pp. 279-286
    • Menschikowski, M.1    Hagelgans, A.2    Gussakovsky, E.3
  • 29
    • 36849004469 scopus 로고    scopus 로고
    • Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
    • Linhart H.G., Lin H., Yamada Y., et al. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev 21 (2007) 3110-3122
    • (2007) Genes Dev , vol.21 , pp. 3110-3122
    • Linhart, H.G.1    Lin, H.2    Yamada, Y.3
  • 30
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane M.F., Loda M., Gaida G.M., et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57 (1997) 808-811
    • (1997) Cancer Res , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3
  • 31
    • 9144240010 scopus 로고    scopus 로고
    • DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway
    • Niida A., Hiroko T., Kasai M., et al. DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway. Oncogene 23 (2004) 8520-8526
    • (2004) Oncogene , vol.23 , pp. 8520-8526
    • Niida, A.1    Hiroko, T.2    Kasai, M.3
  • 32
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/β-catenin/TcF signaling induces the transcription of axin-2, a negative regulator of the signaling pathway
    • Jho E., Zhang T., Domon C., et al. Wnt/β-catenin/TcF signaling induces the transcription of axin-2, a negative regulator of the signaling pathway. Mol Cell Biol 22 (2002) 1172-1183
    • (2002) Mol Cell Biol , vol.22 , pp. 1172-1183
    • Jho, E.1    Zhang, T.2    Domon, C.3
  • 33
    • 25444497707 scopus 로고    scopus 로고
    • The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis
    • Li Q., Ishikawa T.O., Oshima M., et al. The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res 65 (2005) 8622-8627
    • (2005) Cancer Res , vol.65 , pp. 8622-8627
    • Li, Q.1    Ishikawa, T.O.2    Oshima, M.3
  • 34
    • 0035873225 scopus 로고    scopus 로고
    • Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
    • Fuks F., Burgers W.A., Godin N., et al. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 20 (2001) 2536-2544
    • (2001) EMBO J , vol.20 , pp. 2536-2544
    • Fuks, F.1    Burgers, W.A.2    Godin, N.3
  • 35
    • 0034333498 scopus 로고    scopus 로고
    • The murine A33 antigen is expressed at two distinct sites during development, the ICM of the blastocyst and the intestinal epithelium
    • Abud H.E., Johnstone C.N., Tebbutt N.C., et al. The murine A33 antigen is expressed at two distinct sites during development, the ICM of the blastocyst and the intestinal epithelium. Mech Dev 98 (2000) 111-114
    • (2000) Mech Dev , vol.98 , pp. 111-114
    • Abud, H.E.1    Johnstone, C.N.2    Tebbutt, N.C.3
  • 36
    • 0035031279 scopus 로고    scopus 로고
    • Methylation matters
    • Costello J.F., and Plass C. Methylation matters. J Med Genet 38 (2001) 285-303
    • (2001) J Med Genet , vol.38 , pp. 285-303
    • Costello, J.F.1    Plass, C.2
  • 37
    • 44449094545 scopus 로고    scopus 로고
    • Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    • Chan T.A., Glockner S., Yi J.M., et al. Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. PLoS Med 5 (2008) e114
    • (2008) PLoS Med , vol.5
    • Chan, T.A.1    Glockner, S.2    Yi, J.M.3
  • 38
    • 0036334007 scopus 로고    scopus 로고
    • Small changes in expression affect predisposition to tumorigenesis
    • Yan H., Dobbie Z., Gruber S.B., et al. Small changes in expression affect predisposition to tumorigenesis. Nat Genet 30 (2002) 25-26
    • (2002) Nat Genet , vol.30 , pp. 25-26
    • Yan, H.1    Dobbie, Z.2    Gruber, S.B.3
  • 39
    • 33745765883 scopus 로고    scopus 로고
    • Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
    • Aguilera O., Fraga M.F., Ballestar E., et al. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 25 (2006) 4116-4121
    • (2006) Oncogene , vol.25 , pp. 4116-4121
    • Aguilera, O.1    Fraga, M.F.2    Ballestar, E.3
  • 40
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker N., Ridgway R.A., et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457 (2009) 608-611
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2
  • 42
    • 23244448347 scopus 로고    scopus 로고
    • Expression pattern of Wnt signaling components in the adult intestine
    • Gregorieff A., Pinto D., Begthel H., et al. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 129 (2005) 626-638
    • (2005) Gastroenterology , vol.129 , pp. 626-638
    • Gregorieff, A.1    Pinto, D.2    Begthel, H.3
  • 43
    • 36949016699 scopus 로고    scopus 로고
    • Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state
    • Kanai Y., and Hirohashi S. Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis 28 (2007) 2434-2442
    • (2007) Carcinogenesis , vol.28 , pp. 2434-2442
    • Kanai, Y.1    Hirohashi, S.2
  • 44
    • 34548746357 scopus 로고    scopus 로고
    • Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence
    • Schmidt W.M., Sedivy R., Forstner B., et al. Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence. Mol Carcinog 46 (2007) 766-772
    • (2007) Mol Carcinog , vol.46 , pp. 766-772
    • Schmidt, W.M.1    Sedivy, R.2    Forstner, B.3
  • 45
    • 38449115628 scopus 로고    scopus 로고
    • DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer
    • Gokul G., Gautami B., Malathi S., et al. DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer. Epigenetics 2 (2007) 80-85
    • (2007) Epigenetics , vol.2 , pp. 80-85
    • Gokul, G.1    Gautami, B.2    Malathi, S.3
  • 46
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M., Garzon R., Cimmino A., et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 104 (2007) 15805-15810
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 47
    • 34547935029 scopus 로고    scopus 로고
    • Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins
    • Ostler K.R., Davis E.M., Payne S.L., et al. Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene 26 (2007) 5553-5563
    • (2007) Oncogene , vol.26 , pp. 5553-5563
    • Ostler, K.R.1    Davis, E.M.2    Payne, S.L.3
  • 48
    • 48749112915 scopus 로고    scopus 로고
    • Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b
    • Gowher H., Stuhlmann H., and Felsenfeld G. Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b. Genes Dev 22 (2008) 2075-2084
    • (2008) Genes Dev , vol.22 , pp. 2075-2084
    • Gowher, H.1    Stuhlmann, H.2    Felsenfeld, G.3
  • 49
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann C., Brueckner B., Musch T., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 66 (2006) 2794-2800
    • (2006) Cancer Res , vol.66 , pp. 2794-2800
    • Stresemann, C.1    Brueckner, B.2    Musch, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.