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Volumn 124, Issue 3 SUPPL., 2003, Pages 18S-25S

Thrombin and platelet activation

Author keywords

G protein coupled receptors; G proteins; Phospholipase C; Platelet; Protease activated receptors; Thrombin

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; ANTITHROMBOCYTIC AGENT; BLOOD CLOTTING FACTOR 10A; CD39 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; COLLAGEN; CYCLIC AMP; DIPYRIDAMOLE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; PHOSPHOLIPASE C; PROSTACYCLIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; THROMBIN INHIBITOR; THROMBIN RECEPTOR; THROMBOXANE A2; VON WILLEBRAND FACTOR;

EID: 0141484537     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.124.3_suppl.18S     Document Type: Article
Times cited : (325)

References (49)
  • 1
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu TKH, Hung DT, Wheaton VI, et al. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64:1057-1068
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.H.1    Hung, D.T.2    Wheaton, V.I.3
  • 2
    • 0025784847 scopus 로고
    • cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+ mobilization
    • Rasmussen UB, Vouret-Craviari V, Jallat S, et al. cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett 1991; 288:123-128
    • (1991) FEBS Lett , vol.288 , pp. 123-128
    • Rasmussen, U.B.1    Vouret-Craviari, V.2    Jallat, S.3
  • 3
    • 0037158606 scopus 로고    scopus 로고
    • Thrombotic microangiopathies
    • Moake JL. Thrombotic microangiopathies. N Engl J Med 2002; 347:589-600
    • (2002) N Engl J Med , vol.347 , pp. 589-600
    • Moake, J.L.1
  • 4
    • 0030816051 scopus 로고    scopus 로고
    • Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
    • Murata T, Ushikubi F, Matsuoka T, et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 1997; 388:678-682
    • (1997) Nature , vol.388 , pp. 678-682
    • Murata, T.1    Ushikubi, F.2    Matsuoka, T.3
  • 5
    • 0030945186 scopus 로고    scopus 로고
    • The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
    • Marcus AJ, Broekman MJ, Drosopoulos JH, et al. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest 1997; 99:1351-1360
    • (1997) J Clin Invest , vol.99 , pp. 1351-1360
    • Marcus, A.J.1    Broekman, M.J.2    Drosopoulos, J.H.3
  • 6
    • 0032080420 scopus 로고    scopus 로고
    • Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39
    • Gayle RB III, Maliszewski CR, Gimpel SD, et al. Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39. J Clin Invest 1998; 101:1851-1859
    • (1998) J Clin Invest , vol.101 , pp. 1851-1859
    • Gayle R.B. III1    Maliszewski, C.R.2    Gimpel, S.D.3
  • 7
    • 0036799775 scopus 로고    scopus 로고
    • Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse
    • Falati S, Gross P, Merrill-Skoloff G, et al. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med 2002; 8:1175-1181
    • (2002) Nat Med , vol.8 , pp. 1175-1181
    • Falati, S.1    Gross, P.2    Merrill-Skoloff, G.3
  • 8
    • 0033605135 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets
    • Gross BS, Lee JR, Clements JL, et al. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J Biol Chem 1999; 274:5963-5971
    • (1999) J Biol Chem , vol.274 , pp. 5963-5971
    • Gross, B.S.1    Lee, J.R.2    Clements, J.L.3
  • 9
    • 0035942220 scopus 로고    scopus 로고
    • How activated receptors couple to G proteins
    • Hamm HE. How activated receptors couple to G proteins. Proc Natl Acad Sci U S A 2001; 98:4819-4821
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4819-4821
    • Hamm, H.E.1
  • 11
    • 0033593667 scopus 로고    scopus 로고
    • Activation of G12/G13 results in shape change and Rho/ Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
    • Klages B, Brandt U, Simon MI, et al. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999; 144:745-754
    • (1999) J Cell Biol , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3
  • 12
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in G alpha(q)-deficient mice
    • Offermanns S, Toombs CF, Hu YH, et al. Defective platelet activation in G alpha(q)-deficient mice. Nature 1997; 389:183-186
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.H.3
  • 13
    • 0032541586 scopus 로고    scopus 로고
    • Genetic analysis of mammalian G-protein signalling
    • Offermanns S, Simon MI. Genetic analysis of mammalian G-protein signalling. Oncogene 1998; 17:1375-1381
    • (1998) Oncogene , vol.17 , pp. 1375-1381
    • Offermanns, S.1    Simon, M.I.2
  • 14
    • 0013166880 scopus 로고    scopus 로고
    • Signal transduction during the initiation, extension and perpetuation of platelet plug formation
    • Michelson AD, ed. New York, NY: Academic Press
    • Woulfe D, Yang J, Prevost N, et al. Signal transduction during the initiation, extension and perpetuation of platelet plug formation. In: Michelson AD, ed. Platelets. New York, NY: Academic Press; 2002; 197-214
    • (2002) Platelets , pp. 197-214
    • Woulfe, D.1    Yang, J.2    Prevost, N.3
  • 15
    • 0037195456 scopus 로고    scopus 로고
    • Signaling through Gi family members in platelets: Redundancy and specificity in the regulation of adenylyl cyclase and other effectors
    • Yang J, Wu J, Jiang H, et al. Signaling through Gi family members in platelets: redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem 2002; 277:46035-46042
    • (2002) J Biol Chem , vol.277 , pp. 46035-46042
    • Yang, J.1    Wu, J.2    Jiang, H.3
  • 16
    • 0034730185 scopus 로고    scopus 로고
    • Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
    • Yang J, Wu J, Kowalska MA, et al. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci U S A 2000; 97:9984-9989
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9984-9989
    • Yang, J.1    Wu, J.2    Kowalska, M.A.3
  • 17
    • 0034897374 scopus 로고    scopus 로고
    • Impaired activation of murine platelets lacking G alpha(i2)
    • Jantzen HM, Milstone DS, Gousset L, et al. Impaired activation of murine platelets lacking G alpha(i2). J Clin Invest 2001; 108:477-483
    • (2001) J Clin Invest , vol.108 , pp. 477-483
    • Jantzen, H.M.1    Milstone, D.S.2    Gousset, L.3
  • 18
    • 0037189528 scopus 로고    scopus 로고
    • Activation of Rap1B by G(i) family members in platelets
    • Woulfe D, Jiang H, Mortensen R, et al. Activation of Rap1B by G(i) family members in platelets. J Biol Chem 2002; 277:23382-23390
    • (2002) J Biol Chem , vol.277 , pp. 23382-23390
    • Woulfe, D.1    Jiang, H.2    Mortensen, R.3
  • 19
    • 0032493295 scopus 로고    scopus 로고
    • Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
    • Jin J, Kunapuli SP. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci U S A 1998; 95:8070-8074
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8070-8074
    • Jin, J.1    Kunapuli, S.P.2
  • 20
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter G, Jantzen HM, Vincent D, et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001; 409:202-207
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1    Jantzen, H.M.2    Vincent, D.3
  • 21
    • 0034978187 scopus 로고    scopus 로고
    • Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
    • Foster CJ, Prosser DM, Agans JM, et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001; 107:1591-1598
    • (2001) J Clin Invest , vol.107 , pp. 1591-1598
    • Foster, C.J.1    Prosser, D.M.2    Agans, J.M.3
  • 22
    • 0034911702 scopus 로고    scopus 로고
    • ADP receptors of platelets and their inhibition
    • Gachet C. ADP receptors of platelets and their inhibition. Thromb Haemost 2001; 86:222-232
    • (2001) Thromb Haemost , vol.86 , pp. 222-232
    • Gachet, C.1
  • 23
    • 0034742636 scopus 로고    scopus 로고
    • Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling
    • Phillips DR, Nannizzi-Alaimo L, Prasad KS. Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Thromb Haemost 2001; 86:246-258
    • (2001) Thromb Haemost , vol.86 , pp. 246-258
    • Phillips, D.R.1    Nannizzi-Alaimo, L.2    Prasad, K.S.3
  • 24
    • 0037047122 scopus 로고    scopus 로고
    • Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred
    • Prevost N, Woulfe D, Tanaka T, et al. Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. Proc Natl Acad Sci U S A 2002; 99:9219-9224
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9219-9224
    • Prevost, N.1    Woulfe, D.2    Tanaka, T.3
  • 25
    • 0037143597 scopus 로고    scopus 로고
    • Platelet-derived CD40L: The switch-hitting player of cardiovascular disease
    • Andre P, Nannizzi-Alaimo L, Prasad SK, et al. Platelet-derived CD40L: the switch-hitting player of cardiovascular disease. Circulation 2002; 106:896-899
    • (2002) Circulation , vol.106 , pp. 896-899
    • Andre, P.1    Nannizzi-Alaimo, L.2    Prasad, S.K.3
  • 26
    • 0021918266 scopus 로고
    • Thrombin binds to a high-affinity approximately 900,000-Dalton site on human platelets
    • Harmon JT, Jamieson GA. Thrombin binds to a high-affinity approximately 900,000-Dalton site on human platelets. Biochemistry 1985; 24:58-64
    • (1985) Biochemistry , vol.24 , pp. 58-64
    • Harmon, J.T.1    Jamieson, G.A.2
  • 27
    • 0022870417 scopus 로고
    • The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity binding sites for thrombin
    • Harmon JT, Jamieson GA. The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity binding sites for thrombin. J Biol Chem 1986; 261:13224-13229
    • (1986) J Biol Chem , vol.261 , pp. 13224-13229
    • Harmon, J.T.1    Jamieson, G.A.2
  • 28
    • 0027933068 scopus 로고
    • Molecular cloning of a potential proteinase activated receptor
    • Nystedt S, Emilsson K, Wahlestedt C, et al. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci U S A 1994; 91:9208-9212
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9208-9212
    • Nystedt, S.1    Emilsson, K.2    Wahlestedt, C.3
  • 29
    • 0029113121 scopus 로고
    • Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
    • Nystedt S, Emilsson K, Larsson AK, et al. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem 1995; 232:84-89
    • (1995) Eur J Biochem , vol.232 , pp. 84-89
    • Nystedt, S.1    Emilsson, K.2    Larsson, A.K.3
  • 30
    • 0029849778 scopus 로고    scopus 로고
    • Cleavage of the thrombin receptor: Identification of potential activators and inactivators
    • Parry MA, Myles T, Tschopp J, et al. Cleavage of the thrombin receptor: identification of potential activators and inactivators. Biochem J 1996; 320:335-341
    • (1996) Biochem J , vol.320 , pp. 335-341
    • Parry, M.A.1    Myles, T.2    Tschopp, J.3
  • 31
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
    • Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A 2000; 97:5255-5260
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 32
    • 0033527565 scopus 로고    scopus 로고
    • Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene
    • Camerer E, Rottingen JA, Gjernes E, et al. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene. J Biol Chem 1999; 274:32225-32233
    • (1999) J Biol Chem , vol.274 , pp. 32225-32233
    • Camerer, E.1    Rottingen, J.A.2    Gjernes, E.3
  • 33
    • 0030008312 scopus 로고    scopus 로고
    • Role of the thrombin receptor in development and evidence for a second receptor
    • Connolly AJ, Ishihara H, Kahn ML, et al. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996; 381:516-519
    • (1996) Nature , vol.381 , pp. 516-519
    • Connolly, A.J.1    Ishihara, H.2    Kahn, M.L.3
  • 34
    • 0030979972 scopus 로고    scopus 로고
    • Protease-activated receptor 3 is a second thrombin receptor in humans
    • Ishihara H, Connolly AJ, Zeng D, et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997; 386:502-506
    • (1997) Nature , vol.386 , pp. 502-506
    • Ishihara, H.1    Connolly, A.J.2    Zeng, D.3
  • 35
    • 0034611727 scopus 로고    scopus 로고
    • PAR3 is a cofactor for PAR4 activation by thrombin
    • Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. PAR3 is a cofactor for PAR4 activation by thrombin. Nature 2000; 404:609-613
    • (2000) Nature , vol.404 , pp. 609-613
    • Nakanishi-Matsui, M.1    Zheng, Y.W.2    Sulciner, D.J.3
  • 36
    • 0032514474 scopus 로고    scopus 로고
    • A dual thrombin receptor system for platelet activation
    • Kahn ML, Zheng YW, Huang W, et al. A dual thrombin receptor system for platelet activation. Nature 1998; 394:690-694
    • (1998) Nature , vol.394 , pp. 690-694
    • Kahn, M.L.1    Zheng, Y.W.2    Huang, W.3
  • 37
    • 0032499696 scopus 로고    scopus 로고
    • Cloning and characterization of human protease-activated receptor 4
    • Xu WF, Andersen H, Whitmore TE, et al. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A 1998; 95:6642-6646
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6642-6646
    • Xu, W.F.1    Andersen, H.2    Whitmore, T.E.3
  • 38
    • 0033559805 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
    • Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest 1999; 103:879-887
    • (1999) J Clin Invest , vol.103 , pp. 879-887
    • Kahn, M.L.1    Nakanishi-Matsui, M.2    Shapiro, M.J.3
  • 39
    • 0035817822 scopus 로고    scopus 로고
    • Role of thrombin signalling in platelets in haemostasis and thrombosis
    • Sambrano GR, Weiss EJ, Zheng YW, et al. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 2001; 413:74-78
    • (2001) Nature , vol.413 , pp. 74-78
    • Sambrano, G.R.1    Weiss, E.J.2    Zheng, Y.W.3
  • 40
    • 0029026320 scopus 로고
    • Determinants of thrombin receptor cleavage: Receptor domains involved, specificity, and role of the P3 aspartate
    • Ishii K, Gerszten R, Zheng YW, et al. Determinants of thrombin receptor cleavage: receptor domains involved, specificity, and role of the P3 aspartate. J Biol Chem 1995; 270:16435-16440
    • (1995) J Biol Chem , vol.270 , pp. 16435-16440
    • Ishii, K.1    Gerszten, R.2    Zheng, Y.W.3
  • 41
    • 0034625055 scopus 로고    scopus 로고
    • Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets
    • Covic L, Gresser AL, Kuliopulos A. Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets. Biochemistry 2000; 39:5458-5467
    • (2000) Biochemistry , vol.39 , pp. 5458-5467
    • Covic, L.1    Gresser, A.L.2    Kuliopulos, A.3
  • 42
    • 0034682810 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin
    • Shapiro MJ, Weiss EJ, Faruqi TR, et al. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. J Biol Chem 2000; 275:25216-25221
    • (2000) J Biol Chem , vol.275 , pp. 25216-25221
    • Shapiro, M.J.1    Weiss, E.J.2    Faruqi, T.R.3
  • 44
    • 0034635224 scopus 로고    scopus 로고
    • The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of α-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III
    • De Cristofaro R, De Candia E, Rutella S, et al. The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of α-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III. J Biol Chem 2000; 275:3887-3895
    • (2000) J Biol Chem , vol.275 , pp. 3887-3895
    • De Cristofaro, R.1    De Candia, E.2    Rutella, S.3
  • 45
    • 0026317444 scopus 로고
    • Function of glycoprotein Ib α in platelet activation induced by alpha-thrombin
    • De Marco L, Mazzucato M, Masotti A, et al. Function of glycoprotein Ib α in platelet activation induced by alpha-thrombin. J Biol Chem 1991; 266:23776-23783
    • (1991) J Biol Chem , vol.266 , pp. 23776-23783
    • De Marco, L.1    Mazzucato, M.2    Masotti, A.3
  • 46
    • 0023900677 scopus 로고
    • Platelet activation by thrombin in the absence of the high-affinity thrombin receptor
    • Harmon JT, Jamieson GA. Platelet activation by thrombin in the absence of the high-affinity thrombin receptor. Biochemistry 1988; 27:2151-2157
    • (1988) Biochemistry , vol.27 , pp. 2151-2157
    • Harmon, J.T.1    Jamieson, G.A.2
  • 47
    • 0031893823 scopus 로고    scopus 로고
    • Characterization of the initial α-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation
    • Mazzucato M, Marco LD, Masotti A, et al. Characterization of the initial α-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation. J Biol Chem 1998; 273:1880-1887
    • (1998) J Biol Chem , vol.273 , pp. 1880-1887
    • Mazzucato, M.1    Marco, L.D.2    Masotti, A.3
  • 48
    • 0035895962 scopus 로고    scopus 로고
    • Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
    • De Candia E, Hall SW, Rutella S, et al. Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets. J Biol Chem 2001; 276:4692-4698
    • (2001) J Biol Chem , vol.276 , pp. 4692-4698
    • De Candia, E.1    Hall, S.W.2    Rutella, S.3
  • 49
    • 0035952643 scopus 로고    scopus 로고
    • Protease activated receptors: Theme and variations
    • O'Brien PJ, Molino M, Kahn M, et al. Protease activated receptors: theme and variations. Oncogene 2001; 20:1570-1581
    • (2001) Oncogene , vol.20 , pp. 1570-1581
    • O'Brien, P.J.1    Molino, M.2    Kahn, M.3


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